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IL129315A0 - Oxadiazoles process for their preparation and their use as medicaments - Google Patents

Oxadiazoles process for their preparation and their use as medicaments

Info

Publication number
IL129315A0
IL129315A0 IL12931597A IL12931597A IL129315A0 IL 129315 A0 IL129315 A0 IL 129315A0 IL 12931597 A IL12931597 A IL 12931597A IL 12931597 A IL12931597 A IL 12931597A IL 129315 A0 IL129315 A0 IL 129315A0
Authority
IL
Israel
Prior art keywords
oxadiazoles
medicaments
preparation
oxadiazoles process
Prior art date
Application number
IL12931597A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL129315A0 publication Critical patent/IL129315A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12931597A 1996-10-18 1997-10-15 Oxadiazoles process for their preparation and their use as medicaments IL129315A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP1997/005693 WO1998017652A1 (de) 1996-10-18 1997-10-15 Oxadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
IL129315A0 true IL129315A0 (en) 2000-02-17

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12931597A IL129315A0 (en) 1996-10-18 1997-10-15 Oxadiazoles process for their preparation and their use as medicaments

Country Status (31)

Country Link
US (1) US6277872B1 (pt)
EP (1) EP0934288B1 (pt)
JP (1) JP3333523B2 (pt)
KR (1) KR20000049253A (pt)
CN (1) CN1086698C (pt)
AR (1) AR008496A1 (pt)
AT (1) ATE315034T1 (pt)
AU (1) AU737552B2 (pt)
BG (1) BG103251A (pt)
BR (1) BR9714354A (pt)
CA (1) CA2268954C (pt)
CO (1) CO4920253A1 (pt)
CZ (1) CZ138099A3 (pt)
DE (2) DE19643037A1 (pt)
EE (1) EE9900147A (pt)
ES (1) ES2256880T3 (pt)
HR (1) HRP970553A2 (pt)
HU (1) HUP0001652A3 (pt)
ID (1) ID18613A (pt)
IL (1) IL129315A0 (pt)
NO (1) NO312512B1 (pt)
NZ (1) NZ335598A (pt)
PE (1) PE11199A1 (pt)
PL (1) PL332432A1 (pt)
RU (1) RU2182905C2 (pt)
SK (1) SK49999A3 (pt)
TR (1) TR199900848T2 (pt)
TW (1) TW413678B (pt)
WO (1) WO1998017652A1 (pt)
YU (1) YU40997A (pt)
ZA (1) ZA979220B (pt)

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IT1300055B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
IT1300056B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU767849B2 (en) 1999-02-15 2003-11-27 Eisai R&D Management Co., Ltd. Heterodiazinone derivatives
DE60007697T2 (de) * 1999-07-21 2004-12-09 F. Hoffmann-La Roche Ag Triazolderivate
JP3790472B2 (ja) * 1999-08-19 2006-06-28 エヌピーエス ファーマシューティカルズ インコーポレーテッド ヘテロ多環式化合物および代謝型グルタミン酸受容体アンタゴニストとしてのその使用
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US6579880B2 (en) * 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
DE60137426D1 (de) 2000-06-12 2009-03-05 Eisai R&D Man Co Ltd 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung
KR100770327B1 (ko) * 2000-09-18 2007-10-25 에자이 알앤드디 매니지먼트 가부시키가이샤 피리다지논 및 트리아지논 화합물류 및 그들의 의약 용도
ATE375340T1 (de) * 2001-02-21 2007-10-15 Nps Pharma Inc Heteropolycyclische verbindungen und deren verwendung als metabotrope glutamatrezeptorantagonisten
US7253190B2 (en) * 2001-10-04 2007-08-07 Merck & Co., Inc. Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
TWI341314B (en) * 2002-08-09 2011-05-01 Astrazeneca Ab New compounds
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
AU2003262831A1 (en) 2002-08-23 2004-03-11 Rigel Pharmaceuticals, Inc. Pyridyl substituted heterocycles useful for treating or preventing hcv infection
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
RU2338746C2 (ru) * 2003-02-27 2008-11-20 НьюроСёрч А/С Новые диазабициклические арильные производные, содержащие их фармацевтические композиции и их применение
WO2004099164A1 (en) * 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection
US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
NZ547965A (en) * 2003-12-24 2009-12-24 Prosidion Ltd 1,2,4-Oxadiazole derivatives as GPCR receptor agonists
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
BRPI0607913A2 (pt) * 2005-04-08 2010-03-23 Eisai R&D Man Co Ltd agente terapÊutico para discinesia
CN101203498A (zh) 2005-05-02 2008-06-18 里格尔药品股份有限公司 包括可代谢部分的杂环抗病毒化合物及其用途
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
DE102005061427A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxadiazol-Derivate
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
NZ577111A (en) * 2006-12-15 2012-05-25 Abbott Lab Novel oxadiazole compounds
US20110207704A1 (en) * 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
MX2010003614A (es) * 2007-10-04 2010-04-21 Merck Serono Sa Compuestos de diarilo oxadiazol.
US9045442B2 (en) * 2007-12-21 2015-06-02 University Of Notre Dame Du Lac Antibacterial compounds and methods of using same
HUE053352T2 (hu) 2008-06-09 2021-06-28 Univ Muenchen Ludwig Maximilians Új hatóanyagok fehérje-aggregációval kapcsolatos betegségeknél és/vagy neurodegeneratív betegségeknél szerepet játszó fehérjék aggregációjának gátlására
RU2398770C1 (ru) * 2009-03-27 2010-09-10 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) Меченная тритием 3-[5-(2-фторфенил)-1,2,4-оксадиазол-3-ил]бензойная кислота
WO2011047129A1 (en) 2009-10-15 2011-04-21 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
AU2013305663B2 (en) * 2012-08-24 2017-11-02 Treventis Corporation Benzofurazan anti-amyloid compounds and methods
JP6663361B2 (ja) 2014-02-27 2020-03-11 トレヴェンティス コーポレーション ベンゾフラザンを含有する抗アミロイド化合物
JP6493394B2 (ja) 2014-04-24 2019-04-03 住友化学株式会社 ジアリール−アゾール化合物
JP2017533187A (ja) 2014-09-25 2017-11-09 ユニヴァーシティー オブ ノートル ダム デュ ラック 非β−ラクタム系抗生物質
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
WO2018049404A1 (en) 2016-09-12 2018-03-15 University Of Notre Dame Du Lac Compounds for the treatment of clostridium difficile infection
AU2018265584B2 (en) 2017-05-12 2023-09-28 Ludwig-Maximilians-Universität München Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
CA3122705A1 (en) 2018-12-14 2020-06-18 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
US20240398775A1 (en) 2021-09-15 2024-12-05 University Of The Ryukyus Pharmaceutical composition for use in treating cognitive decline or for use in treating overweight or obesity
EP4403185A4 (en) 2021-09-15 2025-10-08 Univ Of The Ryukyus PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY
EP4173485A1 (en) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein aggregation inhibiting compounds for plant disease control

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Also Published As

Publication number Publication date
RU2182905C2 (ru) 2002-05-27
NO991815L (no) 1999-04-16
CN1086698C (zh) 2002-06-26
PE11199A1 (es) 1999-03-03
PL332432A1 (en) 1999-09-13
BG103251A (bg) 2000-02-29
CA2268954A1 (en) 1998-04-30
YU40997A (sh) 2000-10-30
TR199900848T2 (xx) 1999-06-21
HK1020956A1 (en) 2000-05-26
NO312512B1 (no) 2002-05-21
JP2000505089A (ja) 2000-04-25
ES2256880T3 (es) 2006-07-16
CA2268954C (en) 2006-06-13
HRP970553A2 (en) 1998-08-31
AR008496A1 (es) 2000-01-19
HUP0001652A3 (en) 2002-12-28
AU4867697A (en) 1998-05-15
NZ335598A (en) 2001-06-29
CO4920253A1 (es) 2000-05-29
TW413678B (en) 2000-12-01
DE59712543D1 (de) 2006-03-30
ZA979220B (en) 1998-04-20
DE19643037A1 (de) 1998-04-23
CZ138099A3 (cs) 1999-11-17
KR20000049253A (ko) 2000-07-25
NO991815D0 (no) 1999-04-16
BR9714354A (pt) 2000-04-11
CN1233245A (zh) 1999-10-27
EP0934288A1 (de) 1999-08-11
EE9900147A (et) 1999-12-15
HUP0001652A2 (hu) 2001-01-29
AU737552B2 (en) 2001-08-23
US6277872B1 (en) 2001-08-21
ID18613A (id) 1998-04-23
EP0934288B1 (de) 2006-01-04
SK49999A3 (en) 1999-11-08
JP3333523B2 (ja) 2002-10-15
ATE315034T1 (de) 2006-02-15
WO1998017652A1 (de) 1998-04-30

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