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PE20091838A1 - Inhibidores de amida hidrolasa de acido graso - Google Patents

Inhibidores de amida hidrolasa de acido graso

Info

Publication number
PE20091838A1
PE20091838A1 PE2009000498A PE2009000498A PE20091838A1 PE 20091838 A1 PE20091838 A1 PE 20091838A1 PE 2009000498 A PE2009000498 A PE 2009000498A PE 2009000498 A PE2009000498 A PE 2009000498A PE 20091838 A1 PE20091838 A1 PE 20091838A1
Authority
PE
Peru
Prior art keywords
amida
fatty acid
hydrolase inhibitors
inhibitors
halogen
Prior art date
Application number
PE2009000498A
Other languages
English (en)
Inventor
Mark L Behnke
Alfredo C Castro
Catherine A Evans
Michael J Grogan
Tao Liu
Daniel A Snyder
Louis Grenier
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40912141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091838(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of PE20091838A1 publication Critical patent/PE20091838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/12—Antidiarrhoeals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN COMPUESTO DE FORMULA III, DONDE Z1 Y Z2 SON DE PREFERENCIA OH; W1 Y W2 SON CADA UNO C, N, CH, ENTRE OTROS; X ES UN ENLACE COVALENTE, -O, -CN.-S-, ENTRE OTROS; RA ES H, HALOGENO, CF3, CN, ENTRE OTROS; R1 ES HALOGENO, CF3, CN, NO2, ENTRE OTROS; n ES 0-3. DICHOS COMPUESTOS SON INHIBIDORES DE ANANDAMIDA AMIDOHIDROLASA UTIL EN EL TRATAMIENTO DE DOLOR, ANSIEDAD, DEPRESION, ENTRE OTROS
PE2009000498A 2008-04-09 2009-04-08 Inhibidores de amida hidrolasa de acido graso PE20091838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4368608P 2008-04-09 2008-04-09

Publications (1)

Publication Number Publication Date
PE20091838A1 true PE20091838A1 (es) 2009-12-18

Family

ID=40912141

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000498A PE20091838A1 (es) 2008-04-09 2009-04-08 Inhibidores de amida hidrolasa de acido graso

Country Status (12)

Country Link
US (2) US8957049B2 (es)
EP (1) EP2282742A1 (es)
JP (1) JP5637982B2 (es)
CN (1) CN102046179B (es)
AR (1) AR072249A1 (es)
AU (1) AU2009233711B2 (es)
CA (1) CA2721060A1 (es)
CL (1) CL2009000870A1 (es)
IL (1) IL208536A0 (es)
PE (1) PE20091838A1 (es)
TW (1) TW201000107A (es)
WO (1) WO2009126691A1 (es)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
PE20091838A1 (es) 2008-04-09 2009-12-18 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
CA2757679A1 (en) * 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
CN102030770B (zh) * 2009-09-25 2012-10-31 北京大学 一种芳香硼酸酯化合物的制备方法
KR101774035B1 (ko) 2009-10-30 2017-09-01 얀센 파마슈티카 엔.브이. 이미다조［１，２―ｂ］피리다진 유도체 및 ＰＤＥ１０ 저해제로서의 그의 용도
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
RU2569061C2 (ru) 2010-02-03 2015-11-20 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
KR101837759B1 (ko) 2010-02-18 2018-04-26 브이티브이 테라퓨틱스 엘엘씨 치환된 융합 이미다졸 유도체, 약학적 조성물, 및 그것의 사용 방법
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
HRP20160431T1 (hr) 2010-06-24 2016-05-20 Gilead Sciences, Inc. Pirazolo[1,5-a]pirimidini i triazini kao antivirusni agensi
NZ608069A (en) 2010-10-06 2014-06-27 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
JP5918264B2 (ja) 2010-12-22 2016-05-18 アッヴィ・インコーポレイテッド Ｃ型肝炎阻害剤およびその使用
JP2012232924A (ja) * 2011-04-28 2012-11-29 Tosoh Corp 新規なナフチルボロン酸化合物及びその製造法
US10604523B2 (en) 2011-06-27 2020-03-31 Janssen Pharmaceutica Nv 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
HRP20190135T1 (hr) * 2011-07-19 2019-03-22 Merck Sharp & Dohme B.V. 4-imidazopiridazin-1-yl-benzamidi i 4-imidazotriazin-1-yl-benzamidi kao inhibitori btk
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
EP2794611B1 (en) 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
US8980878B2 (en) 2012-04-17 2015-03-17 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
JP6426603B2 (ja) 2012-06-26 2018-11-21 ヤンセン ファーマシューティカ エヌ．ベー． 神経障害または代謝障害の治療に使用するための、１−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］−キノキサリン化合物などのＰＤＥ２阻害剤とＰＤＥ１０阻害剤との組合せ
EP2869822B1 (en) 2012-07-09 2016-09-14 Janssen Pharmaceutica, N.V. Inhibitors of phosphodiesterase 10 enzyme
CA2893460C (en) 2012-12-03 2018-01-09 F. Hoffmann-La Roche Ag Substituted triazole boronic acid compounds
EP3763367A1 (en) 2012-12-06 2021-01-13 Celgene Quanticel Research, Inc. Pyridine-pyrazole derivatives as histone demethylase inhibitors
CA2900652C (en) 2013-02-15 2021-05-04 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
KR102277833B1 (ko) 2013-02-20 2021-07-14 칼라 파마슈티컬스, 인크. 치료 화합물 및 그의 용도
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN106061261B (zh) 2013-11-01 2018-04-24 卡拉制药公司 治疗化合物的结晶形式及其用途
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2015164213A1 (en) 2014-04-23 2015-10-29 The Research Foundation For The State University Of New York A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
US9828351B2 (en) 2014-06-26 2017-11-28 Monash University Enzyme interacting agents
JP6725501B2 (ja) * 2014-07-02 2020-07-22 ザビエル・ユニバーシティ・オブ・ルイジアナＸａｖｉｅｒ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｌｏｕｉｓｉａｎａ 少なくとも１つのフェノール（または芳香族ヒドロキシル）基を含有する薬物分子に関する増大された生物学的利用能及びより低い必要用量のためのホウ素系プロドラッグ戦略
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
MX378998B (es) 2015-06-03 2025-03-11 Bristol Myers Squibb Co Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril) piridin-2-ona como para uso en el tratamiento de trastornos cardiovasculares.
CN106800569B (zh) * 2016-12-12 2019-04-16 上海中医药大学附属龙华医院 Atg类似物及其制备方法和应用
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
JP2019533641A (ja) 2016-09-08 2019-11-21 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物の結晶形態およびその使用
WO2018048750A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509422A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
WO2018090717A1 (zh) * 2016-11-16 2018-05-24 上海中医药大学附属龙华医院 Atg类似物及其制备方法和应用
CA3091142C (en) 2018-02-26 2023-04-11 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
CN109180712B (zh) * 2018-08-08 2020-12-25 南京医科大学 一类2-茨醇的芳基硼酸酯衍生物及其应用
CN109096043B (zh) * 2018-08-24 2021-03-12 盐城师范学院 一种2,5-二溴碘苯的合成方法
RS65335B1 (sr) 2018-10-05 2024-04-30 Annapurna Bio Inc Jedinjenja i kompozicije za lečenje stanja povezanih sa aktivnošću receptora apj
WO2020097400A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
US12522583B2 (en) 2018-11-07 2026-01-13 Dana-Farber Cancer Institute, Inc. Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof
US12415816B2 (en) 2018-11-07 2025-09-16 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
AU2020397059A1 (en) 2019-12-06 2022-07-21 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
SMT202400344T1 (it) 2020-02-07 2024-11-15 Gasherbrum Bio Inc Agonisti di glp-1 eterociclici
WO2021222637A1 (en) * 2020-04-30 2021-11-04 United States Government As Represented By The Department Of Veterans Affairs Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease
EP4146639A1 (en) 2020-05-06 2023-03-15 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN112147273B (zh) * 2020-11-02 2022-08-16 北京市理化分析测试中心 一种检测油品中微量酸的方法
TW202241889A (zh) 2020-12-23 2022-11-01 美商雅捷可斯治療公司 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
KR102567789B1 (ko) * 2021-06-08 2023-08-17 한국원자력의학원 신규한 벤조사이아졸 유도체 및 붕소 중성자 포획 요법에 있어서의 이의 용도
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer
TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
WO2023122778A1 (en) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Pyridazinone derivatives useful as t cell activators
KR102668048B1 (ko) * 2022-08-02 2024-05-22 한국원자력의학원 신규한 벤조사이아졸 유도체 및 이의 용도
WO2024169952A1 (en) 2023-02-16 2024-08-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024254704A1 (en) * 2023-06-15 2024-12-19 The Governors Of The University Of Alberta Hemiboronic heterocyclic compounds and uses thereof

Family Cites Families (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4270537A (en) * 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1268808A (en) * 1985-07-23 1990-05-08 Alan G. Macdiarmid High capacity polyaniline electrodes
CH671400A5 (es) * 1986-12-17 1989-08-31 Nii Prikladnych
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) * 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) * 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3807862A1 (de) * 1988-03-10 1989-09-21 Merck Patent Gmbh Smektische fluessigkristallphase
US5273680A (en) 1988-03-10 1993-12-28 Merck Patent Gesellschaft Mit Beschrankter Haftung Fluorinated oligophenyls and their use in liquid crystal materials
US5339163A (en) * 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) * 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5064413A (en) * 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) * 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
DE59108963D1 (de) 1990-02-01 1998-05-20 Merck Patent Gmbh Verfahren zur Umsetzung von fluorierten Aromaten mit Elektrophilen
DE4014488A1 (de) 1990-05-07 1991-11-14 Merck Patent Gmbh Dioxaborinane und fluessigkristallines medium
US5190521A (en) * 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
EP0501268B1 (de) * 1991-02-25 1996-06-12 F. Hoffmann-La Roche Ag Flüssigkristalline Verbindungen mit endständigem 1-Alkinylrest
DE69206795T2 (de) 1991-04-30 1996-09-05 Procter & Gamble ARYLBORONSäURE ENTHALTENDE FLüSSIGWASCHMITTEL
GB2258232B (en) 1991-07-31 1995-03-15 Merck Patent Gmbh Alkoxymethylene fluoroterphenyls and liquid crystalline medium
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) * 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
US5328483A (en) * 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
FR2688790B1 (fr) * 1992-03-23 1994-05-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adhesifs.
FR2688783A1 (fr) 1992-03-23 1993-09-24 Rhone Poulenc Chimie Nouveaux borates d'onium ou de complexe organometallique amorceurs cationiques de polymerisation.
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
PL167141B1 (pl) 1992-05-12 1995-07-31 Wojskowa Akad Tech Sposób otrzymywania związków ciekłokrystalicznych zawierających pierścień 1,3-dioksa- -2-boranu
JP3255965B2 (ja) 1992-05-26 2002-02-12 昭和シェル石油株式会社 反強誘電性液晶化合物
DE4220065A1 (de) 1992-06-19 1993-12-23 Merck Patent Gmbh Verfahren zur Herstellung von Pyrimidin-Derivaten
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9220189D0 (en) * 1992-09-24 1992-11-04 Central Research Lab Ltd Dioxane derivatives
US5569189A (en) * 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
GB9220750D0 (en) * 1992-10-02 1992-11-18 Merck Patent Gmbh Liquid crystalline material forming ananisotropic
DE4236103A1 (de) * 1992-10-26 1994-04-28 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Boronsäuren mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
US5334144A (en) * 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
TW240217B (es) 1992-12-30 1995-02-11 Glaxo Group Ltd
US5576220A (en) * 1993-02-19 1996-11-19 Arris Pharmaceutical Corporation Thin film HPMP matrix systems and methods for constructing and displaying ligands
FR2702485B1 (fr) 1993-03-10 1995-04-14 Rhone Poulenc Chimie Compositions à base de polyorganosiloxanes réticulables par voie cationique et leur utilisation dans le domaine de l'antiadhérence papier, de la protection des fibres optiques et des circuits imprimés.
US5563127A (en) 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5417885A (en) * 1993-08-03 1995-05-23 Showa Shell Sekiyu Kabushiki Kaisha Antiferroelectric liquid crystal compound
US5431842A (en) 1993-11-05 1995-07-11 The Procter & Gamble Company Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme
JPH07145174A (ja) 1993-11-22 1995-06-06 Takeda Chem Ind Ltd ジオキサボリナン系化合物、それらの製造方法、該化合物を含む液晶組成物および該組成物を用いた液晶光変調装置
JPH07165717A (ja) 1993-12-16 1995-06-27 Sumitomo Chem Co Ltd 複素環化合物およびその製造法
JPH07206715A (ja) 1994-01-21 1995-08-08 Sumitomo Chem Co Ltd 複素環化合物の製造法
DE19502178A1 (de) 1994-01-27 1995-08-03 Hoechst Ag Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen
WO1995024176A1 (en) * 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) * 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5643893A (en) * 1994-06-22 1997-07-01 Macronex, Inc. N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines
JP3702426B2 (ja) 1994-08-03 2005-10-05 関東化学株式会社 トリフルオロメチルベンゼン誘導体および液晶組成物
FR2724660B1 (fr) 1994-09-16 1997-01-31 Rhone Poulenc Chimie Amorceurs de reticulation, par voie cationique, de polymeres a groupements organofonctionnels, compositions a base de polyorganosiloxanes reticulables et contenant ces amorceurs et application desdites compositions en antiadherence
JPH0892137A (ja) 1994-09-26 1996-04-09 Sumitomo Chem Co Ltd 芳香族エステル化合物、その製造法および用途
FR2727416A1 (fr) 1994-11-24 1996-05-31 Rhone Poulenc Chimie Nouveaux amorceurs cationiques thermoactivables, de polymerisation et/ou de reticulation et compositions monomeres et/ou polymeres fonctionnels les mettant en oeuvre
DE4445224B4 (de) 1994-12-17 2014-03-27 Merck Patent Gmbh Benzolderivate
US5599302A (en) * 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6271015B1 (en) * 1995-06-12 2001-08-07 The Scripps Research Institute Fatty-acid amide hydrolase
JP3783246B2 (ja) 1995-07-18 2006-06-07 大日本インキ化学工業株式会社 ｐ−テルフェニル誘導体
EP0755918B1 (de) * 1995-07-28 2000-09-06 Rolic AG Photovernetzbare flüssigkristalline 1,2-Phenylen-Derivate
EP0846670A4 (en) 1995-08-09 1999-01-13 Chisso Corp CYCLOHEXANE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS
US5893397A (en) * 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9605334D0 (en) 1996-03-13 1996-05-15 British Nuclear Fuels Plc Biodecontamination reactor
US5998673A (en) 1996-06-03 1999-12-07 American Cyanamid Company 1, 4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
ZA974582B (en) 1996-06-03 1998-11-26 American Cyanamid Co Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
US5849958A (en) 1997-03-17 1998-12-15 American Cyanamid Company 1,4,diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
ATE221037T1 (de) 1996-06-03 2002-08-15 Basf Ag 1,4-diaryl-2-fluoro-2-butene als insectizide und akarizide mittel
US5892131A (en) * 1997-05-29 1999-04-06 American Cyanamid Company Process for the preparation of pesticidal fluoroolefin compounds
CA2206192A1 (en) 1996-06-13 1997-12-13 F. Hoffmann-La Roche Ag Modulation of lc132 (opioid-like) receptor function
US5856537A (en) * 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
JPH1025261A (ja) 1996-07-09 1998-01-27 Chisso Corp フェノール誘導体の製造方法
RU2200730C2 (ru) * 1996-07-31 2003-03-20 Шионоги Энд Ко., Лтд. Пара-терфенильные соединения, способ их получения (варианты) и фармацевтическая композиция (варианты)
FR2752582B1 (fr) * 1996-08-21 2003-06-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adherents
JP3899557B2 (ja) 1996-08-21 2007-03-28 大日本インキ化学工業株式会社 フルオロビフェニル誘導体
JP4526605B2 (ja) * 1996-08-28 2010-08-18 チッソ株式会社 ラテラルハロゲン置換基を有する４環化合物および液晶組成物
US6177440B1 (en) * 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US5925672A (en) 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
FR2757530A1 (fr) 1996-12-24 1998-06-26 Rhodia Chimie Sa Utilisation pour la stereophotolithographie - d'une composition liquide photoreticulable par voie cationique comprenant un photoamorceur du type sels d'onium ou de complexes organometalliques
FR2757870B1 (fr) * 1996-12-30 1999-03-26 Rhodia Chimie Sa Utilisation de compositions silicones reticulables par voie cationique sous uv et d'un photoamorceur du type borate d'onium, pour le revetements de joints plats, notamment de joints de culasse
FR2758329B1 (fr) 1997-01-16 1999-02-12 Synthelabo Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
FR2758560B1 (fr) 1997-01-20 2000-02-04 Adir Nouveaux derives d'acides aminophenylboronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
EP0987238A1 (en) 1997-02-13 2000-03-22 Chisso Corporation Liquid-crystalline compounds having bicyclo 1.1.1]pentane structure, liquid-crystal composition, and liquid-crystal display element
DE19710614A1 (de) 1997-03-14 1998-09-17 Hoechst Ag (1,2,4)-Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
JP2002504122A (ja) * 1997-06-13 2002-02-05 ノースウエスタン ユニバーシティー ベータラクタマーゼ阻害剤及びその使用方法
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
DE19909761A1 (de) 1998-04-17 1999-10-21 Merck Patent Gmbh Benzofuran- und Benzodifuran-Derivate
DZ2769A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2000001463A (ja) 1998-06-12 2000-01-07 Dainippon Ink & Chem Inc ４−シアノベンゼン誘導体の製造方法
GB9814450D0 (en) 1998-07-04 1998-09-02 Sharp Kk Novel compounds
GB2339778A (en) 1998-07-17 2000-02-09 Secr Defence Terphenyl Liquid Crystals
WO2000020466A1 (de) 1998-10-01 2000-04-13 Targor Gmbh Katalysatorsystem
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
DE19858594A1 (de) 1998-12-18 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Cyanbenzolboronsäuren
BR9916382A (pt) * 1998-12-19 2001-09-11 Basell Polypropylen Gmbh Processo para a preparação de um composto
EP1147214B1 (en) * 1999-01-13 2011-01-05 The Research Foundation Of State University Of New York A novel method for designing protein kinase inhibitors
EP1214306A1 (en) 1999-09-21 2002-06-19 Qinetiq Limited Liquid crystal compounds
US6309406B1 (en) * 1999-11-24 2001-10-30 Hamit-Darwin-Fresh, Inc. Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
TWI224597B (en) * 1999-12-03 2004-12-01 Ono Pharmaceutical Co Triazaspiro[5.5]undecane derivatives and a medicine containing the derivatives as an active ingredient
US20030096854A1 (en) * 2002-06-12 2003-05-22 Ho-Shen Lin Substituted tricyclics
FR2805273B1 (fr) * 2000-02-18 2006-08-11 Rhodia Chimie Sa Traitement de surface de materiau plastique avec une composition a fonctions reactives polymerisable et/ou reticulable
DE10009714A1 (de) 2000-03-01 2001-09-06 Targor Gmbh Verfahren zur Herstellung von Mono- oder Di-organo-boranen
GB2362882A (en) 2000-06-02 2001-12-05 Sharp Kk Liquid crystalline optionally laterally fluorinated terphenyl with chiral 3,4-di[(un)saturated-alkoxy]butoxy or 1,4-di[(un)saturated-alkoxy]but-2-oxy terminus
AU2001287399A1 (en) 2000-08-16 2002-02-25 University Of Alberta Non-pressurized methods for the preparation of conjugated solid supports for boronic acids
AU2001284658A1 (en) * 2000-08-23 2002-03-13 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
US6927216B2 (en) * 2000-10-03 2005-08-09 Bristol-Myers Squibb Pharma Company Cyclic sulfonyl compounds as inhibitors of metalloproteases
AU2002211446A1 (en) * 2000-10-05 2002-04-15 Millenium Pharmaceuticals, Inc. 32144, a human fatty acid amide hydrolase and uses thereof
GB0100110D0 (en) 2001-01-04 2001-02-14 Univ Leeds Modulation of calcium channel activity
US20040235792A1 (en) * 2001-01-20 2004-11-25 Deadman John J Serine protease inhibitors compromising a hydrogen-bond acceptor
JP4721027B2 (ja) 2001-03-29 2011-07-13 Ｄｉｃ株式会社 フェニルピリミジン誘導体の製造方法
US20030022864A1 (en) 2001-04-24 2003-01-30 Ishaq Khalid S. 9-[(5-dihydroxyboryl)-pentyl] purines, useful as an inhibitor of inflammatory cytokines
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US6617125B2 (en) * 2001-06-29 2003-09-09 Perkinelmer Life Sciences, Inc. Compositions for enhanced catalyzed reporter deposition
DE60205824T2 (de) * 2001-07-09 2006-05-18 Merck Patent Gmbh Thienothiophenderivate
US7217701B2 (en) * 2001-10-11 2007-05-15 Katsuhiko Mikoshiba Intracellular calcium concentration increase inhibitors
CN1568332A (zh) * 2001-10-12 2005-01-19 陶氏环球技术公司 金属配位组合物和它们作为生产聚二烯烃的催化剂的用途
DE60219569T2 (de) * 2001-11-07 2007-12-27 Merck Patent Gmbh Flüssigkristalline Verbindung, flüssigkristallines Medium und Flüssigkristallanzeige
GB0126844D0 (en) * 2001-11-08 2002-01-02 Qinetiq Ltd Novel compounds
WO2003045228A2 (en) 2001-11-26 2003-06-05 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
AU2002354442A1 (en) * 2001-12-12 2003-06-23 Tokuyama Corporation Organic electroluminescent materials
DE10201764A1 (de) 2002-01-18 2003-07-31 Bayer Cropscience Ag Substituierte 4-Aminopyridin-Derivate
WO2003064484A1 (en) 2002-01-28 2003-08-07 Dow Global Technologies Inc. Metal complex compositions based on cobalt and their use as polymerization catalyst for olefins and dienes
DE10206759A1 (de) * 2002-02-19 2003-08-28 Dragoco Gerberding Co Ag Synergistische Mischungen von 1,2-Alkandiolen
DE10211597A1 (de) 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
AU2003223930A1 (en) * 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
RU2319698C2 (ru) * 2002-06-27 2008-03-20 Астеллас Фарма Инк. АЛЬФА-ФЕНИЛ ИЛИ ПИРИДИЛ-ЭТАНОЛАМИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГОНИСТОВ β3 АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ
EP1388538B1 (en) 2002-07-09 2010-09-01 Merck Patent GmbH Polymerisation Initiator
US20040115475A1 (en) * 2002-08-14 2004-06-17 Matsushita Electric Industrial Co., Ltd. Aromatic methylidene compound, methylstyrul compound for producing the same, production electroluminescent element
AU2003290780B2 (en) 2002-11-14 2009-05-07 The Scripps Research Institute Crystalline form of fatty acid amine hydrolase (FAAH)
DE50307629D1 (de) * 2002-11-27 2007-08-16 Merck Patent Gmbh Tetrahydropyran-derivate
US6924269B2 (en) * 2002-12-04 2005-08-02 Vdf Futureceuticals, Inc. Enzyme inhibitors and methods therefor
US7390806B2 (en) 2002-12-18 2008-06-24 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
US7456169B2 (en) * 2003-02-27 2008-11-25 Abbott Laboratories Inc. Heterocyclic kinase inhibitors
EP1599475A2 (en) * 2003-03-06 2005-11-30 Eisai Co., Ltd. Jnk inhibitors
WO2004080989A1 (ja) 2003-03-10 2004-09-23 Sumitomo Chemical Company Limited フラン化合物の製造方法
BRPI0408256A (pt) * 2003-03-14 2006-03-01 Astrazeneca Ab composto, métodos de tratamento de um humano ou animal, pela limitação da replicação de células, que sofre de cáncer, que sofre de uma doença neoplástica, e que se sofre de doenças proliferativas, uso de um composto, e, processo para a preparação de um composto ou de um seu sal farmaceuticamente aceitável ou de um éster hidrolisável in vivo do mesmo
JP2004292766A (ja) * 2003-03-28 2004-10-21 Tokuyama Corp 有機エレクトロルミネッセンス素子材料
DE10325438A1 (de) * 2003-05-21 2004-12-09 Bayer Cropscience Ag Difluormethylbenzanilide
TWI454465B (zh) 2003-06-03 2014-10-01 Melinta Therapeutics Inc 聯芳基雜環化合物及製法及其用途
US7183267B2 (en) 2003-06-10 2007-02-27 The Johns Hopkins University β-lactamase inhibitors and methods of use thereof
CA2529792A1 (en) 2003-06-16 2005-02-17 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
DE10337497A1 (de) * 2003-08-14 2005-03-10 Bayer Cropscience Ag 4-Biphenylsubstituierte-Pyrazolidin-3,5-dion-Derivate
US20070293542A1 (en) 2003-10-16 2007-12-20 Cali Brian M Selective Cox-2 Inhibitors
EP1682076A4 (en) 2003-10-31 2008-02-06 Fulcrum Pharmaceuticals Inc INHIBITORS OF CORONAVIRUS PROTEASE AND METHODS OF USE THEREOF
US7320972B2 (en) * 2003-11-10 2008-01-22 Microbia, Inc. 4-Biarylyl-1-phenylazetidin-2-ones
US20070010559A1 (en) * 2003-11-25 2007-01-11 Novo Nordisk A/S Indole derivatives for use as chemical uncoupler
JP4491666B2 (ja) 2003-12-02 2010-06-30 東ソー株式会社 フルオレン骨格を有するアリールアミン誘導体の製造方法とその合成中間体
GB2410745B (en) 2004-02-06 2007-07-25 Merck Patent Gmbh Cholestanyl derivatives
BRPI0507629A (pt) * 2004-02-13 2007-07-03 Banyu Pharma Co Ltd composto, antagonista do receptor e agonista inverso do receptor da histamina h3, agente profilático ou terapêutico para uma doença metabólica, uma doença circulatória ou uma doença do sistema nervoso, ou um seu sal farmaceuticamente aceitável
GB0403744D0 (en) * 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
DE102004041532A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
DE102004041530A1 (de) * 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
EP1812451A4 (en) 2004-11-01 2009-10-21 Nuada Llc COMPOUNDS AND METHODS OF USE THEREOF
US20080269204A1 (en) 2004-11-01 2008-10-30 Tatyana Dyakonov Compounds and Methods of Use Thereof
WO2006050236A2 (en) 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
US20090209492A1 (en) 2004-11-12 2009-08-20 Trustees Of Tufts College Lipase Inhibitors
DE102005023834A1 (de) * 2004-11-20 2006-05-24 Bayer Healthcare Ag Substituierte[(Phenylethanoyl)amino]benzamide
WO2006060625A2 (en) * 2004-12-02 2006-06-08 Displaytech, Inc. Liquid crystal compositions comprising an organogermanium compound and methods for using the same
US7553496B2 (en) * 2004-12-21 2009-06-30 University Of Kentucky Research Foundation VEGF-A as an inhibitor of angiogenesis and methods of using same
EP1844042A1 (en) 2005-01-14 2007-10-17 Genelabs Technologies, Inc. Indole derivatives for treating viral infections
EP1851197A2 (en) * 2005-02-09 2007-11-07 Microbia, Inc. Phenylazetidinone derivatives
PL1853251T3 (pl) * 2005-02-16 2013-09-30 Anacor Pharmaceuticals Inc Halogenopodstawione boronoftalidy do leczenia infekcji
US8822633B2 (en) 2005-02-22 2014-09-02 Sumitomo Chemical Co., Ltd. High bandgap arylene polymers
WO2006099261A2 (en) 2005-03-11 2006-09-21 The University Of North Carolina At Chapel Hill Potent and specific immunoproteasome inhibitors
GB2424881B (en) 2005-04-07 2010-11-24 Merck Patent Gmbh Halophenyl derivatives of bisalkylfluorene
JP4792796B2 (ja) 2005-04-08 2011-10-12 東ソー株式会社 ２，３−ジハロビフェニレン誘導体、その前駆化合物及び製造方法
EP1879860A2 (en) 2005-05-10 2008-01-23 Microbia Inc. 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia
JP2008540573A (ja) 2005-05-13 2008-11-20 マイクロビア インコーポレーテッド ４−ビアリーリル−１−フェニラゼチジン−２−オン類
EP1726581A1 (en) 2005-05-25 2006-11-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Synthesis of novel monomers containing the Trifluorovinylidene-group and the Cyanato-group and polymers thereof
EP1893562A4 (en) 2005-06-14 2010-04-28 Merck Frosst Canada Ltd REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE-A AND -B
KR100659088B1 (ko) * 2005-07-15 2006-12-21 삼성에스디아이 주식회사 디플루오로피리딘계 화합물 및 이를 이용한 유기 발광 소자
TW200740823A (en) * 2005-08-01 2007-11-01 Ihara Chemical Ind Co Oxadiazole-substituted Sym-triindole derivative and organic el element employing the same
DE102005037925A1 (de) 2005-08-11 2007-02-15 Merck Patent Gmbh Hydro-cyclopenta[a]naphthaline
WO2007028104A2 (en) * 2005-09-02 2007-03-08 Auspex Pharmaceuticals, Inc. Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
JP2009507813A (ja) * 2005-09-13 2009-02-26 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト 殺有害生物剤ビ−フェニル−アミジン誘導体
PT1959951E (pt) * 2005-12-01 2010-03-02 Hoffmann La Roche Derivados de piperidina substituídos com heteroarilo, como inibidores de pct1-f
ES2455166T3 (es) 2005-12-02 2014-04-14 Sachem, Inc. Procedimiento de cromatografía de desplazamiento de intercambio aniónico
CN106008583A (zh) * 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
US20100048713A1 (en) * 2006-01-06 2010-02-25 Aarhus Universitet Compounds acting on the serotonin transporter
GB0602046D0 (en) * 2006-02-01 2006-03-15 Smithkline Beecham Corp Compounds
EP2719388B1 (en) * 2006-02-16 2019-04-10 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
DE102007009944B4 (de) 2006-03-15 2016-04-28 Merck Patent Gmbh Flüssigkristallines Medium und seine Verwendung
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
BRPI0710133A2 (pt) 2006-04-13 2012-10-30 Aegera Therapeutics Inc uso de compostos de imidazo[2,1-b]-1,3,4-tiadiazol-2-sulfonamida para tratar dor neuropática
JP5145753B2 (ja) 2006-04-20 2013-02-20 Ｊｎｃ株式会社 フルオロイソプロピル基を側鎖として有する化合物およびこれを用いた液晶組成物
AU2007257689A1 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
RU2008151762A (ru) 2006-07-27 2010-06-27 Си Ви Терапьютикс, Инк. (Us) Adlh-2 ингибиторы для лечения аддикции
US8034940B2 (en) * 2006-08-09 2011-10-11 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008020920A1 (en) * 2006-08-15 2008-02-21 Duke University Ros-sensitive iron chelators and methods of using the same
ATE515553T1 (de) 2006-08-16 2011-07-15 Merck Patent Gmbh Cyclohexen-verbindungen für flüssigkristalline mischungen
EP1900792B1 (de) * 2006-09-13 2010-08-04 Merck Patent GmbH Fluorphenyl-Verbindungen für flüssigkristalline Mischungen
WO2008039829A2 (en) 2006-09-26 2008-04-03 Ironwood Pharmaceuticals, Inc. Diphenylheterocycle cholesterol absorption inhibitors
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
ATE493984T1 (de) 2006-10-18 2011-01-15 Pfizer Prod Inc Biaryl-ether-harnstoffverbindungen
EP2123623B1 (en) 2007-01-24 2013-08-07 JNC Corporation Liquid crystalline compound, liquid crystal composition, liquid crystal display element
JP5299265B2 (ja) 2007-02-28 2013-09-25 Ｊｎｃ石油化学株式会社 Ｃｆ２ｏ結合基を有する５環液晶化合物、液晶組成物および液晶表示素子
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
AU2008221718A1 (en) * 2007-03-07 2008-09-12 Dong-A Pharm. Co., Ltd. Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
US7741347B2 (en) * 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2009011904A1 (en) 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof
PE20091838A1 (es) 2008-04-09 2009-12-18 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso
WO2009136646A1 (ja) 2008-05-08 2009-11-12 住友化学株式会社 不飽和有機化合物の製造方法
DE102008023801A1 (de) 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine

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AR072249A1 (es) 2010-08-18
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AU2009233711A1 (en) 2009-10-15
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