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TR200201166T1 - Saf sitalopram hazırlanması için yöntem - Google Patents

Saf sitalopram hazırlanması için yöntem

Info

Publication number
TR200201166T1
TR200201166T1 TR2002/01166T TR200201166T TR200201166T1 TR 200201166 T1 TR200201166 T1 TR 200201166T1 TR 2002/01166 T TR2002/01166 T TR 2002/01166T TR 200201166 T TR200201166 T TR 200201166T TR 200201166 T1 TR200201166 T1 TR 200201166T1
Authority
TR
Turkey
Prior art keywords
citalopram
treated
preparation
amide
subjected
Prior art date
Application number
TR2002/01166T
Other languages
English (en)
Inventor
Villa Marco
Sbrogio Federico
Dancer Robert
Original Assignee
H.Lundbecks A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbecks A/S filed Critical H.Lundbecks A/S
Publication of TR200201166T1 publication Critical patent/TR200201166T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Mevcut bulus sitalopram (I)'in hazirlanmasi ve saflastirilmasi için bir yöntem ile ilgili olup, formülde Z'nin iyodo, bromo, kloro ya da n'nin 0,1,2,3,4,5,6,7 ya da 8 oldugu CF3-(CF2)n-SO2-O-'yu ifade ettigi formül (II)'ye göre olan bir bilesik bir siyanid kaynagi ile bir siyanid degisim tepkimesine tabi tutulmakta, sonuçta elde edilen ham sitalopram ürün istege bagli olarak bazi birincil saflastirma islemine tabi tutulmakta ve ardindan bir amid veya bir amid benzeri grup olusturucu madde ile muamele edilmekte; tepkime karisimi bir asit/baz yikamasina ve/veya sitalopram'in kristalizasyon ve yeniden kristalizasyonuna tabi tutulmakta ve bu sekilde ham sitalopram karisimindan olusan amidler uzaklastirilmakta; ve sonuçta ortaya çikan sitalopram ürünü daha sonra istege bagli olarak ayrica saflastirilmakta, islenmekte ve baz ya da onun farmasötik olarak kabul edilebilir olan tuzu olarak izole edilmektedir.
TR2002/01166T 2000-12-22 2001-03-07 Saf sitalopram hazırlanması için yöntem TR200201166T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (1)

Publication Number Publication Date
TR200201166T1 true TR200201166T1 (tr) 2002-10-21

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01166T TR200201166T1 (tr) 2000-12-22 2001-03-07 Saf sitalopram hazırlanması için yöntem

Country Status (43)

Country Link
US (1) US6455710B1 (tr)
EP (2) EP1462447A3 (tr)
JP (1) JP3798982B2 (tr)
KR (1) KR100439329B1 (tr)
CN (1) CN1282648C (tr)
AR (1) AR030056A1 (tr)
AT (2) ATE277920T1 (tr)
AU (2) AU2001100405B4 (tr)
BE (2) BE1013212A6 (tr)
BG (1) BG65131B1 (tr)
BR (1) BR0106272A (tr)
CA (1) CA2360303C (tr)
CH (1) CH691535A5 (tr)
CZ (1) CZ292200B6 (tr)
DE (2) DE60105926T2 (tr)
DK (1) DK1181713T3 (tr)
EA (1) EA003581B1 (tr)
ES (2) ES2228824T3 (tr)
FI (2) FI108639B (tr)
FR (1) FR2812877B1 (tr)
GB (1) GB2357763B (tr)
GR (1) GR1003874B (tr)
HK (1) HK1048812B (tr)
HR (1) HRP20020004A2 (tr)
HU (2) HU0101029D0 (tr)
IE (1) IES20010254A2 (tr)
IL (1) IL147226A (tr)
IS (1) IS2060B (tr)
IT (1) ITMI20010602A1 (tr)
MX (1) MXPA01013151A (tr)
NL (2) NL1017525C1 (tr)
NO (1) NO20011271A (tr)
NZ (1) NZ516298A (tr)
PL (1) PL205724B1 (tr)
PT (1) PT1181713E (tr)
SE (1) SE517623C2 (tr)
SG (1) SG167655A1 (tr)
SI (1) SI1181713T1 (tr)
SK (2) SK286283B6 (tr)
TR (1) TR200201166T1 (tr)
UA (1) UA71634C2 (tr)
WO (1) WO2001045483A2 (tr)
ZA (1) ZA200110179B (tr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) * 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
CN1398263A (zh) 1999-12-28 2003-02-19 H·隆德贝克有限公司 制备西酞普兰的方法
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
NZ521204A (en) * 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CZ20032567A3 (en) * 2001-03-09 2004-04-14 Ranbaxy Laboratories Limited Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
PL368452A1 (en) * 2001-11-08 2005-03-21 Sepracor, Inc. Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
US20060030726A1 (en) * 2002-11-15 2006-02-09 Akzo Nobel N.V. Purification decolorization treatment for fatty nitriles
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
BR0318581A (pt) * 2003-10-28 2006-10-10 Wockhardt Ltd processo melhorando para fabriacação de bromidrato de citalopram
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

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DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
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DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143703A (tr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) * 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
CA2325909C (en) * 1997-06-30 2006-07-04 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
SK283309B6 (sk) * 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EP1140886B1 (en) 1998-12-23 2003-04-02 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu

Also Published As

Publication number Publication date
DE60105926D1 (de) 2004-11-04
DE10112829C1 (de) 2002-07-25
ES2170732A1 (es) 2002-08-01
IL147226A0 (en) 2002-08-14
AU3920101A (en) 2001-07-03
EP1462447A3 (en) 2004-11-17
CN1282648C (zh) 2006-11-01
BR0106272A (pt) 2004-06-15
IS5883A (is) 2001-06-20
NL1017525C1 (nl) 2001-04-26
GB0105983D0 (en) 2001-05-02
ES2170732B2 (es) 2003-09-16
EA003581B1 (ru) 2003-06-26
NO312462B1 (no) 2002-05-13
ES2228824T3 (es) 2005-04-16
BG65131B1 (bg) 2007-03-30
NO20011271A (no) 2002-05-13
SE517623C2 (sv) 2002-06-25
BG106203A (en) 2002-08-30
PT1181713E (pt) 2005-02-28
HUP0102817A3 (en) 2003-07-28
HRP20020004A2 (en) 2003-04-30
FR2812877B1 (fr) 2003-04-04
BE1013213A6 (fr) 2001-10-02
EP1181713A2 (en) 2002-02-27
SE0103045D0 (sv) 2001-09-14
PL353398A1 (en) 2003-11-17
NL1018360C1 (nl) 2001-10-04
AU2001100405B4 (en) 2002-03-21
CN1366525A (zh) 2002-08-28
SK286283B6 (sk) 2008-06-06
NZ516298A (en) 2002-12-20
GB2357763B (en) 2002-01-16
IES20010254A2 (en) 2002-03-06
ZA200110179B (en) 2002-12-11
BE1013212A6 (fr) 2001-10-02
HU0101029D0 (en) 2001-05-28
AU2001100405A4 (en) 2001-11-01
FI108639B (fi) 2002-02-28
CZ292200B6 (cs) 2003-08-13
US6455710B1 (en) 2002-09-24
CA2360303A1 (en) 2001-06-28
CH691535A5 (de) 2001-08-15
HU0102817D0 (en) 2001-09-28
FI20011577A0 (fi) 2001-07-26
HUP0102817A2 (hu) 2001-12-28
WO2001045483A2 (en) 2001-06-28
HK1048812B (zh) 2007-06-01
SG167655A1 (en) 2011-01-28
FR2812877A1 (fr) 2002-02-15
HK1048812A1 (en) 2003-04-17
SI1181713T1 (en) 2005-02-28
NO20011271D0 (no) 2001-03-13
AT4367U1 (de) 2001-06-25
IL147226A (en) 2006-04-10
JP2003517484A (ja) 2003-05-27
IS2060B (is) 2005-11-15
EP1462447A2 (en) 2004-09-29
KR100439329B1 (ko) 2004-07-07
UA71634C2 (uk) 2004-12-15
FI20010500A0 (fi) 2001-03-13
MXPA01013151A (es) 2002-08-12
CZ2001890A3 (cs) 2002-08-14
JP3798982B2 (ja) 2006-07-19
CA2360303C (en) 2003-08-12
SK18482001A3 (sk) 2002-05-09
ITMI20010602A0 (it) 2001-03-22
DE60105926T2 (de) 2005-11-24
DK1181713T3 (da) 2005-01-31
PL205724B1 (pl) 2010-05-31
SE0103045L (sv) 2002-06-23
AR030056A1 (es) 2003-08-13
KR20020065345A (ko) 2002-08-13
GR1003874B (el) 2002-04-24
ATE277920T1 (de) 2004-10-15
GB2357763A (en) 2001-07-04
EA200200018A1 (ru) 2002-04-25
WO2001045483A3 (en) 2001-12-27
EP1181713B1 (en) 2004-09-29
US20020120005A1 (en) 2002-08-29
ITMI20010602A1 (it) 2002-09-22
SK284428B6 (sk) 2005-04-01

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