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PT1349593E - Injector do tipo caneta com uma unidade de controlo electrónico - Google Patents

Injector do tipo caneta com uma unidade de controlo electrónico Download PDF

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Publication number
PT1349593E
PT1349593E PT01272097T PT01272097T PT1349593E PT 1349593 E PT1349593 E PT 1349593E PT 01272097 T PT01272097 T PT 01272097T PT 01272097 T PT01272097 T PT 01272097T PT 1349593 E PT1349593 E PT 1349593E
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Portugal
Prior art keywords
dose
control unit
electronic control
arm
button
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PT01272097T
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English (en)
Inventor
Christopher Nigel Langley
Robert Woolston
Shane Alistair Day
Robert Frederick Veasey
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Dca Design Int Ltd
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Publication of PT1349593E publication Critical patent/PT1349593E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
    • A61M2205/215—Tilt detection, e.g. for warning or shut-off
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/01—Motorized syringe

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Fuel-Injection Apparatus (AREA)
  • Read Only Memory (AREA)
  • External Artificial Organs (AREA)
  • Knitting Machines (AREA)
  • Electrical Control Of Air Or Fuel Supplied To Internal-Combustion Engine (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coating Apparatus (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polarising Elements (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Elimination Of Static Electricity (AREA)
  • Vehicle Body Suspensions (AREA)
  • Seal Device For Vehicle (AREA)
  • Valve Device For Special Equipments (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Medicinal Preparation (AREA)
  • Disintegrating Or Milling (AREA)
  • Catching Or Destruction (AREA)
  • Electrostatic Spraying Apparatus (AREA)

Description

DESCRIÇÃO
"INJECTOR DO TIPO CANETA COM UMA UNIDADE DE CONTROLO ELECTRÓNICO" A presente invenção refere-se a aperfeiçoamentos num dispositivo de injecção e, em particular, a aperfeiçoamentos num dispositivo de injecção portátil destinado a administrar quantidades controladas de um medicamento.
Estes dispositivos de injecção são utilizados, tipicamente, pelas pessoas que sofrem de diabetes para administrar a si próprios uma dose de insulina ou um medicamento do tipo insulina. Deve compreender-se que estes dispositivos de injecção são adequados para injectar outros medicamentos.
Anteriormente, essas doses eram administradas utilizando uma seringa descartável; sendo a seringa, em primeiro lugar, cheia a partir de um pequeno frasco ou de outro recipiente e, em seguida, utilizada para injectar a dose. No entanto, uma configuração desse tipo apresentava uma série de dificuldades. Em particular, uma configuração desse tipo não era adequada para o enfermo. Para outros, o estigma social associado com essas seringas tornava problemática a sua utilização pública.
Para ultrapassar estas dificuldades criaram-se uma série de, assim denominados, injectores do tipo caneta. Estes dispositivos são pequenos, e estão aptos a serem transportados num bolso dum casaco ou afim e permitem obter uma série de doses a partir dum 1 cartucho ou ampola contida dentro do injector. A presente invenção aplica-se particularmente a estes injectores do tipo caneta.
Apesar destes injectores do tipo caneta serem um aperfeiçoamento considerável em relação às seringas hipodérmicas descartáveis, há problemas que, no entanto, permanecem. A presente invenção tem a vantagem de eliminar, ou, pelo menos, reduzir substancialmente, esses problemas. A presente invenção também proporciona uma facilidade de utilização aperfeiçoada e uma interacção aperfeiçoada com um utilizador. A invenção vai agora ser descrita, apenas a titulo de exemplo, fazendo referência aos desenhos em anexo, nos quais: A Figura 1 mostra uma planta de um injector do tipo caneta de acordo com a presente invenção; A Figura 2 mostra uma vista idêntica à da Figura 1, com uma tampa da extremidade do injector omitida; A Figura 3 mostra uma vista em corte do injector das Figuras 1 e 2; e A Figura 3A mostra uma vista idêntica à da Figura 3, com um cartucho cheio no injector.
No que se refere, em primeiro lugar, às Figuras 1 a 3, pode ver-se um injector 2 do tipo caneta de acordo com a presente invenção. 0 injector 2 compreende um invólucro 4 principal ao 2 qual está presa, de modo a poder libertar-se, uma tampa da extremidade ou cobertura 6.
Numa primeira extremidade do invólucro 4 principal é proporcionada uma zona 8 de painel de controlo. Esta zona inclui um painel 10 de visualização, tipicamente um visor LCD, e um primeiro botão 12 de dose e um segundo botão 14 de dose, sendo o primeiro e segundo botões de dose accionados para aumentar ou diminuir uma dose de medicamento a ser administrada. A zona 10 de painel de controlo na forma de realização ilustrada também inclui um botão 16 de armar.
Na primeira extremidade do invólucro principal é também proporcionado um botão 18 de administração de medicamento. Quando não está premido, o botão 18 de administração de medicamento está, de um modo preferido, nivelado com o invólucro 4 principal.
Ao longo de um eixo longitudinal do injector 2, em cada lado da zona 10 de painel de controlo, existe uma série de ranhuras ou recessos 20. Estes recessos ajudam o utilizador a agarrar o injector 2.
Numa segunda extremidade do invólucro 4 principal, uma unidade 22 de agulha está presa ao invólucro principal, de modo a poder libertar-se. A segunda extremidade do invólucro 4 principal também está dotada de uma parcela 24 modelada.
Em utilização, um cartucho 40, ou ampola, de medicamento está armazenado no invólucro 4, atrás da parcela 24 modelada. A 3 parcela modelada é, de um modo preferido, transparente para permitir que o cartucho 40 seja visto pelo utilizador.
Na segunda extremidade do invólucro 4 também se proporciona um botão 26 de escorvamento. Deve compreender-se que, quando a tampa 6 está colocada sobre a segunda extremidade do invólucro, não será possível premir inadvertidamente o botão 26 de escorvamento ou ser picado pela unidade 22 de agulha. Um interruptor 28 de detecção de cobertura também pode estar incluído na segunda extremidade do invólucro 4 principal, para detectar se a tampa da extremidade ou cobertura 6 está ou não colocada.
Na Figura 3 pode ver-se um contacto 30 de escorvamento, um contacto 32 de armar, um primeiro contacto 34 de dose e um segundo contacto 36 de dose, correspondentes aos botões respectivos. Também se mostra um contacto 19 de administração de medicamento, correspondente ao botão 18 de administração de medicamento.
No que se refere à Figura 3, pode ver-se que é proporcionado um local adequado para uma fonte 38 de alimentação, como por exemplo uma bateria ou baterias. Também existe uma zona adequada para colocar um cartucho 40, ou ampola, de medicamento. Pode aceder-se a esta zona através da parcela 24 modelada removível do invólucro 4 principal de modo a permitir a substituição do cartucho 40, ou ampola, conforme requerido pelo utilizador.
Numa terceira zona do invólucro 4 principal é proporcionado um mecanismo 42 de accionamento que é alimentado pela fonte 38 4 de alimentação e actua sobre o cartucho 40, ou ampola de medicamento. O cartucho 40, ou ampola, compreende um recipiente 44, ou manga, fechado numa extremidade por uma cobertura 46 numa respectiva extremidade principal, e vedado na outra por um tampão 48 amovível, ou rolha. Quando está em posição, a unidade 22 de agulha perfura a cobertura 46 e o movimento do tampão 48, na direcção da cobertura 46, vai fazer com que o medicamento contido no interior do cartucho 40, ou ampola, seja expelido. O cartucho pode ser um cartucho de 3 ml, de acordo com a norma ISO/FDIS 11608 Parte 3, ou qualquer outro cartucho adequado que se adapte ao injector. O movimento do tampão 48, ou rolha, é provocado pelo movimento de um pistão ou êmbolo 50 que constitui uma parte do mecanismo 42 de accionamento. O pistão ou êmbolo 50 é móvel entre uma primeira posição completamente retraída (não mostrada) que permite a substituição do cartucho 40, ou ampola, e uma segunda posição completamente estendida, na qual foi expelida a maior quantidade possível de medicamento do cartucho 40, ou ampola. Pode proporcionar-se um interruptor 52 de fim-de-curso no invólucro 4 principal, para detectar quando que o pistão 50 se encontra na posição completamente retraída. O disparo do interruptor 52 de fim-de-curso pode libertar um trinco ou outro dispositivo de fixação, para permitir o acesso ao invólucro 4 principal para substituir o cartucho 40. O mecanismo 42 de accionamento é accionado por um motor 54 sob o controlo de uma unidade de controlo electrónico (não mostrada) . O motor 54 deve ser reversível, de modo a permitir 5 que o pistão 54 seja deslocado entre a primeira posição e a segunda posição. Na Figura 3, pode ver-se que o motor 54 acciona o pistão 50 por intermédio de um jogo de engrenagens 42, de modo que a rotação de um terceiro rotor 58 faça com que o pistão 50 seja deslocado, relativamente ao terceiro rotor 58. O utilizador pode, de um modo preferido, sentir a vibração do motor 54 e do mecanismo 42 de accionamento associado e/ou ouvi-los em funcionamento. Deste modo, proporciona-se ao utilizador um maior grau de confiança relativamente ao funcionamento do injector 2.
Será agora descrita a funcionalidade de um injector do tipo caneta de acordo com a presente invenção, com referência, em particular, às Figuras 1, 2 e 3. O injector 2 está dotado com uma unidade de controlo electrónico. A unidade de controlo electrónico está acoplada quer ao mecanismo de accionamento, quer a uma interface de utilizador. A interface de utilizador inclui o painel 10 de visualização bem como os botões accionáveis pelo utilizador (e contactos associados) . A unidade de controlo electrónico funciona com base num microprocessador. Pode utilizar-se uma memória volátil ou não volátil para armazenamento da "história das dosagens" e de informação especifica relacionada com o doente. A unidade de controlo electrónico é, de um modo preferido, alimentada pela fonte 38 de alimentação do injector. 6 0 injector 2 também inclui, de um modo preferido, uma porta para comunicação entre a unidade de controlo electrónico e um equipamento externo, como por exemplo um computador pessoal. 0 injector 2 também possui um acessório de detecção de escorvamento (como por exemplo um detector de inclinação ou acelerómetro) para identificar quando o injector 2 é invertido. Após a detecção de uma posição invertida (agulha virada para cima) o injector 2 irá, automaticamente, alterar o estado para estar pronto para ser escorvado. 0 escorvamento pode ser iniciado premindo o botão 26 de escorvamento, para provocar uma acção de administração de medicamento pequena e fixa. A unidade de controlo electrónico pode fazer com que um altifalante emita som quando o botão 26 de escorvamento é premido. 0 botão 26 de escorvamento está inactivo, em todas as outras ocasiões. Quando o botão 26 de escorvamento está activo, todos os outros botões existentes na zona de painel de controlo estão inactivos, ou seja, os botões que são utilizados para ajustar ou administrar uma dose. A unidade de controlo electrónico pode fazer com que um altifalante emita som quando o botão 16 de armar é premido durante um período de tempo suficiente para proporcionar uma informação de retorno audível ao utilizador.
A função do botão 16 de armar é fazer com que o botão 18 de administração fique activo. 0 botão de armar é, de um modo preferido, mantido premido durante um período de tempo predeterminado antes do injector 2 ser armado. 0 estado armado pode, além disso, ser mostrado no painel 10 de visualização. A 7 funcionalidade do botão de armar está, de um modo preferido, ligada ao interruptor 28 de detecção de cobertura, para que o botão 16 de armar funcione, apenas, para armar o injector 2 quando a cobertura 6 não está presente.
Além disso, numa forma de realização preferida, um relógio existente no interior da unidade de controlo electrónico vai detectar se o botão 18 de administração foi pressionado durante um intervalo de tempo especificado, após a armação do injector 2. Se o botão 18 de administração não tiver sido pressionado durante o intervalo de tempo especificado, a unidade de controlo electrónico irá desarmar o injector 2.
De uma forma alternativa, se o botão de armar for premido uma segunda vez pelo utilizador, durante um período de tempo predeterminado, o injector será desactivado.
Numa forma de realização alternativa, o botão de dose 18 pode funcionar, quer como um botão de escorvamento, quer como o botão de dose. Quando o detector de escorvamento é activado, pelo facto do injector 2 estar orientado com a agulha virada para cima, o botão 18 de dose vai alterar a sua função, de modo a actuar como o botão de escorvamento da forma de realização anterior.
Os botões do injector 2 apresentam, de um modo preferido, uma natureza táctil de modo a proporcionarem uma informação de retorno ao utilizador. 0 painel 10 de visualização é, tipicamente, um visor LCD e irá proporcionar uma informação alfanumérica e gráfica referente 8 ao funcionamento do dispositivo. 0 painel 10 de visualização indica, de um modo preferido, a quantidade de dose seleccionada, a quantidade de dose anterior, e o tempo que decorreu desde que a dose anterior foi administrada. O tempo decorrido desde a dose anterior está, tipicamente, limitado a um período de tempo dentro das 48 horas anteriores, embora seja possível utilizar outros períodos de tempo. A informação adicional que pode ser exibida inclui: - que o injector está armado e pronto a administrar uma dose (gráfica) - que o injector está a administrar uma dose (gráfica) - que o injector administrou a dose seleccionada e que um utilizador deve esperar antes de remover a agulha do seu corpo - que este período de espera já passou - o histórico das dosagens, tipicamente das últimas 48 horas, em termos da dosagem recebida e do tempo decorrido entre doses - a quantidade de medicamento que resta no cartucho, de um modo preferido em termos de unidades de dosagem do medicamento - que o dispositivo está na posição de escorvamento (ou além da indicação acústica acima referida, ou em vez desta) - a regulação do volume do altifalante, por exemplo alto, baixo ou inactivo 9 - que o injeetor está a aproximar-se do fim da sua vida útil (por exemplo uma indicação do nivel de energia da bateria -gráfica ou por contagem decrescente, em termos do número de dias ou de ciclos de funcionamento completos até à expiração predeterminada da vida útil do produto - alfanumérica) - que a agulha está provavelmente bloqueada - que a substituição do cartucho 40 está a ser efectuada - que a dose seleccionada é a máxima disponível no cartucho 40 - que a máxima dose disponível é inferior à dose esperada. 0 painel 10 de visualização pode oferecer ao utilizador uma escolha de opções de linguagem, conforme for apropriado para o mercado e/ou utilizador. 0 texto exibido pode incluir o acima referido e/ou informação adicional. A opção de linguagem pode ser pré-programada ou passível de ser seleccionada pelo utilizador. 0 utilizador pode, de um modo preferido, seleccionar a opção de linguagem através de um menu proporcionado no painel 10 de visualização. O valor da dose actualmente seleccionada, o valor da dose anteriormente utilizada e o tempo (em horas) desde que a dose anterior foi administrada, podem ser todos mostrados, claramente e ao mesmo tempo, em caracteres grandes e fáceis de ler no visor. O visor também pode ser, de um modo preferido, retroiluminado. 10 0 visor 10 faculta, de um modo preferido, uma indicação gráfica que indica que a dose seleccionada está a ser administrada. Esta indicação pode ser obtida, por exemplo, ou através de uma animação gráfica ou através de uma contagem decrescente (ou através de uma combinação das duas).
Os botões de controlo têm várias funções. Os botões 12, 14 de dose, permitem que um utilizador seleccione uma dosagem pretendida. O botão 16 de armar a dose permite que um utilizador confirme a selecçâo de uma dosagem pretendida. O primeiro botão de dose pode incrementar o nível de dosagem e o segundo botão de dose pode decrementar o nível de dosagem. Os botões 12, 14 de marcação de dose, podem ser pressionados no sentido descendente (e mantidos durante um curto período de tempo, 1-2 segundos) de modo a repor um valor de dose a zero. O utilizador pode, em seguida, marcar as doses, subindo (ou descendo) os valores em incrementos simples (ou em metades).
Os botões 12, 14, de marcação de dose destinam-se a ser pressionados uma vez para um incremento simples (ou metade) no valor da dose seleccionada. Numa forma de realização alternativa, o acto de pressionar e manter pressionado um dos botões vai fazer com que o valor da dose comece a desenrolar-se no visor (para cima ou para baixo) de modo a alterar o tamanho da dose mais rapidamente. O botão de administração de dose 18 permite que um utilizador inicie a administração da dosagem. O botão 26 de escorvamento administra uma unidade de dosagem a partir do cartucho 40. Consequentemente, se algum ar ficar aprisionado no injector 2, pode ser expelido utilizando o botão 26 de 11 É proporcionado um trinco de para permitir o acesso ao cartucho 40. escorvamento. abertura de porta
Lisboa, 4 de Junho de 2007 12

Claims (5)

  1. REIVINDICAÇÕES 1. Dispositivo de injecção tendo um mecanismo (42) de accionamento para expelir selectivamente uma dose de medicamento, a partir de um cartucho (40) de medicamento, através de uma unidade (22) de agulha, uma unidade de controlo electrónico para controlar o mecanismo (42) de accionamento, e um botão (18) de administração, para gerar um sinal de botão de administração, indicativo da dose a ser expelida, para a unidade de controlo electrónico, em que um botão (16) de armar faz com que um primeiro sinal de botão de armar seja enviado para a unidade de controlo electrónico, para permitir que a dose seja expelida, em que o botão (16) de armar está ligado a um interruptor (28) de detecção de cobertura, de modo a que o botão (16) de armar apenas irá funcionar para armar um injector (2) quando não estiver presente uma cobertura.
  2. 2. Dispositivo de injecção de acordo com a reivindicação 1, caracterizado por, quando o sinal do botão de administração não for gerado dentro de um período predeterminado do sinal de armar, a unidade de controlo electrónico não ir accionar o mecanismo (42) de accionamento, em resposta ao sinal do botão de administração.
  3. 3. Dispositivo de injecção de acordo com a reivindicação 1 ou reivindicação 2, caracterizado por o botão de armar ter de gerar o primeiro sinal do botão de armar por um período de tempo predeterminado, antes de a unidade de controlo electrónico responder ao sinal do botão de armar. 1
  4. 4. Dispositivo de injecção de acordo com qualquer das reivindicações 1 a 3, caracterizado por o dispositivo de injecção ser, além disso, dotado com um painel (10) de visualização, proporcionando o painel (10) de visualização uma indicação de que a dose pode ser expelida.
  5. 5. Dispositivo de injecção de acordo com qualquer das reivindicações 1 a 4, caracterizado por, quando o botão de armar gera um sinal do botão de armar subsequente, dentro de um período predeterminado do primeiro sinal do botão de armar, a unidade de controlo electrónico não ir accionar o mecanismo (42) de accionamento, em resposta ao sinal do botão de administração. Lisboa, 4 de Junho de 2007 2
PT01272097T 2000-12-22 2001-12-21 Injector do tipo caneta com uma unidade de controlo electrónico PT1349593E (pt)

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PT01272106T PT1351728E (pt) 2000-12-22 2001-12-21 Mecanismo de acionamento para um dispositivo de injeccao
PT01272107T PT1349588E (pt) 2000-12-22 2001-12-21 Dispositivo de injeccao com cartucho substituivel
PT01272093T PT1353712E (pt) 2000-12-22 2001-12-21 Mecanismo de accionamento para um dispositivo de injecção
PT01272097T PT1349593E (pt) 2000-12-22 2001-12-21 Injector do tipo caneta com uma unidade de controlo electrónico
PT01273458T PT1349595E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272092T PT1349587E (pt) 2000-12-22 2001-12-21 Mecanismo de accionamento para um dispositivo de injeccao
PT01273459T PT1349596E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272104T PT1349594E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com um mecanismo de suporte para um cartucho de medicamento
PT01272094T PT1349591E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272101T PT1353713E (pt) 2000-12-22 2001-12-21 Meio de doseamento para um dispositivo de injeccao
PT01272095T PT1349592E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272098T PT1353715E (pt) 2000-12-22 2001-12-21 Injector do tipo caneta com uma unidade de controlo electronico

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PT01272107T PT1349588E (pt) 2000-12-22 2001-12-21 Dispositivo de injeccao com cartucho substituivel
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PT01272092T PT1349587E (pt) 2000-12-22 2001-12-21 Mecanismo de accionamento para um dispositivo de injeccao
PT01273459T PT1349596E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272104T PT1349594E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com um mecanismo de suporte para um cartucho de medicamento
PT01272094T PT1349591E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272101T PT1353713E (pt) 2000-12-22 2001-12-21 Meio de doseamento para um dispositivo de injeccao
PT01272095T PT1349592E (pt) 2000-12-22 2001-12-21 Injector tipo caneta com uma unidade de controlo electronico
PT01272098T PT1353715E (pt) 2000-12-22 2001-12-21 Injector do tipo caneta com uma unidade de controlo electronico

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DE60112472T3 (de) 2016-08-11
AU2002216236B2 (en) 2005-08-04
CN1482927A (zh) 2004-03-17
KR100788318B1 (ko) 2007-12-27
CA2430928A1 (en) 2002-07-04
CA2430922C (en) 2010-02-02
ES2240341T3 (es) 2005-10-16
US6997906B2 (en) 2006-02-14
WO2002051472A1 (en) 2002-07-04
CN100400117C (zh) 2008-07-09
KR20030066738A (ko) 2003-08-09
WO2002051475A1 (en) 2002-07-04
DE60110642D1 (de) 2005-06-09
ATE294601T1 (de) 2005-05-15
WO2002051481A1 (en) 2002-07-04
KR100826221B1 (ko) 2008-04-30
DE60112472T2 (de) 2006-08-17
BR0116276A (pt) 2003-12-30
JP4694095B2 (ja) 2011-06-01
CA2430931A1 (en) 2002-07-04
EP1349594B1 (en) 2005-05-04
EP1353712B1 (en) 2006-10-11
IL156270A0 (en) 2004-01-04
WO2002051476A1 (en) 2002-07-04
CN1481262A (zh) 2004-03-10
HK1059579A1 (en) 2004-07-09
KR20030066739A (ko) 2003-08-09
CY1106295T1 (el) 2011-10-12
CN1505534A (zh) 2004-06-16
HK1059902A1 (en) 2004-07-23
US6869413B2 (en) 2005-03-22
DE60119164D1 (de) 2006-06-01
DK1349591T4 (en) 2016-05-30
JP2004516107A (ja) 2004-06-03
CA2430940A1 (en) 2002-07-04
JP4308524B2 (ja) 2009-08-05
CN1292809C (zh) 2007-01-03
CN1290588C (zh) 2006-12-20
DE60110639T2 (de) 2006-01-19
KR20030066728A (ko) 2003-08-09
PT1349591E (pt) 2005-11-30
JP2011062538A (ja) 2011-03-31
EP1349591A1 (en) 2003-10-08
EP1349593A1 (en) 2003-10-08
BR0116280B1 (pt) 2009-12-01
US6969370B2 (en) 2005-11-29
DK1349591T3 (da) 2005-11-28
EP1349587A1 (en) 2003-10-08
AU2007201951A1 (en) 2007-05-24
DK1349593T3 (da) 2007-07-16
ES2240343T3 (es) 2005-10-16
US20040030296A1 (en) 2004-02-12
CA2430914A1 (en) 2002-08-01
JP5054739B2 (ja) 2012-10-24
JP2004516106A (ja) 2004-06-03
BR0116295A (pt) 2004-08-17
CA2430788A1 (en) 2002-07-04
AU2007201951B2 (en) 2009-07-16
KR100788319B1 (ko) 2007-12-27
EP1349593B1 (en) 2007-03-14
IL156244A (en) 2009-05-04
JP2004516109A (ja) 2004-06-03
ATE294603T1 (de) 2005-05-15
AU2002216230B2 (en) 2005-08-04
GB0031466D0 (en) 2001-02-07
JP2004516111A (ja) 2004-06-03
DE60110929T2 (de) 2006-04-27
EP1351728A1 (en) 2003-10-15
PT1349594E (pt) 2005-08-31
US20040073173A1 (en) 2004-04-15
DE60110463T2 (de) 2006-02-23
CN1482926A (zh) 2004-03-17
IL156251A (en) 2009-02-11
KR100826227B1 (ko) 2008-04-30
BR0116295B1 (pt) 2009-12-01
JP4308523B2 (ja) 2009-08-05
IL156239A0 (en) 2004-01-04
EP1349592B1 (en) 2005-05-04
KR100826222B1 (ko) 2008-04-30
MXPA03005596A (es) 2004-05-17
BR0116294A (pt) 2004-08-17
DE60127303D1 (de) 2007-04-26
JP2004516105A (ja) 2004-06-03
CA2430940C (en) 2009-11-24
BR0116277A (pt) 2003-12-30
KR100788321B1 (ko) 2007-12-27
JP4436043B2 (ja) 2010-03-24
JP4955637B2 (ja) 2012-06-20
AU2002222302B2 (en) 2005-08-04
US6949082B2 (en) 2005-09-27
DE60119164T2 (de) 2007-02-01
JP2004516108A (ja) 2004-06-03
EP1349588B1 (en) 2005-05-18
MXPA03005592A (es) 2004-05-14
MXPA03005594A (es) 2004-05-17
HK1059586A1 (en) 2004-07-09
KR20040023580A (ko) 2004-03-18
KR100788316B1 (ko) 2007-12-27
US7052484B2 (en) 2006-05-30
MXPA03005578A (es) 2004-05-17
BR0116298B1 (pt) 2009-12-01
IL156240A0 (en) 2004-01-04
ES2263550T3 (es) 2006-12-16
CA2430935C (en) 2010-02-02
EP1349594A1 (en) 2003-10-08
IL156242A (en) 2007-12-03
WO2002051480A1 (en) 2002-07-04
JP4614621B2 (ja) 2011-01-19
CY1106652T1 (el) 2012-01-25
WO2002058767A1 (en) 2002-08-01
AU2002217288B2 (en) 2005-08-04
WO2002051477A1 (en) 2002-07-04
AU2002216254B2 (en) 2007-01-25
CA2430920A1 (en) 2002-07-04
BR0116278B1 (pt) 2010-09-21
CN1501821A (zh) 2004-06-02
HK1059903A1 (en) 2004-07-23
JP2010005414A (ja) 2010-01-14
EP1345641A1 (en) 2003-09-24
CA2430920C (en) 2009-04-07
DK1349588T3 (da) 2005-09-05
KR100788317B1 (ko) 2007-12-27
JP4164362B2 (ja) 2008-10-15
JP2004523282A (ja) 2004-08-05
ATE294600T1 (de) 2005-05-15
ATE294602T1 (de) 2005-05-15
PT1349588E (pt) 2005-09-30
CN1481261A (zh) 2004-03-10
MXPA03005576A (es) 2004-05-05
PT1349592E (pt) 2005-08-31
JP2009000557A (ja) 2009-01-08
EP1349592A1 (en) 2003-10-08
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AU2002216232B2 (en) 2005-08-18
JP2004516103A (ja) 2004-06-03
US20040054329A1 (en) 2004-03-18
US7699815B2 (en) 2010-04-20
EP1349591B8 (en) 2005-12-28
JP4287145B2 (ja) 2009-07-01
US20040030298A1 (en) 2004-02-12
PT1353713E (pt) 2006-08-31
ATE294002T1 (de) 2005-05-15
JP2004516104A (ja) 2004-06-03
US6942646B2 (en) 2005-09-13
IL156245A0 (en) 2004-01-04
EP1349596B1 (en) 2005-05-04
EP1349596A1 (en) 2003-10-08
IL156248A0 (en) 2004-01-04
HK1059747A1 (en) 2004-07-16
JP4676673B2 (ja) 2011-04-27
BR0116274B1 (pt) 2009-12-01
IL156239A (en) 2008-11-26
DK1349595T3 (da) 2005-11-21
BR0116279B1 (pt) 2009-12-01
WO2002051471A1 (en) 2002-07-04
DE60110637D1 (de) 2005-06-09
US20040078001A1 (en) 2004-04-22
DE60127303T2 (de) 2007-12-20
KR20030066742A (ko) 2003-08-09
ES2246289T3 (es) 2006-02-16
ES2240348T3 (es) 2005-10-16
ATE294599T1 (de) 2005-05-15
HK1059584A1 (en) 2004-07-09
AU2002217283B2 (en) 2007-01-25
JP2004516102A (ja) 2004-06-03
JP2004521681A (ja) 2004-07-22
CA2430922A1 (en) 2002-07-04
CN1568205A (zh) 2005-01-19
CA2430788C (en) 2010-02-02
CA2430917C (en) 2009-02-17
AU2002216231B2 (en) 2005-08-04
PT1349596E (pt) 2005-08-31
MXPA03005595A (es) 2004-05-17
EP1353715B1 (en) 2005-05-04
DK1349593T4 (en) 2018-06-25
KR20030066724A (ko) 2003-08-09
PT1353715E (pt) 2005-08-31
MXPA03005584A (es) 2004-05-17
AU2007202032B2 (en) 2009-11-05
ES2240342T3 (es) 2005-10-16
HK1059581A1 (en) 2004-07-09
CN1284609C (zh) 2006-11-15
WO2002058766A1 (en) 2002-08-01
DK1353715T3 (da) 2005-08-22
CN1267161C (zh) 2006-08-02
IL156238A (en) 2009-02-11
KR100788323B1 (ko) 2007-12-27
CN1270786C (zh) 2006-08-23
IL156241A0 (en) 2004-01-04
US20040054328A1 (en) 2004-03-18
KR20030066725A (ko) 2003-08-09
EP1349595B1 (en) 2005-07-27
BR0116298A (pt) 2004-08-17
IL156243A0 (en) 2004-01-04
ES2247008T3 (es) 2006-03-01
CN1261171C (zh) 2006-06-28
CA2430938C (en) 2009-11-24
PT1351728E (pt) 2005-08-31
CA2430931C (en) 2010-02-02
US8469922B2 (en) 2013-06-25
KR20030066729A (ko) 2003-08-09
PT1353712E (pt) 2007-01-31
EP1349591B2 (en) 2016-03-09
CN1482928A (zh) 2004-03-17
DE60110463D1 (de) 2005-06-02
DE60110642T2 (de) 2006-01-19
CA2430925A1 (en) 2002-07-04
IL156251A0 (en) 2004-01-04
DE60110638D1 (de) 2005-06-09
IL156244A0 (en) 2004-01-04
JP2004516110A (ja) 2004-06-03
CN1482930A (zh) 2004-03-17
EP1349593B2 (en) 2018-04-04
BR0116280A (pt) 2003-12-30
EP1349588A1 (en) 2003-10-08
CA2430938A1 (en) 2002-07-04
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BR0116274A (pt) 2003-12-30
IL156240A (en) 2007-12-03
CN1290587C (zh) 2006-12-20
MXPA03005575A (es) 2004-05-05
DE60112326D1 (de) 2005-09-01
DK1349594T3 (da) 2005-08-29
BR0116275A (pt) 2003-12-30
HK1059583A1 (en) 2004-07-09
DE60110636D1 (de) 2005-06-09
US20040097873A1 (en) 2004-05-20
CA2430942C (en) 2010-02-02
CY1106128T1 (el) 2011-06-08
CA2431135C (en) 2009-11-24
MXPA03005590A (es) 2004-05-14
IL156245A (en) 2007-12-03
US20040044317A1 (en) 2004-03-04
WO2002051473A1 (en) 2002-07-04
MXPA03005593A (es) 2004-05-17
EP1353715A1 (en) 2003-10-22
DE60127303T3 (de) 2018-08-16
JP4150589B2 (ja) 2008-09-17
DE60112326T2 (de) 2006-04-20
HK1059904A1 (en) 2004-07-23
CA2430928C (en) 2010-11-30
WO2002051479A1 (en) 2002-07-04
BR0116279A (pt) 2003-12-30
DK1349596T3 (da) 2005-08-22
US20040054319A1 (en) 2004-03-18
US20040024364A1 (en) 2004-02-05
DK1353712T3 (da) 2007-02-12
JP2004516112A (ja) 2004-06-03
BR0116273B1 (pt) 2009-12-01
EP1349591B1 (en) 2005-08-03
ATE300324T1 (de) 2005-08-15
CA2430917A1 (en) 2002-07-04
BR0116296B1 (pt) 2009-12-01
MXPA03005591A (es) 2004-05-14
DE60123836D1 (de) 2006-11-23
DE60123836T2 (de) 2007-05-24
IL156238A0 (en) 2004-01-04
IL156243A (en) 2008-11-03
AU2002216235B2 (en) 2007-05-24
IL156242A0 (en) 2004-01-04
DK1349592T3 (da) 2005-08-29
CN1482931A (zh) 2004-03-17
ES2283375T3 (es) 2007-11-01
HK1059585A1 (en) 2004-07-09
IL156270A (en) 2009-02-11
CN1482933A (zh) 2004-03-17
US20040122355A1 (en) 2004-06-24
ATE342076T1 (de) 2006-11-15
BR0116275B1 (pt) 2010-09-21
KR20030066726A (ko) 2003-08-09
HK1059580A1 (en) 2004-07-09
CA2431135A1 (en) 2002-07-04
WO2002051474A1 (en) 2002-07-04
BR0116278A (pt) 2003-12-30
AU2007202032A1 (en) 2007-05-24
CN1482929A (zh) 2004-03-17
ES2247008T5 (es) 2016-06-24
DE60110929D1 (de) 2005-06-23
KR20030066743A (ko) 2003-08-09
PT1349595E (pt) 2005-11-30
CN1482932A (zh) 2004-03-17
CA2430935A1 (en) 2002-07-04
ATE295749T1 (de) 2005-06-15
BR0116273A (pt) 2003-12-30
DE60110639D1 (de) 2005-06-09
MXPA03005589A (es) 2004-05-14
KR20030066741A (ko) 2003-08-09
US7081108B2 (en) 2006-07-25
CA2430942A1 (en) 2002-08-01
CN1248746C (zh) 2006-04-05
IL156246A0 (en) 2004-01-04
EP1353713A1 (en) 2003-10-22
EP1349595A1 (en) 2003-10-08
CN1325127C (zh) 2007-07-11

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