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CL2012000560A1 - Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08). - Google Patents

Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Info

Publication number
CL2012000560A1
CL2012000560A1 CL2012000560A CL2012000560A CL2012000560A1 CL 2012000560 A1 CL2012000560 A1 CL 2012000560A1 CL 2012000560 A CL2012000560 A CL 2012000560A CL 2012000560 A CL2012000560 A CL 2012000560A CL 2012000560 A1 CL2012000560 A1 CL 2012000560A1
Authority
CL
Chile
Prior art keywords
preparation
tetrahydrothiophene
oxo
carboxylic acid
divisional
Prior art date
Application number
CL2012000560A
Other languages
English (en)
Inventor
Chris Hugh Senanayake
Sonia Rodriguez
Rogelio Frutos
Dhileepkumar Krishnamurthy
Jason Alan Mulder
Thomas G Tampone
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40158557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012000560(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2012000560A1 publication Critical patent/CL2012000560A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento de preparación de compuestos intermediarios derivados de ésteres del ácido 3-oxo-tetrahidrotiofeno-2-carboxílico (Divisional Solicitud Nº 3095-08)
CL2012000560A 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08). CL2012000560A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98110507P 2007-10-18 2007-10-18

Publications (1)

Publication Number Publication Date
CL2012000560A1 true CL2012000560A1 (es) 2012-09-14

Family

ID=40158557

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2008003095A CL2008003095A1 (es) 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.
CL2012000560A CL2012000560A1 (es) 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2008003095A CL2008003095A1 (es) 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.

Country Status (20)

Country Link
US (1) US8653282B2 (es)
EP (1) EP2205608B1 (es)
JP (1) JP5538231B2 (es)
KR (1) KR20100095528A (es)
CN (2) CN103497201A (es)
AR (1) AR069077A1 (es)
AU (1) AU2008312624B2 (es)
BR (1) BRPI0818671A2 (es)
CA (1) CA2702500A1 (es)
CL (2) CL2008003095A1 (es)
DK (1) DK2205608T3 (es)
ES (1) ES2424445T3 (es)
IL (1) IL204854A0 (es)
MX (1) MX2010003826A (es)
NZ (2) NZ584962A (es)
PL (1) PL2205608T3 (es)
RU (1) RU2528340C2 (es)
TW (1) TW200918541A (es)
WO (1) WO2009052138A1 (es)
ZA (1) ZA201002425B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
BRPI0722082A8 (pt) 2006-12-26 2018-03-13 Lantheus Medical Imaging Inc ligantes para imagiologia da inervação cardíaca
CN101827853A (zh) 2007-10-19 2010-09-08 贝林格尔.英格海姆国际有限公司 杂环取代的哌嗪子基-二氢噻吩并嘧啶
ATE537175T1 (de) 2007-10-19 2011-12-15 Boehringer Ingelheim Int Neue piperazino-dihydrothienopyrimidin-derivate
KR101548975B1 (ko) * 2007-10-19 2015-09-01 베링거 인겔하임 인터내셔날 게엠베하 치환된 피페리디노-디하이드로티에노피리미딘
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
SG11201601980XA (en) 2013-09-18 2016-04-28 Beijing Hanmi Pharmaceutical Co Ltd Compound inhibiting activities of btk and/or jak3 kinases
JP2025528779A (ja) * 2022-08-09 2025-09-02 シーザン ハイスーク ファーマシューティカル カンパニー リミテッド Ｐｄｅ４ｂ阻害剤及びその用途
JP2025534418A (ja) 2022-09-29 2025-10-15 蘇州愛科百発生物医薬技術有限公司 含窒素縮合複素環化合物、その調製方法、および医薬におけるその使用
AU2024227968A1 (en) * 2023-02-28 2025-08-28 Innovstone Therapeutics Limited Preparation method for and use of dihydrothienopyrimidine derivative
CN116925099B (zh) * 2023-07-21 2025-06-03 厦门大学 手性二氢噻吩并嘧啶亚砜的制备方法及其应用与其2、4位取代化合物
TW202535412A (zh) * 2024-02-04 2025-09-16 大陸商西藏海思科製藥有限公司 Pde4b抑制劑的晶型及其在醫藥上的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
CH632755A5 (de) * 1976-04-10 1982-10-29 Basf Ag Verfahren zur herstellung von thiophenverbindungen.
DE2700215A1 (de) 1977-01-05 1978-07-13 Basf Ag Thiophenverbindungen und verfahren zur herstellung von thiophenverbindungen
US4974609A (en) * 1986-08-18 1990-12-04 Philip Morris Incorporated Tobacco flavorants
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
DE19540737A1 (de) 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
ID23978A (id) * 1997-11-11 2000-06-14 Pfizer Prod Inc Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
JP5021624B2 (ja) * 2005-04-21 2012-09-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の治療用新規化合物
EP1847543A1 (de) * 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
PL2205569T3 (pl) * 2007-09-25 2012-08-31 Actimis Pharmaceuticals Inc Alkilotiopirymidyny jako antagoniści crth2
CN101827853A (zh) * 2007-10-19 2010-09-08 贝林格尔.英格海姆国际有限公司 杂环取代的哌嗪子基-二氢噻吩并嘧啶
KR101548975B1 (ko) * 2007-10-19 2015-09-01 베링거 인겔하임 인터내셔날 게엠베하 치환된 피페리디노-디하이드로티에노피리미딘

Also Published As

Publication number Publication date
AU2008312624A1 (en) 2009-04-23
RU2010119647A (ru) 2011-11-27
ES2424445T3 (es) 2013-10-02
TW200918541A (en) 2009-05-01
BRPI0818671A2 (pt) 2015-09-15
CL2008003095A1 (es) 2010-01-22
US20100222585A1 (en) 2010-09-02
AR069077A1 (es) 2009-12-30
CN103497201A (zh) 2014-01-08
US8653282B2 (en) 2014-02-18
WO2009052138A8 (en) 2012-11-15
RU2528340C2 (ru) 2014-09-10
JP2011500701A (ja) 2011-01-06
NZ592534A (en) 2013-03-28
PL2205608T3 (pl) 2013-09-30
DK2205608T3 (da) 2013-07-01
EP2205608A1 (en) 2010-07-14
KR20100095528A (ko) 2010-08-31
ZA201002425B (en) 2011-02-23
IL204854A0 (en) 2010-11-30
JP5538231B2 (ja) 2014-07-02
AU2008312624B2 (en) 2014-07-10
CA2702500A1 (en) 2009-04-23
CN101903394B (zh) 2013-12-25
MX2010003826A (es) 2010-04-21
NZ584962A (en) 2011-07-29
EP2205608B1 (en) 2013-05-08
WO2009052138A1 (en) 2009-04-23
CN101903394A (zh) 2010-12-01

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