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MX2018005674A - Receptores de antigenos quimericos dirigidos a her2. - Google Patents

Receptores de antigenos quimericos dirigidos a her2.

Info

Publication number
MX2018005674A
MX2018005674A MX2018005674A MX2018005674A MX2018005674A MX 2018005674 A MX2018005674 A MX 2018005674A MX 2018005674 A MX2018005674 A MX 2018005674A MX 2018005674 A MX2018005674 A MX 2018005674A MX 2018005674 A MX2018005674 A MX 2018005674A
Authority
MX
Mexico
Prior art keywords
her2
receivers
antigens directed
chemical antigens
chemical
Prior art date
Application number
MX2018005674A
Other languages
English (en)
Inventor
J Forman Stephen
E Brown Christine
J Priceman Saul
Original Assignee
J Priceman Saul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Priceman Saul filed Critical J Priceman Saul
Publication of MX2018005674A publication Critical patent/MX2018005674A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/86—Viral vectors
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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Abstract

Se describen inmunorreceptores de transmembrana quiméricos (CAR) que incluyen un dominio extracelular dirigido a HER2, una región de transmembrana, un dominio coestimulador y un dominio de señalización intracelular.
MX2018005674A 2015-11-04 2016-11-04 Receptores de antigenos quimericos dirigidos a her2. MX2018005674A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562251052P 2015-11-04 2015-11-04
PCT/US2016/060724 WO2017079694A2 (en) 2015-11-04 2016-11-04 Chimeric antigen receptors targeting her2

Publications (1)

Publication Number Publication Date
MX2018005674A true MX2018005674A (es) 2019-01-10

Family

ID=58662864

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005674A MX2018005674A (es) 2015-11-04 2016-11-04 Receptores de antigenos quimericos dirigidos a her2.
MX2022013498A MX2022013498A (es) 2015-11-04 2018-05-04 Receptores de antigenos quimericos dirigidos a her2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022013498A MX2022013498A (es) 2015-11-04 2018-05-04 Receptores de antigenos quimericos dirigidos a her2.

Country Status (13)

Country Link
US (3) US11197919B2 (es)
EP (2) EP3371227B8 (es)
JP (3) JP6932709B2 (es)
KR (1) KR20180083874A (es)
CN (2) CN108779174B (es)
AU (2) AU2016349722A1 (es)
BR (1) BR112018009129A2 (es)
CA (1) CA3004306A1 (es)
ES (1) ES2909973T3 (es)
IL (2) IL259120B (es)
MX (2) MX2018005674A (es)
RU (1) RU2753695C2 (es)
WO (1) WO2017079694A2 (es)

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KR20210014210A (ko) 2014-05-15 2021-02-08 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
CN108779174B (zh) * 2015-11-04 2022-11-29 希望之城公司 靶向her2的嵌合抗原受体
RU2757308C2 (ru) 2016-02-05 2021-10-13 Сити Оф Хоуп Введение сконструированных т-клеток для лечения рака центральной нервной системы
WO2018102761A1 (en) * 2016-12-02 2018-06-07 City Of Hope Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors
US20190336533A1 (en) 2016-12-28 2019-11-07 Green Cross Lab Cell Corporation Chimeric antigen receptor and natural killer cells expressing same
US11834506B2 (en) 2017-02-08 2023-12-05 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind NKG2D, CD16, and a tumor-associated antigen for activation of natural killer cells and therapeutic uses thereof to treat cancer
US11884732B2 (en) 2017-02-20 2024-01-30 Dragonfly Therapeutics, Inc. Proteins binding HER2, NKG2D and CD16
IL269553B2 (en) 2017-03-27 2025-10-01 Nat Univ Singapore Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells
KR102624509B1 (ko) 2017-03-27 2024-01-12 싱가포르국립대학교 자연 살해 세포의 ex vivo 확장 및 활성화를 위한 자극성 세포주
JP7386796B2 (ja) * 2017-11-14 2023-11-27 グリーン クロス ラボ セル コーポレーション 抗－ｈｅｒ２抗体又はその抗原結合フラグメント、及びこれを含むキメラ抗原受容体
US11649294B2 (en) 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
CN109608547B (zh) * 2017-12-29 2022-03-15 郑州大学第一附属医院 表达Her2的嵌合抗原受体、慢病毒表达载体及其应用
US12384847B2 (en) 2018-02-08 2025-08-12 Dragonfly Therapeutics, Inc. Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen
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