RU2010150799A - НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО(4,5-d)ПИРИМИДИНА - Google Patents
НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО(4,5-d)ПИРИМИДИНА Download PDFInfo
- Publication number
- RU2010150799A RU2010150799A RU2010150799/04A RU2010150799A RU2010150799A RU 2010150799 A RU2010150799 A RU 2010150799A RU 2010150799/04 A RU2010150799/04 A RU 2010150799/04A RU 2010150799 A RU2010150799 A RU 2010150799A RU 2010150799 A RU2010150799 A RU 2010150799A
- Authority
- RU
- Russia
- Prior art keywords
- powder
- mixture according
- pharmaceutical composition
- mixture
- containing characteristic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1. Смесь соединения формулы (I): ! ! которое характеризуется порошковой рентгенограммой, содержащей характерные пики высокой интенсивности при 5,5° (±0,1°), 13,5° (±0,1), 18,3° (±0,1°), 22,7° (±0,1°) и 24,3° (±0,1°) 2θ, или ! характеризуется порошковой рентгенограммой, содержащей характерные пики при 5,5° (±0,1°), 6,8° (±0,1°), 10,6° (±0,1°), 13,5° (±0,1°), 14,9° (±0,1°), 18,3° (±0,1°), 19,2° (±0,1°), 22,7° (±0,1°), 24,3° (±0,1°) и 27,1° (±0,1°) 2θ, или ! характеризуется кривой дифференциальной сканирующей калориметрии, имеющей точку начала плавления, находящуюся в интервале 136-139°С, ! и соединения указанной формулы (I), ! которое характеризуется порошковой рентгенограммой, содержащей характерные пики высокой интенсивности при 14,0° (±0,1°), 17,4° (±0,1), 18,4° (±0,1°), 21,4° (±0,1°) и 24,1° (±0,1°) 2θ, или ! характеризуется порошковой рентгенограммой, содержащей характерные пики при 5,6° (±0,1°), 12,5° (±0,1°), 14,0° (±0,1°), 17,4° (±0,1°), 18,4° (±0,1°), 21,4° (±0,1°), 22,2° (±0,1°), 22,9° (±0,1°), 24,1° (±0,1°) и 24,5° (±0,1°) 2θ, или ! характеризуется кривой дифференциальной сканирующей калориметрии, имеющей точку начала плавления, находящуюся в пределах 127-132°С. ! 2. Смесь по п.1 для применения в качестве лекарственного препарата. ! 3. Фармацевтическая композиция, содержащая смесь по п.1 в смеси с фармацевтически приемлемым адъювантом, разбавителем или носителем. ! 4. Фармацевтическая композиция, содержащая смесь по п.1, для применения в целях профилактики артериальных тромботических осложнений у пациентов при заболеваниях коронарной артерии, цереброваскулярным и периферическим сосудистым заболеванием. ! 5. Фармацевтическая композиция, содержащая смесь по п.1, для производстве лекарственного препарата для применения в целях профилактики артериальны
Claims (5)
1. Смесь соединения формулы (I):
которое характеризуется порошковой рентгенограммой, содержащей характерные пики высокой интенсивности при 5,5° (±0,1°), 13,5° (±0,1), 18,3° (±0,1°), 22,7° (±0,1°) и 24,3° (±0,1°) 2θ, или
характеризуется порошковой рентгенограммой, содержащей характерные пики при 5,5° (±0,1°), 6,8° (±0,1°), 10,6° (±0,1°), 13,5° (±0,1°), 14,9° (±0,1°), 18,3° (±0,1°), 19,2° (±0,1°), 22,7° (±0,1°), 24,3° (±0,1°) и 27,1° (±0,1°) 2θ, или
характеризуется кривой дифференциальной сканирующей калориметрии, имеющей точку начала плавления, находящуюся в интервале 136-139°С,
и соединения указанной формулы (I),
которое характеризуется порошковой рентгенограммой, содержащей характерные пики высокой интенсивности при 14,0° (±0,1°), 17,4° (±0,1), 18,4° (±0,1°), 21,4° (±0,1°) и 24,1° (±0,1°) 2θ, или
характеризуется порошковой рентгенограммой, содержащей характерные пики при 5,6° (±0,1°), 12,5° (±0,1°), 14,0° (±0,1°), 17,4° (±0,1°), 18,4° (±0,1°), 21,4° (±0,1°), 22,2° (±0,1°), 22,9° (±0,1°), 24,1° (±0,1°) и 24,5° (±0,1°) 2θ, или
характеризуется кривой дифференциальной сканирующей калориметрии, имеющей точку начала плавления, находящуюся в пределах 127-132°С.
2. Смесь по п.1 для применения в качестве лекарственного препарата.
3. Фармацевтическая композиция, содержащая смесь по п.1 в смеси с фармацевтически приемлемым адъювантом, разбавителем или носителем.
4. Фармацевтическая композиция, содержащая смесь по п.1, для применения в целях профилактики артериальных тромботических осложнений у пациентов при заболеваниях коронарной артерии, цереброваскулярным и периферическим сосудистым заболеванием.
5. Фармацевтическая композиция, содержащая смесь по п.1, для производстве лекарственного препарата для применения в целях профилактики артериальных тромботических осложнений у пациентов при заболеваниях коронарной артерии, цереброваскулярным и периферическим сосудистым заболеванием.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0013407.2A GB0013407D0 (en) | 2000-06-02 | 2000-06-02 | Forms of a chemical compound |
| GB0013407.2 | 2000-06-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010150799A true RU2010150799A (ru) | 2012-06-20 |
Family
ID=9892841
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002135589/04A RU2325391C2 (ru) | 2000-06-02 | 2001-05-31 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО[4,5-d]ПИРИМИДИНА |
| RU2005127356/04A RU2418802C2 (ru) | 2000-06-02 | 2005-08-30 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА ТРИАЗОЛО (4,5-d) ПИРИМИДИНА |
| RU2010150799/04A RU2010150799A (ru) | 2000-06-02 | 2010-12-10 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО(4,5-d)ПИРИМИДИНА |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002135589/04A RU2325391C2 (ru) | 2000-06-02 | 2001-05-31 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО[4,5-d]ПИРИМИДИНА |
| RU2005127356/04A RU2418802C2 (ru) | 2000-06-02 | 2005-08-30 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА ТРИАЗОЛО (4,5-d) ПИРИМИДИНА |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US20030181469A1 (ru) |
| EP (3) | EP2292622A1 (ru) |
| JP (3) | JP5036947B2 (ru) |
| KR (1) | KR100781864B1 (ru) |
| CN (2) | CN1247583C (ru) |
| AR (2) | AR032335A1 (ru) |
| AT (2) | ATE320430T1 (ru) |
| AU (4) | AU6287401A (ru) |
| BG (3) | BG65837B1 (ru) |
| BR (1) | BR0111328A (ru) |
| CA (1) | CA2408596C (ru) |
| CY (1) | CY1113047T1 (ru) |
| CZ (2) | CZ304347B6 (ru) |
| DE (1) | DE60117972T2 (ru) |
| DK (2) | DK1289992T3 (ru) |
| EE (1) | EE05222B1 (ru) |
| ES (2) | ES2259031T3 (ru) |
| GB (1) | GB0013407D0 (ru) |
| HK (1) | HK1052347B (ru) |
| HU (2) | HU230471B1 (ru) |
| IL (4) | IL152777A0 (ru) |
| IS (2) | IS2609B (ru) |
| MX (1) | MXPA02011795A (ru) |
| MY (2) | MY140674A (ru) |
| NO (3) | NO323780B1 (ru) |
| NZ (1) | NZ522638A (ru) |
| PH (1) | PH12011000127A1 (ru) |
| PL (2) | PL359172A1 (ru) |
| PT (2) | PT1289992E (ru) |
| RU (3) | RU2325391C2 (ru) |
| SG (1) | SG135965A1 (ru) |
| SI (2) | SI1493745T1 (ru) |
| SK (1) | SK287817B6 (ru) |
| UA (1) | UA73181C2 (ru) |
| WO (1) | WO2001092262A1 (ru) |
| ZA (1) | ZA200209324B (ru) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
| JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
| US20080045548A1 (en) * | 2006-08-21 | 2008-02-21 | Astrazeneca Ab | Pharmaceutical Compositions |
| TWI482772B (zh) | 2006-08-21 | 2015-05-01 | Astrazeneca Ab | 適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物 |
| WO2008054795A2 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as adp p2y12 receptor antagonists |
| MX2009010953A (es) * | 2007-04-13 | 2009-10-29 | Millenium Pharmaceuticals Inc | Terapia anticoagulante en combinacion, con un compuesto que actua como un inhibidor del factor xa. |
| TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
| UA100864C2 (ru) * | 2007-12-03 | 2013-02-11 | Астразенека Аб | Способ лечения или предотвращения аневризмы брюшной аорты |
| MY156796A (en) | 2008-09-09 | 2016-03-31 | Astrazeneca Ab | A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3h-1,2,3-triazolo [4,5-d] pyrimidin-3-yl] -5-(2-hydroxyethoxy) cyclopentane-1, 2-diol and to it's intermediates. |
| CA2768043A1 (en) | 2009-07-27 | 2011-02-10 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of p2y12 receptor |
| JP2013512886A (ja) * | 2009-12-03 | 2013-04-18 | アストラゼネカ アクチボラグ | 血小板の凝集阻害剤トリアゾロ［４，５−ｄ］ピリミジン共結晶 |
| CA2785487C (en) | 2009-12-23 | 2017-11-28 | Ratiopharm Gmbh | Solid pharmaceutical dosage form of ticagrelor |
| CZ2011229A3 (cs) | 2011-04-19 | 2012-08-15 | Zentiva, K.S. | Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy |
| RU2013154741A (ru) | 2011-06-01 | 2015-07-20 | Астразенека Аб | Новый сокристалл тикагрелора |
| JP2015500219A (ja) * | 2011-11-30 | 2015-01-05 | アクタビス・グループ・ピーティーシー・イーエイチエフ | 新規な結晶形を有するチカグレロル及びその調製方法 |
| US9233966B2 (en) | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
| WO2014000719A1 (en) | 2012-06-29 | 2014-01-03 | Zentiva, K.S. | Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol |
| WO2014006091A1 (en) | 2012-07-04 | 2014-01-09 | Lek Pharmaceuticals D.D. | Ticagrelor adducts with divalent metal salts |
| CZ2012705A3 (cs) * | 2012-10-16 | 2014-04-23 | Zentiva, K.S. | Pevná orální farmaceutická formulace obsahující ticagrelor |
| CN103772393B (zh) * | 2012-10-18 | 2017-08-04 | 博瑞生物医药（苏州）股份有限公司 | 替卡格雷的晶型及其制备方法 |
| WO2014083139A1 (en) * | 2012-11-29 | 2014-06-05 | Actavis Group Ptc Ehf | Novel amorphous form of ticagrelor |
| CN103848836B (zh) * | 2012-12-07 | 2016-08-03 | 天津市汉康医药生物技术有限公司 | 替卡格雷倍半水合物及其制备方法 |
| WO2014118808A2 (en) * | 2013-02-04 | 2014-08-07 | Hetero Research Foundation | Ticagrelor solid dispersion |
| CZ307217B6 (cs) | 2013-03-14 | 2018-04-04 | Zentiva, K.S. | Zlepšený způsob výroby a nové intermediáty syntézy ticagreloru |
| WO2014155389A2 (en) * | 2013-03-25 | 2014-10-02 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of ticagrelor |
| CN104098570A (zh) * | 2013-04-07 | 2014-10-15 | 杭州领业医药科技有限公司 | 替卡格雷晶型及其制备方法和用途 |
| CN104098572A (zh) * | 2013-04-08 | 2014-10-15 | 博瑞生物医药技术(苏州)有限公司 | 替卡格雷共晶型 |
| CN107573333B (zh) * | 2013-04-10 | 2019-10-18 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
| WO2014170026A1 (en) | 2013-04-18 | 2014-10-23 | Zentiva, K.S. | Stabilized amorphous ticagrelor |
| EP2813216A1 (en) | 2013-06-10 | 2014-12-17 | Zentiva, a.s. | Stabilized amorphous ticagrelor |
| US20160120869A1 (en) | 2013-05-29 | 2016-05-05 | Ratiopharm Gmbh | Solid pharmaceutical dosage form |
| CN106496234B (zh) * | 2013-06-03 | 2019-08-30 | 杭州领业医药科技有限公司 | 结晶形态的三唑[4,5-d]嘧啶化合物及其制备方法和用途 |
| EP3004113A2 (en) * | 2013-06-04 | 2016-04-13 | Dr. Reddy's Laboratories Ltd. | Preparation of ticagrelor |
| EP2816043A1 (en) | 2013-06-21 | 2014-12-24 | LEK Pharmaceuticals d.d. | Spherical ticagrelor particles |
| WO2015001489A1 (en) * | 2013-07-01 | 2015-01-08 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of ticagrelor |
| CN104341423B (zh) * | 2013-08-02 | 2017-03-01 | 上海京新生物医药有限公司 | 替格瑞洛的一水合物及其制备方法与在制药中的应用 |
| CN104370912A (zh) * | 2013-08-13 | 2015-02-25 | 开原亨泰制药股份有限公司 | 替卡格雷多晶型体及其制备方法 |
| WO2015037016A2 (en) * | 2013-09-10 | 2015-03-19 | Laurus Labs Private Limited | An improved process for the preparation of ticagrelor and intermediates thereof |
| CZ2013866A3 (cs) | 2013-11-08 | 2015-05-20 | Zentiva, K.S. | Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru |
| CN104650085A (zh) * | 2013-11-22 | 2015-05-27 | 天津市汉康医药生物技术有限公司 | 替卡格雷倍半水合物化合物 |
| CN103601726B (zh) * | 2013-12-02 | 2016-09-28 | 浙江大学 | 两种替格瑞洛药物共晶及其制备方法 |
| CN104710425B (zh) * | 2013-12-16 | 2019-06-14 | 石药集团中奇制药技术（石家庄）有限公司 | 一种替格瑞洛新结晶及其制备方法 |
| CN104650091B (zh) * | 2014-01-24 | 2016-10-05 | 福州乾正药业有限公司 | 替格瑞洛的微粉化及其晶型，以及制备方法和药物应用 |
| CN104940204A (zh) * | 2014-03-27 | 2015-09-30 | 广东东阳光药业有限公司 | 一种替格瑞洛固体制剂及其制备方法 |
| WO2015162537A1 (en) * | 2014-04-23 | 2015-10-29 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of ticagrelor |
| WO2015162630A1 (en) | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
| CN105315282B (zh) * | 2014-07-15 | 2018-09-21 | 博瑞生物医药（苏州）股份有限公司 | 一种制备替卡格雷无定型的方法 |
| WO2016016907A1 (en) * | 2014-08-01 | 2016-02-04 | Msn Laboratories Private Limited | Novel polymorphs of (1s,2s,3r,5s)-3-[7-{[(1r,2s)-2-(3,4-difluorophenyl) cyclopropyl]amino}-5-(propylthio)-3h-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yi]-5-(2-hydroxvethoxy) cyclopentane-1,2-diol |
| US10017515B2 (en) | 2014-08-11 | 2018-07-10 | Sun Pharmaceutical Industries Limited | Stable amorphous ticagrelor and a process for its preparation |
| CN104193747B (zh) * | 2014-08-12 | 2016-05-11 | 许彩霞 | 替卡格雷无定形的制备 |
| WO2016116942A1 (en) | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
| CN105968113B (zh) * | 2015-03-12 | 2019-06-07 | 四川海思科制药有限公司 | 一种三唑并嘧啶衍生物及其应用 |
| WO2017072790A1 (en) * | 2015-10-26 | 2017-05-04 | Avra Laboratories Pvt. Ltd. | An improved process for synthesis of ticagrelor |
| US20190002471A1 (en) * | 2016-01-05 | 2019-01-03 | Amneal Pharmaceuticals Company Gmbh | Crystalline Form Of Ticagrelor |
| CN107595789B (zh) | 2016-04-21 | 2021-01-15 | 阿斯利康(瑞典)有限公司 | 口腔崩解片 |
| US10905691B2 (en) | 2016-09-09 | 2021-02-02 | Université de Liège | Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection |
| ES2731658T3 (es) * | 2016-09-09 | 2019-11-18 | Univ Liege | Derivados triazolo(4,5-d)pirimidina para uso en la prevención y tratamiento de infección bacteriana |
| KR101916956B1 (ko) | 2016-12-13 | 2018-11-08 | 보령제약 주식회사 | 티카그렐러의 신규한 고체 형태 및 이의 제조방법 |
| WO2018178997A1 (en) | 2017-03-31 | 2018-10-04 | Natco Pharma Limited | Novel crystalline form of ticagrelor |
| WO2019127294A1 (zh) * | 2017-12-29 | 2019-07-04 | 浙江天宇药业股份有限公司 | 一种纯化替格瑞洛的方法 |
| WO2019170244A1 (en) | 2018-03-08 | 2019-09-12 | Pharmaceutical Oriented Services Ltd. | Ticagrelor—containing tablet formulation |
| EA202190328A1 (ru) | 2018-07-27 | 2021-07-01 | КРКА, д.д., НОВО МЕСТО | Фармацевтическая композиция, содержащая тикагрелор |
| CN110194771A (zh) * | 2019-05-08 | 2019-09-03 | 北京济美堂医药研究有限公司 | 一种替格瑞洛药用ii晶型的制备方法 |
| CN114634489B (zh) * | 2022-04-19 | 2023-07-04 | 奎马特里克斯有限公司 | 结晶形式 |
| CN117510508A (zh) * | 2023-11-14 | 2024-02-06 | 江苏普润生物医药有限公司 | 一种高纯度ii晶型替格瑞洛的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| FR2687677B1 (fr) * | 1992-02-24 | 1996-10-11 | Union Pharma Scient Appl | Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| SK283206B6 (sk) * | 1995-07-11 | 2003-03-04 | Astra Pharmaceuticals Ltd. | Inhibítory agregácie krvných doštičiek, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie |
| AU5501598A (en) * | 1996-12-20 | 1998-07-17 | Astra Pharmaceuticals Limited | Triazolo{4,5-(d)}pyrimidinyl derivatives and their use as medicaments |
| TW530058B (en) * | 1997-07-22 | 2003-05-01 | Astra Pharma Prod | Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation |
| ES2249511T3 (es) * | 1997-07-25 | 2006-04-01 | Gilead Sciences, Inc. | Composiciones de analogos de nucleotido y procedimiento de sintesis. |
| TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| SE9904129D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| GB0013407D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Forms of a chemical compound |
-
2000
- 2000-06-02 GB GBGB0013407.2A patent/GB0013407D0/en not_active Ceased
-
2001
- 2001-05-22 AR ARP010102432A patent/AR032335A1/es unknown
- 2001-05-31 IL IL15277701A patent/IL152777A0/xx unknown
- 2001-05-31 AU AU6287401A patent/AU6287401A/xx active Pending
- 2001-05-31 ES ES01937109T patent/ES2259031T3/es not_active Expired - Lifetime
- 2001-05-31 PT PT01937109T patent/PT1289992E/pt unknown
- 2001-05-31 AT AT01937109T patent/ATE320430T1/de active
- 2001-05-31 EP EP10182133A patent/EP2292622A1/en not_active Withdrawn
- 2001-05-31 PT PT04015299T patent/PT1493745E/pt unknown
- 2001-05-31 SG SG200500599-6A patent/SG135965A1/en unknown
- 2001-05-31 UA UA20021210808A patent/UA73181C2/uk unknown
- 2001-05-31 DK DK01937109T patent/DK1289992T3/da active
- 2001-05-31 KR KR1020027016379A patent/KR100781864B1/ko not_active Ceased
- 2001-05-31 BR BR0111328-3A patent/BR0111328A/pt not_active Application Discontinuation
- 2001-05-31 CZ CZ2002-3918A patent/CZ304347B6/cs not_active IP Right Cessation
- 2001-05-31 CN CNB018105823A patent/CN1247583C/zh not_active Expired - Lifetime
- 2001-05-31 WO PCT/SE2001/001239 patent/WO2001092262A1/en not_active Ceased
- 2001-05-31 HK HK03104536.0A patent/HK1052347B/en not_active IP Right Cessation
- 2001-05-31 DK DK04015299.3T patent/DK1493745T3/da active
- 2001-05-31 DE DE60117972T patent/DE60117972T2/de not_active Expired - Lifetime
- 2001-05-31 CN CN2006100025095A patent/CN1817883B/zh not_active Expired - Lifetime
- 2001-05-31 EE EEP200200665A patent/EE05222B1/xx unknown
- 2001-05-31 HU HU1300386A patent/HU230471B1/hu unknown
- 2001-05-31 JP JP2002500875A patent/JP5036947B2/ja not_active Expired - Lifetime
- 2001-05-31 MY MYPI20012578A patent/MY140674A/en unknown
- 2001-05-31 MX MXPA02011795A patent/MXPA02011795A/es active IP Right Grant
- 2001-05-31 SK SK1685-2002A patent/SK287817B6/sk not_active IP Right Cessation
- 2001-05-31 RU RU2002135589/04A patent/RU2325391C2/ru active
- 2001-05-31 SI SI200131013T patent/SI1493745T1/sl unknown
- 2001-05-31 EP EP01937109A patent/EP1289992B1/en not_active Expired - Lifetime
- 2001-05-31 PL PL01359172A patent/PL359172A1/xx not_active IP Right Cessation
- 2001-05-31 ES ES04015299T patent/ES2384708T3/es not_active Expired - Lifetime
- 2001-05-31 MY MYPI20092026A patent/MY148652A/en unknown
- 2001-05-31 EP EP04015299.3A patent/EP1493745B2/en not_active Expired - Lifetime
- 2001-05-31 SI SI200130541T patent/SI1289992T1/sl unknown
- 2001-05-31 AT AT04015299T patent/ATE555115T1/de active
- 2001-05-31 US US10/296,990 patent/US20030181469A1/en not_active Abandoned
- 2001-05-31 CA CA2408596A patent/CA2408596C/en not_active Expired - Lifetime
- 2001-05-31 PL PL392882A patent/PL392882A1/pl not_active Application Discontinuation
- 2001-05-31 AU AU2001262874A patent/AU2001262874B2/en not_active Expired
- 2001-05-31 NZ NZ522638A patent/NZ522638A/en not_active IP Right Cessation
- 2001-05-31 HU HU0302284A patent/HU229374B1/hu unknown
- 2001-05-31 CZ CZ2012-293A patent/CZ307468B6/cs not_active IP Right Cessation
-
2002
- 2002-11-11 IL IL152777A patent/IL152777A/en active IP Right Grant
- 2002-11-15 ZA ZA200209324A patent/ZA200209324B/en unknown
- 2002-11-15 IS IS6623A patent/IS2609B/is unknown
- 2002-11-28 BG BG107331A patent/BG65837B1/bg unknown
- 2002-11-29 NO NO20025756A patent/NO323780B1/no not_active IP Right Cessation
-
2005
- 2005-08-30 RU RU2005127356/04A patent/RU2418802C2/ru active Protection Beyond IP Right Term
- 2005-10-03 US US11/240,801 patent/US7265124B2/en not_active Expired - Lifetime
-
2007
- 2007-03-05 AU AU2007200958A patent/AU2007200958B2/en active Active
- 2007-03-23 NO NO20071547A patent/NO332306B1/no not_active IP Right Cessation
- 2007-08-24 US US11/892,597 patent/US20070293513A1/en not_active Abandoned
- 2007-11-19 IL IL187482A patent/IL187482A/en active IP Right Grant
-
2008
- 2008-07-24 AR ARP080103205A patent/AR068086A2/es unknown
-
2009
- 2009-06-02 IS IS8825A patent/IS3019B/is unknown
- 2009-08-12 BG BG10110440A patent/BG66332B1/bg unknown
- 2009-12-07 IL IL202582A patent/IL202582A/en active IP Right Grant
-
2010
- 2010-12-10 RU RU2010150799/04A patent/RU2010150799A/ru not_active Application Discontinuation
- 2010-12-24 AU AU2010257449A patent/AU2010257449B2/en not_active Expired
-
2011
- 2011-04-19 PH PH12011000127A patent/PH12011000127A1/en unknown
- 2011-08-18 BG BG10111017A patent/BG111017A/bg unknown
-
2012
- 2012-05-01 JP JP2012104575A patent/JP5684192B2/ja not_active Expired - Lifetime
- 2012-05-14 NO NO20120595A patent/NO333289B1/no not_active IP Right Cessation
- 2012-06-21 CY CY20121100559T patent/CY1113047T1/el unknown
-
2014
- 2014-04-07 JP JP2014078665A patent/JP2014129423A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2010150799A (ru) | НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО(4,5-d)ПИРИМИДИНА | |
| RU2002135589A (ru) | Новая кристаллическая и аморфная форма триазоло(4,5-d) пиримидина | |
| RU2325389C2 (ru) | Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью | |
| KR0180019B1 (ko) | 개량된 화학적 화합물 | |
| SE0104340D0 (sv) | New compounds | |
| SI1326613T1 (en) | Use of substituted imidazo 1,2-a)pyridine-, imidazo (1,2-a)pyrimidine and imidazo (1,2-a)pyrazine-3-yl-amine derivatives for producing nos-inhibiting medicaments | |
| WO2004026863A8 (en) | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors | |
| RU2007101653A (ru) | Производные 1-азабицикло[3.3.1]нонанов | |
| MXPA01006474A (es) | Derivados colquinol como agentes perjudiciales vasculares. | |
| NO20021728L (no) | Pyrimidin derivater | |
| TW200817402A (en) | Substituted pteridines | |
| WO2002088100A3 (de) | Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel | |
| AU2002359162A1 (en) | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 | |
| CA2467269A1 (en) | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | |
| JP2911239B2 (ja) | スクアレンエポキシダーゼの抑制剤としてのスクアレンのジ−及びテトラ−フルオロ類似体類 | |
| JPH02255652A (ja) | ベンゼンスルホンアミド類およびその製造方法 | |
| IL150817A0 (en) | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases | |
| RU2004102398A (ru) | Производные бензо[g]хинолина для лечения глаукомы и близорукости | |
| MX2010012540A (es) | Derivados de imidazo[2,1-b]quinazolin-2-ona y su uso como agentes para inhibir la agregación plaquetaria. | |
| CN1128999A (zh) | 杂环化合物 | |
| RU2003126176A (ru) | Кислотно-аддитивные соли тербинафина и яблочной кислоты | |
| JP2005507424A (ja) | 固形腫瘍の処置における７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の使用 | |
| RU2004131220A (ru) | Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих | |
| HUP0400869A2 (hu) | Fenileténszulfonamid-pirimidin-származék új kristályalakjai, valamint eljárás ezek előállítására | |
| JPH05105627A (ja) | 腸機能性疾患の治療に用いられる新規な医薬組成物と、その調整方法と、治療用医薬の調製方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160219 |