PE20081845A1 - Nuevos derivados de aminopirimidina como inhibidores de plk1 - Google Patents
Nuevos derivados de aminopirimidina como inhibidores de plk1Info
- Publication number
- PE20081845A1 PE20081845A1 PE2008000054A PE2008000054A PE20081845A1 PE 20081845 A1 PE20081845 A1 PE 20081845A1 PE 2008000054 A PE2008000054 A PE 2008000054A PE 2008000054 A PE2008000054 A PE 2008000054A PE 20081845 A1 PE20081845 A1 PE 20081845A1
- Authority
- PE
- Peru
- Prior art keywords
- ethylimidazole
- carbonitrile
- pyridin
- pyrimidine
- phenyl
- Prior art date
Links
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 title abstract 2
- 108010056274 polo-like kinase 1 Proteins 0.000 title abstract 2
- 150000005005 aminopyrimidines Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003927 aminopyridines Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- IIHQNAXFIODVDU-UHFFFAOYSA-N pyrimidine-2-carbonitrile Chemical compound N#CC1=NC=CC=N1 IIHQNAXFIODVDU-UHFFFAOYSA-N 0.000 abstract 1
- XVIAPHVAGFEFFN-UHFFFAOYSA-N pyrimidine-5-carbonitrile Chemical compound N#CC1=CN=CN=C1 XVIAPHVAGFEFFN-UHFFFAOYSA-N 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A DERIVADOS DE AMINOPIRIDINA DE FORMULA (I), EN DONDE CADA R1 Y R2 SON INDEPENDIENTEMENTE H, HALO, ALQUILO(C1-C2), OPCIONALMENTE SUSTITUIDOS; UN R3 Y R4 ES H, Y EL OTRO ES ALQUILO INFERIOR SUSTITUIDO CON NRaRb, HETEROCICLO ALIFATICO DE 4-6 MIEMBROS, ENTRE OTROS; R5 ES H, CIANO, HALOGENO, ALQUILO INFERIOR, ENTRE OTROS. SON SELECCIONADOS: 2-[((1S)-1-{4-[2-(TERC-BUTILAMINO)-1-HIDROXIETIL]FENIL}ETIL)AMINO]-4-(8-ETILIMIDAZOL[1,2-a]PIRIDIN-3-IL)PIRIMIDINA-5-CARBONITRILO, 4-(8-ETILIMIDAZOL[1,2-a]PIRIDIN-3-IL)-2-[((1S)-1-{4-[HIDROXI(1-METILPIPERIDIN-4-IL)METIL]FENIL}ETIL)AMINO]PIRIMIDINA-CARBONITRILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS INHIBEN LA PROLIFERACION DE CELULAS TUMORALES DEBIDO A SU EFECTO INHIBIDOR DE PLK1 SIENDO UTIL COMO AGENTE ANTITUMORAL
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006356575 | 2006-12-28 | ||
| JP2007265783 | 2007-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081845A1 true PE20081845A1 (es) | 2008-12-27 |
Family
ID=39588592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000054A PE20081845A1 (es) | 2006-12-28 | 2008-01-02 | Nuevos derivados de aminopirimidina como inhibidores de plk1 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7977336B2 (es) |
| EP (2) | EP2114942B1 (es) |
| JP (1) | JPWO2008081914A1 (es) |
| KR (1) | KR101481388B1 (es) |
| CN (1) | CN101573361B (es) |
| AR (1) | AR064619A1 (es) |
| AU (1) | AU2007340530B2 (es) |
| BR (1) | BRPI0718966B8 (es) |
| CA (1) | CA2668738A1 (es) |
| CL (1) | CL2007003758A1 (es) |
| CO (1) | CO6190523A2 (es) |
| CR (1) | CR10784A (es) |
| EC (1) | ECSP099324A (es) |
| GT (1) | GT200900124A (es) |
| IL (1) | IL198675A0 (es) |
| MA (1) | MA31109B1 (es) |
| MX (1) | MX2009004920A (es) |
| NO (1) | NO20092770L (es) |
| NZ (1) | NZ577273A (es) |
| PE (1) | PE20081845A1 (es) |
| RU (1) | RU2458062C2 (es) |
| SV (1) | SV2009003258A (es) |
| TW (1) | TW200835485A (es) |
| WO (2) | WO2008081914A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010013633A1 (ja) * | 2008-07-31 | 2010-02-04 | 萬有製薬株式会社 | 細胞のｒｂステイタス及びｐｌｋ１阻害剤に対する感受性を予測する方法 |
| JP4489132B2 (ja) * | 2008-08-22 | 2010-06-23 | 株式会社東芝 | 磁気記録媒体の製造方法 |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| US8445674B2 (en) | 2009-10-21 | 2013-05-21 | Hoffmann-La Roche Inc | Heterocyclyl compounds |
| CA2778949C (en) | 2009-10-30 | 2018-02-27 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors |
| UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| AU2012277912B2 (en) | 2011-06-27 | 2017-03-23 | Janssen Pharmaceutica Nv | 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives |
| EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
| WO2013046136A1 (en) | 2011-09-27 | 2013-04-04 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CA2872216C (en) | 2012-06-26 | 2021-07-20 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| CN104411314B (zh) | 2012-07-09 | 2017-10-20 | 詹森药业有限公司 | 磷酸二酯酶10的抑制剂 |
| EP2879712B1 (en) | 2012-07-31 | 2018-04-25 | Crown Bioscience, Inc. (Taicang) | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
| WO2014046617A1 (en) * | 2012-09-19 | 2014-03-27 | Agency For Science, Technology And Research | Compositions and methods for treating cancer |
| EP3194367B1 (en) | 2014-09-17 | 2021-08-18 | Boehringer Ingelheim International GmbH | Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes |
| US20230190717A1 (en) * | 2017-04-10 | 2023-06-22 | City Of Hope | P38 gamma inhibitors and method of use thereof |
| WO2021003517A1 (en) * | 2019-07-10 | 2021-01-14 | Aucentra Therapeutics Pty Ltd | Derivatives of 4-(imidazo[l,2-a]pyridin-3-yl)-n-(pyridinyl)pyrimidin- 2-amine as therapeutic agents |
| IL289953B2 (en) * | 2019-07-24 | 2025-03-01 | Merck Patent Gmbh | 4-(Imidazo[1,2-a]pyridin-3-yl)-pyrimidine derivatives |
| CN112592318B (zh) * | 2020-12-12 | 2022-05-03 | 贵州医科大学 | 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用 |
| WO2024071401A1 (ja) | 2022-09-29 | 2024-04-04 | 公益財団法人がん研究会 | Ｐｌｋ１キナーゼ活性化による染色体制御破綻が誘導するがん細胞増殖抑制を創薬概念とする医薬のスクリーニング方法 |
| CN119318874B (zh) * | 2024-12-18 | 2025-04-15 | 淄博凯美可工贸有限公司 | 一种节能型复合脱硫剂的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5223608A (en) | 1987-08-28 | 1993-06-29 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
| FI95708C (fi) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| JPH045029A (ja) | 1990-04-23 | 1992-01-09 | Bridgestone Corp | 空気入りタイヤ |
| ES2137932T3 (es) | 1990-09-28 | 2000-01-01 | Smithkline Beecham Corp | Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina. |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5191082A (en) | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
| US5243050A (en) | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5247089A (en) | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
| US5200524A (en) | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
| EP1238986B1 (en) | 1992-10-28 | 2008-06-25 | Genentech, Inc. | Use of Vascular endothelial cell growth factor antagonists |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス．アー． | 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法 |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| UA70350C2 (en) * | 1999-11-10 | 2004-10-15 | Ortho Mcneil Pharm Inc | SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-a]PYSUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-a]PYRIMIDINES, A METHOD FOR THE PREPARATION THEREOF (VRIMIDINES, A METHOD FOR THE PREPARATION THEREOF (VARIANTS) AND A PHARMACEUTICAL COMPOSITION BASED THARIANTS) AND A PHARMACEUTICAL COMPOSITION BASED THEREON EREON |
| AU2002237704A1 (en) | 2000-12-04 | 2002-06-18 | Sepracor, Inc. | Methods for the stereoselective synthesis of substituted piperidines |
| CA2450555A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
| US6852727B2 (en) | 2001-08-01 | 2005-02-08 | Merck & Co., Inc. | Benzimisazo[4,5-f]isoquinolinone derivatives |
| UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| AU2003284399A1 (en) | 2002-11-14 | 2004-06-03 | Kyowa Hakko Kogyo Co., Ltd. | Plk inhibitors |
| JP5319113B2 (ja) | 2004-03-26 | 2013-10-16 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| AU2005278292B2 (en) * | 2004-08-31 | 2011-09-08 | Msd K.K. | Novel substituted imidazole derivatives |
-
2007
- 2007-12-18 US US12/002,546 patent/US7977336B2/en active Active
- 2007-12-20 WO PCT/JP2007/075240 patent/WO2008081914A1/ja not_active Ceased
- 2007-12-20 KR KR1020097013324A patent/KR101481388B1/ko active Active
- 2007-12-20 RU RU2009128966/04A patent/RU2458062C2/ru active
- 2007-12-20 CA CA002668738A patent/CA2668738A1/en not_active Abandoned
- 2007-12-20 AR ARP070105784A patent/AR064619A1/es not_active Application Discontinuation
- 2007-12-20 EP EP07851112A patent/EP2114942B1/en active Active
- 2007-12-20 MX MX2009004920A patent/MX2009004920A/es active IP Right Grant
- 2007-12-20 NZ NZ577273A patent/NZ577273A/en not_active IP Right Cessation
- 2007-12-20 CN CN2007800488795A patent/CN101573361B/zh active Active
- 2007-12-20 BR BRPI0718966A patent/BRPI0718966B8/pt active IP Right Grant
- 2007-12-20 TW TW096149071A patent/TW200835485A/zh unknown
- 2007-12-20 AU AU2007340530A patent/AU2007340530B2/en active Active
- 2007-12-20 JP JP2008552168A patent/JPWO2008081914A1/ja not_active Ceased
- 2007-12-20 CL CL200703758A patent/CL2007003758A1/es unknown
- 2007-12-20 WO PCT/JP2007/075224 patent/WO2008081910A1/en not_active Ceased
- 2007-12-20 EP EP07851126A patent/EP2116543A4/en not_active Withdrawn
-
2008
- 2008-01-02 PE PE2008000054A patent/PE20081845A1/es not_active Application Discontinuation
-
2009
- 2009-05-08 CR CR10784A patent/CR10784A/es not_active Application Discontinuation
- 2009-05-10 IL IL198675A patent/IL198675A0/en unknown
- 2009-05-12 CO CO09048000A patent/CO6190523A2/es not_active Application Discontinuation
- 2009-05-12 GT GT200900124A patent/GT200900124A/es unknown
- 2009-05-12 EC EC2009009324A patent/ECSP099324A/es unknown
- 2009-05-12 SV SV2009003258A patent/SV2009003258A/es active IP Right Grant
- 2009-07-23 MA MA32115A patent/MA31109B1/fr unknown
- 2009-07-27 NO NO20092770A patent/NO20092770L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |