RU2015109631A - Способ и композиции для клеточной иммунотерапии - Google Patents
Способ и композиции для клеточной иммунотерапии Download PDFInfo
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- RU2015109631A RU2015109631A RU2015109631A RU2015109631A RU2015109631A RU 2015109631 A RU2015109631 A RU 2015109631A RU 2015109631 A RU2015109631 A RU 2015109631A RU 2015109631 A RU2015109631 A RU 2015109631A RU 2015109631 A RU2015109631 A RU 2015109631A
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- nucleic acid
- chimeric receptor
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Abstract
1. Нуклеиновая кислота, кодирующая химерный рецептор, содержащая:a) полинуклеотид, кодирующий лиганд-связывающий домен, где лиганд-связывающий домен связывается с лигандом, при этом лигандом является опухолеспецифическая молекула, вирусная молекула или любая другая молекула, экспрессируемая в популяции клеток-мишеней, пригодная для опосредования распознавания и удаления лимфоцитом;b) полинуклеотид, кодирующий полипептидный спейсер, имеющий длину, специфичную для лиганда, где спейсер обеспечивает повышенные пролиферацию Т-клеток и/или выработку цитокинов в ответ на воздействие лиганда по сравнению с эталонным химерным рецептором;c) полинуклеотид, кодирующий трансмембранный домен; иd) полинуклеотид, кодирующий внутриклеточный сигнальный домен.2. Нуклеиновая кислота, кодирующая химерный рецептор, по п.1, где лиганд-связывающим доменом является фрагмент антитела.3. Нуклеиновая кислота, кодирующая химерный рецептор, по п.2, где лиганд-связывающим доменом является одноцепочечный вариабельный фрагмент.4. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-3, где опухолеспецифическая молекула выбрана из группы, включающей CD19, CD20, CD22, CD23, CD123, CS-1, ROR1, мезотелин, c-Met, PSMA, Her2, GD-2, TCR MAGE A3 и их комбинации.5. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-4, где спейсер содержит аминокислотную последовательность XPPXP.6. Нуклеиновая кислота, кодирующая химерный рецептор, по п.5, где спейсерный участок содержит часть шарнирного участка антитела человека.7. Нуклеиновая кислота, кодирующая химерный рецептор, по п.5, где спейсерный участок содержит шарнирный участок и по меньшей мере одну другую часть домена Fc антитела человека, выбранную из группы, включающей CH1, CH2, CH
Claims (35)
1. Нуклеиновая кислота, кодирующая химерный рецептор, содержащая:
a) полинуклеотид, кодирующий лиганд-связывающий домен, где лиганд-связывающий домен связывается с лигандом, при этом лигандом является опухолеспецифическая молекула, вирусная молекула или любая другая молекула, экспрессируемая в популяции клеток-мишеней, пригодная для опосредования распознавания и удаления лимфоцитом;
b) полинуклеотид, кодирующий полипептидный спейсер, имеющий длину, специфичную для лиганда, где спейсер обеспечивает повышенные пролиферацию Т-клеток и/или выработку цитокинов в ответ на воздействие лиганда по сравнению с эталонным химерным рецептором;
c) полинуклеотид, кодирующий трансмембранный домен; и
d) полинуклеотид, кодирующий внутриклеточный сигнальный домен.
2. Нуклеиновая кислота, кодирующая химерный рецептор, по п.1, где лиганд-связывающим доменом является фрагмент антитела.
3. Нуклеиновая кислота, кодирующая химерный рецептор, по п.2, где лиганд-связывающим доменом является одноцепочечный вариабельный фрагмент.
4. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-3, где опухолеспецифическая молекула выбрана из группы, включающей CD19, CD20, CD22, CD23, CD123, CS-1, ROR1, мезотелин, c-Met, PSMA, Her2, GD-2, TCR MAGE A3 и их комбинации.
5. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-4, где спейсер содержит аминокислотную последовательность X1PPX2P.
6. Нуклеиновая кислота, кодирующая химерный рецептор, по п.5, где спейсерный участок содержит часть шарнирного участка антитела человека.
7. Нуклеиновая кислота, кодирующая химерный рецептор, по п.5, где спейсерный участок содержит шарнирный участок и по меньшей мере одну другую часть домена Fc антитела человека, выбранную из группы, включающей CH1, CH2, CH3 и их комбинации.
8. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-7, где спейсерный участок имеет длину, выбранную из группы, включающей 12 аминокислот или менее, 119 аминокислот или менее и 229 аминокислот или менее.
9. Нуклеиновая кислота, кодирующая химерный рецептор, по п.5, где лиганд-связывающий домен связывается с лигандом ROR1, а спейсерный участок выбран из группы, включающей SEQ ID NO:4 и SEQ ID NO:49 (шарнирный участок-CH3).
10. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-9, где домен, активирующий лимфоциты, содержит весь CD3-зета или его часть в комбинации с костимулирующим доменом, выбранным из группы, включающей CD27, CD28, 4-1BB, OX-40, CD30, CD40, PD-1, ICOS, LFA-1, CD2, CD7, NKG2C, B7-H3 и их комбинации.
11. Нуклеиновая кислота, кодирующая химерный рецептор, по п.10, где внутриклеточный сигнальный домен содержит часть CD3-зета, а также часть 4-1BB, часть CD28 или их обе.
12. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.4-11, где лиганд-связывающий домен связывается с ROR1, а спейсерный участок содержит 12 аминокислот или менее и имеет последовательность SEQ ID NO:4.
13. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.4-11, где лиганд-связывающий домен связывается с ROR1, а спейсерный участок имеет последовательность SEQ ID NO:50.
14. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.4-11, где лиганд-связывающий домен связывается с CD19, а спейсерный участок содержит 12 аминокислот или менее и имеет последовательность SEQ ID NO:4.
15. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.4-11, где лиганд-связывающий домен связывается с Her2, а спейсерный участок имеет последовательность SEQ ID NO:50.
16. Нуклеиновая кислота, кодирующая химерный рецептор, по любому из пп.1-15, дополнительно содержащая нуклеиновую кислоту, которая кодирует маркерную последовательность.
17. Полипептидный химерный рецептор, кодируемый нуклеиновой кислотой, кодирующей химерный рецептор, по любому из пп.1-16.
18. Вектор экспрессии, содержащий выделенную нуклеиновую кислоту, кодирующую химерный рецептор, по любому из пп.1-16.
19. Клетка-хозяин, содержащая нуклеиновую кислоту по любому из пп.1-16 или вектор экспрессии по п.18.
20. Клетка-хозяин по п.19, где клеткой-хозяином является цитотоксический Т-лимфоцит CD8+, выбранный из группы, включающей наивные Т-клетки CD8+, центральные T-клетки памяти CD8+, эффекторные T-клетки памяти CD8+ и общую популяцию T-клеток CD8+.
21. Клетка-хозяин по п.20, где цитотоксическим Т-лимфоцитом CD8+ является центральная Т-клетка памяти, при этом центральная Т-клетка памяти является положительной по CD45RO+, CD62L+ и CD8+.
22. Клетка-хозяин по п.19, где клеткой-хозяином является Т-лимфоцит-хелпер CD4+, выбранный из группы, включающей наивные Т-клетки CD4+, центральные T-клетки памяти CD4+, эффекторные T-клетки памяти CD4+ и общую популяцию T-клеток CD4+.
23. Клетка-хозяин по п.22, где лимфоцитом-хелпером CD4+ является наивная Т-клетка CD4+, при этом наивная Т-клетка CD4+ является положительной по CD45RА+, CD62L+ и CD4+ и отрицательной по CD45RO.
24. Композиция, содержащая клетку-хозяина по любому из пп.19-23 в фармацевтически приемлемом наполнителе.
25. Композиция по п.24, содержащая клетку-хозяина по п.20 или 21 и клетку-хозяина по п.23 или 34.
26. Способ получения клетки-хозяина по любому из пп.19-23 in vitro, включающий:
a) обеспечение наличия библиотеки нуклеиновых кислот, кодирующих химерный рецептор, по любому из пп.1-16 или п.18, в которой каждая из множества нуклеиновых кислот кодирует химерный рецептор, отличающийся по длине;
b) введение каждой из множества нуклеиновых кислот в отдельную выделенную популяцию Т-лимфоцитов и размножение каждой популяции Т-лимфоцитов in vitro;
c) введение каждой генетически модифицированной популяции T-лимфоцитов опухоленосителю в животной модели и определение того, обладает ли генетически модифицированная популяция Т-лимфоцитов противоопухолевой эффективностью; и
d) выбор нуклеиновой кислоты, кодирующей химерный рецептор, который обеспечивает противоопухолевую эффективность in vitro и/или в животной модели.
27. Способ по п.26, дополнительно включающий введение выбранной нуклеиновой кислоты, кодирующей химерный рецептор, в клетку-хозяина.
28. Способ получения клетки-хозяина по любому из пп.19-23 in vitro, включающий:
a) введение нуклеиновой кислоты по любому из пп.1-16 или вектора экспрессии по п.18 в популяцию лимфоцитов, которая имеет фенотип CD45RA-, CD45RO+ и CD62L+; и
b) культивирование клеток в присутствии антител к CD3 и/или антител к CD28 и по меньшей мере одного гомеостатического цитокина до получения количества размножившихся клеток, достаточного для применения в инфузии клеток.
29. Способ по любому из пп.26-28, где лимфоцит является CD8+ или CD4+.
30. Применение клетки-хозяина по любому из пп.19-23 или композиции по пп.24-25 в лечении рака или вирусной инфекции.
31. Применение по п.30, где рак представляет собой солидную опухоль или гематологическую злокачественную опухоль.
32. Применение по п.31, где солидная опухоль выбрана из группы, включающей рак молочной железы, рак легких, рак кишечника, рак почек, рак поджелудочной железы, рак предстательной железы и рак яичников.
33. Способ проведения клеточной иммунотерапии у субъекта, имеющего рак или вирусную инфекцию, включающий введение субъекту композиции по любому из пп.24-25 или клетки-хозяина по пп.19-23.
34. Способ по п.33, где рак выбран из солидной опухоли или гематологической злокачественной опухоли.
35. Способ по п.34, где солидная опухоль выбрана из группы, включающей рак молочной железы, рак легких, рак кишечника, рак почек, рак поджелудочной железы, рак предстательной железы и рак яичников.
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Families Citing this family (476)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102073901B1 (ko) | 2011-09-08 | 2020-02-05 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 항 제3자 중심 기억 ｔ 세포, 이의 제조 방법, 및 이식 및 질환 치료에서의 이의 용도 |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| SI2884999T2 (sl) | 2012-08-20 | 2026-01-30 | Fred Hutchinson Cancer Center | Metoda in sestavki za celično imunoterapijo |
| ES2776698T3 (es) | 2012-12-20 | 2020-07-31 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗－ｃｄ１２３嵌合抗原受體工程化ｔ細胞之初級人類白血病有效靶向 |
| HUE046961T2 (hu) | 2013-02-20 | 2020-04-28 | Univ Pennsylvania | Rák kezelése humanizált EGFRVIII elleni kiméra antigénreceptor alkalmazásával |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| BR112016013187A2 (pt) | 2013-12-19 | 2017-09-26 | Novartis Ag | receptores de antígenos quiméricos de mesotelina humanos e usos dos mesmos |
| JP6942467B2 (ja) | 2013-12-20 | 2021-10-06 | フレッド ハッチンソン キャンサー リサーチ センター | タグ化キメラエフェクター分子およびそのレセプター |
| US10287354B2 (en) | 2013-12-20 | 2019-05-14 | Novartis Ag | Regulatable chimeric antigen receptor |
| EP3097117B1 (en) | 2014-01-21 | 2023-10-04 | Novartis Ag | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
| MX395149B (es) | 2014-04-07 | 2025-03-24 | Novartis Ag | Terapias de combinación que comprenden un receptor quimérico de antígeno cd19 para el cáncer. |
| CN106661570B (zh) * | 2014-04-10 | 2020-02-07 | 西雅图儿童医院（Dba西雅图儿童研究所） | 通过与氨甲蝶呤选择偶联的睡美人转座子制备工程化t细胞 |
| US11274278B2 (en) | 2014-04-16 | 2022-03-15 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| BR112016024579A2 (pt) | 2014-04-23 | 2017-10-10 | Juno Therapeutics Inc | métodos para isolamento, cultura e engenharia genética de populações de célula imune para terapia adotiva |
| RS62733B1 (sr) * | 2014-04-25 | 2022-01-31 | 2Seventy Bio Inc | Mnd promoter himernih antigenskih receptora |
| JP6817069B2 (ja) | 2014-04-25 | 2021-01-20 | ブルーバード バイオ， インコーポレイテッド | 養子細胞療法薬を製造するための改善された方法 |
| SG10201810723VA (en) | 2014-06-06 | 2018-12-28 | Bluebird Bio Inc | Improved t cell compositions |
| CA2954414A1 (en) | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| MX2017001011A (es) | 2014-07-21 | 2018-05-28 | Novartis Ag | Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma. |
| US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
| AR101829A1 (es) | 2014-07-21 | 2017-01-18 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 |
| ES2878449T3 (es) | 2014-07-24 | 2021-11-18 | 2Seventy Bio Inc | Receptores antigénicos quiméricos de BCMA |
| EP3511413B1 (en) * | 2014-07-25 | 2022-09-07 | Theravectys | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule |
| DK3174557T3 (en) | 2014-07-29 | 2019-02-04 | Cellectis | ROR1 (NTRKR1) -specific Chimeric Antigen Receptors for Cancer Immunotherapy |
| EP3194432B1 (en) * | 2014-07-31 | 2019-04-10 | Cellectis | Ror1 specific multi-chain chimeric antigen receptor |
| ES2767399T3 (es) * | 2014-08-19 | 2020-06-17 | Miltenyi Biotec Bv & Co Kg | Receptor de antígeno quimérico específico para el antígeno SSEA4 |
| TW202140557A (zh) | 2014-08-19 | 2021-11-01 | 瑞士商諾華公司 | 使用cd123嵌合抗原受體治療癌症 |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| DK3189073T4 (da) | 2014-09-04 | 2025-08-18 | Cellectis | Trofoblastglykoprotein (5t4, tpbg)-specifikke kimære antigenreceptorer til cancerimmunterapi |
| KR20210149228A (ko) | 2014-09-17 | 2021-12-08 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| JP6657195B2 (ja) * | 2014-09-19 | 2020-03-04 | シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ | Ｌ１３Ｒα２を標的とする共刺激性キメラ抗原レセプターＴ細胞 |
| CA2963935A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof |
| US10507219B2 (en) | 2014-10-20 | 2019-12-17 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
| EP3757206B1 (en) | 2014-11-05 | 2024-04-10 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
| US20180334490A1 (en) | 2014-12-03 | 2018-11-22 | Qilong H. Wu | Methods for b cell preconditioning in car therapy |
| ES2987087T3 (es) | 2014-12-03 | 2024-11-13 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| WO2016094873A2 (en) * | 2014-12-12 | 2016-06-16 | Emergent Product Development Seattle, Llc | Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods |
| RS62527B1 (sr) | 2014-12-12 | 2021-11-30 | 2Seventy Bio Inc | Bcma receptori himernog antigena |
| WO2016100232A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| EP4036109A3 (en) | 2014-12-29 | 2022-10-12 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| CA2973964A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| CN105985444B (zh) * | 2015-02-05 | 2024-02-13 | 博生吉安科细胞技术有限公司 | 一种嵌合抗原受体、以及快速构建嵌合抗原受体的方法及应用 |
| CN119925616A (zh) | 2015-04-08 | 2025-05-06 | 诺华股份有限公司 | Cd20疗法、cd22疗法和与cd19嵌合抗原受体（car）表达细胞的联合疗法 |
| WO2016166568A1 (en) | 2015-04-16 | 2016-10-20 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| CA2982996A1 (en) | 2015-04-17 | 2016-10-20 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
| WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| US11827904B2 (en) | 2015-04-29 | 2023-11-28 | Fred Hutchinson Cancer Center | Modified stem cells and uses thereof |
| RU2754661C2 (ru) | 2015-05-01 | 2021-09-06 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | Гликанзависимые иммунотерапевтические молекулы |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2016263513A1 (en) | 2015-05-20 | 2017-11-23 | Cellectis | Anti-GD3 specific chimeric antigen receptors for cancer immunotherapy |
| EP3303586A1 (en) | 2015-05-29 | 2018-04-11 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
| WO2016196384A1 (en) | 2015-05-29 | 2016-12-08 | Fred Hutchinson Cancer Research Center | Compositions for cellular immunotherapy |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| PL3322425T3 (pl) | 2015-07-16 | 2023-10-09 | Yeda Research And Development Co., Ltd. | Zmodyfikowane genetycznie, skierowane przeciwko osobie trzeciej centralne limfocyty T pamięci i ich zastosowanie w immunoterapii |
| TWI859112B (zh) | 2015-07-21 | 2024-10-21 | 瑞士商諾華公司 | 改良免疫細胞之功效及擴展之方法 |
| CN108348550A (zh) * | 2015-07-21 | 2018-07-31 | 希望之城公司 | 用于表达嵌合抗原受体和其它受体的t细胞 |
| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
| EP3331920A4 (en) | 2015-08-07 | 2019-04-03 | Seattle Children's Hospital, dba Seattle Children's Research Institute | BIS SPECIFIC CAR T CELLS FOR TARGETING OF SOLID TUMORS |
| CN106467906B (zh) * | 2015-08-20 | 2019-09-27 | 北京马力喏生物科技有限公司 | 构建体、转基因淋巴细胞及其制备方法和用途 |
| US11279769B2 (en) * | 2015-08-31 | 2022-03-22 | Helixmith Co., Ltd | Anti-Sialyl Tn chimeric antigen receptors |
| CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
| AU2016318773B2 (en) * | 2015-09-09 | 2024-08-01 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Genetic engineering of macrophages for immunotherapy |
| AU2016318621A1 (en) * | 2015-09-11 | 2018-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically relevant orthogonal cytokine/receptor pairs |
| JP6955487B2 (ja) | 2015-09-24 | 2021-10-27 | アブビトロ， エルエルシー | Ｈｉｖ抗体組成物および使用方法 |
| US10928392B2 (en) | 2015-09-25 | 2021-02-23 | Abvitro Llc | High throughput process for T cell receptor target identification of natively-paired T cell receptor sequences |
| EP3359574B1 (en) * | 2015-10-06 | 2020-04-22 | City of Hope | Chimeric antigen receptors targeted to psca |
| MX395154B (es) | 2015-10-22 | 2025-03-25 | Juno Therapeutics Gmbh | Métodos, kits, agentes y aparatos para transducción. |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| CN108289913A (zh) | 2015-10-30 | 2018-07-17 | 儿童国家医疗中心 | 从未致敏t细胞群体产生hpv抗原特异性t细胞 |
| EA201891066A1 (ru) | 2015-10-30 | 2018-10-31 | ЭнБиИ-ТЕРАПЬЮТИКС АГ | Антитела к ror1 |
| MX2018005674A (es) * | 2015-11-04 | 2019-01-10 | J Priceman Saul | Receptores de antigenos quimericos dirigidos a her2. |
| MA44314A (fr) | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
| US11020429B2 (en) | 2015-11-05 | 2021-06-01 | Juno Therapeutics, Inc. | Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy |
| CA3007262A1 (en) | 2015-12-03 | 2017-06-08 | Lucas James Thompson | Modified chimeric receptors and related compositions and methods |
| WO2017096327A2 (en) | 2015-12-03 | 2017-06-08 | Juno Therapeutics, Inc. | Compositions and methods for reducing immune responses against cell therapies |
| WO2017096331A1 (en) | 2015-12-04 | 2017-06-08 | Juno Therapeutics, Inc. | Methods and compositions related to toxicity associated with cell therapy |
| HK1257295A1 (zh) | 2015-12-04 | 2019-10-18 | Novartis Ag | 用於免疫肿瘤学的组合物和方法 |
| WO2017099712A1 (en) | 2015-12-07 | 2017-06-15 | Bluebird Bio, Inc. | Improved t cell compositions |
| EP3393504B1 (en) | 2015-12-22 | 2025-09-24 | Novartis AG | Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy |
| EP3397756B1 (en) | 2015-12-30 | 2023-03-08 | Novartis AG | Immune effector cell therapies with enhanced efficacy |
| CN109715174A (zh) * | 2016-01-15 | 2019-05-03 | 埃图比克斯公司 | 用于t细胞免疫治疗的方法和组合物 |
| CN106978442B (zh) * | 2016-01-18 | 2020-06-19 | 爱康得生物医学技术（苏州）有限公司 | 一种嵌合抗原受体t细胞的制备方法 |
| UA125718C2 (uk) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Композиції антитіл до ror1 і пов'язані з ними способи |
| AU2017213844A1 (en) | 2016-02-02 | 2018-08-02 | Fred Hutchinson Cancer Center | Anti-ROR1 antibodies and uses thereof |
| KR20180118175A (ko) | 2016-03-04 | 2018-10-30 | 노파르티스 아게 | 다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도 |
| MA43759A (fr) | 2016-03-16 | 2018-11-28 | Jason Connor | Procédés de conception adaptative d'un régime de traitement et traitements associés |
| EP3430548A1 (en) | 2016-03-16 | 2019-01-23 | Juno Therapeutics, Inc. | Methods for determining dosing of a therapeutic agent and related treatments |
| CA3015369A1 (en) | 2016-03-18 | 2017-09-21 | Oliver Press | Compositions and methods for cd20 immunotherapy |
| JP7048571B2 (ja) | 2016-03-22 | 2022-04-05 | シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） | 毒性を予防または改善するための早期介入法 |
| WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
| JP2019509753A (ja) | 2016-03-31 | 2019-04-11 | ライオン ティーシーアール ピーティーイー．エルティーディー． | 外因性ウイルス特異的ｔ細胞受容体（ｔｃｒ）を発現する非活性化ｔ細胞 |
| US12144850B2 (en) | 2016-04-08 | 2024-11-19 | Purdue Research Foundation | Methods and compositions for car T cell therapy |
| JP7497955B6 (ja) | 2016-04-15 | 2024-07-01 | ノバルティス アーゲー | 選択的タンパク質発現のための組成物および方法 |
| WO2017189526A1 (en) * | 2016-04-25 | 2017-11-02 | Musc Foundation For Research Development | Activated cd26-high immune cells and cd26-negative immune cells and uses thereof |
| MA44869A (fr) | 2016-05-06 | 2019-03-13 | Editas Medicine Inc | Cellules génétiquement modifiées et leurs procédés de fabrication |
| EP3464323B1 (en) | 2016-05-27 | 2021-09-22 | Aadigen, LLC | Peptides and nanoparticles for intracellular delivery of genome-editing molecules |
| CA3026453A1 (en) | 2016-06-03 | 2017-12-07 | Memorial Sloan-Kettering Cancer Center | Adoptive cell therapies as early treatment options |
| MA45341A (fr) | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| SG10202012157QA (en) | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| CN107522786A (zh) * | 2016-06-20 | 2017-12-29 | 深圳市体内生物医药科技有限公司 | 一种分子、表达其的细胞及其制备方法和用途 |
| WO2017221850A1 (ja) * | 2016-06-21 | 2017-12-28 | 国立大学法人名古屋大学 | Ｔ細胞機能向上のためのアダプター分子 |
| CN110291402B (zh) | 2016-06-27 | 2023-09-01 | 朱诺治疗学股份有限公司 | 鉴定肽表位的方法、结合此类表位的分子和相关用途 |
| MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
| US20190233534A1 (en) * | 2016-07-14 | 2019-08-01 | Fred Hutchinson Cancer Research Center | Multiple bi-specific binding domain constructs with different epitope binding to treat cancer |
| CA3031955A1 (en) | 2016-07-29 | 2018-02-01 | Juno Therapeutics, Inc. | Immunomodulatory polypeptides and related compositions and methods |
| KR20230107408A (ko) | 2016-07-29 | 2023-07-14 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
| ES2926513T3 (es) | 2016-07-29 | 2022-10-26 | Juno Therapeutics Inc | Métodos para evaluar la presencia o ausencia de virus competente en replicación |
| JP2019527696A (ja) | 2016-08-01 | 2019-10-03 | ノバルティス アーゲー | プロｍ２マクロファージ分子の阻害剤と組み合わせてキメラ抗原受容体を用いる癌の処置 |
| US11242376B2 (en) | 2016-08-02 | 2022-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| BR112019004662A2 (pt) | 2016-09-12 | 2019-05-28 | Juno Therapeutics Inc | conjuntos de sacos de biorreator de perfusão |
| CN109996868A (zh) | 2016-09-23 | 2019-07-09 | 弗雷德哈钦森癌症研究中心 | 特异性用于次要组织相容性(h)抗原ha-1的tcr及其用途 |
| WO2018064076A1 (en) | 2016-09-27 | 2018-04-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| WO2018063985A1 (en) | 2016-09-28 | 2018-04-05 | Atossa Genetics Inc. | Methods of adoptive cell therapy |
| EP3519433A1 (en) | 2016-10-03 | 2019-08-07 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| CN110225927B (zh) | 2016-10-07 | 2024-01-12 | 诺华股份有限公司 | 用于治疗癌症的嵌合抗原受体 |
| GB2564823B8 (en) | 2016-10-07 | 2022-06-29 | Tcr2 Therapeutics Inc | Compositions and methods for TCR reprogramming using fusion proteins |
| MA50839A (fr) | 2016-10-13 | 2019-08-21 | Juno Therapeutics Inc | Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane |
| EP3529359B1 (en) | 2016-10-18 | 2023-12-13 | Regents of the University of Minnesota | Tumor infiltrating lymphocytes for use in therapy |
| WO2018081448A1 (en) | 2016-10-26 | 2018-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modified immunoglobulin hinge regions to reduce hemagglutination |
| CA3040914A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
| CN110139669A (zh) | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | T细胞疗法和btk抑制剂的组合疗法 |
| CN110022906A (zh) | 2016-11-04 | 2019-07-16 | 蓝鸟生物公司 | 抗bcma car t细胞组合物 |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| US11793833B2 (en) | 2016-12-02 | 2023-10-24 | Juno Therapeutics, Inc. | Engineered B cells and related compositions and methods |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| ES2961666T3 (es) | 2016-12-03 | 2024-03-13 | Juno Therapeutics Inc | Métodos para determinar la dosificación de células CAR-T |
| BR112019011025A2 (pt) | 2016-12-03 | 2019-10-08 | Juno Therapeutics Inc | métodos para modulação de células t car |
| CA3045338A1 (en) | 2016-12-05 | 2018-06-14 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| EP3551197B1 (en) | 2016-12-12 | 2023-11-22 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| AU2017384900B2 (en) | 2016-12-28 | 2020-12-10 | GC Cell Corporation | Chimeric antigen receptor and natural killer cells expressing same |
| JP6706394B1 (ja) * | 2017-01-09 | 2020-06-03 | レンティジェン・テクノロジー・インコーポレイテッドＬｅｎｔｉｇｅｎ Ｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． | 抗メソセリン免疫療法によりがんを処置するための組成物および方法 |
| JP7382829B2 (ja) * | 2017-01-10 | 2023-11-17 | ザ ジェネラル ホスピタル コーポレイション | キメラ抗原受容体を発現するｔ細胞 |
| CN110691792A (zh) | 2017-01-10 | 2020-01-14 | 朱诺治疗学股份有限公司 | 细胞疗法的表观遗传学分析及相关方法 |
| EP3568416A4 (en) | 2017-01-13 | 2020-07-08 | Celdara Medical, LLC | TIM-1 TARGETED CHIMERIC ANTIGENIC RECEPTORS |
| US20190350980A1 (en) * | 2017-01-18 | 2019-11-21 | Drk Blutspendedienst Baden-W?Rttemberg-Hessen Gmbh | Compositions and methods for transplant recipient conditioning |
| WO2018134824A1 (en) | 2017-01-18 | 2018-07-26 | Yeda Research And Development Co. Ltd. | Genetically modified veto cells and use of same in immunotherapy |
| CN110418802A (zh) | 2017-01-20 | 2019-11-05 | 朱诺治疗学有限公司 | 细胞表面缀合物及相关的细胞组合物和方法 |
| EP4043485A1 (en) | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| RU2674894C2 (ru) * | 2017-01-30 | 2018-12-13 | Общество с ограниченной ответственностью "ПЛАНТА" | Новые люциферазы и способы их использования |
| CA3051481A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| EP3585402B1 (en) | 2017-02-27 | 2024-03-06 | Juno Therapeutics, Inc. | Compositions, articles of manufacture and methods related to dosing in cell therapy |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| WO2018170188A2 (en) | 2017-03-14 | 2018-09-20 | Juno Therapeutics, Inc. | Methods for cryogenic storage |
| AU2018234830B2 (en) | 2017-03-15 | 2023-03-02 | Fred Hutchinson Cancer Center | High affinity MAGE-A1-specific TCRs and uses thereof |
| EP3595705A1 (en) | 2017-03-15 | 2020-01-22 | Oxford BioMedica (UK) Limited | Method |
| CN110832075A (zh) | 2017-03-22 | 2020-02-21 | 诺华股份有限公司 | 用于免疫肿瘤学的组合物和方法 |
| EP3607319A1 (en) | 2017-04-07 | 2020-02-12 | Juno Therapeutics, Inc. | Engineered cells expressing prostate-specific membrane antigen (psma) or a modified form thereof and related methods |
| AU2018251188A1 (en) | 2017-04-14 | 2019-10-31 | Juno Therapeutics, Inc. | Methods for assessing cell surface glycosylation |
| EP4083063A3 (en) | 2017-04-18 | 2023-01-04 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP3618842B1 (en) | 2017-05-01 | 2023-10-18 | Juno Therapeutics, Inc. | Combination of a cell therapy and an immunomodulatory compound |
| CN118147137A (zh) * | 2017-05-17 | 2024-06-07 | 西雅图儿童医院（Dba西雅图儿童研究所） | 生成哺乳动物t细胞活化诱导型合成启动子(syn+pro)以改善t细胞疗法 |
| EP3630108A1 (en) | 2017-05-24 | 2020-04-08 | Effector Therapeutics Inc. | Compositions and methods for an improved antitumor immune response |
| CA3064000A1 (en) | 2017-05-24 | 2018-11-29 | Effector Therapeutics, Inc. | Methods and compositions for cellular immunotherapy |
| US11740231B2 (en) | 2017-06-02 | 2023-08-29 | Juno Therapeutics, Inc. | Articles of manufacture and methods related to toxicity associated with cell therapy |
| CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
| DK3538645T3 (da) | 2017-06-20 | 2021-04-19 | Inst Curie | Immunceller der mangler suv39h1 |
| JP2020525010A (ja) | 2017-06-22 | 2020-08-27 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 制御性免疫細胞を産生するための方法及びその使用 |
| AU2018291032A1 (en) | 2017-06-29 | 2020-01-16 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| GB201710838D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | Bispecific antibodies |
| GB201710836D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| GB201710835D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| BR112020001719A2 (pt) | 2017-07-29 | 2020-07-21 | Juno Therapeutics Inc | reagentes para expansão de células que expressam receptores recombinantes |
| KR102486090B1 (ko) | 2017-08-07 | 2023-01-10 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
| MA49981A (fr) | 2017-08-09 | 2020-06-17 | Juno Therapeutics Inc | Procédés et compositions de préparation de cellules génétiquement modifiées |
| BR112020001605A2 (pt) | 2017-08-09 | 2020-08-11 | Juno Therapeutics Inc | métodos para produzir composições de células geneticamente modificadas e composições relacionadas |
| KR20200035104A (ko) | 2017-08-11 | 2020-04-01 | 프레드 헛친슨 켄서 리서치 센터 | Braf 특이적 tcr 및 그의 용도 |
| EP3676403A1 (en) | 2017-09-01 | 2020-07-08 | Juno Therapeutics, Inc. | Gene expression and assessment of risk of developing toxicity following cell therapy |
| US12350312B2 (en) | 2017-09-06 | 2025-07-08 | Fred Hutchinson Cancer Center | Methods for improving adoptive cell therapy |
| CA3072908A1 (en) | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | Strep-tag specific binding proteins and uses thereof |
| US20210023132A1 (en) | 2017-09-06 | 2021-01-28 | Fred Hutchinson Cancer Research Center | Strep-tag specific chimeric receptors and uses thereof |
| EP3679370A1 (en) | 2017-09-07 | 2020-07-15 | Juno Therapeutics, Inc. | Methods of identifying cellular attributes related to outcomes associated with cell therapy |
| CN109517820B (zh) | 2017-09-20 | 2021-09-24 | 北京宇繁生物科技有限公司 | 一种靶向HPK1的gRNA以及HPK1基因编辑方法 |
| CN107641615A (zh) * | 2017-09-22 | 2018-01-30 | 苏州大学 | 一种小鼠胰腺内浸润的免疫细胞分离方法 |
| DK3688032T3 (da) | 2017-09-26 | 2025-12-15 | Cero Therapeutics Holdings Inc | Kimære engulfment-receptormolekyler og anvendelsesfremgangsmåder |
| EP3692063A1 (en) | 2017-10-03 | 2020-08-12 | Juno Therapeutics, Inc. | Hpv-specific binding molecules |
| CA3081336A1 (en) | 2017-10-12 | 2019-04-18 | Gregory LIZEE | T cell receptors for immunotherapy |
| CN111511391B (zh) | 2017-10-18 | 2024-10-22 | 普瑞赛格恩公司 | 包含间隔区的多肽组合物 |
| CN107759699A (zh) * | 2017-10-18 | 2018-03-06 | 银丰生物工程集团有限公司 | 靶向cd30抗原的转基因t细胞及其制备方法与应用 |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2019079777A1 (en) | 2017-10-20 | 2019-04-25 | Fred Hutchinson Cancer Research Center | COMPOSITIONS AND METHODS FOR TIGIT AND / OR CD112R TARGETING IMMUNOTHERAPY OR COMPRISING THE OVEREXPRESSION OF CD226 |
| CA3080904A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for b-cell maturation antigen |
| WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| US12258580B2 (en) | 2017-11-01 | 2025-03-25 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| EP3704251A2 (en) | 2017-11-01 | 2020-09-09 | Editas Medicine, Inc. | Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy |
| BR112020008565A2 (pt) | 2017-11-01 | 2020-10-20 | Juno Therapeutics Inc | processo para a produção de uma composição de célula t |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| JP7447006B2 (ja) * | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | Ｂ細胞成熟抗原（ｂｃｍａ）に特異的なキメラ抗原受容体 |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| AU2018360031B2 (en) * | 2017-11-03 | 2025-08-21 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-ROR1 immunotherapy |
| US20230137729A1 (en) | 2017-11-06 | 2023-05-04 | Editas Medicine, Inc. | Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy |
| JP7233425B2 (ja) | 2017-11-06 | 2023-03-06 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法とガンマセクレターゼ阻害剤との組み合わせ |
| BR112020008978A2 (pt) * | 2017-11-09 | 2020-11-10 | Medimmune, Llc | polipeptídeos de fusão biespecíficos e seus métodos de uso |
| CN111556789A (zh) | 2017-11-10 | 2020-08-18 | 朱诺治疗学股份有限公司 | 封闭系统低温器皿 |
| WO2019094482A1 (en) * | 2017-11-10 | 2019-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting tumor antigens |
| WO2019098682A1 (ko) * | 2017-11-14 | 2019-05-23 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| US20220267403A1 (en) | 2017-12-01 | 2022-08-25 | Fred Hutchinson Cancer Research Center | Binding proteins specific for 5t4 and uses thereof |
| EP3716980A1 (en) | 2017-12-01 | 2020-10-07 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| BR112020011223A2 (pt) | 2017-12-08 | 2020-11-17 | Juno Therapeutics Inc | marcadores fenotípicos para terapia celular e mé-todos relacionados |
| MX2020005908A (es) | 2017-12-08 | 2020-10-07 | Juno Therapeutics Inc | Proceso para producir una composicion de celulas t modificadas. |
| MA51105A (fr) | 2017-12-08 | 2020-10-14 | Juno Therapeutics Inc | Formulation de milieux sans sérum pour la culture de cellules et ses procédés d'utilisation |
| JP2021506260A (ja) | 2017-12-15 | 2021-02-22 | ジュノー セラピューティクス インコーポレイテッド | 抗ｃｃｔ５結合分子およびその使用方法 |
| WO2019126358A1 (en) * | 2017-12-22 | 2019-06-27 | Cell Design Labs, Inc. | Single- and multi-chain chimeric antigen receptors |
| CN109971837A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 一种外源抗体基因拷贝数的检测方法和试剂盒 |
| WO2019136432A1 (en) | 2018-01-08 | 2019-07-11 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
| WO2019139972A1 (en) | 2018-01-09 | 2019-07-18 | Board Of Regents, The University Of Texas System | T cell receptors for immunotherapy |
| WO2019140278A1 (en) | 2018-01-11 | 2019-07-18 | Fred Hutchinson Cancer Research Center | Immunotherapy targeting core binding factor antigens |
| CA3089051A1 (en) * | 2018-01-22 | 2019-07-25 | Endocyte, Inc. | Methods of use for car t cells |
| JP7383620B2 (ja) | 2018-01-31 | 2023-11-20 | セルジーン コーポレイション | 養子細胞療法およびチェックポイント阻害剤を使用する併用療法 |
| WO2019152747A1 (en) | 2018-01-31 | 2019-08-08 | Juno Therapeutics, Inc. | Methods and reagents for assessing the presence or absence of replication competent virus |
| AU2019218729B2 (en) * | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| SG11202007660UA (en) | 2018-02-12 | 2020-09-29 | Hutchinson Fred Cancer Res | Cyclin a1 specific t cell receptors and uses thereof |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| EP3759130A1 (en) | 2018-02-26 | 2021-01-06 | Fred Hutchinson Cancer Research Center | Compositions and methods for cellular immunotherapy |
| EP3762012A1 (en) | 2018-03-09 | 2021-01-13 | Ospedale San Raffaele S.r.l. | Il-1 antagonist and toxicity induced by cell therapy |
| EP4491718A3 (en) | 2018-03-14 | 2025-03-26 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy |
| MX2020009463A (es) | 2018-03-14 | 2021-03-09 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Receptor de antígeno quimérico de receptor de il-13 alfa 2 (il13ra2) para inmunoterapia de células t específica para tumor. |
| US10751399B2 (en) * | 2018-03-20 | 2020-08-25 | Cho Pharma Usa, Inc. | Chimeric antigen receptors that bind to SSEA4 and uses thereof |
| US20210024607A1 (en) | 2018-03-28 | 2021-01-28 | Cero Therapeutics, Inc. | Expression vectors for chimeric engulfment receptors, genetically modified host cells, and uses thereof |
| US20210015865A1 (en) | 2018-03-28 | 2021-01-21 | Cero Therapeutics, Inc. | Chimeric engulfment receptors and uses thereof for neurodegenerative diseases |
| US12291557B2 (en) | 2018-03-28 | 2025-05-06 | Cero Therapeutics Holdings, Inc. | Chimeric TIM4 receptors and uses thereof |
| KR20210024443A (ko) | 2018-03-28 | 2021-03-05 | 세로 테라퓨틱스, 인코포레이티드 | 세포 면역요법 조성물 및 이의 용도 |
| MX2020010461A (es) | 2018-04-05 | 2021-01-15 | Juno Therapeutics Inc | Linfocitos t que expresan un receptor recombinante, polinucleotidos y metodos relacionados. |
| BR112020020245A2 (pt) | 2018-04-05 | 2021-04-06 | Editas Medicine, Inc. | Métodos de produzir células expressando um receptor recombinante e composições relacionadas |
| KR102764123B1 (ko) | 2018-04-05 | 2025-02-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Τ 세포 수용체 및 이를 발현하는 조작된 세포 |
| WO2019200347A1 (en) * | 2018-04-13 | 2019-10-17 | Fred Hutchinson Cancer Research Center | Methods for adoptive cell therapy targeting ror1 |
| EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| BR112020022185A2 (pt) | 2018-05-03 | 2021-02-02 | Juno Therapeutics Inc | terapia de combinação de uma terapia de células t do receptor de antígeno quimérico (car) e um inibidor de quinase |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| CN108441505B (zh) * | 2018-05-28 | 2023-07-07 | 上海恒润达生生物科技股份有限公司 | 一种靶向ror1的嵌合抗原受体及其用途 |
| US20210223248A1 (en) | 2018-06-01 | 2021-07-22 | Fred Hutchinson Cancer Research Center | Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods |
| WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
| CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| BR112021002245A2 (pt) | 2018-08-09 | 2021-05-04 | Juno Therapeutics Inc | métodos para avaliar ácidos nucleicos integrados |
| IL280659B2 (en) | 2018-08-09 | 2024-11-01 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| JP7495137B2 (ja) * | 2018-08-10 | 2024-06-04 | ユーティレックス カンパニー リミテッド | 癌抗原特異的細胞傷害性ｔ細胞 |
| EP3844191A4 (en) * | 2018-08-31 | 2022-06-15 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Methods and compositions comprising b7h3 chimeric antigen receptors |
| MX2021002316A (es) | 2018-08-31 | 2021-07-15 | Invectys SA | Receptores de antígeno quimérico frente a múltiples isoformas de hla-g. |
| KR20210081341A (ko) | 2018-09-11 | 2021-07-01 | 주노 쎄러퓨티크스 인코퍼레이티드 | 조작된 세포 조성물의 질량 분석기 분석을 위한 방법 |
| EP3849565A4 (en) | 2018-09-12 | 2022-12-28 | Fred Hutchinson Cancer Research Center | REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS |
| US20240165232A1 (en) | 2018-09-24 | 2024-05-23 | Fred Hutchinson Cancer Research Center | Chimeric receptor proteins and uses thereof |
| NL2021789B1 (en) | 2018-10-10 | 2020-05-14 | Academisch Ziekenhuis Leiden | Binding proteins specific for HA-1H and uses thereof |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| JP2022512789A (ja) * | 2018-10-31 | 2022-02-07 | ベリカム ファーマシューティカルズ， インコーポレイテッド | 自殺スイッチを有するｔ細胞 |
| WO2020092848A2 (en) | 2018-11-01 | 2020-05-07 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| EP3873937A2 (en) * | 2018-11-01 | 2021-09-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for g protein-coupled receptor class c group 5 member d (gprc5d) |
| KR20210100624A (ko) | 2018-11-06 | 2021-08-17 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전적으로 조작된 ｔ 세포를 제조하는 방법 |
| US12263190B2 (en) | 2018-11-08 | 2025-04-01 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
| EP3880238A1 (en) | 2018-11-16 | 2021-09-22 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| EP3880712A4 (en) | 2018-11-16 | 2022-11-16 | Albert Einstein College of Medicine | MONOCLONAL ANTIBODIES AGAINST IgV DOMAIN OF B7-H3 AND USES THEREOF |
| JP7630832B2 (ja) | 2018-11-19 | 2025-02-18 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｃａｒおよびｔｃｒ形質導入用のモジュール式ポリシストロニックベクター |
| EP3887518A2 (en) | 2018-11-28 | 2021-10-06 | Board of Regents, The University of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| MX2021006393A (es) | 2018-11-29 | 2021-10-13 | Univ Texas | Metodos para expansion ex vivo de celulas exterminadoras naturales y uso de las mismas. |
| IL283298B2 (en) | 2018-11-30 | 2025-03-01 | Juno Therapeutics Inc | Methods for dosing and treating B-cell malignancies with adoptive cell therapy |
| MX2021006238A (es) | 2018-11-30 | 2021-10-01 | Juno Therapeutics Inc | Metodos para tratamiento que usan terapia celular adoptiva. |
| ES2944062T3 (es) * | 2018-12-19 | 2023-06-19 | Inst Nat Sante Rech Med | Células T invariantes asociadas a la mucosa (MAIT) que expresan receptores de antígenos quiméricos |
| AU2019402189B2 (en) | 2018-12-20 | 2023-04-13 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| PE20212198A1 (es) | 2019-01-29 | 2021-11-16 | Juno Therapeutics Inc | Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1) |
| BR112021015672A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos |
| US20220144807A1 (en) | 2019-02-15 | 2022-05-12 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2020172332A1 (en) | 2019-02-20 | 2020-08-27 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| SG11202111372VA (en) | 2019-05-01 | 2021-11-29 | Juno Therapeutics Inc | Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods |
| MX2021013219A (es) | 2019-05-01 | 2022-02-17 | Juno Therapeutics Inc | Celulas que expresan un receptor recombinante de un locus de tgfbr2 modificado, polinucleotidos relacionados y metodos. |
| JP2022533128A (ja) | 2019-05-16 | 2022-07-21 | ユニバーシティ オブ ワシントン | Ｃａｒ ｔ細胞のｌｏｃｋｒ媒介性動員 |
| CN113874398B (zh) | 2019-05-21 | 2025-08-01 | 诺华股份有限公司 | Cd19结合分子及其用途 |
| EP3980530A1 (en) | 2019-06-07 | 2022-04-13 | Juno Therapeutics, Inc. | Automated t cell culture |
| JP2022537700A (ja) | 2019-06-12 | 2022-08-29 | ジュノー セラピューティクス インコーポレイテッド | 細胞媒介細胞傷害性療法と生存促進性ｂｃｌ２ファミリータンパク質の阻害剤との併用療法 |
| CA3143108A1 (en) * | 2019-06-19 | 2020-12-24 | Julius-Maximilians-Universitat Wurzburg | Ultramodular igg3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| US20220257796A1 (en) | 2019-07-02 | 2022-08-18 | Fred Hutchinson Cancer Research Center | Recombinant ad35 vectors and related gene therapy improvements |
| CA3145223A1 (en) * | 2019-07-23 | 2021-01-28 | Wen Yang | Composition and method for adoptive immunotherapy |
| JP7735249B2 (ja) * | 2019-07-23 | 2025-09-08 | ムネモ・セラピューティクス | Ｓｕｖ３９ｈ１欠損免疫細胞 |
| US20220298222A1 (en) | 2019-08-22 | 2022-09-22 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods |
| JP7770306B2 (ja) | 2019-08-30 | 2025-11-14 | ジュノー セラピューティクス インコーポレイテッド | 細胞を分類するための機械学習方法 |
| CA3158775A1 (en) | 2019-09-02 | 2021-03-11 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
| JP7696335B2 (ja) | 2019-09-09 | 2025-06-20 | スクライブ・セラピューティクス・インコーポレイテッド | 免疫療法に使用するための組成物および方法 |
| US12441795B2 (en) * | 2019-09-27 | 2025-10-14 | Nanjing Immunophage Biotech Co., Ltd. | Anti-ROR1 antibodies and preparation method and uses thereof |
| EP4038097A1 (en) | 2019-10-03 | 2022-08-10 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
| EP4048304A1 (en) | 2019-10-22 | 2022-08-31 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
| BR112022008023A2 (pt) | 2019-10-30 | 2022-07-12 | Juno Therapeutics Gmbh | Dispositivos de seleção e/ou estimulação de células e métodos de uso |
| EP4055383A1 (en) | 2019-11-05 | 2022-09-14 | Juno Therapeutics, Inc. | Methods of determining attributes of therapeutic t cell compositions |
| EP4054623A1 (en) | 2019-11-07 | 2022-09-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4 ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]- piperidine-2,6-dione |
| IL292924A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors cd19 and cd22 and their uses |
| CN114761037A (zh) | 2019-11-26 | 2022-07-15 | 诺华股份有限公司 | 结合bcma和cd19的嵌合抗原受体及其用途 |
| WO2021113776A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods |
| KR20220132527A (ko) | 2019-12-06 | 2022-09-30 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ｂ 세포 악성 종양을 치료하기 위한 세포 요법과 연관된 독성 및 반응과 관련된 방법 |
| WO2021113780A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods |
| EP4076660A1 (en) | 2019-12-20 | 2022-10-26 | Novartis AG | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
| IL294724A (en) | 2020-01-24 | 2022-09-01 | Juno Therapeutics Inc | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
| WO2021154887A1 (en) | 2020-01-28 | 2021-08-05 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| CN115768443A (zh) | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
| JP2023519099A (ja) | 2020-02-12 | 2023-05-10 | ジュノー セラピューティクス インコーポレイテッド | Ｂｃｍａ指向性キメラ抗原受容体ｔ細胞組成物ならびにその方法および使用 |
| EP4107173A1 (en) | 2020-02-17 | 2022-12-28 | Board of Regents, The University of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| WO2021173674A1 (en) | 2020-02-26 | 2021-09-02 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
| CN115515971A (zh) * | 2020-03-12 | 2022-12-23 | 希望之城公司 | 治疗IL13Rα2阳性恶性病的靶向性嵌合抗原受体修饰的T细胞 |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| AU2021251265A1 (en) | 2020-04-10 | 2022-11-03 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting B-cell maturation antigen |
| EP4110822A4 (en) * | 2020-04-23 | 2024-04-10 | Alpha Beta Holdings, LLC | COMPOSITIONS AND METHODS FOR TREATING CANCER |
| IL297751A (en) | 2020-04-28 | 2022-12-01 | Lyell Immunopharma Inc | Methods for culturing cells |
| CN116157125A (zh) | 2020-04-28 | 2023-05-23 | 朱诺治疗学股份有限公司 | 针对bcma的t细胞疗法与免疫调节化合物的组合 |
| WO2021228999A1 (en) | 2020-05-12 | 2021-11-18 | Institut Curie | Neoantigenic epitopes associated with sf3b1 mutations |
| IL298114A (en) * | 2020-05-12 | 2023-01-01 | Lyell Immunopharma Inc | Chimeric antigen receptor spacers |
| US20230178239A1 (en) | 2020-05-13 | 2023-06-08 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| CN115835873A (zh) | 2020-05-13 | 2023-03-21 | 朱诺治疗学股份有限公司 | 用于产生表达重组受体的供体分批细胞的方法 |
| EP4153301A2 (en) | 2020-05-21 | 2023-03-29 | Board of Regents, The University of Texas System | T cell receptors with vgll1 specificity and uses thereof |
| KR20230024911A (ko) * | 2020-05-22 | 2023-02-21 | 주식회사 지씨셀 | 항-her2 항체 또는 이의 항원 결합 단편 및 이를 포함하는 키메라 항원 수용체 |
| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| JP2023531676A (ja) | 2020-06-23 | 2023-07-25 | ノバルティス アーゲー | ３－（１－オキソイソインドリン－２－イル）ピぺリジン－２，６－ジオン誘導体を含む投与レジメン |
| JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたｔ細胞、関連ポリヌクレオチド、および方法 |
| AU2021308078A1 (en) | 2020-07-17 | 2023-02-09 | Children's Hospital Los Angeles | Chimeric MyD88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
| EP4188395A1 (en) | 2020-07-30 | 2023-06-07 | Institut Curie | Immune cells defective for socs1 |
| US20230271940A1 (en) | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2022029660A1 (en) | 2020-08-05 | 2022-02-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods |
| WO2022036285A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Compositions and methods for treating cancer with chimeric tim receptors in combination with inhibitors of poly (adp-ribose) polymerase |
| WO2022036287A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Anti-cd72 chimeric receptors and uses thereof |
| WO2022036265A1 (en) | 2020-08-14 | 2022-02-17 | Cero Therapeutics, Inc. | Chimeric tim receptors and uses thereof |
| WO2022036458A1 (en) | 2020-08-21 | 2022-02-24 | 12343096 Canada Inc. | Modular assembly receptors and uses thereof |
| CN112111014A (zh) * | 2020-09-22 | 2020-12-22 | 廖文强 | 一种抗氧化嵌合型抗原受体和免疫细胞 |
| JP2023542528A (ja) | 2020-09-24 | 2023-10-10 | フレッド ハッチンソン キャンサー センター | Ｓｏｘ２抗原を標的とする免疫療法 |
| WO2022066973A1 (en) | 2020-09-24 | 2022-03-31 | Fred Hutchinson Cancer Research Center | Immunotherapy targeting pbk or oip5 antigens |
| NL2026614B1 (en) | 2020-10-02 | 2022-06-03 | Academisch Ziekenhuis Leiden | T cell receptors directed against bob1 and uses thereof |
| TW202222841A (zh) | 2020-10-06 | 2022-06-16 | 福瑞德哈金森腫瘤研究中心 | 用於治療表現mage-a1之疾病的組成物及方法 |
| WO2022087458A1 (en) | 2020-10-23 | 2022-04-28 | Asher Biotherapeutics, Inc. | Fusions with cd8 antigen binding molecules for modulating immune cell function |
| US20240009239A1 (en) * | 2020-11-04 | 2024-01-11 | Fred Hutchinson Cancer Center | Therapeutic targeting of mesothelin in acute myeloid leukemia with chimeric antigen receptor t cell therapy |
| JP2023549780A (ja) | 2020-11-04 | 2023-11-29 | ジュノー セラピューティクス インコーポレイテッド | 改変されたインバリアントｃｄ３免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法 |
| CN116390933A (zh) | 2020-11-06 | 2023-07-04 | 诺华股份有限公司 | 治疗b细胞恶性肿瘤的抗cd19剂和b细胞靶向剂组合疗法 |
| US20230051406A1 (en) | 2020-11-13 | 2023-02-16 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| CN116829161A (zh) * | 2020-11-18 | 2023-09-29 | 卡丽娜生物科技有限公司 | 嵌合抗原受体t细胞及方法 |
| CN116981685A (zh) * | 2020-12-03 | 2023-10-31 | 世纪治疗股份有限公司 | 基因工程化细胞及其用途 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| EP4255922A1 (en) | 2020-12-03 | 2023-10-11 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| CN112481284B (zh) * | 2020-12-07 | 2023-07-25 | 深圳瑞吉生物科技有限公司 | 一种编码CAR基因的mRNA、组合mRNA、构建方法、CAR-T细胞和应用 |
| CA3204368A1 (en) * | 2020-12-08 | 2022-06-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-egfr chimeric antigen receptors |
| US20250032540A1 (en) | 2020-12-14 | 2025-01-30 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| EP4264228A1 (en) | 2020-12-16 | 2023-10-25 | Juno Therapeutics, Inc. | Threshold gating for flow cytometry methods |
| AU2022206324A1 (en) | 2021-01-11 | 2023-07-20 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
| WO2022182891A1 (en) | 2021-02-25 | 2022-09-01 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| EP4298114A1 (en) | 2021-02-26 | 2024-01-03 | Kelonia Therapeutics, Inc. | Lymphocyte targeted lentiviral vectors |
| JP2024509853A (ja) | 2021-03-03 | 2024-03-05 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法およびｄｇｋ阻害剤の組合せ |
| MX2023010640A (es) | 2021-03-11 | 2024-02-07 | Inst Curie | Péptidos neoantigénicos transmembranales. |
| AU2022235060A1 (en) | 2021-03-11 | 2023-09-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tumor neoantigenic peptides and uses thereof |
| IL305810A (en) | 2021-03-11 | 2023-11-01 | Mnemo Therapeutics | Tumor neoantigenic peptides |
| AU2022241654A1 (en) | 2021-03-22 | 2023-09-28 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| KR20230158573A (ko) | 2021-03-22 | 2023-11-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 바이러스 벡터 입자의 효력을 평가하는 방법 |
| JP2024514245A (ja) | 2021-03-29 | 2024-03-29 | ジュノー セラピューティクス インコーポレイテッド | チェックポイント阻害剤療法とｃａｒ ｔ細胞療法との組合せを用いた投薬および処置のための方法 |
| EP4313126A1 (en) | 2021-03-29 | 2024-02-07 | Juno Therapeutics, Inc. | Combination of a car t cell therapy and an immunomodulatory compound for treatment of lymphoma |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| IL307598A (en) | 2021-04-16 | 2023-12-01 | Juno Therapeutics Inc | T-cell therapy in patients who have had a previous stem cell transplant |
| JP2024514163A (ja) | 2021-04-16 | 2024-03-28 | セルジーン コーポレーション | Ｂｃｍａ指向性ｔ細胞療法を用いた併用療法 |
| CN113735978B (zh) * | 2021-04-22 | 2023-06-30 | 河北森朗生物科技有限公司 | 靶向cd19的嵌合抗原受体、制备方法及其应用 |
| WO2022226522A1 (en) | 2021-04-22 | 2022-10-27 | Baylor College Of Medicine | Methods of engineering immune cells having reduced fratricidal activity |
| US20250283037A1 (en) | 2021-05-06 | 2025-09-11 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| WO2023288281A2 (en) | 2021-07-15 | 2023-01-19 | Fred Hutchinson Cancer Center | Chimeric polypeptides |
| KR20240119868A (ko) | 2021-07-28 | 2024-08-06 | 세로 테라퓨틱스, 인코포레이티드 | 키메라 tim4 수용체 및 이의 용도 |
| JP2024528981A (ja) | 2021-08-04 | 2024-08-01 | サナ バイオテクノロジー，インコーポレイテッド | Ｃｄ４標的化ウイルスベクターの使用 |
| WO2023014922A1 (en) | 2021-08-04 | 2023-02-09 | The Regents Of The University Of Colorado, A Body Corporate | Lat activating chimeric antigen receptor t cells and methods of use thereof |
| AU2022330106A1 (en) | 2021-08-16 | 2024-03-21 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
| PE20241173A1 (es) | 2021-10-14 | 2024-05-28 | Arsenal Biosciences Inc | Celulas inmunitarias que tienen arnhc coexpresados y sistemas de compuerta logica |
| KR20240109617A (ko) * | 2021-10-28 | 2024-07-11 | 라이엘 이뮤노파마, 인크. | Ror1-결합 단백질을 발현하는 세포를 배양하는 방법 |
| JP2024540320A (ja) | 2021-11-03 | 2024-10-31 | セルジーン コーポレーション | 骨髄腫を処置する際に使用するための、ｂ細胞成熟抗原に特異的なキメラ抗原受容体 |
| WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| US20250354167A1 (en) | 2021-12-09 | 2025-11-20 | Zygosity Limited | Vector |
| EP4448775A1 (en) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modified paramyxoviridae attachment glycoproteins |
| TW202342498A (zh) | 2021-12-17 | 2023-11-01 | 美商薩那生物科技公司 | 經修飾副黏液病毒科融合醣蛋白 |
| JP2025501272A (ja) | 2021-12-28 | 2025-01-17 | ムネモ・セラピューティクス | 不活性化されたｓｕｖ３９ｈ１及び改変ｔｃｒを有する免疫細胞 |
| US20250115916A1 (en) | 2022-01-21 | 2025-04-10 | Mnemo Therapeutics | Modulation of suv39h1 expression by rnas |
| JP2025504002A (ja) | 2022-01-28 | 2025-02-06 | ジュノー セラピューティクス インコーポレイテッド | 細胞組成物を製造する方法 |
| EP4472646A1 (en) | 2022-02-01 | 2024-12-11 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| WO2023150801A2 (en) * | 2022-02-07 | 2023-08-10 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Recombinant proteins that stimulate an immune response in the presence of naturally inhibitory ligand binding |
| NL2030990B1 (en) | 2022-02-17 | 2023-09-01 | Academisch Ziekenhuis Leiden | T cell receptors directed against jchain and uses thereof |
| WO2023156587A1 (en) | 2022-02-18 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
| AU2023223404A1 (en) | 2022-02-22 | 2024-08-29 | Juno Therapeutics, Inc. | Proteinase 3 (pr3) chimeric autoantibody receptor t cells and related methods and uses |
| NL2031118B1 (en) | 2022-03-01 | 2023-09-07 | Academisch Ziekenhuis Leiden | T cell receptors directed against transcription factor wt1 and uses thereof |
| CA3245554A1 (en) | 2022-03-18 | 2023-09-21 | The Regents Of The University Of Colorado, A Body Corporate | Genetically modified T lymphocyte co-receptors and their methods of use |
| US20250302930A1 (en) | 2022-03-24 | 2025-10-02 | Institut Curie | Immunotherapy targeting tumor transposable element derived neoantigenic peptides in glioblastoma |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| US20250304913A1 (en) | 2022-04-06 | 2025-10-02 | The Regents Of The University Of Colorado, A Body Corporate | Chimeric antigen receptor t cells and methods of use thereof |
| WO2023196921A1 (en) | 2022-04-06 | 2023-10-12 | The Regents Of The University Of Colorado, A Body Corporate | Granzyme expressing t cells and methods of use |
| JP2025515324A (ja) | 2022-04-28 | 2025-05-14 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | がんを処置するためのキメラ抗原受容体改変調節性ｔ細胞 |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| US20250297282A1 (en) | 2022-05-05 | 2025-09-25 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
| IL316839A (en) | 2022-05-17 | 2025-01-01 | Umoja Biopharma Inc | Production of viral particles |
| EP4279085A1 (en) | 2022-05-20 | 2023-11-22 | Mnemo Therapeutics | Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease |
| US20250345432A1 (en) | 2022-05-25 | 2025-11-13 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
| AU2023281726A1 (en) * | 2022-06-01 | 2025-01-09 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Recombinant receptors binding b cell activation factor receptor and uses thereof |
| WO2023237663A1 (en) | 2022-06-09 | 2023-12-14 | Institut National de la Santé et de la Recherche Médicale | Use of the f359l missense irf4 variant for increasing the stability of regulatory t cells |
| NL2032130B1 (en) | 2022-06-10 | 2023-12-18 | Academisch Ziekenhuis Leiden | T cell receptors directed against melanoma-associated antigen and uses thereof |
| WO2023250400A1 (en) | 2022-06-22 | 2023-12-28 | Juno Therapeutics, Inc. | Treatment methods for second line therapy of cd19-targeted car t cells |
| EP4547230A1 (en) | 2022-06-29 | 2025-05-07 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| CA3263560A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | GPRC5D AND BCMA SPECIFIC CHIMERICAL ANTIGENIC RECEPTORS |
| CN120435310A (zh) | 2022-08-26 | 2025-08-05 | 朱诺治疗学股份有限公司 | 对δ样配体3（DLL3）具有特异性的抗体和嵌合抗原受体 |
| EP4580658A1 (en) | 2022-08-31 | 2025-07-09 | Institut National de la Santé et de la Recherche Médicale | Method to generate more efficient car-t cells |
| CN120152717A (zh) | 2022-09-08 | 2025-06-13 | 朱诺治疗学股份有限公司 | T细胞疗法和连续或间歇dgk抑制剂给药的组合 |
| WO2024062138A1 (en) | 2022-09-23 | 2024-03-28 | Mnemo Therapeutics | Immune cells comprising a modified suv39h1 gene |
| EP4598565A1 (en) | 2022-10-07 | 2025-08-13 | Institut National de la Santé et de la Recherche Médicale | Method to generate improving car-t cells |
| EP4602174A1 (en) | 2022-10-13 | 2025-08-20 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
| WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| KR20250096730A (ko) | 2022-11-03 | 2025-06-27 | 난징 프로바이오 바이오테크 씨오., 엘티디. | 인간화 ror1을 표적화 하는 단일 도메인 항체 |
| WO2024097992A2 (en) | 2022-11-04 | 2024-05-10 | Umoja Biopharma, Inc. | Particles displaying adhesion-molecule fusions |
| JP2026500897A (ja) | 2022-11-04 | 2026-01-09 | ウモジャ バイオファーマ インコーポレイテッド | 融合分子を呈示するレンチウイルス粒子およびその使用 |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| WO2024102948A1 (en) | 2022-11-11 | 2024-05-16 | Celgene Corporation | Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods |
| NL2033510B1 (en) | 2022-11-11 | 2024-05-28 | Academisch Ziekenhuis Leiden | T cell receptors directed against cancer-associated antigens and uses thereof |
| CN115725001A (zh) * | 2022-12-08 | 2023-03-03 | 湖南光琇高新生命科技有限公司 | 靶向cd19的嵌合抗原受体、核酸、重组载体及car-t细胞 |
| EP4630782A1 (en) | 2022-12-09 | 2025-10-15 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
| KR20250135354A (ko) | 2022-12-13 | 2025-09-12 | 주노 쎄러퓨티크스 인코퍼레이티드 | Baff-r 및 cd19에 특이적인 키메라 항원 수용체 및 그의 방법 및 용도 |
| EP4634216A1 (en) | 2022-12-16 | 2025-10-22 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
| WO2024145599A1 (en) * | 2022-12-29 | 2024-07-04 | Kelonia Therapeutics, Inc. | Recombinant retrovirus, compositions, and methods of use |
| EP4642900A1 (en) | 2022-12-29 | 2025-11-05 | Astellas Pharma, Inc. | Engineered natural killer cells and related methods |
| JP2026504491A (ja) | 2023-02-03 | 2026-02-05 | ツェー３エス２ ゲーエムベーハー | 操作された免疫細胞の非ウイルス的製造のための方法 |
| TW202502363A (zh) | 2023-02-28 | 2025-01-16 | 美商奇諾治療有限公司 | 用於治療全身性自體免疫疾病之細胞療法 |
| IL322949A (en) | 2023-03-03 | 2025-10-01 | Arsenal Biosciences Inc | Systems targeting PSMA and CA9 |
| TW202436346A (zh) | 2023-03-13 | 2024-09-16 | 美商亞森諾生物科學公司 | 合成路徑活化劑 |
| EP4626447A4 (en) | 2023-03-31 | 2026-02-18 | Abelzeta Inc | BISPECIFIC CHIMERIC ANTIGENIC RECEPTORS TARGETING CD20 AND BCMA |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| WO2024220560A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Engineered protein g fusogens and related lipid particles and methods thereof |
| WO2024220598A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Lentiviral vectors with two or more genomes |
| WO2024220574A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Universal protein g fusogens and adapter systems thereof and related lipid particles and uses |
| KR20250169631A (ko) | 2023-04-18 | 2025-12-03 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 평가하기 위한 세포독성 검정 |
| NL2034658B1 (en) | 2023-04-21 | 2024-10-28 | Academisch Ziekenhuis Leiden | TIMP3-derived TEIPP neoantigens and uses thereof |
| NL2034657B1 (en) | 2023-04-21 | 2024-10-28 | Academisch Ziekenhuis Leiden | RCN1-derived TEIPP neoantigens and uses thereof |
| CN121038806A (zh) | 2023-04-25 | 2025-11-28 | 阿森纳生物科学公司 | 用于转录调控的新颖受体 |
| WO2024226858A1 (en) | 2023-04-26 | 2024-10-31 | Juno Therapeutics, Inc. | Methods for viral vector manufacturing |
| WO2024243365A2 (en) | 2023-05-23 | 2024-11-28 | Juno Therapeutics, Inc. | Activation markers of t cells and method for assessing t cell activation |
| TW202500126A (zh) | 2023-05-24 | 2025-01-01 | 美商金橘生物科技公司 | 雜環化合物及其用途 |
| CN121399270A (zh) | 2023-06-14 | 2026-01-23 | 阿森纳生物科学公司 | 非病毒细胞工程化 |
| WO2025054202A1 (en) | 2023-09-05 | 2025-03-13 | Sana Biotechnology, Inc. | Method of screening a sample comprising a transgene with a unique barcode |
| WO2025052001A1 (en) | 2023-09-07 | 2025-03-13 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| EP4520334A1 (en) | 2023-09-07 | 2025-03-12 | Mnemo Therapeutics | Methods and compositions for improving immune response |
| WO2025059362A1 (en) | 2023-09-13 | 2025-03-20 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025081123A1 (en) | 2023-10-12 | 2025-04-17 | Fred Hutchinson Cancer Center | Methods and compositions for improving t cell immunotherapy |
| WO2025082603A1 (en) | 2023-10-18 | 2025-04-24 | Institut Curie | Engineered immune cells overexpressing cd74 molecule |
| WO2025096975A1 (en) | 2023-11-02 | 2025-05-08 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods of enhancing immune cell therapies by runx2 modulation |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| CN117535324B (zh) * | 2023-11-24 | 2025-05-23 | 上海恩凯细胞技术有限公司 | 多功能基因修饰的免疫细胞及其制备方法和应用 |
| WO2025125363A1 (en) | 2023-12-11 | 2025-06-19 | Institut National de la Santé et de la Recherche Médicale | Host cells engineered to bypass the cd28 co-stimulation pathway and uses thereof for inducing durable immune responses under non-inflammatory conditions |
| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025151838A1 (en) | 2024-01-12 | 2025-07-17 | Sana Biotechnology, Inc. | Safety switches to control in vitro and in vivo proliferation of cell therapy products |
| NL2036853B1 (en) | 2024-01-22 | 2025-08-01 | Academisch Ziekenhuis Leiden | Haematopoietic-restricted minor histocompatibility antigens and uses thereof |
| NL2036854B1 (en) | 2024-01-22 | 2025-08-01 | Academisch Ziekenhuis Leiden | Haematopoietic-restricted Minor Histocompatibility Antigens and uses thereof |
| WO2025163107A1 (en) | 2024-02-01 | 2025-08-07 | Institut Gustave Roussy | Immune cells defective for znf217 and uses thereof |
| WO2025184421A1 (en) | 2024-02-28 | 2025-09-04 | Juno Therapeutics, Inc. | Chimeric antigen receptors and antibodies specific for delta-like ligand 3 (dll3) and related methods |
| WO2025191531A1 (en) | 2024-03-15 | 2025-09-18 | Takeda Pharmaceutical Company Limited | Cd19 targeting car nk cells in treating systemic lupus erythematosus and lupus nephritis |
| WO2025199338A1 (en) | 2024-03-20 | 2025-09-25 | Arsenal Biosciences, Inc. | Systems targeting slc34a2 and tmprss4 and methods of use thereof |
| WO2025199346A1 (en) | 2024-03-20 | 2025-09-25 | Arsenal Biosciences, Inc. | Antigen binding proteins that bind tmprss4 and methods of use thereof |
| WO2025231174A1 (en) | 2024-04-30 | 2025-11-06 | Umoja Biopharma, Inc. | Manufacturing viral particles |
| WO2025235604A1 (en) | 2024-05-08 | 2025-11-13 | Umoja Biopharma, Inc. | Fusion protein for use as immune cell engager |
| WO2025235851A1 (en) | 2024-05-10 | 2025-11-13 | Juno Therapeutics, Inc. | Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy |
| WO2025233867A1 (en) | 2024-05-10 | 2025-11-13 | Adaptam Therapeutics, S.L. | Anti-siglec-9 antibodies and uses thereof |
| WO2025242732A1 (en) | 2024-05-21 | 2025-11-27 | Institut National de la Santé et de la Recherche Médicale | Pan antibodies against sars-cov-2 spike protein and uses thereof for therapeutical purposes |
| WO2025245381A1 (en) | 2024-05-23 | 2025-11-27 | The Trustrees Of Dartmouth College | Methods and compositions for enhancing the persistence of car expressing tregs in the cns and other tissues |
| NL2037811B1 (en) | 2024-05-29 | 2025-12-12 | Univ Oslo | Treatment for Cancer |
| WO2025264864A1 (en) * | 2024-06-18 | 2025-12-26 | Fred Hutchinson Cancer Center | Human anti-cd45 antibodies and uses thereof |
| WO2026002973A1 (en) | 2024-06-25 | 2026-01-02 | Institut National de la Santé et de la Recherche Médicale | Host immune cells engineered to overexpress a foxk1 polypeptide |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
| WO2026025092A1 (en) | 2024-07-26 | 2026-01-29 | Juno Therapeutics, Inc. | Synthetic promoters for t cell expression |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992008796A1 (en) | 1990-11-13 | 1992-05-29 | Immunex Corporation | Bifunctional selectable fusion genes |
| IL101147A (en) * | 1991-03-07 | 2004-06-20 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
| US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
| EP0804590A1 (en) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| EP1334188B1 (en) * | 2000-11-07 | 2006-08-30 | City of Hope | Cd19-specific redirected immune cells |
| US20030148982A1 (en) | 2001-11-13 | 2003-08-07 | Brenner Malcolm K. | Bi-spcific chimeric T cells |
| PL1755674T3 (pl) | 2004-05-14 | 2015-05-29 | Alexion Pharma Inc | Wydłużanie przeżycia alloprzeszczepu poprzez inhibowanie aktywności dopełniacza |
| US20080131415A1 (en) | 2006-11-30 | 2008-06-05 | Riddell Stanley R | Adoptive transfer of cd8 + t cell clones derived from central memory cells |
| ES2666667T3 (es) | 2008-01-29 | 2018-05-07 | Fred Hutchinson Cancer Research Center | Identificación de células T CD8+ que son CD161 hi y/o IL-18R (alfa) hi y tienen una capacidad de evacuación rápida de fármacos |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| HRP20190556T1 (hr) * | 2009-11-03 | 2019-06-14 | City Of Hope | SKRAĆENI OBLIK RECEPTORA EPIDERMALNOG FAKTORA RASTA ZA (EGFRt) ODABIR TRANSDUCIRANIH T-STANICA |
| US9163258B2 (en) | 2010-07-23 | 2015-10-20 | Fred Hutchinson Cancer Research Center | Method for the treatment of obesity |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN110200997A (zh) * | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| CN103917319B (zh) | 2011-09-06 | 2017-09-08 | 艾默生电气公司 | 便携式紧凑型攻丝机 |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| CN104159909A (zh) | 2012-02-22 | 2014-11-19 | 宾夕法尼亚大学董事会 | 产生用于癌症治疗的t细胞持续性群体的组合物和方法 |
| SI2884999T2 (sl) | 2012-08-20 | 2026-01-30 | Fred Hutchinson Cancer Center | Metoda in sestavki za celično imunoterapijo |
| WO2014097442A1 (ja) | 2012-12-20 | 2014-06-26 | 三菱電機株式会社 | 車載装置及びプログラム |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
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