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PE20050338A1 - Compuestos de aminotriazoles como inhibidores de proteina quinasas - Google Patents

Compuestos de aminotriazoles como inhibidores de proteina quinasas

Info

Publication number
PE20050338A1
PE20050338A1 PE2004000768A PE2004000768A PE20050338A1 PE 20050338 A1 PE20050338 A1 PE 20050338A1 PE 2004000768 A PE2004000768 A PE 2004000768A PE 2004000768 A PE2004000768 A PE 2004000768A PE 20050338 A1 PE20050338 A1 PE 20050338A1
Authority
PE
Peru
Prior art keywords
ring
heteroatoms selected
heteroatoms
compounds
aminotriazoles
Prior art date
Application number
PE2004000768A
Other languages
English (en)
Inventor
Robert J Davies
Mark W Ledeboer
Brian Ledford
David Messersmith
Jian Wang
Guy W Bemis
Cornelia J Forster
Ronald Grey Jr
Michael J Arnost
Francesco G Salituro
Craig Marhefka
Albert C Pierce
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20050338A1 publication Critical patent/PE20050338A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

SE REFIERE A COMPUESTOS DE AMINOTRIAZOLES DE FORMULA I, EN DONDE R1 ES H o ALQUILO C1-C6; R2 ES (T)nR, (T)nAr1 o (T)nCi1; T ES UNA CADENA OPCIONALMENTE SUSTITUIDA DE ALQUILIDENO C1-C4; n ES 0 o 1; Ar1 ES UN GRUPO ARILO SELECCIONADO ENTRE UN MONOCICLO DE 5-6 MIEMBROS o UN ANILLO BICICLICO DE 8-10 MIEMBROS CON 0-5 HETEROATOMOS SELECCIONADOS DE N, O o S; Ci1ES UN ANILLO MONOCICLICO DE 3-7 MIEMBROS CON 0-3 HETEROATOMOS SELECCIONADOS DE N, O o S o UN ANILLO BICICLICO DE 8-10 MIEMBROS CON 0-5 HETEROATOMOS SELECCIONADOS DE N, O o S; o R1 Y R2 TOMADOS JUNTOS CON EL N FORMAN UN ANILLO DE HETEROARILO DE 5-8 MIEMBROS o UN ANILLO HETEROARILO DE 5-8 MIEMBROS CON 1-3 HETEROATOMOS SELECCIONADOS DE N, O o S; R3 ES (L)mR; (L)mCi2, ENTRE OTROS; L ES UNA CADENA DE ALQUILIDENO C1-C4 OPCIONALMENTE SUSTITUIDA; m ES 0 o 1; Ci2 ES UN ANILLO MONOCICLICO DE 3-7 MIEMBROS CON 0-3 HETEROATOMOS SELECCIONADOS DE N, O o S o UN ANILLO BICICLICO DE 8-10 MIEMBROS CON 0-5 HETEROATOMOS SELECCIONADOS DE N, O o S; o R2 Y R3 TOMADOS EN CONJUNTO FORMAN UN ANILLO COMPLETAMENTE NO SATURADO QUE CON 0-3 HETEROATOMOS SELECCIONADOS DE N, O o S, UN ANILLO DE 8-10 MIEMBROS CON 0-3 HETEROATOMOS SELECCIONADOS DE N, O o S, ENTRE OTROS; R ES H o UN GRUPO ALIFATICO C1-C6 OPCIONALMENTE SUSTITUIDO. UN COMPUESTO PREFERIDO ES 1-{4-[6-(3-FENILAMINO-[1,4]TRIAZOL-1-IL]-[1,4]DIAZEPAM-1-IL}-ETANONA. TAMBIEN SE REFIERE A UNA COMPOSICON FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASAS
PE2004000768A 2003-08-06 2004-08-06 Compuestos de aminotriazoles como inhibidores de proteina quinasas PE20050338A1 (es)

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US49278703P 2003-08-06 2003-08-06

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PE20050338A1 true PE20050338A1 (es) 2005-05-16

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US (2) US7226920B2 (es)
EP (1) EP1663211B1 (es)
JP (1) JP4889489B2 (es)
AR (1) AR045731A1 (es)
AT (1) ATE455546T1 (es)
AU (1) AU2004263148B2 (es)
CA (1) CA2534921C (es)
DE (1) DE602004025258D1 (es)
PE (1) PE20050338A1 (es)
TW (1) TW200514776A (es)
WO (1) WO2005013982A1 (es)

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TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
DE602004025258D1 (de) * 2003-08-06 2010-03-11 Vertex Pharma Aminotriazol-verbindungen als proteinkinase-hemmer
US7534798B2 (en) 2004-02-11 2009-05-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CN101039933B (zh) 2004-09-17 2012-06-06 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的二氨基三唑化合物
DE602005024293D1 (de) 2004-10-21 2010-12-02 Vertex Pharma Triazole als hemmer von proteinkinasen
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