PE20060569A1 - Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc - Google Patents
Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhcInfo
- Publication number
- PE20060569A1 PE20060569A1 PE2005000809A PE2005000809A PE20060569A1 PE 20060569 A1 PE20060569 A1 PE 20060569A1 PE 2005000809 A PE2005000809 A PE 2005000809A PE 2005000809 A PE2005000809 A PE 2005000809A PE 20060569 A1 PE20060569 A1 PE 20060569A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- indol
- het
- compounds
- amino
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- MLNCQWGIBLBLJD-UHFFFAOYSA-N N=C=O.C1=CC=C2NC=CC2=C1 Chemical class N=C=O.C1=CC=C2NC=CC2=C1 MLNCQWGIBLBLJD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 108060004795 Methyltransferase Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
- 229960003805 amantadine Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960000329 ribavirin Drugs 0.000 abstract 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE INDOL FORMULA (I), EN DONDE A O B SON INDISTINTAMENTE N Y C, LAS LINEAS PUNTEADAS REPRESENTAN UN DOBLE ENLACE SI ESTA ENTRE DOS CARBONOS Y SIMPLE SI ESTA ENTRE C Y N; R1 ES H O ALQUILO(C1-C6); R2 ES ALQUILO(C1-C6), ARILO O Het OPCIONALMENTE SUSTITUIDO CON R21, DONDE Het ES UN HETEROCICLO MONOCICLICO AROMATICO DE 5 A 6 MIEMBROS DE 1 A 4 HETEROATOMOS DE O, N O S Y OPCIONALMENTE CONDENSADO A OTRO CICLO; R3 ES CICLOALQUILO(C5-C6); R5 ES ALQUILO(C1-C6), ALQUENILO(C1-C6), Het, Het-ALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; R6 ES H, ALQUILO, HALO, ENTRE OTROS O R5 Y R6 PUEDEN ESTAR ENLAZADOS; R7 ES H, ALQUILO O ALCOXI(C1-C6), ENTRE OTROS; R9 Y R10 SON INDEPENDIENTEMENTE ALQUILO(C1-C6) O JUNTOS UNIDOS COVALENTEMENTE FORMAN UN CICLOAQUILO O CICLOALQUENILO(C5-C6), HETEROCICLO DE 5 A 6 MIEMBROS. SON PREFERIDOS: (E)-3-[4-({1-[(3-CICLOPENTIL-1-METIL-2-PIRIDIN-2-IL-1H-INDOL-6-CARBONIL)-AMINO]CICLOBUTANOLCARBONIL}AMINO)-2,6-DIMETOXIFENIL]ACRILICO, ACIDO (E)-3-{4-[(1-{[2-(5-CLORO-PIRIMIDIN-2-IL)-3-CICLOPENTIL-1-METIL-1H-INDOL-6-CARBONIL]-AMINO}CICLOBUTANOCARBONIL)AMINO]2-ETOXI-FENIL}-ACRILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS PUEDE COMPRENDER OTRO AGENTE ANTIVIRAL COMO RIBAVIRINA, AMANTADINA, INMUNOMODULADORES, INHIBIDOR DE PROTEASA NE3 DE VHC, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE ARN POLIMERASA DEPENDIENTE DE ARN DE LA ENZIMA NE5B, CODIFICADA POR VHC Y SON UTILES EN LA INFECCION POR VHC
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58867004P | 2004-07-16 | 2004-07-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060569A1 true PE20060569A1 (es) | 2006-06-22 |
Family
ID=35784831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000809A PE20060569A1 (es) | 2004-07-16 | 2005-07-14 | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7241801B2 (es) |
| EP (1) | EP1771442A4 (es) |
| JP (1) | JP2008506638A (es) |
| KR (1) | KR20070035092A (es) |
| CN (1) | CN1984908A (es) |
| AR (1) | AR050172A1 (es) |
| AU (1) | AU2005263135A1 (es) |
| BR (1) | BRPI0513431A (es) |
| CA (1) | CA2573210A1 (es) |
| EA (1) | EA200700038A1 (es) |
| EC (1) | ECSP077171A (es) |
| IL (1) | IL180665A0 (es) |
| MX (1) | MX2007000007A (es) |
| NO (1) | NO20070368L (es) |
| PE (1) | PE20060569A1 (es) |
| TW (1) | TW200617003A (es) |
| UY (1) | UY29017A1 (es) |
| WO (1) | WO2006007693A1 (es) |
| ZA (1) | ZA200609578B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| UA86962C2 (en) * | 2004-02-20 | 2009-06-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Viral polymerase inhibitors |
| US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| JP2008526980A (ja) * | 2005-01-14 | 2008-07-24 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染症を治療するためのインドール誘導体 |
| CA2597680A1 (en) * | 2005-02-11 | 2006-08-17 | Boehringer Ingelheim International Gmbh | Process for preparing 2,3-disubstituted indoles |
| WO2006127289A1 (en) * | 2005-05-20 | 2006-11-30 | Valeant Research & Development | Treatment of hcv with subtherapeutic doses of ribavirin |
| US8076365B2 (en) * | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2007092000A1 (en) * | 2006-02-06 | 2007-08-16 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
| GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
| FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
| WO2009008906A2 (en) | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
| NZ580917A (en) | 2007-05-04 | 2012-06-29 | Vertex Pharma | Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection |
| JP2010533698A (ja) | 2007-07-17 | 2010-10-28 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | Ｃ型肝炎感染症の治療のための大環状インドール誘導体 |
| US20100286131A1 (en) * | 2007-08-03 | 2010-11-11 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| CA2693997C (en) * | 2007-08-03 | 2013-01-15 | Pierre L. Beaulieu | Viral polymerase inhibitors |
| JP5529036B2 (ja) | 2007-12-05 | 2014-06-25 | エナンタ ファーマシューティカルズ インコーポレイテッド | フッ素化トリペプチドｈｃｖセリンプロテアーゼ阻害剤 |
| EA201000948A1 (ru) * | 2007-12-19 | 2011-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
| EP2385838A1 (en) | 2009-01-07 | 2011-11-16 | Scynexis, Inc. | Cyclosporine derivative for use in the treatment of hcv and hiv infection |
| TW201100398A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted indolo-pyridinone compounds |
| CN102458444A (zh) | 2009-05-13 | 2012-05-16 | 英安塔制药有限公司 | 用作丙型肝炎病毒抑制剂的大环化合物 |
| EP2618831B1 (en) | 2010-09-21 | 2016-01-06 | Enanta Pharmaceuticals, Inc. | Macrocyclic proline derived hcv serine protease inhibitors |
| US9233921B2 (en) | 2013-03-08 | 2016-01-12 | The Trustees Of The University Of Pennsylvania | Potent poxvirus inhibitor |
| CN113444046B (zh) * | 2016-07-20 | 2023-10-27 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| US12060148B2 (en) | 2022-08-16 | 2024-08-13 | Honeywell International Inc. | Ground resonance detection and warning system and method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| JP2004520839A (ja) | 2001-03-08 | 2004-07-15 | ベーリンガー インゲルハイム （カナダ） リミテッド | Ｈｃｖのｒｎａ依存性ｒｎａポリメラーゼ（ｎｓ５ｂ）の阻害剤を同定するための分析法 |
| EP1411928A1 (en) | 2001-07-20 | 2004-04-28 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
-
2005
- 2005-07-14 UY UY29017A patent/UY29017A1/es not_active Application Discontinuation
- 2005-07-14 PE PE2005000809A patent/PE20060569A1/es not_active Application Discontinuation
- 2005-07-15 MX MX2007000007A patent/MX2007000007A/es active IP Right Grant
- 2005-07-15 EP EP05768261A patent/EP1771442A4/en not_active Withdrawn
- 2005-07-15 AU AU2005263135A patent/AU2005263135A1/en not_active Abandoned
- 2005-07-15 CN CNA2005800237228A patent/CN1984908A/zh active Pending
- 2005-07-15 AR ARP050102935A patent/AR050172A1/es unknown
- 2005-07-15 TW TW094124015A patent/TW200617003A/zh unknown
- 2005-07-15 BR BRPI0513431-5A patent/BRPI0513431A/pt not_active IP Right Cessation
- 2005-07-15 WO PCT/CA2005/001103 patent/WO2006007693A1/en not_active Ceased
- 2005-07-15 EA EA200700038A patent/EA200700038A1/ru unknown
- 2005-07-15 KR KR1020077003911A patent/KR20070035092A/ko not_active Withdrawn
- 2005-07-15 CA CA002573210A patent/CA2573210A1/en not_active Abandoned
- 2005-07-15 JP JP2007520631A patent/JP2008506638A/ja active Pending
- 2005-07-15 US US11/182,987 patent/US7241801B2/en not_active Expired - Lifetime
-
2006
- 2006-11-17 ZA ZA200609578A patent/ZA200609578B/xx unknown
-
2007
- 2007-01-11 IL IL180665A patent/IL180665A0/en unknown
- 2007-01-16 EC EC2007007171A patent/ECSP077171A/es unknown
- 2007-01-19 NO NO20070368A patent/NO20070368L/no not_active Application Discontinuation
- 2007-05-25 US US11/753,678 patent/US20070249629A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR050172A1 (es) | 2006-10-04 |
| EA200700038A1 (ru) | 2007-08-31 |
| MX2007000007A (es) | 2007-03-07 |
| ZA200609578B (en) | 2008-08-27 |
| EP1771442A1 (en) | 2007-04-11 |
| WO2006007693A1 (en) | 2006-01-26 |
| EP1771442A4 (en) | 2009-12-30 |
| JP2008506638A (ja) | 2008-03-06 |
| KR20070035092A (ko) | 2007-03-29 |
| US7241801B2 (en) | 2007-07-10 |
| BRPI0513431A (pt) | 2008-05-06 |
| AU2005263135A1 (en) | 2006-01-26 |
| ECSP077171A (es) | 2007-02-28 |
| UY29017A1 (es) | 2006-02-24 |
| US20060052418A1 (en) | 2006-03-09 |
| NO20070368L (no) | 2007-01-30 |
| TW200617003A (en) | 2006-06-01 |
| CA2573210A1 (en) | 2006-01-26 |
| US20070249629A1 (en) | 2007-10-25 |
| IL180665A0 (en) | 2007-06-03 |
| CN1984908A (zh) | 2007-06-20 |
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