AR008331A1 - Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen - Google Patents
Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienenInfo
- Publication number
- AR008331A1 AR008331A1 ARP980100284A ARP980100284A AR008331A1 AR 008331 A1 AR008331 A1 AR 008331A1 AR P980100284 A ARP980100284 A AR P980100284A AR P980100284 A ARP980100284 A AR P980100284A AR 008331 A1 AR008331 A1 AR 008331A1
- Authority
- AR
- Argentina
- Prior art keywords
- cr8r8
- alkyl
- alkenyl
- integer
- value
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 108090001007 Interleukin-8 Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 102000010681 interleukin-8 receptors Human genes 0.000 abstract 1
- 108010038415 interleukin-8 receptors Proteins 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto antagonista de un receptor de IL-8, caracterizado porque comprende la fórmula (I) en la que R es -NH-C(X2)-NH-(CR13R14)y-Z, o de fórmula(II); Z es W,HET, alquilo C1-10 opcionalmente sustituído, alquenilo C2-10 opcionalmentes ustituido o alquinilo C2-10 opcionalmente sustituido; X es O,N-R18; C=O, o S (O)m; X2 es =O ó =S; A es CH2, C(O)ó C(S); R1 se selecciona independientemente entre hidrógeno, halógeno, nitro, ciano, alquilo C1-10sustituido con halo, alquilo,alquil o C1-10, alquenilo C2-10, alcoxi C1-10, alcoxi C1-10 sustituido con halo, azido, (CR8R8)qS(O)tR4, hidroxi-alquilo C1-10arilo, aril-alquilo C1-4, ariloxi, aril-alquil C1-4-oxi, heteroarilo, heteroarilalquilo, heterocíclico,heterocíclico -alquilo-C1-4, heteroaril-alquil C1-4-oxi, aril-alquenilo C2-10, heteroaril-alquenilo C2-10, heterocíclico-alquenilo C2-10, (CR8R8)qNR4R5, alquenil C2-10-C(O)-RN4R5,(CR8R8)qC(O)NR4R5, (CR8R8)qC(O)NR4R10, S(O)3H, S(O)3R8,(CR8R8)qC(O)R11, alquenil C2-10-C(O)R11, alquenil C2-10-C(O)OR11, C(O)R11, (CR8R8)qC(O)OR12,(CR8R8)qOC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)q-NHS(O)2R17 ó (CR8R8)qS(O)2NR4R5, ó dos restos R1 en común pueden formar O-(CH2)s-O- o un anillo saturadooinsaturado de 5 a 6 miembros; y en el que los anillos que contienen arilo, heteroarilo y heterociclico pueden todos ellos estar opocionalmente sustituidosn es un número entero que tiene un valor de 1 a 3; m es un número entero que tiene unvalor de 1 a 3; m es un número entero que tiene un valor de 1 o 2; qes 0, o un número entero que tiene un valor de 1 a 10; s es un número entero que tiene un valor de 1 a 3; t es 0 o un número entero que tiene un valor de 1o 2; v es 0, o unnúmero entero que tien e un valor de 1 a 4; p es un número entero que tiene un valor de 1 a 3; HET es un heteroarilo opocionalmente
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3599097P | 1997-01-23 | 1997-01-23 | |
| US4283097P | 1997-04-08 | 1997-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008331A1 true AR008331A1 (es) | 1999-12-29 |
Family
ID=26712686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100284A AR008331A1 (es) | 1997-01-23 | 1998-01-22 | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6166055A (es) |
| EP (1) | EP1005341B1 (es) |
| JP (1) | JP2002515055A (es) |
| KR (1) | KR20000070369A (es) |
| CN (1) | CN1253501A (es) |
| AR (1) | AR008331A1 (es) |
| AT (1) | ATE381330T1 (es) |
| AU (1) | AU729893B2 (es) |
| BR (1) | BR9807085A (es) |
| CA (1) | CA2278427A1 (es) |
| DE (1) | DE69838874T2 (es) |
| ES (1) | ES2299200T3 (es) |
| HU (1) | HUP0001940A3 (es) |
| IL (1) | IL131005A0 (es) |
| NO (1) | NO313913B1 (es) |
| NZ (1) | NZ336859A (es) |
| PE (1) | PE103699A1 (es) |
| PL (1) | PL334774A1 (es) |
| TR (1) | TR199901761T2 (es) |
| WO (1) | WO1998032438A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
| AR015426A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
| EP1121360A4 (en) * | 1998-10-13 | 2002-01-23 | Smithkline Beecham Corp | INTERLEUKIN-8 (IL-8) RECEPTOR ANTAGONISTS |
| WO2000069435A1 (en) * | 1999-05-18 | 2000-11-23 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| JP2003505379A (ja) * | 1999-07-16 | 2003-02-12 | ビーエーエスエフ アクチェンゲゼルシャフト | 置換ベンゾイソチアゾール化合物 |
| US6440993B1 (en) | 1999-10-12 | 2002-08-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| PE20011124A1 (es) | 2000-03-31 | 2001-10-28 | Upjohn Co | Nuevos agentes antibacterianos de benzosultam oxazolidinona |
| DE10038709A1 (de) * | 2000-08-09 | 2002-02-28 | Aventis Pharma Gmbh | Substituierte und unsubstituierte Benzooxathiazole sowie daraus abgeleitete Verbindungen |
| GB0403038D0 (en) * | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| EP1745032B1 (en) | 2004-05-12 | 2013-07-31 | Merck Sharp & Dohme Corp. | CXCR1 and CXCR2 chemokine antagonists |
| PE20081785A1 (es) | 2007-02-19 | 2009-01-12 | Novartis Ag | Derivados de ciclohexil-amida del acido aril carboxilico |
| CN104640856B (zh) | 2012-05-11 | 2017-09-15 | 复位治疗公司 | 作为隐花色素调节剂的含有咔唑的磺酰胺类 |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09511998A (ja) * | 1994-04-15 | 1997-12-02 | グラクソ、ウェルカム、インコーポレーテッド | １，４ − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法 |
| JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
| CN1097043C (zh) * | 1995-10-05 | 2002-12-25 | 京都药品工业株式会社 | 新的杂环衍生物及其医药用途 |
| US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| AR015426A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion |
| AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
| JP2002509105A (ja) * | 1998-01-16 | 2002-03-26 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体アンタゴニスト |
-
1998
- 1998-01-22 AR ARP980100284A patent/AR008331A1/es not_active Application Discontinuation
- 1998-01-23 ES ES98901852T patent/ES2299200T3/es not_active Expired - Lifetime
- 1998-01-23 PL PL98334774A patent/PL334774A1/xx unknown
- 1998-01-23 BR BR9807085-1A patent/BR9807085A/pt not_active Application Discontinuation
- 1998-01-23 HU HU0001940A patent/HUP0001940A3/hu unknown
- 1998-01-23 IL IL13100598A patent/IL131005A0/xx unknown
- 1998-01-23 CN CN98803564A patent/CN1253501A/zh active Pending
- 1998-01-23 EP EP98901852A patent/EP1005341B1/en not_active Expired - Lifetime
- 1998-01-23 US US09/341,382 patent/US6166055A/en not_active Expired - Fee Related
- 1998-01-23 TR TR1999/01761T patent/TR199901761T2/xx unknown
- 1998-01-23 JP JP53213998A patent/JP2002515055A/ja not_active Ceased
- 1998-01-23 AU AU58278/98A patent/AU729893B2/en not_active Ceased
- 1998-01-23 CA CA002278427A patent/CA2278427A1/en not_active Abandoned
- 1998-01-23 NZ NZ336859A patent/NZ336859A/xx unknown
- 1998-01-23 AT AT98901852T patent/ATE381330T1/de not_active IP Right Cessation
- 1998-01-23 DE DE69838874T patent/DE69838874T2/de not_active Expired - Fee Related
- 1998-01-23 WO PCT/US1998/001292 patent/WO1998032438A1/en not_active Ceased
- 1998-01-23 KR KR1019997006602A patent/KR20000070369A/ko not_active Ceased
- 1998-07-22 PE PE1998000656A patent/PE103699A1/es not_active Application Discontinuation
-
1999
- 1999-07-22 NO NO19993585A patent/NO313913B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69838874D1 (de) | 2008-01-31 |
| BR9807085A (pt) | 2000-04-18 |
| NO993585L (no) | 1999-09-21 |
| EP1005341A1 (en) | 2000-06-07 |
| PL334774A1 (en) | 2000-03-13 |
| JP2002515055A (ja) | 2002-05-21 |
| ATE381330T1 (de) | 2008-01-15 |
| CA2278427A1 (en) | 1998-07-30 |
| CN1253501A (zh) | 2000-05-17 |
| NO313913B1 (no) | 2002-12-23 |
| AU729893B2 (en) | 2001-02-15 |
| NO993585D0 (no) | 1999-07-22 |
| WO1998032438A1 (en) | 1998-07-30 |
| DE69838874T2 (de) | 2008-12-04 |
| PE103699A1 (es) | 1999-12-30 |
| EP1005341B1 (en) | 2007-12-19 |
| HUP0001940A3 (en) | 2002-09-30 |
| EP1005341A4 (en) | 2004-09-08 |
| NZ336859A (en) | 2001-01-26 |
| AU5827898A (en) | 1998-08-18 |
| ES2299200T3 (es) | 2008-05-16 |
| KR20000070369A (ko) | 2000-11-25 |
| HUP0001940A2 (hu) | 2001-01-29 |
| TR199901761T2 (xx) | 1999-10-21 |
| IL131005A0 (en) | 2001-01-28 |
| US6166055A (en) | 2000-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |