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MX2020012744A - Metodo y composiciones para inmunoterapia celular. - Google Patents

Metodo y composiciones para inmunoterapia celular.

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Publication number
MX2020012744A
MX2020012744A MX2020012744A MX2020012744A MX2020012744A MX 2020012744 A MX2020012744 A MX 2020012744A MX 2020012744 A MX2020012744 A MX 2020012744A MX 2020012744 A MX2020012744 A MX 2020012744A MX 2020012744 A MX2020012744 A MX 2020012744A
Authority
MX
Mexico
Prior art keywords
cells
polynucleotide
chimeric receptor
modified
compositions
Prior art date
Application number
MX2020012744A
Other languages
English (en)
Inventor
Michael Hudecek
Michael Jensen
Stanley R Riddell
Original Assignee
Fred Hutchinson Cancer Center Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49054932&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020012744(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fred Hutchinson Cancer Center Star filed Critical Fred Hutchinson Cancer Center Star
Publication of MX2020012744A publication Critical patent/MX2020012744A/es

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Abstract

La presente invención proporciona ácidos nucleicos, vectores, células hospedadoras, métodos y composiciones para conferir y/o aumentar respuestas inmunitarias mediadas por inmunoterapia celular, tal al de manera adoptiva células T de memoria central CD8+ o combinaciones de células T de memoria central con células T CD4+ que modifican genéticamente para expresar un receptor quimérico. En modalidades la célula hospedadora genéticamente modificada comprende un ácido nucleico que comprende un polinucleótido que codifica para dominio de unión a ligando, un polinucleótido que comprende una región personalizada, un polinucleótido que comprende un dominio transmembrana y un polinucleótido que comprende un dominio de señalización intracelular. De manera sorprendente, se ha encontrado que la longitud de la región separadora puede afectar la capacidad de las células T modificadas con receptor quimérico para reconocer células diana in vitro y afectar la eficiencia in vivo de las células T modificadas con receptor quimérico. Las formulaciones farmacéuticas producidas por el método, y métodos de uso de los mismos, también se describen.
MX2020012744A 2012-08-20 2015-02-17 Metodo y composiciones para inmunoterapia celular. MX2020012744A (es)

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Families Citing this family (476)

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Publication number Priority date Publication date Assignee Title
EP2753351B1 (en) 2011-09-08 2017-06-21 Yeda Research and Development Co. Ltd. Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
CN106940268B (zh) 2012-02-23 2021-09-21 朱诺治疗有限公司 细胞和其它复杂生物材料的色谱分离
ES2842102T3 (es) 2012-08-20 2021-07-12 Hutchinson Fred Cancer Res Método y composiciones para inmunoterapia celular
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