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TR200200018T1 - Saf sitalopram hazırlanması için yöntem. - Google Patents

Saf sitalopram hazırlanması için yöntem.

Info

Publication number
TR200200018T1
TR200200018T1 TR2002/00018T TR200200018T TR200200018T1 TR 200200018 T1 TR200200018 T1 TR 200200018T1 TR 2002/00018 T TR2002/00018 T TR 2002/00018T TR 200200018 T TR200200018 T TR 200200018T TR 200200018 T1 TR200200018 T1 TR 200200018T1
Authority
TR
Turkey
Prior art keywords
subjected
cyanide
citalopram
formula
preparation
Prior art date
Application number
TR2002/00018T
Other languages
English (en)
Inventor
Castellin Andrea
Volpe Giulio
Sbrogio Federico
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200200018T1 publication Critical patent/TR200200018T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Formül (I)'in sitalopraminin hazirlanmasi için bir yöntem; öyle ki bu yöntemde Z'nin iyodo, bromo, kloro ya da n'nin 0, 1, 2, 3, 4, 5, 6, 7 ya da 8 oldugu CF3-(CF2)n-SO2-O- oldugu formül (II)'in bir bilesimi bir siyanid degisim tepkimesine tabi tutulur ki burada bir siyanid kaynagiyla tepkimeye sokulan Z grubu siyanid ile degistirilir; sonuçta elde edilen ham sitalopram ürün istege bagli olarak bazi birincil saflastirmalara tabi tutulur ve ham sitalopram baz daha sonra bir film damitma yöntemine tabi tutulur; sonuçta ortaya çikan sitalopram ürün daha sonra istege bagli olarak ayrica saflastirilir, islenir ve baz ya da onun farmasötik olarak kabul edilebilir olan tuzu halinde izole edilir.
TR2002/00018T 2000-12-28 2001-03-07 Saf sitalopram hazırlanması için yöntem. TR200200018T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28

Publications (1)

Publication Number Publication Date
TR200200018T1 true TR200200018T1 (tr) 2002-06-21

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00018T TR200200018T1 (tr) 2000-12-28 2001-03-07 Saf sitalopram hazırlanması için yöntem.

Country Status (41)

Country Link
US (2) US6855834B2 (tr)
EP (1) EP1181272B1 (tr)
JP (1) JP2003519121A (tr)
KR (1) KR100430746B1 (tr)
CN (1) CN1366526A (tr)
AR (1) AR029898A1 (tr)
AT (2) ATE222899T1 (tr)
AU (3) AU3920201A (tr)
BE (2) BE1013417A6 (tr)
BG (1) BG106219A (tr)
BR (1) BR0106271A (tr)
CA (1) CA2359810C (tr)
CH (1) CH691536A5 (tr)
CZ (1) CZ293140B6 (tr)
DE (1) DE60100016T2 (tr)
DK (1) DK1181272T3 (tr)
EA (1) EA003459B1 (tr)
ES (2) ES2181663T3 (tr)
FI (2) FI108640B (tr)
FR (1) FR2818977B1 (tr)
GB (2) GB2356199B (tr)
GR (1) GR20010100131A (tr)
HK (1) HK1049332A1 (tr)
HR (1) HRP20020005A2 (tr)
HU (2) HU0101028D0 (tr)
IE (2) IES20010253A2 (tr)
IL (1) IL147162A0 (tr)
IS (1) IS5884A (tr)
IT (1) ITMI20010604A1 (tr)
MX (1) MXPA01013336A (tr)
NL (1) NL1017534C1 (tr)
NO (1) NO313047B1 (tr)
NZ (1) NZ516299A (tr)
PL (1) PL353369A1 (tr)
PT (1) PT1181272E (tr)
SE (1) SE0103044L (tr)
SK (1) SK284418B6 (tr)
TR (1) TR200200018T1 (tr)
UA (1) UA71635C2 (tr)
WO (1) WO2001047877A2 (tr)
ZA (1) ZA200110133B (tr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) * 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CN1398263A (zh) 1999-12-28 2003-02-19 H·隆德贝克有限公司 制备西酞普兰的方法
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
NZ521204A (en) * 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

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Publication number Priority date Publication date Assignee Title
NL135959C (tr) 1964-12-23
GB1143703A (tr) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
DE69725717T2 (de) 1996-05-21 2004-07-29 Exxonmobil Chemical Patents Inc., Baytown Reinigung von glycidylestern durch dünnschichtverdampfung
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
SK283309B6 (sk) 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EP0965593B2 (en) 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EP1140886B1 (en) 1998-12-23 2003-04-02 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
IS5884A (is) 2002-06-28
PL353369A1 (en) 2003-11-17
GR20010100131A (el) 2002-10-09
ES2170733B1 (es) 2003-12-16
HU0101028D0 (en) 2001-05-28
AU750006B1 (en) 2002-07-11
WO2001047877A2 (en) 2001-07-05
GB2361697A (en) 2001-10-31
JP2003519121A (ja) 2003-06-17
HUP0102818A3 (en) 2003-07-28
SK284418B6 (sk) 2005-04-01
ITMI20010604A0 (it) 2001-03-22
CA2359810A1 (en) 2001-07-05
HK1049332A1 (zh) 2003-05-09
CA2359810C (en) 2002-11-05
GB2356199B (en) 2001-10-03
EP1181272B1 (en) 2002-08-28
EA003459B1 (ru) 2003-06-26
NZ516299A (en) 2002-12-20
NO20011272L (no) 2002-07-01
EA200200016A1 (ru) 2002-04-25
FI20011578A0 (fi) 2001-07-26
EP1181272A2 (en) 2002-02-27
CZ2001891A3 (cs) 2002-08-14
US20020087012A1 (en) 2002-07-04
DE60100016D1 (de) 2002-10-02
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
KR20020073379A (ko) 2002-09-26
CH691536A5 (de) 2001-08-15
NL1017534C1 (nl) 2001-04-26
US20030178295A1 (en) 2003-09-25
WO2001047877A3 (en) 2001-12-27
DK1181272T3 (da) 2002-12-30
BR0106271A (pt) 2002-05-21
HUP0102818A2 (hu) 2001-12-28
ZA200110133B (en) 2003-01-13
ES2181663T3 (es) 2003-03-01
GB0117095D0 (en) 2001-09-05
AU2001100399B4 (en) 2002-03-21
NO313047B1 (no) 2002-08-05
IES20010253A2 (en) 2002-03-06
DE60100016T2 (de) 2003-04-17
HRP20020005A2 (en) 2003-04-30
ITMI20010604A1 (it) 2002-09-22
IES20010632A2 (en) 2002-03-06
SE0103044D0 (sv) 2001-09-14
BE1013316A6 (fr) 2001-11-06
AU3920201A (en) 2001-07-09
US6855834B2 (en) 2005-02-15
ES2170733A1 (es) 2002-08-01
IL147162A0 (en) 2002-08-14
BE1013417A6 (fr) 2001-12-04
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
FR2818977A1 (fr) 2002-07-05
GB0105981D0 (en) 2001-05-02
SE0103044L (sv) 2002-06-29
ATE222899T1 (de) 2002-09-15
BG106219A (en) 2002-08-30
KR100430746B1 (ko) 2004-05-10
HU0102818D0 (en) 2001-09-28
CZ293140B6 (cs) 2004-02-18
AU2001100399A4 (en) 2001-11-01
PT1181272E (pt) 2003-01-31
FI108640B (fi) 2002-02-28
CN1366526A (zh) 2002-08-28
AT4368U1 (de) 2001-06-25
SK18472001A3 (sk) 2002-05-09
FR2818977B1 (fr) 2003-12-05
AR029898A1 (es) 2003-07-23
MXPA01013336A (es) 2002-07-09

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