IL111424A - Extraction process for the recovery of naturally occurring neutral non-polypeptide macrolides - Google Patents
Extraction process for the recovery of naturally occurring neutral non-polypeptide macrolidesInfo
- Publication number
- IL111424A IL111424A IL11142494A IL11142494A IL111424A IL 111424 A IL111424 A IL 111424A IL 11142494 A IL11142494 A IL 11142494A IL 11142494 A IL11142494 A IL 11142494A IL 111424 A IL111424 A IL 111424A
- Authority
- IL
- Israel
- Prior art keywords
- macrolide
- solvent
- solution
- impurities
- macrolides
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 11
- 230000007935 neutral effect Effects 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title abstract 2
- 229940041033 macrolides Drugs 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 5
- 239000012535 impurity Substances 0.000 abstract 4
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011877 solvent mixture Substances 0.000 abstract 2
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extraction Or Liquid Replacement (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12155697A IL121556A0 (en) | 1993-11-05 | 1997-08-15 | Process for the recovery of naturally occurring macrolides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14809693A | 1993-11-05 | 1993-11-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL111424A0 IL111424A0 (en) | 1994-12-29 |
| IL111424A true IL111424A (en) | 1999-10-28 |
Family
ID=22524259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11142494A IL111424A (en) | 1993-11-05 | 1994-10-27 | Extraction process for the recovery of naturally occurring neutral non-polypeptide macrolides |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5508398A (pt) |
| EP (1) | EP0652219B1 (pt) |
| JP (1) | JP4202433B2 (pt) |
| KR (1) | KR100393952B1 (pt) |
| CN (1) | CN1037772C (pt) |
| AT (1) | ATE202356T1 (pt) |
| AU (1) | AU7759594A (pt) |
| BR (1) | BR9404265A (pt) |
| CA (1) | CA2134844C (pt) |
| CZ (1) | CZ291865B6 (pt) |
| DE (1) | DE69427513T2 (pt) |
| DK (1) | DK0652219T3 (pt) |
| ES (1) | ES2157239T3 (pt) |
| FI (1) | FI112378B (pt) |
| GR (1) | GR3036207T3 (pt) |
| HU (1) | HU222576B1 (pt) |
| IL (1) | IL111424A (pt) |
| NZ (1) | NZ264852A (pt) |
| PT (1) | PT652219E (pt) |
| RU (1) | RU2152998C2 (pt) |
| SG (1) | SG48919A1 (pt) |
| SK (1) | SK130494A3 (pt) |
| TW (1) | TW408125B (pt) |
| UA (1) | UA41884C2 (pt) |
| ZA (1) | ZA948641B (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| IT1289815B1 (it) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
| GB9713730D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| EP1474404A4 (en) * | 2002-02-13 | 2006-01-11 | Biogal Gyogyszergyar | PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL |
| US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
| WO2004007709A2 (en) * | 2002-07-16 | 2004-01-22 | Biotica Technology Limited | Production of polyketides |
| TR200500302T3 (tr) | 2003-03-31 | 2005-04-21 | Biogal Gyogyszergyar Rt. | Makrolidlerin kristalizasyonu ve saflaştırılması. |
| US20060169199A1 (en) * | 2003-03-31 | 2006-08-03 | Vilmos Keri | Crystallization and purification of macrolides |
| ATE378345T1 (de) | 2003-07-24 | 2007-11-15 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur aufreinigung von makroliden |
| WO2005019226A1 (en) * | 2003-08-26 | 2005-03-03 | Biocon Limited | A process for the recovery of substantially pure tricyclic macrolide |
| US20050112786A1 (en) * | 2003-11-25 | 2005-05-26 | Qing Wang | Method of immobilizing a substance of interest to a solid phase |
| US7473366B2 (en) * | 2003-12-05 | 2009-01-06 | Biocon Limited | Process for the purification of macrolides |
| GT200500035A (es) * | 2004-03-02 | 2005-10-24 | Macrolidos y metodos para producir los mismos | |
| BRPI0508084A (pt) * | 2004-03-02 | 2007-07-17 | Wyeth Corp | método para o tratamento de um distúrbio neurológico, e, uso de meridamicina ou um sal do mesmo |
| JP4620405B2 (ja) * | 2004-08-02 | 2011-01-26 | アサヒビール株式会社 | 酵母変異株、グルタチオン高含有酵母の製造方法、その培養物、その分画物、酵母エキスおよびグルタチオン含有飲食品 |
| AR050374A1 (es) * | 2004-08-20 | 2006-10-18 | Wyeth Corp | Forma polimorfica de rafampicina |
| WO2006060615A1 (en) * | 2004-12-01 | 2006-06-08 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Non-hygroscopic and powdery amorphous pimecrolimus |
| WO2006069386A1 (en) * | 2004-12-22 | 2006-06-29 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method of purifying tacrolimus |
| CA2588480A1 (en) * | 2005-01-05 | 2006-08-10 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Amorphous tacrolimus and preparation thereof |
| JP4700022B2 (ja) * | 2006-03-15 | 2011-06-15 | アイバックス ファーマシューティカルズ スポレツノスト エス ルチェニム オメゼニム | タクロリマスの精製方法 |
| KR100740582B1 (ko) * | 2006-09-27 | 2007-07-19 | 한국과학기술연구원 | 가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법 |
| MX2009005012A (es) * | 2006-11-10 | 2009-09-07 | Biocon Ltd | Una forma pura de rapamicina y procedimiento para la recuperacion y purificacion de la misma. |
| CN102070652B (zh) * | 2011-02-21 | 2012-05-02 | 西南大学 | 一种从发酵液中分离提取西罗莫司的方法 |
| WO2014072984A1 (en) | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Improved process for isolation and purification of rapamycin from fermentation broth |
| CN108976245B (zh) * | 2017-11-09 | 2020-08-07 | 北大方正集团有限公司 | 一种雷帕霉素的提取方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5091389A (en) * | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| GB9125660D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compound |
-
1994
- 1994-10-26 UA UA94105969A patent/UA41884C2/uk unknown
- 1994-10-27 IL IL11142494A patent/IL111424A/xx not_active IP Right Cessation
- 1994-10-27 BR BR9404265A patent/BR9404265A/pt not_active Application Discontinuation
- 1994-10-27 SK SK1304-94A patent/SK130494A3/sk unknown
- 1994-10-28 RU RU94039281/13A patent/RU2152998C2/ru not_active IP Right Cessation
- 1994-10-28 TW TW083109959A patent/TW408125B/zh not_active IP Right Cessation
- 1994-11-01 CZ CZ19942674A patent/CZ291865B6/cs not_active IP Right Cessation
- 1994-11-01 KR KR1019940028472A patent/KR100393952B1/ko not_active Expired - Fee Related
- 1994-11-01 CA CA002134844A patent/CA2134844C/en not_active Expired - Fee Related
- 1994-11-01 JP JP26862094A patent/JP4202433B2/ja not_active Expired - Lifetime
- 1994-11-01 CN CN94113741A patent/CN1037772C/zh not_active Expired - Fee Related
- 1994-11-02 ZA ZA948641A patent/ZA948641B/xx unknown
- 1994-11-02 AU AU77595/94A patent/AU7759594A/en not_active Abandoned
- 1994-11-03 DK DK94308107T patent/DK0652219T3/da active
- 1994-11-03 EP EP94308107A patent/EP0652219B1/en not_active Expired - Lifetime
- 1994-11-03 ES ES94308107T patent/ES2157239T3/es not_active Expired - Lifetime
- 1994-11-03 SG SG1996003747A patent/SG48919A1/en unknown
- 1994-11-03 FI FI945186A patent/FI112378B/fi not_active IP Right Cessation
- 1994-11-03 AT AT94308107T patent/ATE202356T1/de active
- 1994-11-03 HU HU9403164A patent/HU222576B1/hu not_active IP Right Cessation
- 1994-11-03 PT PT94308107T patent/PT652219E/pt unknown
- 1994-11-03 DE DE69427513T patent/DE69427513T2/de not_active Expired - Lifetime
- 1994-11-03 NZ NZ264852A patent/NZ264852A/en not_active IP Right Cessation
-
1995
- 1995-01-04 US US08/368,675 patent/US5508398A/en not_active Expired - Lifetime
-
2001
- 2001-07-11 GR GR20010401060T patent/GR3036207T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |