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BR9714354A - Oxadiazóis, processos para sua preparação e seu emprego como medicamentos - Google Patents

Oxadiazóis, processos para sua preparação e seu emprego como medicamentos

Info

Publication number
BR9714354A
BR9714354A BR9714354-5A BR9714354A BR9714354A BR 9714354 A BR9714354 A BR 9714354A BR 9714354 A BR9714354 A BR 9714354A BR 9714354 A BR9714354 A BR 9714354A
Authority
BR
Brazil
Prior art keywords
processes
preparation
medicines
oxadiazoles
oxadiazols
Prior art date
Application number
BR9714354-5A
Other languages
English (en)
Inventor
Michael Brenner
Roland Maier
Marion Wienrich
Thomas Weiser
Rainer Palluk
Wolf-Dietrich Bechtel
Angelo Sagrada
Helmut Ensinger
Uwe Pschorn
Raffaele Cesana
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR9714354A publication Critical patent/BR9714354A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: <B>"OXADIAZóIS, PROCESSOS PARA SUA PREPARAçãO E SEU EMPREGO COMO MEDICAMENTOS"<D>. A invenção refere-se a derivador de oxadiazol da fórmula geral (I), na qual X, Y, Z, e R^ 1^ são definidos tal como indicado na descrição e nas reivindicações, processos para a sua preparação e sua aplicação como medicamento.
BR9714354-5A 1996-10-18 1997-10-15 Oxadiazóis, processos para sua preparação e seu emprego como medicamentos BR9714354A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP1997/005693 WO1998017652A1 (de) 1996-10-18 1997-10-15 Oxadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BR9714354A true BR9714354A (pt) 2000-04-11

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9714354-5A BR9714354A (pt) 1996-10-18 1997-10-15 Oxadiazóis, processos para sua preparação e seu emprego como medicamentos

Country Status (31)

Country Link
US (1) US6277872B1 (pt)
EP (1) EP0934288B1 (pt)
JP (1) JP3333523B2 (pt)
KR (1) KR20000049253A (pt)
CN (1) CN1086698C (pt)
AR (1) AR008496A1 (pt)
AT (1) ATE315034T1 (pt)
AU (1) AU737552B2 (pt)
BG (1) BG103251A (pt)
BR (1) BR9714354A (pt)
CA (1) CA2268954C (pt)
CO (1) CO4920253A1 (pt)
CZ (1) CZ138099A3 (pt)
DE (2) DE19643037A1 (pt)
EE (1) EE9900147A (pt)
ES (1) ES2256880T3 (pt)
HR (1) HRP970553A2 (pt)
HU (1) HUP0001652A3 (pt)
ID (1) ID18613A (pt)
IL (1) IL129315A0 (pt)
NO (1) NO312512B1 (pt)
NZ (1) NZ335598A (pt)
PE (1) PE11199A1 (pt)
PL (1) PL332432A1 (pt)
RU (1) RU2182905C2 (pt)
SK (1) SK49999A3 (pt)
TR (1) TR199900848T2 (pt)
TW (1) TW413678B (pt)
WO (1) WO1998017652A1 (pt)
YU (1) YU40997A (pt)
ZA (1) ZA979220B (pt)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1300055B1 (it) 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
IT1300056B1 (it) 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
US6825192B1 (en) 1999-02-15 2004-11-30 Eisai Co., Ltd. Heterodiazinone derivatives
EP1070708B1 (en) 1999-07-21 2004-01-14 F. Hoffmann-La Roche Ag Triazole derivatives
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
KR100875222B1 (ko) * 1999-08-19 2008-12-19 아스트라제네카 아베 헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도
US6579880B2 (en) * 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
HU229553B1 (en) 2000-06-12 2014-01-28 Eisai R & D Man Co 1,2-dihydropyridine compound, process for preparation of the same and use thereof
IL154709A0 (en) * 2000-09-18 2003-10-31 Eisai Co Ltd Pyridazinone and triazinone derivatives and pharmaceutical compositions containing the same
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2462289C (en) * 2001-10-04 2010-02-23 Nicholas D. Cosford Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
JP4637578B2 (ja) * 2002-08-09 2011-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
JP2006501312A (ja) 2002-08-23 2006-01-12 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
RU2338746C2 (ru) * 2003-02-27 2008-11-20 НьюроСёрч А/С Новые диазабициклические арильные производные, содержащие их фармацевтические композиции и их применение
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
EP1711491A1 (en) * 2003-12-24 2006-10-18 Prosidion Limited Heterocyclic derivatives as gpcr receptor agonists
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
EP1875912A4 (en) * 2005-04-08 2008-06-04 Eisai R&D Man Co Ltd MEANS OF TREATING UNWILLING MOVEMENTS
CN101203498A (zh) 2005-05-02 2008-06-18 里格尔药品股份有限公司 包括可代谢部分的杂环抗病毒化合物及其用途
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
DE102005061427A1 (de) * 2005-12-22 2007-06-28 Grünenthal GmbH Substituierte Oxadiazol-Derivate
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
US20110207704A1 (en) * 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
AU2007334436A1 (en) * 2006-12-15 2008-06-26 Abbott Laboratories Novel oxadiazole compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
BRPI0817597A2 (pt) * 2007-10-04 2015-04-07 Merck Serono Sa Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos
WO2009082398A1 (en) * 2007-12-21 2009-07-02 University Of Notre Dame Du Lac Antibacterial compounds and methods of using same
KR101787112B1 (ko) 2008-06-09 2017-11-15 루드비히-막시밀리안스-우니버지테트 뮌헨 신경변성 질환 및/또는 단백질 응집과 연관된 질환과 관련된 단백질의 응집을 억제하기 위한 신규 약물
RU2398770C1 (ru) * 2009-03-27 2010-09-10 Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) Меченная тритием 3-[5-(2-фторфенил)-1,2,4-оксадиазол-3-ил]бензойная кислота
WO2011047129A1 (en) * 2009-10-15 2011-04-21 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
WO2014031873A2 (en) * 2012-08-24 2014-02-27 Treventis Corporation Benzofurazan anti-amyloid compounds and methods
LT3110812T (lt) 2014-02-27 2019-07-10 Treventis Corporation Anti-amiloidų junginiai, turintys benzofurazano
JP6493394B2 (ja) 2014-04-24 2019-04-03 住友化学株式会社 ジアリール−アゾール化合物
AU2015319834A1 (en) 2014-09-25 2017-04-20 University Of Notre Dame Du Lac Non-beta lactam antibiotics
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
US11168062B2 (en) 2016-09-12 2021-11-09 University Of Notre Dame Du Lac Compounds for the treatment of Clostridium difficile infection
US11180518B2 (en) 2017-05-12 2021-11-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
EP3893844A1 (en) 2018-12-14 2021-10-20 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
EP4403184A4 (en) 2021-09-15 2025-09-24 Univ Of The Ryukyus PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY
WO2023042888A1 (ja) 2021-09-15 2023-03-23 国立大学法人 琉球大学 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物
EP4173485A1 (en) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein aggregation inhibiting compounds for plant disease control

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003909A (en) * 1974-07-22 1977-01-18 E. R. Squibb & Sons, Inc. [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters
JPS52272A (en) * 1975-10-17 1977-01-05 Takeda Chem Ind Ltd Process for preparing 1,2,4-oxadiazole derivatives
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
EP0276432A3 (de) * 1986-12-12 1988-10-26 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
JPH02250873A (ja) * 1989-03-24 1990-10-08 Mitsubishi Petrochem Co Ltd １，２，４―オキサジアゾール誘導体及びそれを有効成分とする除草剤
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DK443489D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
JPH04295470A (ja) * 1991-03-22 1992-10-20 Wakamoto Pharmaceut Co Ltd モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法
EP0596933A1 (en) * 1991-08-03 1994-05-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
WO1994017048A1 (fr) * 1993-01-21 1994-08-04 Nippon Soda Co., Ltd. Derive d'oxadiazole
DE4401108A1 (de) * 1994-01-17 1995-07-20 Bayer Ag 1,2,4-Oxadiazol-Derivate
DE4401107A1 (de) * 1994-01-17 1995-07-20 Bayer Ag 3-Aryl-alkenyl-1,2,4-oxadiazol-Derivate
DE19528189A1 (de) * 1995-08-01 1997-02-06 Basf Ag Benzolderivate mit einem heterocyclischen Rest

Also Published As

Publication number Publication date
ZA979220B (en) 1998-04-20
HK1020956A1 (en) 2000-05-26
NZ335598A (en) 2001-06-29
NO991815D0 (no) 1999-04-16
CN1233245A (zh) 1999-10-27
KR20000049253A (ko) 2000-07-25
ES2256880T3 (es) 2006-07-16
ID18613A (id) 1998-04-23
TR199900848T2 (xx) 1999-06-21
PE11199A1 (es) 1999-03-03
JP2000505089A (ja) 2000-04-25
RU2182905C2 (ru) 2002-05-27
US6277872B1 (en) 2001-08-21
CA2268954A1 (en) 1998-04-30
CA2268954C (en) 2006-06-13
JP3333523B2 (ja) 2002-10-15
HRP970553A2 (en) 1998-08-31
DE59712543D1 (de) 2006-03-30
CN1086698C (zh) 2002-06-26
AU737552B2 (en) 2001-08-23
DE19643037A1 (de) 1998-04-23
IL129315A0 (en) 2000-02-17
BG103251A (bg) 2000-02-29
SK49999A3 (en) 1999-11-08
EP0934288B1 (de) 2006-01-04
YU40997A (sh) 2000-10-30
TW413678B (en) 2000-12-01
ATE315034T1 (de) 2006-02-15
HUP0001652A2 (hu) 2001-01-29
HUP0001652A3 (en) 2002-12-28
CO4920253A1 (es) 2000-05-29
CZ138099A3 (cs) 1999-11-17
PL332432A1 (en) 1999-09-13
EE9900147A (et) 1999-12-15
AR008496A1 (es) 2000-01-19
EP0934288A1 (de) 1999-08-11
AU4867697A (en) 1998-05-15
WO1998017652A1 (de) 1998-04-30
NO991815L (no) 1999-04-16
NO312512B1 (no) 2002-05-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1833 DE 21/02/2006.