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PE20081581A1 - COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA - Google Patents

COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA

Info

Publication number
PE20081581A1
PE20081581A1 PE2007001796A PE2007001796A PE20081581A1 PE 20081581 A1 PE20081581 A1 PE 20081581A1 PE 2007001796 A PE2007001796 A PE 2007001796A PE 2007001796 A PE2007001796 A PE 2007001796A PE 20081581 A1 PE20081581 A1 PE 20081581A1
Authority
PE
Peru
Prior art keywords
pirrolo
raf
compounds
pyridines
benzenosulfonamide
Prior art date
Application number
PE2007001796A
Other languages
English (en)
Inventor
Wayne Spevak
Hanna Cho
Prabha N Ibrahim
Shenghua Shi
Shumeye Mano
Samuel J Gillette
Hongyao Zhu
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39281754&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081581(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of PE20081581A1 publication Critical patent/PE20081581A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLO[2,3-b]PIRIDINAS DE FORMULA (I), (II) Y (III), EN DONDE R1 ES H, HALOGENO, ALQUILO INFERIOR, ENTRE OTROS; R2 ES HALOGENO, ALQUILO INFERIOR, CICLOALQUILO, ENTRE OTROS; R3 ES H, FLUOR Y CLORO. SON SELECCIONADOS: 4-BUTOXI-N-[3-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-BENZENOSULFONAMIDA, N-[3-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-4-PIRAZOL-1-IL-BENZENOSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DE LAS QUINASAS, SIENDO PREFERIDAS LAS PROTEINAS QUINASAS A-Raf, B- Raf, Y/O C-Raf; SIENDO UTILES EN EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES TAL COMO: LINFOMA, DOLOR AGUDO, CANCER DE COLON, LEUCEMIA, MIOPATIAS INFLAMATORIAS, ENTRE OTRAS
PE2007001796A 2006-12-21 2007-12-14 COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA PE20081581A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87695306P 2006-12-21 2006-12-21

Publications (1)

Publication Number Publication Date
PE20081581A1 true PE20081581A1 (es) 2008-11-12

Family

ID=39281754

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012000195A PE20121126A1 (es) 2006-12-21 2007-12-14 Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
PE2007001796A PE20081581A1 (es) 2006-12-21 2007-12-14 COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2012000195A PE20121126A1 (es) 2006-12-21 2007-12-14 Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa

Country Status (24)

Country Link
US (2) US7863289B2 (es)
EP (1) EP2097414A1 (es)
JP (1) JP2010514687A (es)
KR (1) KR20090095654A (es)
CN (1) CN101668757A (es)
AR (1) AR064476A1 (es)
AU (1) AU2007336906A1 (es)
BR (1) BRPI0722088A2 (es)
CA (1) CA2673000A1 (es)
CL (1) CL2007003797A1 (es)
CO (1) CO6190519A2 (es)
CR (1) CR10860A (es)
EC (1) ECSP099444A (es)
HN (1) HN2009001202A (es)
MA (1) MA31153B1 (es)
MX (1) MX2009006162A (es)
MY (1) MY148468A (es)
NO (1) NO20092251L (es)
PE (2) PE20121126A1 (es)
RU (1) RU2009122436A (es)
TW (1) TW200845975A (es)
UA (1) UA98629C2 (es)
UY (1) UY30816A1 (es)
WO (2) WO2008079906A1 (es)

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AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
PT1893612E (pt) * 2005-06-22 2011-11-21 Plexxikon Inc Derivados de pirrolo [2,3-b]piridina como inibidores de proteína quinase
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
EP2265270A1 (en) * 2008-02-04 2010-12-29 OSI Pharmaceuticals, Inc. 2-aminopyridine kinase inhibitors
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
EP2250172B1 (en) 2008-02-25 2011-08-31 F. Hoffmann-La Roche AG Pyrrolopyrazine kinase inhibitors
WO2009106444A1 (en) 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
JP5485178B2 (ja) 2008-02-25 2014-05-07 エフ．ホフマン−ラ ロシュ アーゲー ピロロピラジンキナーゼ阻害剤
WO2009106441A1 (en) 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
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