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PE20141360A1 - Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos. - Google Patents

Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.

Info

Publication number
PE20141360A1
PE20141360A1 PE2013001837A PE2013001837A PE20141360A1 PE 20141360 A1 PE20141360 A1 PE 20141360A1 PE 2013001837 A PE2013001837 A PE 2013001837A PE 2013001837 A PE2013001837 A PE 2013001837A PE 20141360 A1 PE20141360 A1 PE 20141360A1
Authority
PE
Peru
Prior art keywords
kinases
compounds
indications
modulation
methods
Prior art date
Application number
PE2013001837A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Chao Zhang
Wayne Spevak
Jiazhong Zhang
Guoxian Wu
Jack Lin
Hanna Cho
Marika Nespi
Songyuan Shi
Todd Ewing
Ying Zhang
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46638904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141360(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of PE20141360A1 publication Critical patent/PE20141360A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, O SALES, HIDRATOS, SOLVATOS, ENTRE OTROS, DONDE Y1 SE SELECCIONA DEL GRUPO QUE CONSISTE EN CN, HALOGENO, -OH, ENTRE OTROS; Y2 ES H, HALOGENO, CN, C1-C6 ALQUILO, ENTRE OTROS; Q ES SELECCIONADO DE H, F, CL, ENTRE OTROS; Z ES -N(R4)(R5), -C(R6)(R7)(R8), DONDE R4 Y R5 SON SELECCIONADOS CADA UNO POR SEPARADO DEL GRUPO QUE CONSISTE EN H, C1-C6ALQUILO, ENTRE OTROS, R6, R7, R8 SON CADA UNO POR SEPARADO H, C1-C6 ALQUILO, C1-C6HALOALCOXI, C3-C8CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS [2-FLUORO-3-(FENILOSULFAMOILAMINO)FENILO]-[5-(2-METOXIPIRIMIDIN-5-IL)-1H-PIRROLO[2,3-B]PIRIDIN-3-IL]METANONA, 3-[2-FLUORO-3-[[METIL(FENILO)SULFAMOIL]AMINO]BENZOIL]-5-(2-METOXIPIRIMIDIN-5-IL)-1H-PIRROLO[2,3-B]PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA TRATAR ENFERMEDADES Y ESTADOS VINCULADOS CON LA ACTIVIDAD ABERRANTE DE LAS PROTEINAS QUINASAS.
PE2013001837A 2011-02-07 2012-02-01 Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos. PE20141360A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161440339P 2011-02-07 2011-02-07

Publications (1)

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PE20141360A1 true PE20141360A1 (es) 2014-10-13

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Application Number Title Priority Date Filing Date
PE2013001837A PE20141360A1 (es) 2011-02-07 2012-02-01 Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.

Country Status (37)

Country Link
US (4) US9624213B2 (es)
EP (1) EP2672967B1 (es)
JP (3) JP5941069B2 (es)
KR (1) KR101911972B1 (es)
CN (1) CN103517710B (es)
AR (1) AR085316A1 (es)
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