PE20010690A1 - Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 - Google Patents
Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1Info
- Publication number
- PE20010690A1 PE20010690A1 PE2000000812A PE0008122000A PE20010690A1 PE 20010690 A1 PE20010690 A1 PE 20010690A1 PE 2000000812 A PE2000000812 A PE 2000000812A PE 0008122000 A PE0008122000 A PE 0008122000A PE 20010690 A1 PE20010690 A1 PE 20010690A1
- Authority
- PE
- Peru
- Prior art keywords
- avermitilis
- sequence
- avec
- allel
- avermectins
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 5
- 241001468227 Streptomyces avermitilis Species 0.000 title abstract 5
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN POLINUCLEOTIDO QUE COMPRENDE UNA SECUENCIA DE NUCLEOTIDOS QUE ES IGUAL AL ALELO DE AVEC DE STREPTOMYCES AVERMITILIS, LA SECUENCIA QUE CODIFICA EL PRODUCTO GENICO AVEC DE S. AVERMITILIS DEL PLASMIDO pSE186 O LA SECUENCIA DE NUCLEOTIDOS DE LA ORF DE AVEC DE S. AVERMITILIS SECUENCIA 1 O UNA VARIANTE DEGENERADA DE LA MISMA QUE COMPRENDE UNA O MAS MUTACIONES QUE CODIFICAN UNA SUSTITUCION DE AMINOACIDOS DE LAS POSICIONES 38, 48, 89, 99, 111, 136, 154, 179, 228, 238, 289, 298 DE LA SECUENCIA 2 DE TAL FORMA QUE EN S. AVERMITILIS EN LAS QUE EL ALELO DE AVEC DE TIPO SILVESTRE SE HA INACTIVADO Y EXPRESAN LA MOLECULA POLINUCLEOTIDICA QUE COMPRENDE LA SECUENCIA DE NUCLEOTIDOS MUTADA, PRODUCEN UNA RELACION DE AVERMECTINAS DE CLASE 2:1 QUE ES DIFERENTE DE LA RELACION PRODUCIDA POR LAS CELULAS DE LA S. AVERMITILIS QUE EN SU LUGAR SE EXPRESAN SOLO EL ALELO DE AVEC DE TIPO SILVESTRE. LAS AVERMECTINAS DE CLASES 2:1 SON CICLOHEXIL B2 CICLOHEXIL B1 AVERMECTINAS. TAMBIEN SE REFIERE A VECTORES, CELULAS HUESPED Y CEPAS MUTANTES DE S AVERMITILIS EN LAS QUE EL GEN AVEC SE HA INACTIVADO O MUTADO PARA CAMBIAR LA RELACION O CANTIDAD DE AVERMECTINAS DE CLASES 2:1 PRODUCIDAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14864599P | 1999-08-12 | 1999-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010690A1 true PE20010690A1 (es) | 2001-07-06 |
Family
ID=22526696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000812A PE20010690A1 (es) | 1999-08-12 | 2000-08-10 | Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US6632673B1 (es) |
| EP (1) | EP1200606B1 (es) |
| JP (1) | JP3884651B2 (es) |
| KR (1) | KR100489856B1 (es) |
| CN (1) | CN1186446C (es) |
| AP (1) | AP2002002418A0 (es) |
| AR (1) | AR022646A1 (es) |
| AT (1) | ATE341632T1 (es) |
| AU (1) | AU778837B2 (es) |
| BG (1) | BG65902B1 (es) |
| BR (1) | BRPI0013119B8 (es) |
| CA (1) | CA2380872C (es) |
| CO (1) | CO5290295A1 (es) |
| CY (1) | CY1105778T1 (es) |
| CZ (1) | CZ304402B6 (es) |
| DE (1) | DE60031126T2 (es) |
| DK (1) | DK1200606T3 (es) |
| EA (1) | EA200200056A1 (es) |
| ES (1) | ES2272299T3 (es) |
| GT (1) | GT200000136A (es) |
| HK (1) | HK1046710B (es) |
| HR (1) | HRP20020130A2 (es) |
| HU (1) | HU230600B1 (es) |
| IL (2) | IL147563A0 (es) |
| IS (1) | IS6250A (es) |
| MA (1) | MA26813A1 (es) |
| MX (1) | MXPA02001513A (es) |
| NO (1) | NO20020664D0 (es) |
| NZ (1) | NZ516517A (es) |
| OA (1) | OA11998A (es) |
| PA (1) | PA8499501A1 (es) |
| PE (1) | PE20010690A1 (es) |
| PL (1) | PL203818B1 (es) |
| PT (1) | PT1200606E (es) |
| SK (1) | SK288086B6 (es) |
| TN (1) | TNSN00171A1 (es) |
| UY (1) | UY26286A1 (es) |
| WO (1) | WO2001012821A1 (es) |
| ZA (1) | ZA200201072B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230600B1 (hu) * | 1999-08-12 | 2017-02-28 | Zoetis Services Llc | Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén |
| DE60326824D1 (de) * | 2002-02-12 | 2009-05-07 | Pfizer Prod Inc | Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine |
| US7943160B2 (en) * | 2002-05-09 | 2011-05-17 | Scimetrics Limited Corp. | Pest control methods |
| US9493744B2 (en) * | 2012-06-20 | 2016-11-15 | Genentech, Inc. | Methods for viral inactivation and other adventitious agents |
| KR102657859B1 (ko) | 2021-04-07 | 2024-04-16 | 윤재식 | 일체형 내화 소켓 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN167980B (es) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| US5238848A (en) | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
| US5525506A (en) | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| US5234831A (en) | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
| ES2054822T3 (es) | 1987-10-23 | 1994-08-16 | Pfizer | Procedimiento para la produccion de agliconas de avermectinas y sus cultivos. |
| US5240850A (en) | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
| ES2079436T3 (es) | 1989-03-31 | 1996-01-16 | Merck & Co Inc | Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso. |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| DK0711349T3 (da) | 1993-07-30 | 2003-11-24 | Pfizer | Gener, der koder for forgrenet alfaketosyredehydrogenasekompleks fra Streptomyces avermitilis |
| FI942725A7 (fi) | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
| AU4503797A (en) | 1996-09-27 | 1998-04-17 | Maxygen, Inc. | Methods for optimization of gene therapy by recursive sequence shuffling and selection |
| EP1717322B1 (en) | 1997-01-17 | 2012-07-18 | Codexis Mayflower Holdings, LLC | Evolution of whole cells and organisms by recursive sequence recombination |
| US6596539B1 (en) | 1997-10-31 | 2003-07-22 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| HRP20000539A2 (en) * | 1998-02-13 | 2001-04-30 | Pfizer Prod Inc | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| HU230600B1 (hu) * | 1999-08-12 | 2017-02-28 | Zoetis Services Llc | Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén |
-
2000
- 2000-07-24 HU HU0202487A patent/HU230600B1/hu unknown
- 2000-07-24 EP EP00944154A patent/EP1200606B1/en not_active Expired - Lifetime
- 2000-07-24 HR HR20020130A patent/HRP20020130A2/hr not_active Application Discontinuation
- 2000-07-24 CA CA002380872A patent/CA2380872C/en not_active Expired - Lifetime
- 2000-07-24 ES ES00944154T patent/ES2272299T3/es not_active Expired - Lifetime
- 2000-07-24 HK HK02108367.6A patent/HK1046710B/zh unknown
- 2000-07-24 KR KR10-2002-7001807A patent/KR100489856B1/ko not_active Expired - Lifetime
- 2000-07-24 MX MXPA02001513A patent/MXPA02001513A/es active IP Right Grant
- 2000-07-24 JP JP2001516908A patent/JP3884651B2/ja not_active Expired - Lifetime
- 2000-07-24 NZ NZ516517A patent/NZ516517A/en unknown
- 2000-07-24 EA EA200200056A patent/EA200200056A1/ru unknown
- 2000-07-24 WO PCT/IB2000/001017 patent/WO2001012821A1/en not_active Ceased
- 2000-07-24 CN CNB008117470A patent/CN1186446C/zh not_active Expired - Lifetime
- 2000-07-24 DK DK00944154T patent/DK1200606T3/da active
- 2000-07-24 DE DE60031126T patent/DE60031126T2/de not_active Expired - Lifetime
- 2000-07-24 SK SK139-2002A patent/SK288086B6/sk not_active IP Right Cessation
- 2000-07-24 AU AU58386/00A patent/AU778837B2/en not_active Expired
- 2000-07-24 AT AT00944154T patent/ATE341632T1/de active
- 2000-07-24 OA OA1200200025A patent/OA11998A/en unknown
- 2000-07-24 PT PT00944154T patent/PT1200606E/pt unknown
- 2000-07-24 PL PL353874A patent/PL203818B1/pl unknown
- 2000-07-24 BR BRPI0013119A patent/BRPI0013119B8/pt not_active IP Right Cessation
- 2000-07-24 AP APAP/P/2002/002418A patent/AP2002002418A0/en unknown
- 2000-07-24 CZ CZ2002-296A patent/CZ304402B6/cs not_active IP Right Cessation
- 2000-07-24 IL IL14756300A patent/IL147563A0/xx unknown
- 2000-08-04 CO CO00058605A patent/CO5290295A1/es not_active Application Discontinuation
- 2000-08-10 PE PE2000000812A patent/PE20010690A1/es not_active Application Discontinuation
- 2000-08-10 AR ARP000104131A patent/AR022646A1/es active IP Right Grant
- 2000-08-10 UY UY26286A patent/UY26286A1/es not_active Application Discontinuation
- 2000-08-10 GT GT200000136A patent/GT200000136A/es unknown
- 2000-08-10 PA PA20008499501A patent/PA8499501A1/es unknown
- 2000-08-10 US US09/637,040 patent/US6632673B1/en not_active Expired - Lifetime
- 2000-08-11 TN TNTNSN00171A patent/TNSN00171A1/fr unknown
-
2002
- 2002-01-10 IL IL147563A patent/IL147563A/en active IP Right Grant
- 2002-01-25 IS IS6250A patent/IS6250A/is unknown
- 2002-02-07 ZA ZA200201072A patent/ZA200201072B/en unknown
- 2002-02-07 MA MA26513A patent/MA26813A1/fr unknown
- 2002-02-11 NO NO20020664A patent/NO20020664D0/no not_active Application Discontinuation
- 2002-03-05 BG BG106479A patent/BG65902B1/bg unknown
-
2003
- 2003-06-11 US US10/412,450 patent/US7858340B2/en not_active Expired - Fee Related
- 2003-06-11 US US10/412,444 patent/US20040009560A1/en not_active Abandoned
-
2006
- 2006-11-13 CY CY20061101647T patent/CY1105778T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |