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PE20070189A1 - COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA - Google Patents

COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA

Info

Publication number
PE20070189A1
PE20070189A1 PE2006000762A PE2006000762A PE20070189A1 PE 20070189 A1 PE20070189 A1 PE 20070189A1 PE 2006000762 A PE2006000762 A PE 2006000762A PE 2006000762 A PE2006000762 A PE 2006000762A PE 20070189 A1 PE20070189 A1 PE 20070189A1
Authority
PE
Peru
Prior art keywords
alkyl
amino
imidazolone
members
haloalkyl
Prior art date
Application number
PE2006000762A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Ping Zhou
William Floyd Fobare
William Ronald Solvibile
Iwan Suwandi Gunawan
James Joseph Erdei
Yinfa Yan
Patrick Michael Andrae
Dominick Anthony Quagliato
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070189A1 publication Critical patent/PE20070189A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE W ES CO, CS, CH2; X ES N, NR, NO, S, CR9, ENTRE OTROS; Y ES N, NR, NO, S, CR10, ENTRE OTROS; Z ES C, N, NR, NO, S, ENTRE OTROS; R ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C8, ENTRE OTROS; R1 Y R2 SON CADA UNO H, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, ALQUINILO C2-C6, ENTRE OTROS; R4, R5, R9 Y R10 SON CADA UNO H, HALOGENO, NO2, CN, ENTRE OTROS; R6 Y R8 SON CADA UNO H, HALOGENO, NO2, CN, ALQUILO C1-C6, CICLOALQUILO C3-C8, ARILO, ENTRE OTROS; R7 ES HALOGENO, H, CN, HALOALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C8, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (5S)-2-AMINO-5-(1-ETIL-5-PROPIONIL-1H-PIRROL-3-IL)-5-[4-FLUORO-3-(2-FLUOROPIRIDIN-3-IL)FENIL]-3-METIL-3,5-DIHIDRO-4H-IMIDAZOL-4-ONA; 2-AMINO-5-[3-(2-FLUOROPIRIDIN-3-IL)FENIL]-3-METIL-5-(5-PROPIONIL-1-PROPIL-1H-PIRROL-3-IL)-3,5-DIHIDRO-4H-IMIDAZOL-4-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE B-SECRETASA (BACE) UTILES EN EL TRATAMIENTO DE ALZHEIMER
PE2006000762A 2005-06-30 2006-06-28 COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA PE20070189A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69535305P 2005-06-30 2005-06-30

Publications (1)

Publication Number Publication Date
PE20070189A1 true PE20070189A1 (es) 2007-02-23

Family

ID=37081588

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000762A PE20070189A1 (es) 2005-06-30 2006-06-28 COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA

Country Status (12)

Country Link
US (3) US7417047B2 (es)
EP (1) EP1896454A1 (es)
JP (1) JP2009500327A (es)
CN (1) CN101213188A (es)
AR (1) AR054809A1 (es)
AU (1) AU2006266129A1 (es)
CA (1) CA2613045A1 (es)
GT (1) GT200600283A (es)
MX (1) MX2008000213A (es)
PE (1) PE20070189A1 (es)
TW (1) TW200738683A (es)
WO (1) WO2007005366A1 (es)

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JP2009500327A (ja) 2009-01-08
CA2613045A1 (en) 2007-01-11
AU2006266129A8 (en) 2008-04-17
GT200600283A (es) 2007-02-14
AR054809A1 (es) 2007-07-18
EP1896454A1 (en) 2008-03-12
WO2007005366A1 (en) 2007-01-11
MX2008000213A (es) 2008-03-24
US7417047B2 (en) 2008-08-26
US20080306091A1 (en) 2008-12-11
US20070004786A1 (en) 2007-01-04
AU2006266129A1 (en) 2007-01-11
US20100168106A1 (en) 2010-07-01
CN101213188A (zh) 2008-07-02
TW200738683A (en) 2007-10-16

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