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RU2013158986A - АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents

АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ Download PDF

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RU2013158986A
RU2013158986A RU2013158986/10A RU2013158986A RU2013158986A RU 2013158986 A RU2013158986 A RU 2013158986A RU 2013158986/10 A RU2013158986/10 A RU 2013158986/10A RU 2013158986 A RU2013158986 A RU 2013158986A RU 2013158986 A RU2013158986 A RU 2013158986A
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hvr
seq
sequence
methods
application
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RU2013158986/10A
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RU2694688C2 (ru
RU2694688C3 (ru
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Ивонн ЧЭНЬ
Марк ДЕННИС
Дэвид ДОРНАН
Кристи ЭЛКИНС
Джагатх Редди ДЖУНУТУЛА
Эндрю Полсон
Бин ЧЖЭН
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Дженентек, Инк.
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Abstract

Гуманизированное анти-CD79b антитело или антиген-связывающий фрагмент, содержащие:последовательности HVR:(i) HVR-L1, содержащей последовательность A1-A15, где A1-A15 представляет собой KASQSVDYDGDSFLN (SEQ ID NO:131);(j) HVR-L2, содержащей последовательность B1-B7, где B1-B7 представляет собой AASNLES (SEQ ID NO:132);(k) HVR-L3, содержащей последовательность C1-C9, где C1-C9 представляет собой QQSNEDPLT (SEQ ID NO:133);(l) HVR-H1, содержащей последовательность D1-D10, где D1-D10 представляет собой GYTFSSYWIE (SEQ ID NO:134);(m) HVR-H2, содержащей последовательность E1-E18, где E1-E18 представляет собой GEILPGGGDTNYNEIFKG (SEQ ID NO:135); и(n) HVR-H3, содержащей последовательность F1-F10, где F1-F10 представляет собой TRRVPIRLDY (SEQ ID NO:204).

Claims (1)

  1. Гуманизированное анти-CD79b антитело или антиген-связывающий фрагмент, содержащие:
    последовательности HVR:
    (i) HVR-L1, содержащей последовательность A1-A15, где A1-A15 представляет собой KASQSVDYDGDSFLN (SEQ ID NO:131);
    (j) HVR-L2, содержащей последовательность B1-B7, где B1-B7 представляет собой AASNLES (SEQ ID NO:132);
    (k) HVR-L3, содержащей последовательность C1-C9, где C1-C9 представляет собой QQSNEDPLT (SEQ ID NO:133);
    (l) HVR-H1, содержащей последовательность D1-D10, где D1-D10 представляет собой GYTFSSYWIE (SEQ ID NO:134);
    (m) HVR-H2, содержащей последовательность E1-E18, где E1-E18 представляет собой GEILPGGGDTNYNEIFKG (SEQ ID NO:135); и
    (n) HVR-H3, содержащей последовательность F1-F10, где F1-F10 представляет собой TRRVPIRLDY (SEQ ID NO:204).
RU2013158986A 2007-07-16 2013-12-30 АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ RU2694688C3 (ru)

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