SG48919A1 - New extractive process for the recovery of naturally occuring macrolides - Google Patents
New extractive process for the recovery of naturally occuring macrolidesInfo
- Publication number
- SG48919A1 SG48919A1 SG1996003747A SG1996003747A SG48919A1 SG 48919 A1 SG48919 A1 SG 48919A1 SG 1996003747 A SG1996003747 A SG 1996003747A SG 1996003747 A SG1996003747 A SG 1996003747A SG 48919 A1 SG48919 A1 SG 48919A1
- Authority
- SG
- Singapore
- Prior art keywords
- macrolide
- solvent
- solution
- impurities
- macrolides
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 3
- 229940041033 macrolides Drugs 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 5
- 239000012535 impurity Substances 0.000 abstract 4
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 239000011877 solvent mixture Substances 0.000 abstract 2
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14809693A | 1993-11-05 | 1993-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG48919A1 true SG48919A1 (en) | 1998-05-18 |
Family
ID=22524259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996003747A SG48919A1 (en) | 1993-11-05 | 1994-11-03 | New extractive process for the recovery of naturally occuring macrolides |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5508398A (pt) |
| EP (1) | EP0652219B1 (pt) |
| JP (1) | JP4202433B2 (pt) |
| KR (1) | KR100393952B1 (pt) |
| CN (1) | CN1037772C (pt) |
| AT (1) | ATE202356T1 (pt) |
| AU (1) | AU7759594A (pt) |
| BR (1) | BR9404265A (pt) |
| CA (1) | CA2134844C (pt) |
| CZ (1) | CZ291865B6 (pt) |
| DE (1) | DE69427513T2 (pt) |
| DK (1) | DK0652219T3 (pt) |
| ES (1) | ES2157239T3 (pt) |
| FI (1) | FI112378B (pt) |
| GR (1) | GR3036207T3 (pt) |
| HU (1) | HU222576B1 (pt) |
| IL (1) | IL111424A (pt) |
| NZ (1) | NZ264852A (pt) |
| PT (1) | PT652219E (pt) |
| RU (1) | RU2152998C2 (pt) |
| SG (1) | SG48919A1 (pt) |
| SK (1) | SK130494A3 (pt) |
| TW (1) | TW408125B (pt) |
| UA (1) | UA41884C2 (pt) |
| ZA (1) | ZA948641B (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| IT1289815B1 (it) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| HRP20040765A2 (en) | 2002-02-13 | 2005-02-28 | Biogal Gyogyszergyar Rt. | Method for extracting a macrolide from biomatter |
| US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
| WO2004007709A2 (en) * | 2002-07-16 | 2004-01-22 | Biotica Technology Limited | Production of polyketides |
| ES2229975T1 (es) | 2003-03-31 | 2005-05-01 | Teva Gyogyszergyar Reszvenytarsasag | Cristalizacion y purificacion de macrolidos. |
| US20060169199A1 (en) * | 2003-03-31 | 2006-08-03 | Vilmos Keri | Crystallization and purification of macrolides |
| PL1558622T3 (pl) * | 2003-07-24 | 2008-06-30 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Sposób oczyszczania makrolidów |
| AU2003269473A1 (en) * | 2003-08-26 | 2005-03-10 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| US20050112786A1 (en) * | 2003-11-25 | 2005-05-26 | Qing Wang | Method of immobilizing a substance of interest to a solid phase |
| RU2317991C1 (ru) * | 2003-12-05 | 2008-02-27 | Байокон Лимитид | Способ выделения и очистки макролидов |
| KR20070009578A (ko) * | 2004-03-02 | 2007-01-18 | 와이어쓰 | 마크롤라이드 및 이의 제조 방법 |
| EP1720548A1 (en) * | 2004-03-02 | 2006-11-15 | Wyeth | Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents |
| JP4620405B2 (ja) * | 2004-08-02 | 2011-01-26 | アサヒビール株式会社 | 酵母変異株、グルタチオン高含有酵母の製造方法、その培養物、その分画物、酵母エキスおよびグルタチオン含有飲食品 |
| AR050374A1 (es) * | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
| JP2007523069A (ja) * | 2004-12-01 | 2007-08-16 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 非吸湿性及び粉末性非晶質ピメクロリマス |
| CA2586700A1 (en) * | 2004-12-22 | 2006-06-29 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Method of purifying tacrolimus |
| MX2007006119A (es) * | 2005-01-05 | 2007-07-19 | Teva Gyogyszergyar Zartkoruen | Tacrolimus amorfo y preparacion de el. |
| DE602007006601D1 (de) * | 2006-03-15 | 2010-07-01 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von tacrolimus |
| KR100740582B1 (ko) * | 2006-09-27 | 2007-07-19 | 한국과학기술연구원 | 가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법 |
| RU2009122202A (ru) * | 2006-11-10 | 2010-12-20 | Биокон Лимитед (In) | Чистая форма рапамицина и способ ее выделения и очистки |
| CN102070652B (zh) * | 2011-02-21 | 2012-05-02 | 西南大学 | 一种从发酵液中分离提取西罗莫司的方法 |
| WO2014072984A1 (en) | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Improved process for isolation and purification of rapamycin from fermentation broth |
| CN108976245B (zh) * | 2017-11-09 | 2020-08-07 | 北大方正集团有限公司 | 一种雷帕霉素的提取方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| GB9125660D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compound |
-
1994
- 1994-10-26 UA UA94105969A patent/UA41884C2/uk unknown
- 1994-10-27 IL IL11142494A patent/IL111424A/xx not_active IP Right Cessation
- 1994-10-27 SK SK1304-94A patent/SK130494A3/sk unknown
- 1994-10-27 BR BR9404265A patent/BR9404265A/pt not_active Application Discontinuation
- 1994-10-28 RU RU94039281/13A patent/RU2152998C2/ru not_active IP Right Cessation
- 1994-10-28 TW TW083109959A patent/TW408125B/zh not_active IP Right Cessation
- 1994-11-01 JP JP26862094A patent/JP4202433B2/ja not_active Expired - Lifetime
- 1994-11-01 CN CN94113741A patent/CN1037772C/zh not_active Expired - Fee Related
- 1994-11-01 CZ CZ19942674A patent/CZ291865B6/cs not_active IP Right Cessation
- 1994-11-01 KR KR1019940028472A patent/KR100393952B1/ko not_active Expired - Fee Related
- 1994-11-01 CA CA002134844A patent/CA2134844C/en not_active Expired - Fee Related
- 1994-11-02 AU AU77595/94A patent/AU7759594A/en not_active Abandoned
- 1994-11-02 ZA ZA948641A patent/ZA948641B/xx unknown
- 1994-11-03 SG SG1996003747A patent/SG48919A1/en unknown
- 1994-11-03 DK DK94308107T patent/DK0652219T3/da active
- 1994-11-03 HU HU9403164A patent/HU222576B1/hu not_active IP Right Cessation
- 1994-11-03 NZ NZ264852A patent/NZ264852A/en not_active IP Right Cessation
- 1994-11-03 PT PT94308107T patent/PT652219E/pt unknown
- 1994-11-03 DE DE69427513T patent/DE69427513T2/de not_active Expired - Lifetime
- 1994-11-03 FI FI945186A patent/FI112378B/fi not_active IP Right Cessation
- 1994-11-03 EP EP94308107A patent/EP0652219B1/en not_active Expired - Lifetime
- 1994-11-03 ES ES94308107T patent/ES2157239T3/es not_active Expired - Lifetime
- 1994-11-03 AT AT94308107T patent/ATE202356T1/de active
-
1995
- 1995-01-04 US US08/368,675 patent/US5508398A/en not_active Expired - Lifetime
-
2001
- 2001-07-11 GR GR20010401060T patent/GR3036207T3/el unknown
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