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PE20090243A1 - Compuestos de imidazol sustituido como inhibidores de renina - Google Patents

Compuestos de imidazol sustituido como inhibidores de renina

Info

Publication number
PE20090243A1
PE20090243A1 PE2008000701A PE2008000701A PE20090243A1 PE 20090243 A1 PE20090243 A1 PE 20090243A1 PE 2008000701 A PE2008000701 A PE 2008000701A PE 2008000701 A PE2008000701 A PE 2008000701A PE 20090243 A1 PE20090243 A1 PE 20090243A1
Authority
PE
Peru
Prior art keywords
piperazin
imidazol
carbonyl
phenyl
alkyl
Prior art date
Application number
PE2008000701A
Other languages
English (en)
Inventor
Takanobu Kuroita
Tsuneo Oda
Yasutomi Asano
Naohiro Taya
Kouichi Iwanaga
Hidekazu Tokuhara
Yoshiyuki Fukase
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20090243A1 publication Critical patent/PE20090243A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOL SUSTITUIDOS DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6) SUSTITUIDO CON HIDROXI O FENILAMINO, ARALQUILO(C7-C13), ENTRE OTROS; R2 ES ARILO(C6-C14), CICLOALQUILO(C3-C10), ALQUILO(C1-C10), ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO(C1-C6) O ALCOXI(C1-C6); X ES UN ENLACE O ALQUILENO(C1-C6); A ES CICLOALCANO(C5-C7); B ES PIPERAZINA. SON COMPUESTOS PREFERIDOS: (1S,2R)-1-(METOXIMETIL)-2-{4-[((2R)-2-{2-[(2-METIL-1,3-BENZOTIAZOL-5-IL)OXI]ETIL}PIPERAZIN-1-IL)CARBONIL]-5-FENIL-1H-IMIDAZOL-1-IL}CICLOHEXANOL, [(1S,2S)-2-(4-{[(2R)-2-(3,5-DIFLUOROBENCIL)PIPERAZIN-1-IL]CARBONIL}-5-FENIL-1H-IMIDAZOL-1-IL)CICLOHEXIL]CARBAMATO DE METILO, (1S,2R)-1-(METOXIMETIL)-2-[4-({(2R)-2-[2-(2-METOXI-4-METILFENOXI)ETIL]PIPERAZIN-1-IL}CARBONIL)-5-FENIL-1H-IMIDAZOL-1-IL]CICLOHEXANOL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE RENINA SIENDO UTILES EN EL TRATAMIENTO DE HIPERTENSION
PE2008000701A 2007-04-27 2008-04-23 Compuestos de imidazol sustituido como inhibidores de renina PE20090243A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007120292 2007-04-27
JP2007207271 2007-08-08

Publications (1)

Publication Number Publication Date
PE20090243A1 true PE20090243A1 (es) 2009-04-03

Family

ID=39657370

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000701A PE20090243A1 (es) 2007-04-27 2008-04-23 Compuestos de imidazol sustituido como inhibidores de renina

Country Status (6)

Country Link
US (1) US20090156612A1 (es)
AR (1) AR066268A1 (es)
CL (1) CL2008001163A1 (es)
PE (1) PE20090243A1 (es)
TW (1) TW200904433A (es)
WO (1) WO2008139941A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2202228B1 (en) * 2007-10-15 2014-12-10 Takeda Pharmaceutical Company Limited Amide compounds and use of the same
JO3465B1 (ar) 2008-06-19 2020-07-05 Takeda Pharmaceuticals Co مركب متغاير الحلقه واستخدامه
TWI532725B (zh) 2010-01-26 2016-05-11 賽諾菲阿凡提斯公司 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
US20120178813A1 (en) 2011-01-12 2012-07-12 Thetis Pharmaceuticals Llc Lipid-lowering antidiabetic agent
US8765811B2 (en) 2012-07-10 2014-07-01 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US9382187B2 (en) 2012-07-10 2016-07-05 Thetis Pharmaceuticals Llc Tri-salt form of metformin
US9505709B2 (en) 2014-05-05 2016-11-29 Thetis Pharmaceuticals Llc Compositions and methods relating to ionic salts of peptides
US9242008B2 (en) 2014-06-18 2016-01-26 Thetis Pharmaceuticals Llc Mineral amino-acid complexes of fatty acids
MX2016016830A (es) 2014-06-18 2017-07-07 Thetis Pharmaceuticals Llc Complejos de aminoacidos minerales de agentes activos.
EP3454907B1 (en) 2016-06-03 2020-07-22 Thetis Pharmaceuticals LLC Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation
WO2019224765A1 (en) 2018-05-24 2019-11-28 3M Innovative Properties Company N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods
CN117586207A (zh) * 2023-11-27 2024-02-23 浙江东亚药业股份有限公司 一种酮康唑侧链的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
US20100121048A1 (en) * 2006-02-16 2010-05-13 Takanobu Kuroita Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension

Also Published As

Publication number Publication date
US20090156612A1 (en) 2009-06-18
TW200904433A (en) 2009-02-01
WO2008139941A1 (en) 2008-11-20
CL2008001163A1 (es) 2008-12-19
AR066268A1 (es) 2009-08-05

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