PE20140966A1 - Quinazolincarboxamida azetidinas - Google Patents
Quinazolincarboxamida azetidinasInfo
- Publication number
- PE20140966A1 PE20140966A1 PE2013001281A PE2013001281A PE20140966A1 PE 20140966 A1 PE20140966 A1 PE 20140966A1 PE 2013001281 A PE2013001281 A PE 2013001281A PE 2013001281 A PE2013001281 A PE 2013001281A PE 20140966 A1 PE20140966 A1 PE 20140966A1
- Authority
- PE
- Peru
- Prior art keywords
- quinazoline
- azethydines
- hal
- ethylamine
- carboxyl
- Prior art date
Links
- ABVYZAMNSCVWJA-UHFFFAOYSA-N quinazoline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)N)=NC=C21 ABVYZAMNSCVWJA-UHFFFAOYSA-N 0.000 title 1
- -1 COMPOUNDS ACID AMIDE Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE AUN COMPUESTO DE FORMULA (I) Y SUS ESTEREOISOMEROS, TAUTOMEROS, ENTRE OTROS, EN DONDE: R1 ES H; R2 ES HAL, AR, CONH2, ENTRE OTROS; R3', R3", SON H, LA O HAL; AR ES UN HETEROCICLO AROMATICO MONO, BICICLICO QUE TIENE 0, 1, 2, 3, 4 ATOMOS DE N, O ENTRE OTROS. SON COMPUESTOS PREFERIDOS AMIDA DEL ACIDO 4-[(S)-2-AZETIDIN-1-IL-1-(3-FLUOROFENIL)-ETILAMINO]-QUINAZOLIN-8-CARBOXILICO; AMIDA DEL ACIDO 4-[(S)-2-AZETIDIN-1-IL-1-(3-CLOROFENIL)-ETILAMINO]-QUINAZOLIN-8-CARBOXILICO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA, SIENDO UTIL PARA EL TRATAMINETO DE ENFERMEDADES HIPERPROLIFERATIVAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41713110P | 2010-11-24 | 2010-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140966A1 true PE20140966A1 (es) | 2014-08-06 |
Family
ID=45001695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013001281A PE20140966A1 (es) | 2010-11-24 | 2011-11-11 | Quinazolincarboxamida azetidinas |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8946247B2 (es) |
| EP (1) | EP2643313B9 (es) |
| JP (1) | JP5897590B2 (es) |
| KR (1) | KR101894116B1 (es) |
| CN (1) | CN103228649B (es) |
| AR (1) | AR093725A1 (es) |
| AU (1) | AU2011334173B2 (es) |
| BR (1) | BR112013012488B1 (es) |
| CA (1) | CA2818706C (es) |
| CL (1) | CL2013001459A1 (es) |
| CO (1) | CO6721019A2 (es) |
| DK (1) | DK2643313T3 (es) |
| EA (1) | EA023821B1 (es) |
| ES (1) | ES2594404T3 (es) |
| HR (1) | HRP20161183T1 (es) |
| HU (1) | HUE028967T2 (es) |
| IL (1) | IL226233A (es) |
| LT (1) | LT2643313T (es) |
| MX (1) | MX355325B (es) |
| MY (1) | MY186456A (es) |
| NZ (1) | NZ612224A (es) |
| PE (1) | PE20140966A1 (es) |
| PL (1) | PL2643313T3 (es) |
| PT (1) | PT2643313T (es) |
| RS (1) | RS55204B1 (es) |
| SG (1) | SG190318A1 (es) |
| SI (1) | SI2643313T1 (es) |
| UA (1) | UA112167C2 (es) |
| WO (1) | WO2012069146A1 (es) |
| ZA (1) | ZA201304637B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014005468A2 (pt) | 2011-09-12 | 2017-03-21 | Merck Patent Gmbh | derivados de aminopiridina para uso como moduladores de atividade quinase |
| LT2755965T (lt) | 2011-09-12 | 2017-11-10 | Merck Patent Gmbh | Naujieji imidazolo aminai kaip kinazės aktyvumo moduliatoriai |
| ES2656096T3 (es) | 2012-11-16 | 2018-02-23 | Merck Patent Gmbh | Nuevos derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa |
| AU2013344552B2 (en) | 2012-11-16 | 2018-03-15 | Xiaoling Chen | Novel heterocyclic derivatives as modulators of kinase activity |
| EP2925747B1 (en) * | 2012-11-29 | 2020-06-24 | Merck Patent GmbH | Azaquinazoline carboxamide derivatives |
| KR20150124957A (ko) | 2013-03-11 | 2015-11-06 | 메르크 파텐트 게엠베하 | 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체 |
| KR102410696B1 (ko) | 2014-04-03 | 2022-06-17 | 메르크 파텐트 게엠베하 | 암 치료법의 조합 |
| CA2970394C (en) * | 2014-12-11 | 2023-03-14 | Merck Patent Gmbh | Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative |
| WO2017140793A1 (en) * | 2016-02-16 | 2017-08-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Modulators of ccr9 for treating tumor resistance to immune responses |
| EP3416640A1 (en) * | 2016-02-16 | 2018-12-26 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Modulators of tumor immune resistance for the treatment of cancer |
| WO2019170543A1 (en) | 2018-03-07 | 2019-09-12 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| WO2021094209A1 (en) | 2019-11-12 | 2021-05-20 | Bayer Aktiengesellschaft | Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists |
| EP4243819A1 (en) | 2020-11-16 | 2023-09-20 | Merck Patent GmbH | Kinase inhibitor combinations for cancer treatment |
| CN116490187A (zh) * | 2020-11-16 | 2023-07-25 | 默克专利股份公司 | 用于癌症治疗的激酶抑制剂组合 |
| US11866421B2 (en) * | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| KR20250068623A (ko) | 2022-08-11 | 2025-05-16 | 이벡스타 바이오 | 암 치료용 화합물 |
| WO2025168601A1 (en) * | 2024-02-05 | 2025-08-14 | Evexta Bio | Quinazoline carboxamide azetidine compounds for use in treating hormone dependent diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| JPWO2004014873A1 (ja) * | 2002-08-09 | 2005-12-02 | 杏林製薬株式会社 | ４−置換キナゾリン−８−カルボン酸アミド誘導体とその薬理上許容される付加塩 |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| AU2004230841A1 (en) | 2003-04-03 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| AU2004278413B2 (en) | 2003-09-30 | 2008-07-31 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2004283751B2 (en) | 2003-10-24 | 2011-05-19 | Exelixis, Inc. | p70S6 kinase modulators and method of use |
| RU2006121646A (ru) | 2003-11-21 | 2008-01-10 | Новартис АГ (CH) | Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы |
| AU2004296868B2 (en) | 2003-12-09 | 2010-11-25 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for suppressing an immune response or treating a proliferative disorder |
| EP1750727A2 (en) | 2004-04-23 | 2007-02-14 | Exelixis, Inc. | Kinase modulators and methods of use |
| US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| JP2008546751A (ja) | 2005-06-22 | 2008-12-25 | アステックス・セラピューティクス・リミテッド | 医薬組成物 |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| DE102007032739A1 (de) | 2007-07-13 | 2009-01-15 | Merck Patent Gmbh | Chinazolinamidderivate |
| PL2396307T3 (pl) * | 2009-02-11 | 2015-03-31 | Merck Patent Gmbh | Nowe aminowe azaheterocykliczne karboksyamidy |
| BR112013002212A2 (pt) * | 2010-07-29 | 2017-09-26 | Merck Patent Gmbh | carboxamidas aza-heterocíclicas de aminas cíclicas |
| UA110113C2 (xx) * | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди |
-
2011
- 2011-11-11 WO PCT/EP2011/005691 patent/WO2012069146A1/en not_active Ceased
- 2011-11-11 HR HRP20161183TT patent/HRP20161183T1/hr unknown
- 2011-11-11 DK DK11785338.2T patent/DK2643313T3/en active
- 2011-11-11 PE PE2013001281A patent/PE20140966A1/es active IP Right Grant
- 2011-11-11 US US13/989,199 patent/US8946247B2/en active Active
- 2011-11-11 SI SI201130973A patent/SI2643313T1/sl unknown
- 2011-11-11 BR BR112013012488-1A patent/BR112013012488B1/pt active IP Right Grant
- 2011-11-11 KR KR1020137015932A patent/KR101894116B1/ko active Active
- 2011-11-11 EP EP11785338.2A patent/EP2643313B9/en active Active
- 2011-11-11 RS RS20160817A patent/RS55204B1/sr unknown
- 2011-11-11 HU HUE11785338A patent/HUE028967T2/en unknown
- 2011-11-11 PL PL11785338T patent/PL2643313T3/pl unknown
- 2011-11-11 MY MYPI2013700817A patent/MY186456A/en unknown
- 2011-11-11 CN CN201180056687.5A patent/CN103228649B/zh active Active
- 2011-11-11 PT PT117853382T patent/PT2643313T/pt unknown
- 2011-11-11 EA EA201300610A patent/EA023821B1/ru not_active IP Right Cessation
- 2011-11-11 MX MX2013005751A patent/MX355325B/es active IP Right Grant
- 2011-11-11 LT LTEP11785338.2T patent/LT2643313T/lt unknown
- 2011-11-11 JP JP2013540255A patent/JP5897590B2/ja active Active
- 2011-11-11 UA UAA201307880A patent/UA112167C2/uk unknown
- 2011-11-11 SG SG2013038054A patent/SG190318A1/en unknown
- 2011-11-11 CA CA2818706A patent/CA2818706C/en active Active
- 2011-11-11 NZ NZ612224A patent/NZ612224A/en unknown
- 2011-11-11 ES ES11785338.2T patent/ES2594404T3/es active Active
- 2011-11-11 AU AU2011334173A patent/AU2011334173B2/en active Active
- 2011-11-23 AR ARP110104360A patent/AR093725A1/es not_active Application Discontinuation
-
2013
- 2013-05-08 IL IL226233A patent/IL226233A/en active IP Right Grant
- 2013-05-22 CL CL2013001459A patent/CL2013001459A1/es unknown
- 2013-06-17 CO CO13144136A patent/CO6721019A2/es unknown
- 2013-06-21 ZA ZA2013/04637A patent/ZA201304637B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |