PE20091553A1 - Farmacoforos duales - antagonistas muscarinicos de pde4 - Google Patents
Farmacoforos duales - antagonistas muscarinicos de pde4Info
- Publication number
- PE20091553A1 PE20091553A1 PE2009000166A PE2009000166A PE20091553A1 PE 20091553 A1 PE20091553 A1 PE 20091553A1 PE 2009000166 A PE2009000166 A PE 2009000166A PE 2009000166 A PE2009000166 A PE 2009000166A PE 20091553 A1 PE20091553 A1 PE 20091553A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- nitrogens
- cycloalkyl
- methyl
- pharmacoforos
- Prior art date
Links
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 title 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 CYCLOBUTYL Chemical class 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 238000001321 HNCO Methods 0.000 abstract 1
- OWIKHYCFFJSOEH-UHFFFAOYSA-N Isocyanic acid Chemical compound N=C=O OWIKHYCFFJSOEH-UHFFFAOYSA-N 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE X1 ES O, N(R4a); R4a Y R5a SON CADA UNO H, ALQUILO C1-C2; Z ES C(O), CONH, COO, ENTRE OTROS; Z1 ES CO, HNCO, OCO, ENTRE OTROS; v ES 1-5; n ES 1-3; n3 ES 1-4; Y4 ES H, HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R1 ES ALQUILO C1-C3, CH2-FLUOROALQUILO C1-C2, -CH2CH2OH; R2 ES H, ALQUILO C1-C4, CICLOPROPILO, CICLOBUTILO, ENTRE OTROS; R3 ES CICLOALQUILO C4-C7 OPCIONALEMNTE SUSTITUIDO, CICLOALQUENILO C5-C7 MONO-SATURADO, HETEROCICLICO SUSTITUIDO O NO, ENTRE OTROS; Ar1 Y Ar2 SON CADA UNO FENILO SUSTITUIDO O NO, HETEROARILO MONOCICLICO SUSTITUIDO O NO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO C1-C4, CICLOALQUILO C3-C7HETEROCICLILO, ENTRE OTROS; R6 ES ANILLO C5-C7 MIEMBROS SUSTITUIDO O NO QUE CONTIENE 1-2 NITROGENOS O ANILLO BICICLICO CORRESPONDIENTE QUE CONTIENE 1-2 NITROGENOS, ENTRE OTROS; X ES CH2, O-XH2, SO-CH2, ENTRE OTROS. UN COMPUESTO PREFERIDO ES N-{[1,6-DIETIL-4-(TETRAHIDRO-2H-PIRAN-4-ILAMINO)-1H-PIRAZOLO[3,4-b]PIRIDIN-5-IL]METIL}-N'-{[6-FLUORO-3'-(4-MORFOLINILMETIL)-3-BIFENILIL]METIL}-1,3-BENCENODICARBOXAMIDA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFODIESTERASA TIPO IV UTILES EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS, INFLAMATORIAS Y/O ALERGICAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2657208P | 2008-02-06 | 2008-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091553A1 true PE20091553A1 (es) | 2009-10-30 |
Family
ID=40932308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000166A PE20091553A1 (es) | 2008-02-06 | 2009-02-04 | Farmacoforos duales - antagonistas muscarinicos de pde4 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8067408B2 (es) |
| EP (1) | EP2249647A4 (es) |
| JP (1) | JP2011511084A (es) |
| KR (1) | KR20100120296A (es) |
| CN (1) | CN101983010A (es) |
| AR (1) | AR070564A1 (es) |
| AU (1) | AU2009212410A1 (es) |
| BR (1) | BRPI0908075A2 (es) |
| CA (1) | CA2714419A1 (es) |
| CL (1) | CL2009000248A1 (es) |
| DO (1) | DOP2010000238A (es) |
| EA (1) | EA201070927A1 (es) |
| IL (1) | IL207351A0 (es) |
| MX (1) | MX2010008692A (es) |
| PE (1) | PE20091553A1 (es) |
| TW (1) | TW200946526A (es) |
| UY (1) | UY31635A1 (es) |
| WO (1) | WO2009100168A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012010666A (es) | 2010-03-31 | 2012-10-05 | Actelion Pharmaceuticals Ltd | Derivados de isoquinolin-3-ilurea antibacterianos. |
| WO2011143106A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bi - functional pyrazolopyridine compounds |
| EA201591220A1 (ru) | 2012-12-27 | 2016-01-29 | Дрексел Юниверсити | Новые противовирусные агенты против инфекции вирусом гепатита в |
| CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787249A (fr) * | 1971-08-05 | 1973-02-05 | Squibb & Sons Inc | Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation |
| US3856799A (en) * | 1971-08-05 | 1974-12-24 | Squibb & Sons Inc | Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters |
| US3833594A (en) * | 1971-08-05 | 1974-09-03 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carboxylic acids and esters |
| US3925388A (en) * | 1971-08-05 | 1975-12-09 | Squibb & Sons Inc | 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters |
| CA1003419A (en) | 1971-11-23 | 1977-01-11 | Theodor Denzel | Process for the production of pyrazolo (3,4-b) pyridines |
| US3979399A (en) * | 1972-11-15 | 1976-09-07 | E. R. Squibb & Sons, Inc. | Amino derivatives of pyrazolopyridine carboxamides |
| US3840546A (en) * | 1972-11-15 | 1974-10-08 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carboxamides |
| US4364948A (en) | 1981-09-28 | 1982-12-21 | Ici Americas Inc. | Pyrazolo[3,4-b]pyridine compounds |
| US6326379B1 (en) | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
| US6670364B2 (en) * | 2001-01-31 | 2003-12-30 | Telik, Inc. | Antagonists of MCP-1 function and methods of use thereof |
| TWI236474B (en) | 2001-04-03 | 2005-07-21 | Telik Inc | Antagonists of MCP-1 function and methods of use thereof |
| EP1438048A1 (en) * | 2001-10-18 | 2004-07-21 | Boehringer Ingelheim Pharmaceuticals Inc. | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
| US7544675B2 (en) | 2002-04-18 | 2009-06-09 | Ucb, S.A. | Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions |
| UY27927A1 (es) | 2002-08-06 | 2003-12-31 | Glaxo Group Ltd | Antagonistas del receptor muscarínico m3 de acetilcolina |
| GB0230045D0 (en) * | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
| WO2004024728A2 (en) | 2002-09-16 | 2004-03-25 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors |
| WO2004091482A2 (en) | 2003-04-07 | 2004-10-28 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| AR045914A1 (es) | 2003-07-17 | 2005-11-16 | Glaxo Group Ltd | Compuesto alcoholico terciario del 8-azoniabiciclo [3.2.1] octano, composicion farmaceutica que lo comprende y su uso para preparar esta ultima |
| TW200519109A (en) | 2003-07-17 | 2005-06-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| UY28417A1 (es) | 2003-07-17 | 2005-02-28 | Glaxo Group Ltd | Antagonistas de los receptores muscarinicos de la acetilcolina |
| SI1677795T1 (sl) | 2003-10-14 | 2011-04-29 | Glaxo Group Ltd | Antagonisti muskarinskega acetilholinskega receptorja |
| BRPI0415281A (pt) | 2003-10-17 | 2006-12-19 | Glaxo Group Ltd | antagonistas de receptor de acetilcolina muscarìnico |
| AR046225A1 (es) | 2003-11-04 | 2005-11-30 | Glaxo Group Ltd | Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion |
| PE20050897A1 (es) | 2003-12-03 | 2005-11-06 | Glaxo Group Ltd | Nuevos antagonistas del receptor muscarinico m3 de acetilcolina |
| AR046783A1 (es) | 2003-12-03 | 2005-12-21 | Glaxo Group Ltd | Compuesto de sal ciclica de amonio cuaternario composicion farmaceutica que lo comprende y su uso para preparar esta ultima |
| WO2005058892A1 (en) | 2003-12-19 | 2005-06-30 | Glaxo Group Limited | Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors |
| TW200534855A (en) | 2004-01-13 | 2005-11-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| WO2005087236A1 (en) | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| US20070179131A1 (en) | 2004-03-11 | 2007-08-02 | Jian Jin | Novel M3 Muscarinic Acetylcholine Receptor Antagonists |
| AU2005223351A1 (en) | 2004-03-16 | 2005-09-29 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compound, and its use as a PDE4 inhibitor |
| GB0405937D0 (en) | 2004-03-16 | 2004-04-21 | Glaxo Group Ltd | Compounds |
| GB0405933D0 (en) | 2004-03-16 | 2004-04-21 | Glaxo Group Ltd | Compounds |
| US20070185148A1 (en) | 2004-03-17 | 2007-08-09 | Glaxo Group Limited | M3 muscarinic acetylchoine receptor antagonists |
| EP1725241A4 (en) | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC M3 RECEPTOR |
| EP1725240A4 (en) | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2005095407A1 (en) | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| US20070238751A1 (en) | 2004-04-07 | 2007-10-11 | Laine Dramane I | Muscarinic Acetylcholine Receptor Antagonists |
| TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| US7598267B2 (en) | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| TW200606161A (en) | 2004-05-28 | 2006-02-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| JP2008505118A (ja) | 2004-06-30 | 2008-02-21 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
| WO2006017768A2 (en) | 2004-08-05 | 2006-02-16 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| JP2008509158A (ja) | 2004-08-06 | 2008-03-27 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
| WO2006050239A2 (en) | 2004-10-29 | 2006-05-11 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| US20090142279A1 (en) | 2004-11-15 | 2009-06-04 | Budzik Brian W | Novel m3 muscarinic acetylcholine receptor antagonists |
| JP2008520579A (ja) * | 2004-11-15 | 2008-06-19 | グラクソ グループ リミテッド | 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| PE20061162A1 (es) | 2004-12-06 | 2006-10-14 | Smithkline Beecham Corp | Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos |
| PE20060826A1 (es) | 2004-12-06 | 2006-10-08 | Smithkline Beecham Corp | Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende |
| WO2006065788A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Novel muscarinic acetylcholine receptor antagonists |
| WO2006065755A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists |
| WO2007018514A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| WO2007018508A1 (en) | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetycholine receptor antagonists |
| EP1937267A4 (en) | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| EP1937230A4 (en) | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| EP1937068A4 (en) | 2005-08-18 | 2010-08-04 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS |
| WO2007123953A2 (en) * | 2006-04-19 | 2007-11-01 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| GB0614570D0 (en) * | 2006-07-21 | 2006-08-30 | Glaxo Group Ltd | Compounds |
-
2009
- 2009-02-04 TW TW098103480A patent/TW200946526A/zh unknown
- 2009-02-04 UY UY031635A patent/UY31635A1/es not_active Application Discontinuation
- 2009-02-04 AR ARP090100369A patent/AR070564A1/es not_active Application Discontinuation
- 2009-02-04 PE PE2009000166A patent/PE20091553A1/es not_active Application Discontinuation
- 2009-02-04 CL CL2009000248A patent/CL2009000248A1/es unknown
- 2009-02-05 CA CA2714419A patent/CA2714419A1/en not_active Abandoned
- 2009-02-05 CN CN2009801120277A patent/CN101983010A/zh active Pending
- 2009-02-05 WO PCT/US2009/033130 patent/WO2009100168A1/en not_active Ceased
- 2009-02-05 KR KR1020107019715A patent/KR20100120296A/ko not_active Withdrawn
- 2009-02-05 JP JP2010545974A patent/JP2011511084A/ja active Pending
- 2009-02-05 BR BRPI0908075-9A patent/BRPI0908075A2/pt not_active IP Right Cessation
- 2009-02-05 EP EP09708556A patent/EP2249647A4/en not_active Withdrawn
- 2009-02-05 EA EA201070927A patent/EA201070927A1/ru unknown
- 2009-02-05 MX MX2010008692A patent/MX2010008692A/es unknown
- 2009-02-05 US US12/365,934 patent/US8067408B2/en not_active Expired - Fee Related
- 2009-02-05 AU AU2009212410A patent/AU2009212410A1/en not_active Abandoned
-
2010
- 2010-08-02 IL IL207351A patent/IL207351A0/en unknown
- 2010-08-03 DO DO2010000238A patent/DOP2010000238A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL207351A0 (en) | 2010-12-30 |
| EP2249647A4 (en) | 2012-07-18 |
| DOP2010000238A (es) | 2011-03-31 |
| EP2249647A1 (en) | 2010-11-17 |
| EA201070927A1 (ru) | 2011-04-29 |
| US8067408B2 (en) | 2011-11-29 |
| UY31635A1 (es) | 2009-08-31 |
| AU2009212410A1 (en) | 2009-08-13 |
| MX2010008692A (es) | 2010-11-25 |
| CL2009000248A1 (es) | 2009-09-11 |
| JP2011511084A (ja) | 2011-04-07 |
| US20090197871A1 (en) | 2009-08-06 |
| CN101983010A (zh) | 2011-03-02 |
| CA2714419A1 (en) | 2009-08-13 |
| KR20100120296A (ko) | 2010-11-15 |
| AR070564A1 (es) | 2010-04-21 |
| WO2009100168A1 (en) | 2009-08-13 |
| TW200946526A (en) | 2009-11-16 |
| BRPI0908075A2 (pt) | 2015-08-25 |
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