IE47543B1 - Guanidine derivatives - Google Patents

Guanidine derivatives

Info

Publication number: IE47543B1
Authority: IE; Ireland
Prior art keywords: compound; formula; methyl; cyano; addition salt
Prior art date: 1977-06-03

Application number

IE1112/78A

Other languages

English (en)

Other versions

IE781112L (en

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-03

Filing date

1978-06-02

Publication date

1984-04-18

1977-11-07 Priority claimed from US05/848,959 external-priority patent/US4112234A/en

1978-06-02 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1978-06-02 Priority to IE2933/81A priority Critical patent/IE47545B1/en

1978-06-02 Priority to IE2932/81A priority patent/IE47544B1/en

1978-12-03 Publication of IE781112L publication Critical patent/IE781112L/xx

1984-04-18 Publication of IE47543B1 publication Critical patent/IE47543B1/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IE1112/78A 1977-06-03 1978-06-02 Guanidine derivatives IE47543B1 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IE2933/81A IE47545B1 (en)	1977-06-03	1978-06-02	N-cyano-n'-alkynyl-n"-(2-mercaptoethyl)-guanidines
IE2932/81A IE47544B1 (en)	1977-06-03	1978-06-02	N-cyano-n'-alkynyl-s-substituted isothioureas

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US80300977A	1977-06-03	1977-06-03
US82679677A	1977-08-22	1977-08-22
US05/848,959 US4112234A (en)	1977-08-22	1977-11-07	Imidazolylmethylthioethyl alkynyl guanidines

Publications (2)

Publication Number	Publication Date
IE781112L IE781112L (en)	1978-12-03
IE47543B1 true IE47543B1 (en)	1984-04-18

Family

ID=27419995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1112/78A IE47543B1 (en)	1977-06-03	1978-06-02	Guanidine derivatives

Country Status (26)

Country	Link
JP (1)	JPS543067A (de)
AR (2)	AR222797A1 (de)
CA (1)	CA1110251A (de)
CH (2)	CH641167A5 (de)
CY (3)	CY1231A (de)
DD (1)	DD140038A5 (de)
DE (1)	DE2824066A1 (de)
DK (1)	DK243178A (de)
ES (3)	ES470474A1 (de)
FI (1)	FI69069C (de)
FR (2)	FR2401143A1 (de)
GB (3)	GB1598628A (de)
GR (1)	GR73860B (de)
HK (3)	HK38284A (de)
HU (1)	HU186766B (de)
IE (1)	IE47543B1 (de)
IL (1)	IL54819A (de)
KE (1)	KE3373A (de)
LU (1)	LU79725A1 (de)
MY (3)	MY8500451A (de)
NL (1)	NL7805935A (de)
NO (3)	NO152214C (de)
NZ (1)	NZ187376A (de)
SE (3)	SE443784B (de)
SG (1)	SG8584G (de)
YU (4)	YU129778A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS568352A (en) *	1979-07-03	1981-01-28	Shionogi & Co Ltd	Aminoalkylvenzene derivative
US4339439A (en) *	1981-01-19	1982-07-13	Bristol-Myers Company	Pharmaceutical methods and compositions
JPS6018010U (ja) *	1983-07-18	1985-02-07	日産自動車株式会社	車両用空気調和装置の温度調整機構
JPS60113211U (ja) *	1984-01-06	1985-07-31	松下電器産業株式会社	自動車用空気調和装置
ES2007948A6 (es) *	1988-07-06	1989-07-01	Vinas Lab	Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4024271A (en) *	1971-03-09	1977-05-17	Smith Kline & French Laboratories Limited	Pharmacologically active guanidine compounds
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
GB1531221A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for preparing guanidine derivatives
GB1531231A (en) *	1974-09-02	1978-11-08	Smith Kline French Lab	Process for the production of cyanoguanidine derivatives
GB1533380A (en) *	1974-09-02	1978-11-22	Smith Kline French Lab	Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

1978
- 1978-05-25 NZ NZ187376A patent/NZ187376A/xx unknown
- 1978-05-25 CA CA304,045A patent/CA1110251A/en not_active Expired
- 1978-05-26 CY CY1231A patent/CY1231A/en unknown
- 1978-05-26 GB GB23611/78A patent/GB1598628A/en not_active Expired
- 1978-05-26 CY CY1229A patent/CY1229A/en unknown
- 1978-05-26 GB GB18923/80A patent/GB1598630A/en not_active Expired
- 1978-05-26 GB GB27637/79A patent/GB1598629A/en not_active Expired
- 1978-05-26 CY CY1230A patent/CY1230A/en unknown
- 1978-05-29 GR GR56374A patent/GR73860B/el unknown
- 1978-05-29 LU LU79725A patent/LU79725A1/xx unknown
- 1978-05-31 IL IL54819A patent/IL54819A/xx unknown
- 1978-05-31 DK DK243178A patent/DK243178A/da not_active Application Discontinuation
- 1978-05-31 YU YU01297/78A patent/YU129778A/xx unknown
- 1978-05-31 NL NL7805935A patent/NL7805935A/xx not_active Application Discontinuation
- 1978-05-31 AR AR272401A patent/AR222797A1/es active
- 1978-05-31 FI FI781737A patent/FI69069C/fi not_active IP Right Cessation
- 1978-06-01 DE DE19782824066 patent/DE2824066A1/de not_active Withdrawn
- 1978-06-02 IE IE1112/78A patent/IE47543B1/en unknown
- 1978-06-02 ES ES470474A patent/ES470474A1/es not_active Expired
- 1978-06-02 HU HU811135A patent/HU186766B/hu unknown
- 1978-06-02 JP JP6590078A patent/JPS543067A/ja active Granted
- 1978-06-02 NO NO781928A patent/NO152214C/no unknown
- 1978-06-02 FR FR7816601A patent/FR2401143A1/fr active Granted
- 1978-06-02 CH CH609278A patent/CH641167A5/de not_active IP Right Cessation
- 1978-06-02 SE SE7806525A patent/SE443784B/sv unknown
- 1978-06-05 DD DD78205794A patent/DD140038A5/de unknown
1979
- 1979-03-01 ES ES478202A patent/ES478202A1/es not_active Expired
- 1979-03-01 ES ES478203A patent/ES478203A1/es not_active Expired
- 1979-03-05 YU YU530/79A patent/YU41620B/xx unknown
- 1979-05-16 NO NO791637A patent/NO791637L/no unknown
- 1979-10-26 AR AR278645A patent/AR222503A1/es active
- 1979-11-23 FR FR7928943A patent/FR2436138A1/fr active Granted
1982
- 1982-09-27 YU YU2155/82A patent/YU40625B/xx unknown
- 1982-09-27 YU YU2154/82A patent/YU40624B/xx unknown
1983
- 1983-09-12 NO NO833255A patent/NO151824C/no unknown
- 1983-10-07 CH CH549283A patent/CH644591A5/de not_active IP Right Cessation
1984
- 1984-01-30 SG SG85/84A patent/SG8584G/en unknown
- 1984-02-10 KE KE3373A patent/KE3373A/xx unknown
- 1984-03-16 SE SE8401492A patent/SE8401492D0/xx not_active Application Discontinuation
- 1984-03-16 SE SE8401491A patent/SE8401491L/xx not_active Application Discontinuation
- 1984-05-03 HK HK382/84A patent/HK38284A/xx unknown
- 1984-05-03 HK HK380/84A patent/HK38084A/xx unknown
- 1984-05-03 HK HK381/84A patent/HK38184A/xx unknown
1985
- 1985-12-30 MY MY451/85A patent/MY8500451A/xx unknown
- 1985-12-30 MY MY452/85A patent/MY8500452A/xx unknown
- 1985-12-30 MY MY453/85A patent/MY8500453A/xx unknown

Also Published As

Publication number	Publication date
JPS543067A (en)	1979-01-11
HK38284A (en)	1984-05-11
SE8401492L (sv)	1984-03-16
DE2824066A1 (de)	1978-12-14
YU215582A (en)	1983-02-28
IL54819A (en)	1983-03-31
MY8500452A (en)	1985-12-31
FR2436138B1 (de)	1982-12-03
NO151824B (no)	1985-03-04
AR222503A1 (es)	1981-05-29
CY1231A (en)	1984-06-29
SG8584G (en)	1985-02-08
HU186766B (en)	1985-09-30
YU41620B (en)	1987-12-31
YU53079A (en)	1983-09-30
YU40625B (en)	1986-02-28
MY8500453A (en)	1985-12-31
FI69069C (fi)	1985-12-10
GR73860B (de)	1984-05-08
YU129778A (en)	1983-02-28
GB1598628A (en)	1981-09-23
SE8401492D0 (sv)	1984-03-16
FI69069B (fi)	1985-08-30
IE781112L (en)	1978-12-03
FI781737A7 (fi)	1978-12-04
ES478203A1 (es)	1979-06-01
NO833255L (no)	1978-12-05
CY1230A (en)	1984-06-29
CH644591A5 (en)	1984-08-15
FR2401143B1 (de)	1981-12-11
FR2436138A1 (fr)	1980-04-11
FR2401143A1 (fr)	1979-03-23
KE3373A (en)	1984-03-23
GB1598629A (en)	1981-09-23
SE8401491D0 (sv)	1984-03-16
YU40624B (en)	1986-02-28
YU215482A (en)	1983-02-28
ES470474A1 (es)	1979-09-01
NO152214B (no)	1985-05-13
HK38084A (en)	1984-05-11
SE8401491L (sv)	1984-03-16
NO791637L (no)	1978-12-05
NO152214C (no)	1985-08-28
AR222797A1 (es)	1981-06-30
GB1598630A (en)	1981-09-23
NZ187376A (en)	1981-05-29
IL54819A0 (en)	1978-07-31
SE443784B (sv)	1986-03-10
JPS5639313B2 (de)	1981-09-11
CH641167A5 (en)	1984-02-15
HK38184A (en)	1984-05-11
NO781928L (no)	1978-12-05
LU79725A1 (fr)	1979-02-02
SE7806525L (sv)	1978-12-04
NL7805935A (nl)	1978-12-05
CA1110251A (en)	1981-10-06
CY1229A (en)	1984-06-29
MY8500451A (en)	1985-12-31
DK243178A (da)	1978-12-04
NO151824C (no)	1985-06-12
DD140038A5 (de)	1980-02-06
ES478202A1 (es)	1979-06-01

Publication	Publication Date	Title
US4112234A (en)	1978-09-05	Imidazolylmethylthioethyl alkynyl guanidines
IE53274B1 (en)	1988-09-28	Chemical compounds derived from cyclobutene
JP2502343B2 (ja)	1996-05-29	薬学的に活性な置換ベンズアミド
DD220308A5 (de)	1985-03-27	Verfahren zur herstellung von n(piperidinylalkyl)-carboxamiden
GB2088375A (en)	1982-06-09	Imidazolylphenyl amidines
KR840001075B1 (ko)	1984-07-31	티아졸 유도체의 제조방법
US4157347A (en)	1979-06-05	N-cyano isothioureas
IE47543B1 (en)	1984-04-18	Guanidine derivatives
KR910009213B1 (ko)	1991-11-05	4,5,6,7-테트라하이드로티아졸로[5,4-c]피리딘 유도체의 제조방법
KR880001477B1 (ko)	1988-08-13	니플룸산 모르폴리노에틸에스테르 디니플루메이트의 제조방법
US4157340A (en)	1979-06-05	N,N'-[Bis(N-cyanoguanyl)]cystamine derivatives
US4200760A (en)	1980-04-29	Imidazolylalkylthioalkylamino-ethylene derivatives
USRE31588E (en)	1984-05-22	Imidazolylmethylthioethyl alkynyl guanidines
KR860000851B1 (ko)	1986-07-09	N-(2-(((5-(디메틸아미노)-메틸-2-푸라닐)-메틸)-티오)-에틸)-n'-(3,4-메틸렌-디옥시벤질)-2-니트로-1,1-에텐디아민의 제조방법
EP0180500A1 (de)	1986-05-07	Thieno- und Furo[2,3-c]pyrrolderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CA1142544A (en)	1983-03-08	N-cyano-n'-(2-[(4-methyl-5-imidazolyl) methylthio]ethyl) - n"-alkynylguanidines h.sub.2 receptor blocking agents
KR810000632B1 (ko)	1981-06-10	히스타민 h₂수용기 길항제 또는 비독성인 그의 약조제 가능한 산 첨가염의 제조방법
CA1130306A (en)	1982-08-24	N-cyano-n'-[2-[(4-methyl-5-imidazolyl) methylthio]ethyl]- n"-alkynylguanidines h.sub.2 receptor blocking agents
US5322846A (en)	1994-06-21	4-methylthiazole derivatives, their methods of preparation and the pharmaceutical compositions in which they are present
US4221737A (en)	1980-09-09	1-(Alkynyl)amino-1-(mercaptoalkyl)amino ethylenes
KR820001614B1 (ko)	1982-09-11	N-펜에틸 아세트아미드 화합물의 제조방법
KR800000411B1 (ko)	1980-05-20	퀴나졸린 유도체의 제조방법
JPS61221189A (ja)	1986-10-01	縮合２‐置換チアゾール誘導体
KR800000432B1 (ko)	1980-05-26	퀴나졸린 유도체의 제조방법
JPH0688974B2 (ja)	1994-11-09	２−ピリジルアセタミド誘導体、その製法および用途