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PE20091552A1 - Farmacoforos duales - antagonistas muscarinicos de pde4 - Google Patents

Farmacoforos duales - antagonistas muscarinicos de pde4

Info

Publication number
PE20091552A1
PE20091552A1 PE2009000167A PE2009000167A PE20091552A1 PE 20091552 A1 PE20091552 A1 PE 20091552A1 PE 2009000167 A PE2009000167 A PE 2009000167A PE 2009000167 A PE2009000167 A PE 2009000167A PE 20091552 A1 PE20091552 A1 PE 20091552A1
Authority
PE
Peru
Prior art keywords
substituted
methyl
alkyl
pde4
cycloalkyl
Prior art date
Application number
PE2009000167A
Other languages
English (en)
Inventor
James Francis Callahan
Guoliang Lin
Zehong Wan
Hongxing Yan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091552(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20091552A1 publication Critical patent/PE20091552A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE LINK ES PIRROLILO, IMIDAZOLILO, INDAZOLILO, BENZOTIOFENILO, ENTRE OTROS; X1 ES O, NH, NCH3, NCH2CH3; R5a ES H, METILO, ETILO; Z ES CO, CONH, COO, ENTRE OTROS; Z1 ES CO, NHCO, OCO, SO, ENTRE OTROS; n ES 1-3; m ES 1-2; v ES 1-5; R1 ES ALQUILO C1-C3, CH2-FLUOROALQUILO C1-C2, -CH2CH2OH-; R2 ES H, ALQUILO C1-C4, CICLOPROPILO, CICLOBUTILO, ENTRE OTROS; R3 ES CICLOALQUILO C4-C7 SUSTITUIDO O NO, CICLOALQUENILO MONOINSATURADO C5-C7 SUSTITUIDO O NO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO C1-C4 SUSTITUIDO O NO, CICLOALQUILO C3-C7, HETEROCICLICO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R6 ES ANILLO C5-C7 OPCIONALMENTE SUSTITUIDO QUE CONTIENE 1-2 NITROGENOS O SU CORRESPONDIENTE ANILLO BICICLICO; Ar1 Y Ar2 SON CADA UNO FENILO SUSITUIDO O NO, HETEROARILO MONOCICLICO SUSTITUIDO O NO; X ES O, CO, SO2, ENTRE OTROS. UN COMPUESTO PREFERIDO ES: N-{[1,6-DIETIL-4-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)-1H-PIRAZOLO[3,4-b]PIRIDIN-5-IL]METIL}-N'-[(6-FLUORO-3'-{[(3S)-3-METIL-1-PIPERAZINIL]METIL}-3-BIFENIL)METIL]-2,6-PIRIDINDICARBOXAMIDA. DICHOS COMPUESTOS SON INHIBIDORES DE PDE4 Y RECEPTORES MUSCARINICOS DE ACETILCOLINA (mAChRs) UTIL EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS, ALERGICAS
PE2009000167A 2008-02-06 2009-02-04 Farmacoforos duales - antagonistas muscarinicos de pde4 PE20091552A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2656308P 2008-02-06 2008-02-06

Publications (1)

Publication Number Publication Date
PE20091552A1 true PE20091552A1 (es) 2009-10-25

Family

ID=40935342

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000167A PE20091552A1 (es) 2008-02-06 2009-02-04 Farmacoforos duales - antagonistas muscarinicos de pde4

Country Status (19)

Country Link
US (1) US8084449B2 (es)
EP (1) EP2259681A4 (es)
JP (1) JP2011511082A (es)
KR (1) KR20100113155A (es)
CN (1) CN101990401A (es)
AR (1) AR070562A1 (es)
AU (1) AU2009212408A1 (es)
BR (1) BRPI0908008A2 (es)
CA (1) CA2714352A1 (es)
CL (1) CL2009000250A1 (es)
CR (1) CR11665A (es)
DO (1) DOP2010000235A (es)
EA (1) EA201070916A1 (es)
IL (1) IL207352A0 (es)
MX (1) MX2010008690A (es)
PE (1) PE20091552A1 (es)
TW (1) TW201000476A (es)
UY (1) UY31637A1 (es)
WO (1) WO2009100166A1 (es)

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MX2012011784A (es) 2010-04-16 2013-03-21 Bayer Ip Gmbh Nuevos compuestos heterociclicos como pesticidas.
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
RU2013103422A (ru) 2010-06-28 2014-08-10 Байер Интеллектчуал Проперти Гмбх Гетероарил-замещенные пиридиновые соединения для применения в качестве пестицидов
US9763924B2 (en) 2014-06-05 2017-09-19 Chiesi Farmaceutici S.P.A. Aminoester derivatives
CA2967332C (en) 2014-11-11 2024-05-21 Johnson & Johnson Consumer Inc. Amino acid derivatives and their uses
US9321744B1 (en) 2015-06-26 2016-04-26 Industrial Technology Research Institute Method for preparing 2,5-furan dicarboxylic acid
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

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Also Published As

Publication number Publication date
CL2009000250A1 (es) 2009-09-11
EA201070916A1 (ru) 2011-02-28
US20090203657A1 (en) 2009-08-13
CN101990401A (zh) 2011-03-23
AU2009212408A1 (en) 2009-08-13
UY31637A1 (es) 2009-08-03
CR11665A (es) 2011-01-11
EP2259681A1 (en) 2010-12-15
JP2011511082A (ja) 2011-04-07
DOP2010000235A (es) 2011-01-15
WO2009100166A1 (en) 2009-08-13
MX2010008690A (es) 2010-08-30
AR070562A1 (es) 2010-04-21
TW201000476A (en) 2010-01-01
IL207352A0 (en) 2010-12-30
EP2259681A4 (en) 2012-04-04
CA2714352A1 (en) 2009-08-13
US8084449B2 (en) 2011-12-27
KR20100113155A (ko) 2010-10-20
BRPI0908008A2 (pt) 2015-08-18

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