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PE20081785A1 - Derivados de ciclohexil-amida del acido aril carboxilico - Google Patents

Derivados de ciclohexil-amida del acido aril carboxilico

Info

Publication number
PE20081785A1
PE20081785A1 PE2008000326A PE2008000326A PE20081785A1 PE 20081785 A1 PE20081785 A1 PE 20081785A1 PE 2008000326 A PE2008000326 A PE 2008000326A PE 2008000326 A PE2008000326 A PE 2008000326A PE 20081785 A1 PE20081785 A1 PE 20081785A1
Authority
PE
Peru
Prior art keywords
cyclohexyl
hydroxy
amide derivatives
carboxyl acid
aryl carboxyl
Prior art date
Application number
PE2008000326A
Other languages
English (en)
Inventor
Rene Hersperger
Phillip Janser
Wolfgang Miltz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20081785A1 publication Critical patent/PE20081785A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE X ES CH2, NH; n ES 1-2; R ES CICLOALQUILO 3-18 ATOMOS DE CARBONO, HETEROCICLOALQUILO DE 3-18 ATOMOS DE CARBONO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {4-HIDROXI-4-[2-((3S,4S)-4-HIDROXI-3-METIL-PIPERIDIN-1-IL)-ETIL]-CICLOHEXIL}-AMIDA DEL ACIDO 4-CICLOBUTIL-METOXI-1H-INDOL-2-CARBOXILICO; {4-HIDROXI-4-[2-((3S,4S)-4-HIDROXI-3-METIL-PIPERIDIN-1-IL)ETIL]CICLOHEXIL}-AMIDA DEL ACIDO 4-(4-OXO-4,5,6,7-TETRAHIDRO-BENZO-FURAN-3-IL-METOXI)-1H-INDOL-2-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INFECCION POR VIH
PE2008000326A 2007-02-19 2008-02-15 Derivados de ciclohexil-amida del acido aril carboxilico PE20081785A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07102622 2007-02-19

Publications (1)

Publication Number Publication Date
PE20081785A1 true PE20081785A1 (es) 2009-01-12

Family

ID=38058317

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000326A PE20081785A1 (es) 2007-02-19 2008-02-15 Derivados de ciclohexil-amida del acido aril carboxilico

Country Status (35)

Country Link
US (1) US8354431B2 (es)
EP (1) EP2125782B1 (es)
JP (1) JP5180234B2 (es)
KR (1) KR101070984B1 (es)
CN (1) CN101605781B (es)
AR (1) AR065369A1 (es)
AT (1) ATE518854T1 (es)
AU (1) AU2008219317B2 (es)
BR (1) BRPI0807625A2 (es)
CA (1) CA2677565C (es)
CL (1) CL2008000497A1 (es)
CR (1) CR10957A (es)
CY (1) CY1111984T1 (es)
DK (1) DK2125782T3 (es)
EA (1) EA017000B1 (es)
EC (1) ECSP099584A (es)
ES (1) ES2371126T3 (es)
GT (1) GT200900226A (es)
HN (1) HN2009001607A (es)
HR (1) HRP20110793T1 (es)
IL (1) IL200191A (es)
MA (1) MA31206B1 (es)
MX (1) MX2009008145A (es)
MY (1) MY147487A (es)
NZ (1) NZ578663A (es)
PE (1) PE20081785A1 (es)
PL (1) PL2125782T3 (es)
PT (1) PT2125782E (es)
RS (1) RS51986B (es)
SI (1) SI2125782T1 (es)
TN (1) TN2009000345A1 (es)
TW (1) TW200848038A (es)
UA (1) UA97389C2 (es)
WO (1) WO2008101905A1 (es)
ZA (1) ZA200905160B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
AU2021385572A1 (en) 2020-11-25 2023-06-22 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Family Cites Families (28)

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DE69535327T2 (de) 1994-01-13 2007-06-06 The Regents Of The University Of California, Oakland Monocyten protein rezeptoren aus säugern, mit chemoattraktion auslösender wirkung
EP1199360A3 (en) 1996-03-01 2002-05-02 Euroscreen S.A. Active and inactive CC-chemokine receptors and nucleic acid molecules encoding said receptor
WO1997045543A2 (en) * 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Cc chemokine receptor 5, antibodies thereto, transgenic animals
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
EP1039899A2 (en) * 1997-12-19 2000-10-04 Takeda Chemical Industries, Ltd. Pharmaceutical composition for antagonizing ccr5 comprising anilide derivative
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
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WO2001051077A1 (en) 2000-01-14 2001-07-19 The Government Of The United States Of Americarep Resented By The Secretary, Department Of Health And Human Services Methods of regulating il-12 production by administering ccr5 agonists and antagonists
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US20060251651A1 (en) * 2002-12-13 2006-11-09 Ono Pharmaceutical Co., Ltd. Antagonist and agonist which bind to a strong binding site of chemokine receptor
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CA2548502A1 (en) * 2003-12-11 2005-06-30 Yale University Methods and compositions relating to ccr5 antagonist, ifn-.gamma. and il-13 induced inflammation
EP1696919B1 (en) * 2003-12-18 2013-10-02 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
GB0403038D0 (en) * 2004-02-11 2004-03-17 Novartis Ag Organic compounds
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
AP2314A (en) 2004-05-11 2011-10-31 Incyte Corp 3- 4-heteroarylcyclohexylamino cyclopentanecarboxamides as modulators of chemokine receptors.
GB0412468D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
US20070149557A1 (en) 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
BRPI0712843A2 (pt) 2006-06-12 2012-07-31 Pfizer Prod Inc antagonista de ccr5 e seus usos
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
JP2010505878A (ja) 2006-10-05 2010-02-25 セントコア・オーソ・バイオテツク・インコーポレーテツド 線維症の処置のためのｃｃｒ２アンタゴニスト
WO2008045564A2 (en) 2006-10-12 2008-04-17 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
JP2010510224A (ja) 2006-11-17 2010-04-02 アボット・ラボラトリーズ ケモカイン受容体拮抗薬としてのアミノピロリジン類
CA2676352A1 (en) 2007-02-15 2008-08-21 Pfizer Limited Pharmaceutical compositions and methods for ccr5 antagonists
WO2008134076A1 (en) 2007-04-30 2008-11-06 Progenics Pharmaceuticals, Inc. Methods for reducing viral load in hiv-1-infected patients

Also Published As

Publication number Publication date
KR101070984B1 (ko) 2011-10-06
UA97389C2 (en) 2012-02-10
PL2125782T3 (pl) 2011-12-30
EP2125782A1 (en) 2009-12-02
ZA200905160B (en) 2010-05-26
NZ578663A (en) 2011-01-28
PT2125782E (pt) 2011-11-17
EP2125782B1 (en) 2011-08-03
BRPI0807625A2 (pt) 2014-05-27
CN101605781A (zh) 2009-12-16
CL2008000497A1 (es) 2008-08-29
US20100016361A1 (en) 2010-01-21
HN2009001607A (es) 2011-11-23
KR20090103943A (ko) 2009-10-01
GT200900226A (es) 2010-07-02
CA2677565A1 (en) 2008-08-28
US8354431B2 (en) 2013-01-15
CR10957A (es) 2009-09-01
ATE518854T1 (de) 2011-08-15
MX2009008145A (es) 2009-08-12
AR065369A1 (es) 2009-06-03
HK1138836A1 (en) 2010-09-03
ECSP099584A (es) 2009-09-29
MA31206B1 (fr) 2010-02-01
HRP20110793T1 (hr) 2011-11-30
TW200848038A (en) 2008-12-16
TN2009000345A1 (en) 2010-12-31
CY1111984T1 (el) 2015-11-04
JP2010519187A (ja) 2010-06-03
ES2371126T3 (es) 2011-12-27
MY147487A (en) 2012-12-14
EA017000B1 (ru) 2012-09-28
EA200901085A1 (ru) 2010-02-26
CN101605781B (zh) 2014-08-13
SI2125782T1 (sl) 2011-12-30
AU2008219317B2 (en) 2011-09-08
WO2008101905A1 (en) 2008-08-28
CA2677565C (en) 2014-11-18
IL200191A (en) 2013-12-31
AU2008219317A1 (en) 2008-08-28
JP5180234B2 (ja) 2013-04-10
IL200191A0 (en) 2010-04-15
RS51986B (sr) 2012-02-29
DK2125782T3 (da) 2011-11-21

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