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PE20141693A1 - Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek - Google Patents

Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek

Info

Publication number
PE20141693A1
PE20141693A1 PE2014000157A PE2014000157A PE20141693A1 PE 20141693 A1 PE20141693 A1 PE 20141693A1 PE 2014000157 A PE2014000157 A PE 2014000157A PE 2014000157 A PE2014000157 A PE 2014000157A PE 20141693 A1 PE20141693 A1 PE 20141693A1
Authority
PE
Peru
Prior art keywords
seq
hvr
methods
antagonist
treat cancer
Prior art date
Application number
PE2014000157A
Other languages
English (en)
Inventor
Heather Maecker
Bryan Irving
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20141693A1 publication Critical patent/PE20141693A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UNA COMBINACION QUE COMPRENDE UNA CANTIDAD EFECTIVA DE UN ANTAGONISTA DE UNION AL EJE PD-1, QUE SE SELECCIONA DEL GRUPO QUE CONSISTE EN UNA ANTAGONISTA DE UNION DE PD-1, UN ANTAGONISTA DE UNION PD-L1, ENTRE OTROS; Y UN INHIBIDOR DE MEK, QUE SE SELECCIONA DEL GRUPO QUE CONSISTE EN G02442104, G-38963, G02443714, ENTRE OTROS. DICHO ANTAGONISTA DE UNION DE PD-L1 ES UN ANTICUERPO COMPRENDE UNA CADENA PESADA QUE CONTIENE LA SECUENCIA DE HVR-H1 DE SEQ ID NO: 15, LA SECUENCIA DE HVR-H2 DE SEQ ID NO: 16, HVR-H3 DE SEQ ID NO: 3; Y UNA CADENA LIGERA QUE COMPRENDE LA SECUENCIA DE HVR-L1 DE SEQ ID NO:17, HVR-L2 DE SEQ ID NO:18, Y HVR-L3 DE SEQ ID NO:19. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO DE CANCER.
PE2014000157A 2011-08-01 2012-08-01 Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek PE20141693A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161574406P 2011-08-01 2011-08-01

Publications (1)

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PE20141693A1 true PE20141693A1 (es) 2014-11-24

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ID=46717934

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PE2014000157A PE20141693A1 (es) 2011-08-01 2012-08-01 Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1e inhibidores de mek
PE2018003248A PE20190262A1 (es) 2011-08-01 2012-08-01 Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek

Family Applications After (1)

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PE2018003248A PE20190262A1 (es) 2011-08-01 2012-08-01 Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek

Country Status (27)

Country Link
US (2) US9724413B2 (es)
EP (1) EP2739358B1 (es)
JP (3) JP6238459B2 (es)
KR (2) KR20190133790A (es)
CN (1) CN103842030B (es)
AR (2) AR087405A1 (es)
AU (4) AU2012290121B2 (es)
BR (2) BR112014002353B1 (es)
CA (1) CA2843595C (es)
CO (1) CO6900118A2 (es)
CR (1) CR20140034A (es)
EA (1) EA026924B1 (es)
EC (1) ECSP14013223A (es)
ES (1) ES2708669T3 (es)
IL (2) IL230647B (es)
MA (1) MA35366B1 (es)
MX (2) MX368257B (es)
MY (2) MY193562A (es)
PE (2) PE20141693A1 (es)
PH (2) PH12014500270A1 (es)
PL (1) PL2739358T3 (es)
SG (1) SG10201606284UA (es)
TR (1) TR201820873T4 (es)
TW (4) TW202114735A (es)
UA (1) UA117220C2 (es)
WO (1) WO2013019906A1 (es)
ZA (1) ZA201400612B (es)

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US20180021431A1 (en) 2018-01-25
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TW202216199A (zh) 2022-05-01
CA2843595C (en) 2022-10-18
PE20190262A1 (es) 2019-02-25
JP2014525918A (ja) 2014-10-02
SG10201606284UA (en) 2016-09-29
IL274059B (en) 2021-10-31
TW201318638A (zh) 2013-05-16
UA117220C2 (uk) 2018-07-10
AR087405A1 (es) 2014-03-19
EA026924B1 (ru) 2017-05-31

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