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AR091285A1 - Inhibidores de bromodominio y sus usos - Google Patents

Inhibidores de bromodominio y sus usos

Info

Publication number
AR091285A1
AR091285A1 ARP130101995A AR091285A1 AR 091285 A1 AR091285 A1 AR 091285A1 AR P130101995 A ARP130101995 A AR P130101995A AR 091285 A1 AR091285 A1 AR 091285A1
Authority
AR
Argentina
Prior art keywords
nrac
isoxazolo
nrarb
aminopyridin
azepin
Prior art date
Application number
Other languages
English (en)
Inventor
K Albrecht Brian
Charles Hewitt Michael
S Gehling Victor
G Vaswani Rishi
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of AR091285A1 publication Critical patent/AR091285A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos útiles como inhibidores de proteínas que contienen bromodominio. También proporciona composiciones farmacéuticamente aceptables que comprenden compuestos y métodos para usar dichas composiciones en el tratamiento de diversos trastornos. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable de este, donde: R¹ es hidrógeno o alquilo C₁₋₆; R² es un heteroarilo de 5 - 6 miembros opcionalmente sustituido; el anillo fenilo A se encuentra opcionalmente sustituido; y R⁴ se selecciona de alquilo C₁₋₆, alquenilo C₂₋₆ y alquinilo C₂₋₆, cada uno de los cuales puede encontrarse opcionalmente sustituido por uno o más grupos seleccionados de entre -C(=O)ORᵃ, -C(=O)NRᵃRᵇ, -C(=O)Rᵃ, -C(=NORᵃ)Rᵇ, -C(=NRᵃ)NRᵇRᵃ, -NRᵃC(=O)NRᵇRᵃ, -NRᵃC(=O)Rᵇ, -NRᵃC(=NRᵇ)NRᵃRᵇ, -NRᵃC(=O)ORᵇ, -OC(=O)NRᵃRᵇ, -OC(=O)Rᵃ, -OC(=O)ORᵃ, -S(O)₀₋₃Rᵃ, -SO₂NRᵃRᵇ, -NRᵃSO₂Rᵇ, -NRᵃSO₂NRᵇRᵃ y -P(=O)ORᵃORᵇ, donde cada Rᵃ y Rᵇ independientemente hidrógeno o alquilo C₁₋₆; siempre que el compuesto de fórmula (1) no sea 2-(8-(6-aminopiridin-3-il)-1-metil-6-(4-(trifluorometil)fenil)-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida, 2-(8-(6-aminopiridin-3-il)-6-(4-clorofenil)-1-metil-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida, o@@@2-(8-(6-aminopiridin-3-il)-6-(4-fluorofenil)-1-metil-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida; o una sal farmacéuticamente aceptable de estos.
ARP130101995 2012-06-06 2013-06-06 Inhibidores de bromodominio y sus usos AR091285A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261656205P 2012-06-06 2012-06-06

Publications (1)

Publication Number Publication Date
AR091285A1 true AR091285A1 (es) 2015-01-21

Family

ID=48626693

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101995 AR091285A1 (es) 2012-06-06 2013-06-06 Inhibidores de bromodominio y sus usos

Country Status (19)

Country Link
US (2) US9493483B2 (es)
EP (1) EP2859000B1 (es)
JP (1) JP6154004B2 (es)
KR (1) KR20150023562A (es)
CN (1) CN104428304B (es)
AR (1) AR091285A1 (es)
AU (1) AU2013271569B2 (es)
BR (1) BR112014030165A2 (es)
CA (1) CA2874774C (es)
EA (1) EA026894B1 (es)
ES (1) ES2632774T3 (es)
IL (1) IL235844A (es)
IN (1) IN2014DN10386A (es)
MX (1) MX360598B (es)
NZ (1) NZ702458A (es)
SG (1) SG11201407900WA (es)
TW (1) TWI602820B (es)
WO (1) WO2013184876A1 (es)
ZA (1) ZA201408720B (es)

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TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
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KR102026243B1 (ko) * 2018-01-19 2019-09-27 연세대학교 산학협력단 백혈병 치료용 약학적 조성물
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CN111518045A (zh) * 2019-02-02 2020-08-11 博诺康源(北京)药业科技有限公司 一种具有苯并七元环结构的化合物、其制备方法及用途
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