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PE20040983A1 - Derivados sustituidos del 2-pirrolidin-2-ilo[1,3,4]oxadiazol - Google Patents

Derivados sustituidos del 2-pirrolidin-2-ilo[1,3,4]oxadiazol

Info

Publication number
PE20040983A1
PE20040983A1 PE2003000883A PE2003000883A PE20040983A1 PE 20040983 A1 PE20040983 A1 PE 20040983A1 PE 2003000883 A PE2003000883 A PE 2003000883A PE 2003000883 A PE2003000883 A PE 2003000883A PE 20040983 A1 PE20040983 A1 PE 20040983A1
Authority
PE
Peru
Prior art keywords
ilo
pyrrolidin
oxadiazole
oxadiazol
pyridin
Prior art date
Application number
PE2003000883A
Other languages
English (en)
Inventor
Bernd Sundermann
Hagen-Heinrich Hennies
Helmut Heinrich Buschmann
Corina Sundermann
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20040983A1 publication Critical patent/PE20040983A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDO A DERIVADOS SUSTITUIDOS DEL 2-PIRROLIDIN-2-ILO[1,3,4]-OXADIAZOL DE FORMULA I, DONDE R1 ES ARILO HETEROARILO; R2 ES SO2R3 O COR4; R3 Y R4 SON CADA UNO ALQUILO C1-C10, CICLOALQUILO C3-C10, ENTRE OTROS. COMPUESTOS PREFERIDOS SON: (2,4-DIMETOXI-FENIL)-[2-(5-PIRIDIN-4-ILO-[1,3,4]OXADIAZOL-2-ILO)-PIRROLIDIN-1-ILO]-METANONA; (2-CLORO-PIRIDIN-3-ILO)-[2-(5-PIRIDIN-4-ILO-[1,3,4]OXADIAZOL-2-ILO)PIRROLIDIN-1-ILO]-METANONA Y 3-{5-[1-(4-TRIFLUOROMETOXI-BENCILSULFONIL)-PIRROLIDIN-2-ILO]-[1,3,4]OXADIAZOL-2-ILO}PIRIDINA; ENTRE OTROS. TAMBIEN REFERIDO A UN PROCEDIMIENTO PARA LA PREPARACION DE DICHOS COMPUESTOS, LOS CUALES SON UTILES EN EL TRATAMIENTO DE LA INCONTINENCIA URINARIA, DIARREA, DEPRESIONES, ENTRE OTROS
PE2003000883A 2002-08-30 2003-08-28 Derivados sustituidos del 2-pirrolidin-2-ilo[1,3,4]oxadiazol PE20040983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10240818A DE10240818A1 (de) 2002-08-30 2002-08-30 Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate

Publications (1)

Publication Number Publication Date
PE20040983A1 true PE20040983A1 (es) 2005-01-12

Family

ID=31983895

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000883A PE20040983A1 (es) 2002-08-30 2003-08-28 Derivados sustituidos del 2-pirrolidin-2-ilo[1,3,4]oxadiazol

Country Status (18)

Country Link
US (1) US7105538B2 (es)
EP (1) EP1532141B1 (es)
JP (1) JP2006506348A (es)
CN (1) CN100390168C (es)
AR (1) AR041093A1 (es)
AT (1) ATE484503T1 (es)
CA (1) CA2497078A1 (es)
CY (1) CY1110913T1 (es)
DE (2) DE10240818A1 (es)
DK (1) DK1532141T3 (es)
ES (1) ES2351119T3 (es)
MX (1) MXPA05002298A (es)
PE (1) PE20040983A1 (es)
PL (1) PL375627A1 (es)
PT (1) PT1532141E (es)
RU (1) RU2324694C2 (es)
SI (1) SI1532141T1 (es)
WO (1) WO2004024725A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2291080B1 (en) 2008-05-14 2015-08-19 The Scripps Research Institute Novel modulators of sphingosine phosphate receptors
RU2417995C1 (ru) * 2009-09-21 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") Способ получения 3-(2-замещенных-1,3-оксазол-4-ил)пиридин-2(1н)-онов
CN103420998A (zh) * 2012-05-16 2013-12-04 苏州爱斯鹏药物研发有限责任公司 一种新型噁二唑衍生物的合成方法
PT2855453T (pt) 2012-06-04 2017-03-09 Actelion Pharmaceuticals Ltd Derivados de benzimidazol-prolina
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
AU2013328301A1 (en) * 2012-10-10 2015-05-28 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
CN105051040A (zh) * 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
CN103333165B (zh) * 2013-07-01 2016-02-24 河南理工大学 2-苯基-5-(3,4-二甲基)吡咯基-1,3,4-噁二唑及制备方法
MX366642B (es) 2013-12-04 2019-07-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina.
CN111978311B (zh) * 2019-05-21 2024-05-31 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215949B1 (es) * 1973-02-01 1976-07-02 Delalande Sa
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
DE19643037A1 (de) * 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
RU2241709C2 (ru) * 1999-07-09 2004-12-10 Орто-Макнейл Фармасьютикал, Инк. Производные азотсодержащих гетероциклических соединений и способ лечения расстройств, характеризующихся поражением нейронов
JP2001247569A (ja) * 1999-08-12 2001-09-11 Japan Tobacco Inc ピロリジン誘導体又はピペリジン誘導体及びその医薬用途
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives

Also Published As

Publication number Publication date
DE10240818A1 (de) 2004-05-13
AR041093A1 (es) 2005-05-04
WO2004024725A1 (de) 2004-03-25
DK1532141T3 (da) 2010-11-22
EP1532141B1 (de) 2010-10-13
RU2324694C2 (ru) 2008-05-20
EP1532141A1 (de) 2005-05-25
CN1678609A (zh) 2005-10-05
SI1532141T1 (sl) 2010-12-31
DE50313185D1 (de) 2010-11-25
CA2497078A1 (en) 2004-03-25
AU2003264097A1 (en) 2004-04-30
RU2005109164A (ru) 2006-01-20
JP2006506348A (ja) 2006-02-23
ES2351119T3 (es) 2011-01-31
ATE484503T1 (de) 2010-10-15
PT1532141E (pt) 2010-11-02
MXPA05002298A (es) 2005-06-08
US20050187260A1 (en) 2005-08-25
PL375627A1 (en) 2005-12-12
US7105538B2 (en) 2006-09-12
CY1110913T1 (el) 2015-06-10
CN100390168C (zh) 2008-05-28

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FD Application declared void or lapsed