FI911986A0 - Farmaceutiska foereningar. - Google Patents

Farmaceutiska foereningar.

Info

Publication number: FI911986A0
Authority: FI; Finland
Prior art keywords: pharmaceutical form; methyl; thieno; piperazinyl; disorders
Prior art date: 1990-04-25

Application number

FI911986A

Other languages

English (en)

Other versions

FI911986L (fi

FI101379B1 (fi

FI101379B (fi

Inventor

Jiban Kumar Chakrabarti

Terrence Michael Hotten

David Edward Tupper

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-25

Filing date

1991-04-24

Publication date

1991-04-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10674942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI911986(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-04-24 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1991-04-24 Priority to FI971316A priority Critical patent/FI971316A7/fi

1991-04-24 Publication of FI911986A0 publication Critical patent/FI911986A0/fi

1991-10-26 Publication of FI911986L publication Critical patent/FI911986L/fi

1998-06-15 Application granted granted Critical

1998-06-15 Publication of FI101379B1 publication Critical patent/FI101379B1/fi

1998-06-15 Publication of FI101379B publication Critical patent/FI101379B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)

FI911986A 1990-04-25 1991-04-24 Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-pi peratsinyyli)-4H-tieno£2,3-b|£1,5|bentsodiatsepiinin valmistamiseksi FI101379B (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI971316A FI971316A7 (fi)	1990-04-25	1991-04-24	Farmaseuttinen yhdiste

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909009229A GB9009229D0 (en)	1990-04-25	1990-04-25	Pharmaceutical compounds
GB9009229		1990-04-25

Publications (4)

Publication Number	Publication Date
FI911986A0 true FI911986A0 (fi)	1991-04-24
FI911986L FI911986L (fi)	1991-10-26
FI101379B1 FI101379B1 (fi)	1998-06-15
FI101379B FI101379B (fi)	1998-06-15

Family

ID=10674942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI911986A FI101379B (fi)	1990-04-25	1991-04-24	Menetelmä terapeuttisesti käyttökelpoisen 2-metyyli-10-(4-metyyli-1-pi peratsinyyli)-4H-tieno£2,3-b\|£1,5\|bentsodiatsepiinin valmistamiseksi

Country Status (33)

Country	Link
EP (1)	EP0454436B1 (fi)
JP (1)	JP2527860B2 (fi)
KR (1)	KR100195566B1 (fi)
CN (1)	CN1028429C (fi)
AT (1)	ATE127804T1 (fi)
AU (1)	AU643267B2 (fi)
BG (1)	BG61710B2 (fi)
CA (1)	CA2041113C (fi)
CY (1)	CY1900A (fi)
CZ (1)	CZ279937B6 (fi)
DE (3)	DE69112895T4 (fi)
DK (1)	DK0454436T3 (fi)
ES (1)	ES2078440T3 (fi)
FI (1)	FI101379B (fi)
GB (1)	GB9009229D0 (fi)
GE (1)	GEP20032965B (fi)
GR (1)	GR3017877T3 (fi)
HK (1)	HK87596A (fi)
HU (2)	HU212416B (fi)
IE (1)	IE68401B1 (fi)
IL (2)	IL97912A (fi)
LU (2)	LU90009I2 (fi)
LV (1)	LV10262B (fi)
MX (1)	MX173791B (fi)
NL (2)	NL970015I2 (fi)
NO (3)	NO178766C (fi)
NZ (1)	NZ237932A (fi)
PT (1)	PT97446B (fi)
RU (1)	RU2043992C1 (fi)
SI (1)	SI9110739A (fi)
SK (1)	SK279196B6 (fi)
YU (1)	YU48049B (fi)
ZA (1)	ZA913085B (fi)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5817655A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Methods of treatment using a thieno-benzodiazepine
US5627178A (en) *	1991-04-23	1997-05-06	Lilly Industries Limited	2-methyl-thieno-benzodiazepine
US5817656A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Mental disorders
US5817657A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Psychoactive substance disorders
CA2097016A1 (en) *	1992-05-29	1993-11-30	John Fairhurst	Pharmaceutical compounds
US6034078A (en) *	1992-05-29	2000-03-07	Eli Lilly And Company Limited	Thienobenzodiazepine compounds
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
EG24221A (en) *	1995-03-24	2008-11-10	Lilly Co Eli	Process for preparing olanzapine
CR5278A (es) *	1995-03-24	1996-07-04	Lilly Co Eli	Formulacion oral de 2-metil-tieno-benzodiacepina
IL117612A0 (en) *	1995-03-24	1996-07-23	Lilly Co Eli	Granule formulation for olanzapine
EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
ES2180643T3 (es) *	1995-05-30	2003-02-16	Lilly Co Eli	Procedimiento para tratar la disfuncion cognitiva.
CN1131035C (zh) *	1995-05-30	2003-12-17	伊莱利利公司	治疗识别机能障碍的方法
US6506746B2 (en)	1995-05-30	2003-01-14	Eli Lilly And Company	Method for treating cognitive dysfunction
US5891461A (en) *	1995-09-14	1999-04-06	Cygnus, Inc.	Transdermal administration of olanzapine
CA2240836A1 (en) *	1995-12-21	1997-07-03	Pierre Van Tran	Method for treating dermatitis
UA57727C2 (uk) *	1996-03-11	2003-07-15	Елі Ліллі Енд Компані	Спосіб лікування надмірної агресивності
EA001881B1 (ru)	1996-09-23	2001-10-22	Эли Лилли Энд Компани	Форма d дигидрата оланзапина
ZA978515B (en) *	1996-09-23	1999-03-23	Lilly Co Eli	Intermediates and process for preparing olanzapine
ATE244245T1 (de)	1997-09-02	2003-07-15	Mitsubishi Pharma Corp	Kondensierte thiophenderivate und ihre medizinische anwendung
GB9718986D0 (en) *	1997-09-09	1997-11-12	Danbiosyst Uk	Controlled release microsphere delivery system
TR200000812T2 (tr) *	1997-09-30	2001-07-23	Eli Lilly And Company	2-metil-tieno- benzodiazepin formülasyonu.
FR2802101B1 (fr)	1999-12-10	2003-02-28	Aventis Pharma Sa	Association de cymemazine et d'un neuroleptique atypique
JP2004507548A (ja)	2000-08-31	2004-03-11	ドクター・レディーズ・ラボラトリーズ・リミテッド	オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
RU2185383C1 (ru) *	2001-05-22	2002-07-20	Институт молекулярной генетики РАН	ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН
EP2108651A1 (en) *	2001-12-24	2009-10-14	Sun Pharmaceuticals Industries Ltd.	Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno[2,3-B][1,5] benzodiazepine
PL196814B1 (pl) *	2002-05-17	2008-02-29	Inst Farmaceutyczny	Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
DE60336226D1 (de)	2002-05-31	2011-04-14	Sandoz Ag	Verfahren zur herstellung von olanzapin form i
WO2003104239A1 (en) *	2002-06-05	2003-12-18	Ivax Corporation	Compound for the treatment of cns disorders
PL199016B1 (pl) *	2002-06-20	2008-08-29	Adamed Sp Z Oo	Sposób wytwarzania olanzapiny
SI21303A (sl)	2002-10-18	2004-04-30	Krka, Tovarna Zdravil, D.D.,, Novo Mesto	Farmacevtska formulacija olanzapina
PL202856B1 (pl) *	2002-12-20	2009-07-31	Adamed Spo & Lstrok Ka Z Ogran	Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
DE10301923B3 (de) *	2003-01-17	2004-09-16	Krka Tovarna Zdravil, D.D.	Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
HU226410B1 (en) *	2003-04-22	2008-11-28	Egis Gyogyszergyar Nyilvanosan	Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
WO2005063771A1 (en)	2003-12-22	2005-07-14	Teva Pharmaceutical Industries Ltd	Methods of preparing olanzapine
DE602005027308D1 (de)	2004-01-27	2011-05-19	Synthon Bv	Stabile salze von olanzapin
WO2005070937A1 (en) *	2004-01-27	2005-08-04	Synthon B.V.	A process for making olanzapine in a polymorph form i
AR048272A1 (es) *	2004-03-18	2006-04-12	Lek Pharmaceuticals	Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
ES2253091B1 (es) *	2004-07-27	2007-02-01	Inke, S.A.	Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) *	2004-07-28	2006-02-28	Krka, Tovarna Zdravil, D.D., Novo Mesto	Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
KR20130030305A (ko) *	2004-11-16	2013-03-26	엘란 파마 인터내셔널 리미티드	주사가능한 나노입자형 올란자핀 제형
PL198589B1 (pl)	2004-11-22	2008-06-30	Adamed Sp Z Oo	Sposób wytwarzania N-demetyloolanzapiny
DK1838716T3 (da)	2005-01-05	2011-07-25	Lilly Co Eli	Olanzapinpamota-dihydrat
HUP0501046A2 (en) *	2005-11-11	2007-08-28	Egis Gyogyszergyar Nyilvanosan	Process for the preparation of olanzapine
US7834176B2 (en)	2006-01-26	2010-11-16	Sandoz Ag	Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CN100383144C (zh) *	2006-09-11	2008-04-23	杭州盛美医药科技开发有限公司	一种奥氮平的中间体及其制备与应用
AR063043A1 (es) *	2006-09-29	2008-12-23	Synthon Bv	Composicion farmaceutica de olanzapina
PL381564A1 (pl)	2007-01-22	2008-08-04	Koźluk Tomasz Nobilus Ent	Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en)	2007-06-22	2008-12-22	Apotex Pharmachem Inc.	Improved processes for the synthesis of olanzapine
CN101168544B (zh) *	2007-11-16	2010-11-17	西南合成制药股份有限公司	奥氮平的制备工艺
CN101735239B (zh) *	2008-11-06	2011-08-31	齐鲁制药有限公司	一种无水奥氮平晶型ii的制备方法
EP2292624A1 (en)	2009-07-20	2011-03-09	LEK Pharmaceuticals d.d.	Process for the purification of olanzapine
CN102532158A (zh) *	2010-12-17	2012-07-04	北大方正集团有限公司	一种合成奥氮平的方法
EP2486913A1 (en)	2011-02-14	2012-08-15	Labtec GmbH	Rapidly disintegrating oral film formulation for Olanzapin
WO2012153347A2 (en)	2011-05-04	2012-11-15	Zentiva K.S.	Oral pharmaceutical composition of olanzapine form 1
CN102225941B (zh) *	2011-06-01	2013-11-27	宁波人健医药化工有限公司	抗精神病药奥氮平的制备方法
WO2013066280A1 (en) *	2011-10-31	2013-05-10	Mahmut Bilgic	Water soluble antipsychotic formulations
JP5934004B2 (ja) *	2012-03-22	2016-06-15	株式会社トクヤマ	結晶構造を有する４−アミノ−２−メチル−１０Ｈ−チエノ〔２，３−ｂ〕〔１，５〕ベンゾジアゼピン塩酸塩水和物及びその製造方法
WO2014021803A1 (en)	2012-07-31	2014-02-06	Sanovel Hayvan Sagligi Ürünleri Sanayi Ve Ticaret A.S.	Use of olanzapine in animals
US20150216206A1 (en)	2012-07-31	2015-08-06	Sanovel Hayvan Sagligi Urunleri Sanayi Ve Ticaret Anonim Sirketi	Method for increasing meat and milk production
JP6042153B2 (ja) *	2012-09-26	2016-12-14	株式会社トクヤマ	オランザピンの製造方法
KR101641902B1 (ko)	2015-06-24	2016-07-22	주식회사 네이처센스 농업회사법인	스트레스의 완화용 조성물
CN106265541A (zh) *	2016-08-31	2017-01-04	安徽省润生医药股份有限公司	一种注射用奥氮平及其制备方法
CN111004210A (zh) *	2019-10-23	2020-04-14	中山大学	化合物单晶及其制备方法
WO2025056094A1 (zh) *	2023-09-15	2025-03-20	广州帝奇医药技术有限公司	一种冻干制剂和注射液及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU629879A3 (ru)	1974-11-26	1978-10-25	Лилли Индастриз Лимитед, (Фирма)	Способ получени тиено(1,5) бензодиазепинов или их солей
US3953430A (en) *	1975-02-24	1976-04-27	American Cyanamid Company	Substituted benzodiazepin-10-ones and method of use
GB1533236A (en) *	1975-11-24	1978-11-22	Lilly Industries Ltd	Thieno(1,5)benzodiazepine intermediates
GB1577743A (en) *	1977-05-17	1980-10-29	Lilly Industries Ltd	Benzodiazepine derivatives

1990
- 1990-04-25 GB GB909009229A patent/GB9009229D0/en active Pending
1991
- 1991-04-22 IL IL9791291A patent/IL97912A/en not_active IP Right Cessation
- 1991-04-22 AU AU75186/91A patent/AU643267B2/en not_active Expired
- 1991-04-23 IE IE134891A patent/IE68401B1/en not_active IP Right Cessation
- 1991-04-23 PT PT97446A patent/PT97446B/pt not_active IP Right Cessation
- 1991-04-24 ES ES91303679T patent/ES2078440T3/es not_active Expired - Lifetime
- 1991-04-24 DK DK91303679.4T patent/DK0454436T3/da active
- 1991-04-24 CY CY190091A patent/CY1900A/xx unknown
- 1991-04-24 JP JP3228215A patent/JP2527860B2/ja not_active Expired - Lifetime
- 1991-04-24 CN CN91103346A patent/CN1028429C/zh not_active Expired - Lifetime
- 1991-04-24 FI FI911986A patent/FI101379B/fi active Protection Beyond IP Right Term
- 1991-04-24 SK SK1168-91A patent/SK279196B6/sk not_active IP Right Cessation
- 1991-04-24 YU YU73991A patent/YU48049B/sh unknown
- 1991-04-24 EP EP91303679A patent/EP0454436B1/en not_active Expired - Lifetime
- 1991-04-24 MX MX2550291A patent/MX173791B/es unknown
- 1991-04-24 DE DE69112895T patent/DE69112895T4/de not_active Expired - Lifetime
- 1991-04-24 ZA ZA913085A patent/ZA913085B/xx unknown
- 1991-04-24 LU LU90009C patent/LU90009I2/fr unknown
- 1991-04-24 DE DE1996175046 patent/DE19675046I2/de active Active
- 1991-04-24 NZ NZ237932A patent/NZ237932A/en unknown
- 1991-04-24 AT AT91303679T patent/ATE127804T1/de active
- 1991-04-24 CZ CS911168A patent/CZ279937B6/cs not_active IP Right Cessation
- 1991-04-24 CA CA002041113A patent/CA2041113C/en not_active Expired - Lifetime
- 1991-04-24 DE DE69112895A patent/DE69112895D1/de not_active Expired - Lifetime
- 1991-04-24 KR KR1019910006544A patent/KR100195566B1/ko not_active Expired - Lifetime
- 1991-04-24 HU HU911372A patent/HU212416B/hu active IP Right Revival
- 1991-04-24 NO NO911624A patent/NO178766C/no not_active IP Right Cessation
- 1991-04-24 SI SI9110739A patent/SI9110739A/sl unknown
1992
- 1992-09-25 RU SU925052762A patent/RU2043992C1/ru active
1993
- 1993-06-08 LV LVP-93-517A patent/LV10262B/xx unknown
1994
- 1994-02-02 BG BG098434A patent/BG61710B2/bg unknown
1995
- 1995-02-08 IL IL11257595A patent/IL112575A0/xx unknown
- 1995-06-22 HU HU95P/P00335P patent/HU211575A9/hu unknown
- 1995-10-25 GR GR950402982T patent/GR3017877T3/el unknown
1996
- 1996-05-16 HK HK87596A patent/HK87596A/en not_active IP Right Cessation
1997
- 1997-03-21 NL NL970015C patent/NL970015I2/nl unknown
- 1997-05-12 NO NO1997005C patent/NO1997005I1/no unknown
2001
- 2001-10-18 GE GEAP20016159A patent/GEP20032965B/en unknown
- 2001-12-21 LU LU90869C patent/LU90869I2/fr unknown
- 2001-12-28 NO NO2001028C patent/NO2001028I1/no unknown
- 2001-12-28 NL NL300078C patent/NL300078I1/nl unknown

Also Published As

Publication number	Publication date
DE69112895D1 (de)	1995-10-19
YU73991A (sh)	1994-01-20
LV10262A (lv)	1994-10-20
NZ237932A (en)	1993-08-26
GEP20032965B (en)	2003-05-12
NL970015I1 (nl)	1997-06-02
FI911986L (fi)	1991-10-26
DE19675046I2 (de)	2001-05-23
NO1997005I1 (no)	1997-05-12
AU7518691A (en)	1991-11-07
SI9110739A (en)	1997-10-31
DE69112895T2 (de)	1996-03-07
NO911624L (no)	1991-10-28
JP2527860B2 (ja)	1996-08-28
HU211575A9 (en)	1995-12-28
HU212416B (en)	1996-06-28
FI101379B1 (fi)	1998-06-15
CS9101168A2 (en)	1991-12-17
HUT60503A (en)	1992-09-28
IL97912A0 (en)	1992-06-21
YU48049B (sh)	1996-10-18
PT97446B (pt)	1997-07-31
NL970015I2 (nl)	1997-09-01
RU2043992C1 (ru)	1995-09-20
DK0454436T3 (da)	1995-11-13
NO2001028I1 (no)	2002-01-28
KR100195566B1 (ko)	1999-06-15
GB9009229D0 (en)	1990-06-20
EP0454436B1 (en)	1995-09-13
DE69112895T4 (de)	2009-11-12
IL97912A (en)	1995-10-31
CN1056693A (zh)	1991-12-04
GR3017877T3 (en)	1996-01-31
HK87596A (en)	1996-05-24
LV10262B (en)	1995-04-20
CN1028429C (zh)	1995-05-17
MX25502A (es)	1993-10-01
NO178766B (no)	1996-02-19
NL300078I1 (nl)	2002-03-01
EP0454436A1 (en)	1991-10-30
ZA913085B (en)	1992-12-30
IE68401B1 (en)	1996-06-12
NO178766C (no)	1996-05-29
IL112575A0 (en)	1995-05-26
ATE127804T1 (de)	1995-09-15
CA2041113C (en)	1998-07-14
HU911372D0 (en)	1991-10-28
MX173791B (es)	1994-03-25
CZ279937B6 (cs)	1995-09-13
SK279196B6 (sk)	1998-07-08
LU90869I2 (fr)	2002-02-21
ES2078440T3 (es)	1995-12-16
FI101379B (fi)	1998-06-15
CA2041113A1 (en)	1991-10-26
JPH0789965A (ja)	1995-04-04
AU643267B2 (en)	1993-11-11
NO911624D0 (no)	1991-04-24
KR910018387A (ko)	1991-11-30
IE911348A1 (en)	1991-11-06
LU90009I2 (fr)	1997-01-31
CY1900A (en)	1991-04-24
BG61710B2 (bg)	1998-03-31
PT97446A (pt)	1992-01-31

Publication	Publication Date	Title
FI911986A0 (fi)	1991-04-24	Farmaceutiska foereningar.
TW372872B (en)	1999-11-01	Thieno[1,5]benzodiazepine use
KR900009625A (ko)	1990-07-05	피리미딘류 및 그의 약리학적으로 허용되는 염류 및 그 용도
KR0145958B1 (en)	1998-08-17	Antibacterial agents
ATE229806T1 (de)	2003-01-15	Wirkstoff zur behandlung neurodegenerativer störungen
ITMI930699A1 (it)	1994-10-08	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ES2063202T3 (es)	1995-01-01	Nuevas 5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepin-6-onas y -tionas y su uso en la prevencion o tratamiento del sida.
ATE81776T1 (de)	1992-11-15	Verwendung von chinolon und naphthyridinantibiotika zur herstellung von ophthalmischen arzneimitteln.
ES2080736T3 (es)	1996-02-16	Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos.
MY105555A (en)	1994-10-31	Heterocyclicguanidines as 5ht 3 antagonists.
PT935598E (pt)	2004-03-31	Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central
ES2190499T3 (es)	2003-08-01	Uso de antagonistas de bradiquinina para la preparacion de medicamentos para el tratamiento y la prevencion de la enfermedad de alzheimer.
GR3015469T3 (en)	1995-06-30	5,11-dihydro-6H-pyrido[2,3,-b][1,4]benzodiazepin-6-ones and -thiones and their use in the prevention or treatment of AIDS.
SE8802323D0 (sv)	1988-06-21	8alfa-acylaminoergoline, its preparation and pharmaceutical compositions containing it
NO912528D0 (no)	1991-06-27	Behandling av sykdommer forbundet med jodmangel.

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Date	Code	Title	Description
1998-04-15	HC	Name/ company changed in application	Owner name: ELI LILLY AND COMPANY LIMITED
2001-09-04	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: L140 Extension date: 20110926
2001-12-27	SPCF	Supplementary protection certificate application filed	Spc suppl protection certif: L20010020
2006-11-10	FD	Application lapsed
2006-11-10	SPCL	Withdrawal, rejection or dismissal of a supplementary protection certificate	Spc suppl protection certif: L20010020