BR9404265A - Processo para separação de uma macrolida de impurezas neutras acídicas, básicas e não-polares - Google Patents

Processo para separação de uma macrolida de impurezas neutras acídicas, básicas e não-polares

Info

Publication number: BR9404265A
Authority: BR; Brazil
Prior art keywords: macrolide; solvent; solution; acidic; basic
Prior art date: 1993-11-05

Application number

BR9404265A

Other languages

English (en)

Inventor

Constantine Gletsos

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-05

Filing date

1994-10-27

Publication date

1995-07-04

1994-10-27 Application filed by American Home Prod filed Critical American Home Prod

1995-07-04 Publication of BR9404265A publication Critical patent/BR9404265A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Extraction Or Liquid Replacement (AREA)
Peptides Or Proteins (AREA)
Pyrane Compounds (AREA)

BR9404265A 1993-11-05 1994-10-27 Processo para separação de uma macrolida de impurezas neutras acídicas, básicas e não-polares BR9404265A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14809693A	1993-11-05	1993-11-05

Publications (1)

Publication Number	Publication Date
BR9404265A true BR9404265A (pt)	1995-07-04

Family

ID=22524259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9404265A BR9404265A (pt)	1993-11-05	1994-10-27	Processo para separação de uma macrolida de impurezas neutras acídicas, básicas e não-polares

Country Status (25)

Country	Link
US (1)	US5508398A (pt)
EP (1)	EP0652219B1 (pt)
JP (1)	JP4202433B2 (pt)
KR (1)	KR100393952B1 (pt)
CN (1)	CN1037772C (pt)
AT (1)	ATE202356T1 (pt)
AU (1)	AU7759594A (pt)
BR (1)	BR9404265A (pt)
CA (1)	CA2134844C (pt)
CZ (1)	CZ291865B6 (pt)
DE (1)	DE69427513T2 (pt)
DK (1)	DK0652219T3 (pt)
ES (1)	ES2157239T3 (pt)
FI (1)	FI112378B (pt)
GR (1)	GR3036207T3 (pt)
HU (1)	HU222576B1 (pt)
IL (1)	IL111424A (pt)
NZ (1)	NZ264852A (pt)
PT (1)	PT652219E (pt)
RU (1)	RU2152998C2 (pt)
SG (1)	SG48919A1 (pt)
SK (1)	SK130494A3 (pt)
TW (1)	TW408125B (pt)
UA (1)	UA41884C2 (pt)
ZA (1)	ZA948641B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9618952D0 (en)	1996-09-11	1996-10-23	Sandoz Ltd	Process
IT1289815B1 (it) *	1996-12-30	1998-10-16	Sorin Biomedica Cardio Spa	Stent per angioplastica e relativo procedimento di produzione
GB9713730D0 (en) *	1997-06-30	1997-09-03	Ciba Geigy Ag	Organic compounds
JP4261365B2 (ja)	2002-02-13	2009-04-30	テバジョジセルジャールザ−トケルエンムケドレ−スベニュタ−ルシャシャ−グ	生物学的物質からのマクロライドの抽出方法
US7452692B2 (en)	2002-02-13	2008-11-18	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Method for extracting a macrolide from biomatter
US7300942B2 (en) *	2002-07-16	2007-11-27	Biotica Technology Limited	Production of polyketides and other natural products
JP4468943B2 (ja) *	2003-03-31	2010-05-26	テバジョジセルジャールザ−トケルエンムケドレ−スベニュタ−ルシャシャ−グ	マクロライド系の結晶化及び精製
US7645876B2 (en) *	2004-12-01	2010-01-12	TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság	Processes for producing crystalline macrolides
US20060169199A1 (en) *	2003-03-31	2006-08-03	Vilmos Keri	Crystallization and purification of macrolides
DK1558622T3 (da)	2003-07-24	2008-02-25	Teva Gyogyszergyar Zartkoeruee	Fremgangsmåde til oprensning af macrolider
WO2005019226A1 (en) *	2003-08-26	2005-03-03	Biocon Limited	A process for the recovery of substantially pure tricyclic macrolide
US20050112786A1 (en) *	2003-11-25	2005-05-26	Qing Wang	Method of immobilizing a substance of interest to a solid phase
SI1697383T1 (sl) *	2003-12-05	2014-09-30	Biocon Limited	Postopek za ÄŤiĹˇÄŤenje takrolimusa
CN1929837A (zh) *	2004-03-02	2007-03-14	惠氏公司	作为神经保护剂和/或神经再生剂的非免疫抑制的亲免素配体
US7247650B2 (en) *	2004-03-02	2007-07-24	Wyeth	Macrolides and methods for producing same
JP4620405B2 (ja) *	2004-08-02	2011-01-26	アサヒビール株式会社	酵母変異株、グルタチオン高含有酵母の製造方法、その培養物、その分画物、酵母エキスおよびグルタチオン含有飲食品
AR050374A1 (es)	2004-08-20	2006-10-18	Wyeth Corp	Forma polimorfica de rafampicina
TW200637834A (en) *	2004-12-22	2006-11-01	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Method of purifying macrolides
MX2007006119A (es) *	2005-01-05	2007-07-19	Teva Gyogyszergyar Zartkoruen	Tacrolimus amorfo y preparacion de el.
TW200815458A (en) *	2006-03-15	2008-04-01	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Process for purifying Tacrolimus
KR100740582B1 (ko) *	2006-09-27	2007-07-19	한국과학기술연구원	가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법
CA2669714A1 (en) *	2006-11-10	2008-05-15	Biocon Limited	A pure form of rapamycin and a process for recovery and purification thereof
CN102070652B (zh) *	2011-02-21	2012-05-02	西南大学	一种从发酵液中分离提取西罗莫司的方法
WO2014072984A1 (en)	2012-11-06	2014-05-15	Natco Pharma Limited	Improved process for isolation and purification of rapamycin from fermentation broth
CN108976245B (zh) *	2017-11-09	2020-08-07	北大方正集团有限公司	一种雷帕霉素的提取方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3993749A (en) *	1974-04-12	1976-11-23	Ayerst Mckenna And Harrison Ltd.	Rapamycin and process of preparation
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5091389A (en) *	1991-04-23	1992-02-25	Merck & Co., Inc.	Lipophilic macrolide useful as an immunosuppressant
GB9125660D0 (en) *	1991-12-03	1992-01-29	Smithkline Beecham Plc	Novel compound

1994
- 1994-10-26 UA UA94105969A patent/UA41884C2/uk unknown
- 1994-10-27 IL IL11142494A patent/IL111424A/xx not_active IP Right Cessation
- 1994-10-27 BR BR9404265A patent/BR9404265A/pt not_active Application Discontinuation
- 1994-10-27 SK SK1304-94A patent/SK130494A3/sk unknown
- 1994-10-28 RU RU94039281/13A patent/RU2152998C2/ru not_active IP Right Cessation
- 1994-10-28 TW TW083109959A patent/TW408125B/zh not_active IP Right Cessation
- 1994-11-01 KR KR1019940028472A patent/KR100393952B1/ko not_active Expired - Fee Related
- 1994-11-01 JP JP26862094A patent/JP4202433B2/ja not_active Expired - Lifetime
- 1994-11-01 CN CN94113741A patent/CN1037772C/zh not_active Expired - Fee Related
- 1994-11-01 CZ CZ19942674A patent/CZ291865B6/cs not_active IP Right Cessation
- 1994-11-01 CA CA002134844A patent/CA2134844C/en not_active Expired - Fee Related
- 1994-11-02 ZA ZA948641A patent/ZA948641B/xx unknown
- 1994-11-02 AU AU77595/94A patent/AU7759594A/en not_active Abandoned
- 1994-11-03 AT AT94308107T patent/ATE202356T1/de active
- 1994-11-03 NZ NZ264852A patent/NZ264852A/en not_active IP Right Cessation
- 1994-11-03 DE DE69427513T patent/DE69427513T2/de not_active Expired - Lifetime
- 1994-11-03 HU HU9403164A patent/HU222576B1/hu not_active IP Right Cessation
- 1994-11-03 SG SG1996003747A patent/SG48919A1/en unknown
- 1994-11-03 PT PT94308107T patent/PT652219E/pt unknown
- 1994-11-03 DK DK94308107T patent/DK0652219T3/da active
- 1994-11-03 EP EP94308107A patent/EP0652219B1/en not_active Expired - Lifetime
- 1994-11-03 FI FI945186A patent/FI112378B/fi not_active IP Right Cessation
- 1994-11-03 ES ES94308107T patent/ES2157239T3/es not_active Expired - Lifetime
1995
- 1995-01-04 US US08/368,675 patent/US5508398A/en not_active Expired - Lifetime
2001
- 2001-07-11 GR GR20010401060T patent/GR3036207T3/el unknown

Also Published As

Publication number	Publication date
FI112378B (fi)	2003-11-28
EP0652219B1 (en)	2001-06-20
DE69427513D1 (de)	2001-07-26
FI945186A0 (fi)	1994-11-03
PT652219E (pt)	2001-09-28
EP0652219A1 (en)	1995-05-10
FI945186L (fi)	1995-05-06
IL111424A0 (en)	1994-12-29
HU9403164D0 (en)	1994-12-28
DK0652219T3 (da)	2001-08-27
CN1109058A (zh)	1995-09-27
DE69427513T2 (de)	2001-11-22
KR950014311A (ko)	1995-06-15
SG48919A1 (en)	1998-05-18
ZA948641B (en)	1996-05-02
NZ264852A (en)	1995-12-21
ATE202356T1 (de)	2001-07-15
ES2157239T3 (es)	2001-08-16
JPH07184674A (ja)	1995-07-25
KR100393952B1 (ko)	2003-12-11
UA41884C2 (uk)	2001-10-15
CZ267494A3 (en)	1995-05-17
GR3036207T3 (en)	2001-10-31
SK130494A3 (en)	1995-07-11
TW408125B (en)	2000-10-11
IL111424A (en)	1999-10-28
HU222576B1 (hu)	2003-08-28
CA2134844A1 (en)	1995-05-06
HUT71122A (en)	1995-11-28
CZ291865B6 (cs)	2003-06-18
CA2134844C (en)	2007-10-16
CN1037772C (zh)	1998-03-18
AU7759594A (en)	1995-05-18
JP4202433B2 (ja)	2008-12-24
RU2152998C2 (ru)	2000-07-20
RU94039281A (ru)	1997-03-27
US5508398A (en)	1996-04-16

Publication	Publication Date	Title
BR9404265A (pt)	1995-07-04	Processo para separação de uma macrolida de impurezas neutras acídicas, básicas e não-polares
ATE244280T1 (de)	2003-07-15	Transxanthophyllesterkonzenrate von erhöhter reinheit und verfahren zu deren herstellung
WO1994008708A3 (en)	1994-08-18	Compositions of fatty acid esters of hexitans
DE68900939D1 (de)	1992-04-09	Entfernung von sauren verunreinigungen in einem loesungsmittelextraktionsverfahren zur trennung von aromaten von nichtaromaten.
BR8703192A (pt)	1988-03-08	Processo de separacao de acidos aminados
ATE33014T1 (de)	1988-04-15	Verfahren zur reinigung von nassverfahrensphosphorsaeure.
FR2612911B1 (fr)	1991-04-05	Procede de separation des terres rares par extraction liquide-liquide
MA22661A1 (fr)	1993-04-01	Procede de purification et de recuperation d'acide orthophosphorique par extraction liquide-liquide .
ATE395428T1 (de)	2008-05-15	Verfahren zur isolierung und reinigung von lipidezellwandkomponenten
JPS5684307A (en)	1981-07-09	Wet phosphoric acid refining method
CA2133184A1 (en)	1995-04-09	Controlled Acid - Strong Acid Strip Process
KR900003106A (ko)	1990-03-23	아미노산의 수용액으로부터 아미노산의 개량된 추출공정
BR8004138A (pt)	1981-01-21	Processo para a purificacao de uma solucao aquosa de acidofosforico do processo via umida
DE68928249D1 (de)	1997-09-18	Verfahren zur Trennung von Methylester von alpha-L-aspartyl-L-phenylalaninen
DE3773145D1 (de)	1991-10-24	Extraktionsverfahren zur abtrennung einer carbonsaeure aus wasserhaltiger loesung solcher saeure.
SU132753A1 (ru)	1959-11-30	Способ устранени флуоресценции минеральных масел
DE3763068D1 (de)	1990-07-12	Verfahren zur abtrennung und reinigung organischer substanzen von begleitstoffen.
ATE84782T1 (de)	1993-02-15	Isolierung von neutralen aminosaeuren bei hohen ph-werten.

Legal Events

Date	Code	Title	Description
1998-01-21	FA	Application withdrawn