AR008496A1 - Nuevos oxadiazoles, procedimiento para su preparacion asi como su empleo como medicamentos. - Google Patents
Nuevos oxadiazoles, procedimiento para su preparacion asi como su empleo como medicamentos.Info
- Publication number
- AR008496A1 AR008496A1 ARP970104812A ARP970104812A AR008496A1 AR 008496 A1 AR008496 A1 AR 008496A1 AR P970104812 A ARP970104812 A AR P970104812A AR P970104812 A ARP970104812 A AR P970104812A AR 008496 A1 AR008496 A1 AR 008496A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- medicines
- preparation
- oxadiazoles
- procedure
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- FRYPWUYDPUBMRU-UHFFFAOYSA-N 2-[(4-chlorophenoxy)methyl]-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole Chemical compound C1=C(Cl)C(F)=CC(C=2OC(COC=3C=CC(Cl)=CC=3)=NN=2)=C1Cl FRYPWUYDPUBMRU-UHFFFAOYSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002240 furans Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invencion se refiere a derivados de oxadixol de la formula general (I) en donde X e Y significan oxígeno o nitrogeno, no siendo X e Y ambos al mismotiempo oxígeno o nitrogeno; Z significa un radical arilo sustituido, piridilo sustituido,furan ilo sustituido o tienilo sustituido; R1 significa hidrogeno,un radical alquilo, cicloalquilo, alquenilo, alquinilo o fenilo, que eventualmente puede estar sustituido, una o varias veces. También se describenprocedimientos para lapreparaci on de dichos derivados y su empleo como medicamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19643037A DE19643037A1 (de) | 1996-10-18 | 1996-10-18 | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008496A1 true AR008496A1 (es) | 2000-01-19 |
Family
ID=7809114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104812A AR008496A1 (es) | 1996-10-18 | 1997-10-17 | Nuevos oxadiazoles, procedimiento para su preparacion asi como su empleo como medicamentos. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6277872B1 (es) |
| EP (1) | EP0934288B1 (es) |
| JP (1) | JP3333523B2 (es) |
| KR (1) | KR20000049253A (es) |
| CN (1) | CN1086698C (es) |
| AR (1) | AR008496A1 (es) |
| AT (1) | ATE315034T1 (es) |
| AU (1) | AU737552B2 (es) |
| BG (1) | BG103251A (es) |
| BR (1) | BR9714354A (es) |
| CA (1) | CA2268954C (es) |
| CO (1) | CO4920253A1 (es) |
| CZ (1) | CZ138099A3 (es) |
| DE (2) | DE19643037A1 (es) |
| EE (1) | EE9900147A (es) |
| ES (1) | ES2256880T3 (es) |
| HR (1) | HRP970553A2 (es) |
| HU (1) | HUP0001652A3 (es) |
| ID (1) | ID18613A (es) |
| IL (1) | IL129315A0 (es) |
| NO (1) | NO312512B1 (es) |
| NZ (1) | NZ335598A (es) |
| PE (1) | PE11199A1 (es) |
| PL (1) | PL332432A1 (es) |
| RU (1) | RU2182905C2 (es) |
| SK (1) | SK49999A3 (es) |
| TR (1) | TR199900848T2 (es) |
| TW (1) | TW413678B (es) |
| WO (1) | WO1998017652A1 (es) |
| YU (1) | YU40997A (es) |
| ZA (1) | ZA979220B (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1300055B1 (it) | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| IT1300056B1 (it) | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci |
| US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
| US6825192B1 (en) | 1999-02-15 | 2004-11-30 | Eisai Co., Ltd. | Heterodiazinone derivatives |
| EP1070708B1 (en) | 1999-07-21 | 2004-01-14 | F. Hoffmann-La Roche Ag | Triazole derivatives |
| US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| EP1582519A3 (en) * | 1999-08-19 | 2005-12-21 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| KR100875222B1 (ko) * | 1999-08-19 | 2008-12-19 | 아스트라제네카 아베 | 헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도 |
| US6579880B2 (en) * | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
| HU229553B1 (en) | 2000-06-12 | 2014-01-28 | Eisai R & D Man Co | 1,2-dihydropyridine compound, process for preparation of the same and use thereof |
| IL154709A0 (en) * | 2000-09-18 | 2003-10-31 | Eisai Co Ltd | Pyridazinone and triazinone derivatives and pharmaceutical compositions containing the same |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CA2462289C (en) * | 2001-10-04 | 2010-02-23 | Nicholas D. Cosford | Heteroaryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| JP4637578B2 (ja) * | 2002-08-09 | 2011-02-23 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類 |
| DE10240818A1 (de) * | 2002-08-30 | 2004-05-13 | Grünenthal GmbH | Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate |
| JP2006501312A (ja) | 2002-08-23 | 2006-01-12 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環 |
| GB0303503D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| RU2338746C2 (ru) * | 2003-02-27 | 2008-11-20 | НьюроСёрч А/С | Новые диазабициклические арильные производные, содержащие их фармацевтические композиции и их применение |
| US7115642B2 (en) | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
| US7326790B2 (en) | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
| US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
| US7410979B2 (en) | 2003-11-19 | 2008-08-12 | Rigel Pharmaceuticals, Inc. | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections |
| EP1711491A1 (en) * | 2003-12-24 | 2006-10-18 | Prosidion Limited | Heterocyclic derivatives as gpcr receptor agonists |
| US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| EP1875912A4 (en) * | 2005-04-08 | 2008-06-04 | Eisai R&D Man Co Ltd | MEANS OF TREATING UNWILLING MOVEMENTS |
| CN101203498A (zh) | 2005-05-02 | 2008-06-18 | 里格尔药品股份有限公司 | 包括可代谢部分的杂环抗病毒化合物及其用途 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| HUP0500920A2 (en) * | 2005-10-05 | 2007-07-30 | Richter Gedeon Nyrt | Oxadiazole derivatives, process for their preparation and their use |
| DE102005061427A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| US20110207704A1 (en) * | 2006-12-15 | 2011-08-25 | Abbott Laboratories | Novel Oxadiazole Compounds |
| AU2007334436A1 (en) * | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
| JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
| BRPI0817597A2 (pt) * | 2007-10-04 | 2015-04-07 | Merck Serono Sa | Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos |
| WO2009082398A1 (en) * | 2007-12-21 | 2009-07-02 | University Of Notre Dame Du Lac | Antibacterial compounds and methods of using same |
| KR101787112B1 (ko) | 2008-06-09 | 2017-11-15 | 루드비히-막시밀리안스-우니버지테트 뮌헨 | 신경변성 질환 및/또는 단백질 응집과 연관된 질환과 관련된 단백질의 응집을 억제하기 위한 신규 약물 |
| RU2398770C1 (ru) * | 2009-03-27 | 2010-09-10 | Учреждение Российской академии наук Институт молекулярной генетики РАН (ИМГ РАН) | Меченная тритием 3-[5-(2-фторфенил)-1,2,4-оксадиазол-3-ил]бензойная кислота |
| WO2011047129A1 (en) * | 2009-10-15 | 2011-04-21 | Southern Research Institute | Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such |
| WO2014031873A2 (en) * | 2012-08-24 | 2014-02-27 | Treventis Corporation | Benzofurazan anti-amyloid compounds and methods |
| LT3110812T (lt) | 2014-02-27 | 2019-07-10 | Treventis Corporation | Anti-amiloidų junginiai, turintys benzofurazano |
| JP6493394B2 (ja) | 2014-04-24 | 2019-04-03 | 住友化学株式会社 | ジアリール−アゾール化合物 |
| AU2015319834A1 (en) | 2014-09-25 | 2017-04-20 | University Of Notre Dame Du Lac | Non-beta lactam antibiotics |
| CN107286174B (zh) * | 2016-04-11 | 2020-08-18 | 上海勋和医药科技有限公司 | 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用 |
| US11168062B2 (en) | 2016-09-12 | 2021-11-09 | University Of Notre Dame Du Lac | Compounds for the treatment of Clostridium difficile infection |
| US11180518B2 (en) | 2017-05-12 | 2021-11-23 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
| US10676467B2 (en) | 2017-06-30 | 2020-06-09 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof |
| EP3893844A1 (en) | 2018-12-14 | 2021-10-20 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
| EP4403184A4 (en) | 2021-09-15 | 2025-09-24 | Univ Of The Ryukyus | PHARMACEUTICAL COMPOSITION INTENDED FOR USE IN THE TREATMENT OF EITHER THE DECLINE OF COGNITIVE FUNCTIONS OR OVERWEIGHT OR OBESITY |
| WO2023042888A1 (ja) | 2021-09-15 | 2023-03-23 | 国立大学法人 琉球大学 | 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物 |
| EP4173485A1 (en) | 2021-10-27 | 2023-05-03 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Protein aggregation inhibiting compounds for plant disease control |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4003909A (en) * | 1974-07-22 | 1977-01-18 | E. R. Squibb & Sons, Inc. | [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters |
| JPS52272A (en) * | 1975-10-17 | 1977-01-05 | Takeda Chem Ind Ltd | Process for preparing 1,2,4-oxadiazole derivatives |
| DE2801509A1 (de) * | 1978-01-12 | 1979-07-19 | Schering Ag | 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel |
| JPS58150576A (ja) * | 1982-03-03 | 1983-09-07 | Sumitomo Chem Co Ltd | 新規な１，２，４−オキサジアゾ−ル誘導体 |
| EP0276432A3 (de) * | 1986-12-12 | 1988-10-26 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
| DE3905242A1 (de) * | 1989-02-21 | 1990-08-23 | Basf Ag | Verfahren zur herstellung von phenyloxdiazolylanilinen |
| JPH02250873A (ja) * | 1989-03-24 | 1990-10-08 | Mitsubishi Petrochem Co Ltd | １，２，４―オキサジアゾール誘導体及びそれを有効成分とする除草剤 |
| NZ234760A (en) * | 1989-08-18 | 1991-09-25 | Sterling Drug Inc | Antiviral oxazole compounds and compositions |
| DK443489D0 (da) * | 1989-09-08 | 1989-09-08 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| JPH04295470A (ja) * | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法 |
| EP0596933A1 (en) * | 1991-08-03 | 1994-05-18 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| WO1994017048A1 (fr) * | 1993-01-21 | 1994-08-04 | Nippon Soda Co., Ltd. | Derive d'oxadiazole |
| DE4401108A1 (de) * | 1994-01-17 | 1995-07-20 | Bayer Ag | 1,2,4-Oxadiazol-Derivate |
| DE4401107A1 (de) * | 1994-01-17 | 1995-07-20 | Bayer Ag | 3-Aryl-alkenyl-1,2,4-oxadiazol-Derivate |
| DE19528189A1 (de) * | 1995-08-01 | 1997-02-06 | Basf Ag | Benzolderivate mit einem heterocyclischen Rest |
-
1996
- 1996-10-18 DE DE19643037A patent/DE19643037A1/de not_active Withdrawn
-
1997
- 1997-10-15 EE EEP199900147A patent/EE9900147A/xx unknown
- 1997-10-15 DE DE59712543T patent/DE59712543D1/de not_active Expired - Lifetime
- 1997-10-15 JP JP50563998A patent/JP3333523B2/ja not_active Expired - Lifetime
- 1997-10-15 KR KR1019990703360A patent/KR20000049253A/ko not_active Ceased
- 1997-10-15 CN CN97198866A patent/CN1086698C/zh not_active Expired - Fee Related
- 1997-10-15 ES ES97911227T patent/ES2256880T3/es not_active Expired - Lifetime
- 1997-10-15 ZA ZA9709220A patent/ZA979220B/xx unknown
- 1997-10-15 BR BR9714354-5A patent/BR9714354A/pt not_active IP Right Cessation
- 1997-10-15 PE PE1997000910A patent/PE11199A1/es not_active Application Discontinuation
- 1997-10-15 AU AU48676/97A patent/AU737552B2/en not_active Ceased
- 1997-10-15 SK SK499-99A patent/SK49999A3/sk unknown
- 1997-10-15 US US09/284,382 patent/US6277872B1/en not_active Expired - Lifetime
- 1997-10-15 WO PCT/EP1997/005693 patent/WO1998017652A1/de not_active Ceased
- 1997-10-15 EP EP97911227A patent/EP0934288B1/de not_active Expired - Lifetime
- 1997-10-15 RU RU99111781/04A patent/RU2182905C2/ru not_active IP Right Cessation
- 1997-10-15 NZ NZ335598A patent/NZ335598A/en unknown
- 1997-10-15 AT AT97911227T patent/ATE315034T1/de active
- 1997-10-15 HU HU0001652A patent/HUP0001652A3/hu unknown
- 1997-10-15 CA CA002268954A patent/CA2268954C/en not_active Expired - Fee Related
- 1997-10-15 IL IL12931597A patent/IL129315A0/xx unknown
- 1997-10-15 CZ CZ991380A patent/CZ138099A3/cs unknown
- 1997-10-15 PL PL97332432A patent/PL332432A1/xx unknown
- 1997-10-15 TR TR1999/00848T patent/TR199900848T2/xx unknown
- 1997-10-16 ID IDP973449A patent/ID18613A/id unknown
- 1997-10-16 HR HR19643037.2A patent/HRP970553A2/hr not_active Application Discontinuation
- 1997-10-16 YU YU40997A patent/YU40997A/sh unknown
- 1997-10-17 AR ARP970104812A patent/AR008496A1/es not_active Application Discontinuation
- 1997-10-17 CO CO97061157A patent/CO4920253A1/es unknown
- 1997-10-18 TW TW086115386A patent/TW413678B/zh not_active IP Right Cessation
-
1999
- 1999-03-15 BG BG103251A patent/BG103251A/xx unknown
- 1999-04-16 NO NO19991815A patent/NO312512B1/no not_active IP Right Cessation
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