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PE20050250A1 - Antagonistas de los receptores muscarinicos de la acetilcolina - Google Patents

Antagonistas de los receptores muscarinicos de la acetilcolina

Info

Publication number
PE20050250A1
PE20050250A1 PE2004000674A PE2004000674A PE20050250A1 PE 20050250 A1 PE20050250 A1 PE 20050250A1 PE 2004000674 A PE2004000674 A PE 2004000674A PE 2004000674 A PE2004000674 A PE 2004000674A PE 20050250 A1 PE20050250 A1 PE 20050250A1
Authority
PE
Peru
Prior art keywords
muscarinal
receptors
acetylcholin
antagonists
compounds
Prior art date
Application number
PE2004000674A
Other languages
English (en)
Inventor
Kristen E Belmonte
Jakob Busch-Petersen
Michael R Palovich
Dramane I Laine
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20050250A1 publication Critical patent/PE20050250A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE R2 Y R3 SON CADA UNO ALQUILO C1-C6, CICLOALQUILO C5-C6, CICLOALQUILALQUILO C6-C10, ENTRE OTROS; X - ES UN ANION CON CARGA POSITIVA DE N, DE MODO QUE EL COMPUESTO ES UNA SAL CUATERNARIA. TAMBIEN REFERIDA A UNA COMPOSICION FARMACEUTICA QUE INCLUYE ESTOS COMPUESTOS CUYOS PREFERIDOS SON: BROMURO DE (3-ENDO)-3-(2-HIDROXI-2,2-DI-2-TIENILETIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2-HIDROXI-2,2-DIFENILETIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LOS RECEPTORES MUSCARINICOS DE LA ACETILCOLINA TALES COMO BRONQUITIS CRONICA, ASMA, FIBROSIS PULMONAR, ENTRE OTRAS
PE2004000674A 2003-07-17 2004-07-15 Antagonistas de los receptores muscarinicos de la acetilcolina PE20050250A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48798203P 2003-07-17 2003-07-17

Publications (1)

Publication Number Publication Date
PE20050250A1 true PE20050250A1 (es) 2005-04-08

Family

ID=34102736

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000674A PE20050250A1 (es) 2003-07-17 2004-07-15 Antagonistas de los receptores muscarinicos de la acetilcolina

Country Status (19)

Country Link
US (1) US7495010B2 (es)
EP (1) EP1648461A4 (es)
JP (1) JP2007525478A (es)
KR (1) KR20060054316A (es)
CN (1) CN1822839A (es)
AR (1) AR045914A1 (es)
AU (1) AU2004259238A1 (es)
BR (1) BRPI0412537A (es)
CA (1) CA2532433A1 (es)
IL (1) IL172912A0 (es)
IS (1) IS8296A (es)
MA (1) MA27901A1 (es)
MX (1) MXPA06000663A (es)
NO (1) NO20060777L (es)
PE (1) PE20050250A1 (es)
RU (1) RU2006104851A (es)
TW (1) TW200519108A (es)
WO (1) WO2005009362A2 (es)
ZA (1) ZA200600167B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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TW200811172A (en) * 2003-10-14 2008-03-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
AR046114A1 (es) * 2003-10-17 2005-11-23 Glaxo Group Ltd Compuesto de 8- azoniabiciclo (3.2.1) octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos y uso del compuesto para preparar dicha composicion
TW200524577A (en) * 2003-11-04 2005-08-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
US20090253908A1 (en) * 2004-03-11 2009-10-08 Glaxo Group Limited Novel m3 muscarinic acetylchoine receptor antagonists
US7384946B2 (en) * 2004-03-17 2008-06-10 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
WO2005094251A2 (en) * 2004-03-17 2005-10-13 Glaxo Group Limited M3muscarinic acetylcholine receptor antagonists
AU2012202307B2 (en) * 2004-04-27 2015-05-07 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
PE20060259A1 (es) 2004-04-27 2006-03-25 Glaxo Group Ltd Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico
JP2007537261A (ja) * 2004-05-13 2007-12-20 グラクソ　グループ　リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
US7932247B2 (en) * 2004-11-15 2011-04-26 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
WO2007016639A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
EP1937068A4 (en) * 2005-08-18 2010-08-04 Glaxo Group Ltd ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS
UY31637A1 (es) 2008-02-06 2009-08-03 Farmacoforos duales-antagonistas muscarinicos de pde4
AR070564A1 (es) 2008-02-06 2010-04-21 Glaxo Group Ltd Derivados de 1h-pirazolo[3,4-b]piridin-5-ilo,inhibidores de fosfodiesterasas pde4 y antagonistas de receptores muscarinicos de acetilcolina(machr), utiles en el tratamiento y/o profilaxis de enfermedades respiratorias y alergicas,y composiciones farmaceuticas que los comprenden
UY31636A1 (es) 2008-02-06 2009-08-03 Farmacoforos duales-antagonistas muscarinicos de pde4
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria
EP3248970A1 (en) 2016-05-27 2017-11-29 Zentiva K.S. Forms of umeclidinium bromide
CN118987229A (zh) * 2024-09-10 2024-11-22 北京大学 一种Chrm4特异性拮抗剂在制备治疗肺部2型免疫炎症性疾病的药物中的应用

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Also Published As

Publication number Publication date
BRPI0412537A (pt) 2006-09-19
JP2007525478A (ja) 2007-09-06
EP1648461A2 (en) 2006-04-26
WO2005009362A3 (en) 2005-04-07
EP1648461A4 (en) 2009-04-01
IS8296A (is) 2006-02-13
WO2005009362A2 (en) 2005-02-03
MA27901A1 (fr) 2006-05-02
MXPA06000663A (es) 2006-03-30
NO20060777L (no) 2006-04-11
IL172912A0 (en) 2006-06-11
US20060178396A1 (en) 2006-08-10
US7495010B2 (en) 2009-02-24
TW200519108A (en) 2005-06-16
ZA200600167B (en) 2007-01-31
AR045914A1 (es) 2005-11-16
CN1822839A (zh) 2006-08-23
AU2004259238A1 (en) 2005-02-03
KR20060054316A (ko) 2006-05-22
RU2006104851A (ru) 2006-06-27
CA2532433A1 (en) 2005-02-03

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