NO911624L - Farmasoeytiske forbindelser. - Google Patents

Farmasoeytiske forbindelser.

Info

Publication number: NO911624L
Authority: NO; Norway
Prior art keywords: pharmaceutical; relations; methyl; thieno; piperazinyl
Prior art date: 1990-04-25

Application number

NO91911624A

Other languages

English (en)

Other versions

NO178766B (no

NO911624D0 (no

NO178766C (no

Inventor

Jiban Kumar Chakrabarti

Terrence Michael Hotten

David Edward Tupper

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-25

Filing date

1991-04-24

Publication date

1991-10-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10674942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO911624(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-04-24 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1991-04-24 Publication of NO911624D0 publication Critical patent/NO911624D0/no

1991-10-28 Publication of NO911624L publication Critical patent/NO911624L/no

1996-02-19 Publication of NO178766B publication Critical patent/NO178766B/no

1996-05-29 Publication of NO178766C publication Critical patent/NO178766C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO911624A 1990-04-25 1991-04-24 Analogifremgangsmåte for fremstilling av benzodiazepin og mellomprodukter derav NO178766C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909009229A GB9009229D0 (en)	1990-04-25	1990-04-25	Pharmaceutical compounds

Publications (4)

Publication Number	Publication Date
NO911624D0 NO911624D0 (no)	1991-04-24
NO911624L true NO911624L (no)	1991-10-28
NO178766B NO178766B (no)	1996-02-19
NO178766C NO178766C (no)	1996-05-29

Family

ID=10674942

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO911624A NO178766C (no)	1990-04-25	1991-04-24	Analogifremgangsmåte for fremstilling av benzodiazepin og mellomprodukter derav
NO1997005C NO1997005I1 (no)	1990-04-25	1997-05-12	Olanzapin
NO2001028C NO2001028I1 (no)	1990-04-25	2001-12-28	Olanzapine i amorf tilstand

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO1997005C NO1997005I1 (no)	1990-04-25	1997-05-12	Olanzapin
NO2001028C NO2001028I1 (no)	1990-04-25	2001-12-28	Olanzapine i amorf tilstand

Country Status (33)

Country	Link
EP (1)	EP0454436B1 (no)
JP (1)	JP2527860B2 (no)
KR (1)	KR100195566B1 (no)
CN (1)	CN1028429C (no)
AT (1)	ATE127804T1 (no)
AU (1)	AU643267B2 (no)
BG (1)	BG61710B2 (no)
CA (1)	CA2041113C (no)
CY (1)	CY1900A (no)
CZ (1)	CZ279937B6 (no)
DE (3)	DE69112895T4 (no)
DK (1)	DK0454436T3 (no)
ES (1)	ES2078440T3 (no)
FI (1)	FI101379B1 (no)
GB (1)	GB9009229D0 (no)
GE (1)	GEP20032965B (no)
GR (1)	GR3017877T3 (no)
HK (1)	HK87596A (no)
HU (2)	HU212416B (no)
IE (1)	IE68401B1 (no)
IL (2)	IL97912A (no)
LU (2)	LU90009I2 (no)
LV (1)	LV10262B (no)
MX (1)	MX173791B (no)
NL (2)	NL970015I2 (no)
NO (3)	NO178766C (no)
NZ (1)	NZ237932A (no)
PT (1)	PT97446B (no)
RU (1)	RU2043992C1 (no)
SI (1)	SI9110739A (no)
SK (1)	SK279196B6 (no)
YU (1)	YU48049B (no)
ZA (1)	ZA913085B (no)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5817655A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Methods of treatment using a thieno-benzodiazepine
US5817656A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Mental disorders
US5627178A (en) *	1991-04-23	1997-05-06	Lilly Industries Limited	2-methyl-thieno-benzodiazepine
US5817657A (en) *	1991-04-23	1998-10-06	Eli Lilly And Company	Psychoactive substance disorders
CA2097016A1 (en) *	1992-05-29	1993-11-30	John Fairhurst	Pharmaceutical compounds
US6034078A (en) *	1992-05-29	2000-03-07	Eli Lilly And Company Limited	Thienobenzodiazepine compounds
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
IL117612A0 (en) *	1995-03-24	1996-07-23	Lilly Co Eli	Granule formulation for olanzapine
EG24221A (en) *	1995-03-24	2008-11-10	Lilly Co Eli	Process for preparing olanzapine
CR5278A (es) *	1995-03-24	1996-07-04	Lilly Co Eli	Formulacion oral de 2-metil-tieno-benzodiacepina
EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
CN1131035C (zh) *	1995-05-30	2003-12-17	伊莱利利公司	治疗识别机能障碍的方法
HUT77907A (hu) *	1995-05-30	1998-10-28	Eli Lilly And Co.	2-Metil-4-(4-metil-piperazino)-1OH-tieno[2,3-b][1,5] benzodiazepin alkalmazása kognitiv diszfunkció kezelésére gyógyszerkészítmények előállítására
US6506746B2 (en)	1995-05-30	2003-01-14	Eli Lilly And Company	Method for treating cognitive dysfunction
US5891461A (en) *	1995-09-14	1999-04-06	Cygnus, Inc.	Transdermal administration of olanzapine
WO1997023221A1 (en) *	1995-12-21	1997-07-03	Eli Lilly And Company	Method for treating dermatitis
UA57727C2 (uk) *	1996-03-11	2003-07-15	Елі Ліллі Енд Компані	Спосіб лікування надмірної агресивності
ZA978515B (en) *	1996-09-23	1999-03-23	Lilly Co Eli	Intermediates and process for preparing olanzapine
TR199900639T2 (xx)	1996-09-23	1999-06-21	Eli Lilly And Company	Olanzapin dihidrat D.
KR20010021989A (ko) *	1997-09-02	2001-03-15	가마후라 아키오	축합 티오펜 화합물 및 이의 의약 용도
GB9718986D0 (en) *	1997-09-09	1997-11-12	Danbiosyst Uk	Controlled release microsphere delivery system
US6169084B1 (en) *	1997-09-30	2001-01-02	Eli Lilly And Company	2-methyl-thieno-benzodiazepine formulation
FR2802101B1 (fr)	1999-12-10	2003-02-28	Aventis Pharma Sa	Association de cymemazine et d'un neuroleptique atypique
IL154688A0 (en)	2000-08-31	2003-09-17	Reddys Lab Ltd Dr	Hydrates of olanzapine and processes for the preparation thereof
RU2185383C1 (ru) *	2001-05-22	2002-07-20	Институт молекулярной генетики РАН	ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН
AU2002367119A1 (en) *	2001-12-24	2003-07-15	Sun Pharmaceutical Industries Limited	Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
PL196814B1 (pl)	2002-05-17	2008-02-29	Inst Farmaceutyczny	Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
US7297789B2 (en)	2002-05-31	2007-11-20	Sandoz, Inc.	Process of preparation of olanzapine form I
AU2003239967A1 (en) *	2002-06-05	2003-12-22	Ivax Corporation	Compound for the treatment of cns disorders
PL199016B1 (pl) *	2002-06-20	2008-08-29	Adamed Sp Z Oo	Sposób wytwarzania olanzapiny
SI21303A (sl)	2002-10-18	2004-04-30	Krka, Tovarna Zdravil, D.D.,, Novo Mesto	Farmacevtska formulacija olanzapina
PL202856B1 (pl) *	2002-12-20	2009-07-31	Adamed Spo & Lstrok Ka Z Ogran	Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
DE10301923B3 (de)	2003-01-17	2004-09-16	Krka Tovarna Zdravil, D.D.	Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
HU226410B1 (en)	2003-04-22	2008-11-28	Egis Gyogyszergyar Nyilvanosan	Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
WO2005063771A1 (en)	2003-12-22	2005-07-14	Teva Pharmaceutical Industries Ltd	Methods of preparing olanzapine
EP1720885A1 (en) *	2004-01-27	2006-11-15	Synthon B.V.	A process for making olanzapine in a polymorph form i
ATE504588T1 (de)	2004-01-27	2011-04-15	Synthon Bv	Stabile salze von olanzapin
AR048272A1 (es) *	2004-03-18	2006-04-12	Lek Pharmaceuticals	Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
ES2253091B1 (es)	2004-07-27	2007-02-01	Inke, S.A.	Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
SI21850A (sl) *	2004-07-28	2006-02-28	Krka, Tovarna Zdravil, D.D., Novo Mesto	Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
ES2526092T3 (es) *	2004-11-16	2015-01-05	Alkermes Pharma Ireland Limited	Formulaciones de olanzapina en nanopartículas inyectables
PL198589B1 (pl)	2004-11-22	2008-06-30	Adamed Sp Z Oo	Sposób wytwarzania N-demetyloolanzapiny
JP4940152B2 (ja)	2005-01-05	2012-05-30	イーライリリーアンドカンパニー	パモ酸オランザピン二水和物
HUP0501046A2 (en) *	2005-11-11	2007-08-28	Egis Gyogyszergyar Nyilvanosan	Process for the preparation of olanzapine
US7834176B2 (en)	2006-01-26	2010-11-16	Sandoz Ag	Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CN100383144C (zh) *	2006-09-11	2008-04-23	杭州盛美医药科技开发有限公司	一种奥氮平的中间体及其制备与应用
US20080138409A1 (en) *	2006-09-29	2008-06-12	Osinga Niels J	Olanzapine pharmaceutical composition
PL381564A1 (pl)	2007-01-22	2008-08-04	Koźluk Tomasz Nobilus Ent	Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny
CA2593407A1 (en)	2007-06-22	2008-12-22	Apotex Pharmachem Inc.	Improved processes for the synthesis of olanzapine
CN101168544B (zh) *	2007-11-16	2010-11-17	西南合成制药股份有限公司	奥氮平的制备工艺
CN101735239B (zh) *	2008-11-06	2011-08-31	齐鲁制药有限公司	一种无水奥氮平晶型ii的制备方法
EP2292624A1 (en)	2009-07-20	2011-03-09	LEK Pharmaceuticals d.d.	Process for the purification of olanzapine
CN102532158A (zh) *	2010-12-17	2012-07-04	北大方正集团有限公司	一种合成奥氮平的方法
EP2486913A1 (en)	2011-02-14	2012-08-15	Labtec GmbH	Rapidly disintegrating oral film formulation for Olanzapin
WO2012153347A2 (en)	2011-05-04	2012-11-15	Zentiva K.S.	Oral pharmaceutical composition of olanzapine form 1
CN102225941B (zh) *	2011-06-01	2013-11-27	宁波人健医药化工有限公司	抗精神病药奥氮平的制备方法
WO2013066280A1 (en) *	2011-10-31	2013-05-10	Mahmut Bilgic	Water soluble antipsychotic formulations
JP5934004B2 (ja) *	2012-03-22	2016-06-15	株式会社トクヤマ	結晶構造を有する４−アミノ−２−メチル−１０Ｈ−チエノ〔２，３−ｂ〕〔１，５〕ベンゾジアゼピン塩酸塩水和物及びその製造方法
EP2879518A1 (en)	2012-07-31	2015-06-10	Sanovel Hayvan Sagligi Ürünleri Sanayi ve Ticaret A.S.	Use of olanzapine in animals
WO2014021804A1 (en)	2012-07-31	2014-02-06	Sanovel Hayvan Sagligi Ürünleri Sanayi Ve Ticaret A.S.	A method for increasing meat and milk production
JP6042153B2 (ja) *	2012-09-26	2016-12-14	株式会社トクヤマ	オランザピンの製造方法
KR101641902B1 (ko)	2015-06-24	2016-07-22	주식회사 네이처센스 농업회사법인	스트레스의 완화용 조성물
CN106265541A (zh) *	2016-08-31	2017-01-04	安徽省润生医药股份有限公司	一种注射用奥氮平及其制备方法
CN111004210A (zh) *	2019-10-23	2020-04-14	中山大学	化合物单晶及其制备方法
WO2025056094A1 (zh) *	2023-09-15	2025-03-20	广州帝奇医药技术有限公司	一种冻干制剂和注射液及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU629879A3 (ru)	1974-11-26	1978-10-25	Лилли Индастриз Лимитед, (Фирма)	Способ получени тиено(1,5) бензодиазепинов или их солей
US3953430A (en) *	1975-02-24	1976-04-27	American Cyanamid Company	Substituted benzodiazepin-10-ones and method of use
GB1533236A (en) *	1975-11-24	1978-11-22	Lilly Industries Ltd	Thieno(1,5)benzodiazepine intermediates
GB1577743A (en) *	1977-05-17	1980-10-29	Lilly Industries Ltd	Benzodiazepine derivatives

1990
- 1990-04-25 GB GB909009229A patent/GB9009229D0/en active Pending
1991
- 1991-04-22 IL IL9791291A patent/IL97912A/en not_active IP Right Cessation
- 1991-04-22 AU AU75186/91A patent/AU643267B2/en not_active Expired
- 1991-04-23 IE IE134891A patent/IE68401B1/en not_active IP Right Cessation
- 1991-04-23 PT PT97446A patent/PT97446B/pt not_active IP Right Cessation
- 1991-04-24 AT AT91303679T patent/ATE127804T1/de active
- 1991-04-24 CY CY190091A patent/CY1900A/xx unknown
- 1991-04-24 DK DK91303679.4T patent/DK0454436T3/da active
- 1991-04-24 SI SI9110739A patent/SI9110739A/sl unknown
- 1991-04-24 NO NO911624A patent/NO178766C/no not_active IP Right Cessation
- 1991-04-24 FI FI911986A patent/FI101379B1/fi active Protection Beyond IP Right Term
- 1991-04-24 DE DE69112895T patent/DE69112895T4/de not_active Expired - Lifetime
- 1991-04-24 EP EP91303679A patent/EP0454436B1/en not_active Expired - Lifetime
- 1991-04-24 MX MX2550291A patent/MX173791B/es unknown
- 1991-04-24 YU YU73991A patent/YU48049B/sh unknown
- 1991-04-24 SK SK1168-91A patent/SK279196B6/sk not_active IP Right Cessation
- 1991-04-24 KR KR1019910006544A patent/KR100195566B1/ko not_active Expired - Lifetime
- 1991-04-24 HU HU911372A patent/HU212416B/hu active IP Right Revival
- 1991-04-24 DE DE1996175046 patent/DE19675046I2/de active Active
- 1991-04-24 CN CN91103346A patent/CN1028429C/zh not_active Expired - Lifetime
- 1991-04-24 JP JP3228215A patent/JP2527860B2/ja not_active Expired - Lifetime
- 1991-04-24 CA CA002041113A patent/CA2041113C/en not_active Expired - Lifetime
- 1991-04-24 CZ CS911168A patent/CZ279937B6/cs not_active IP Right Cessation
- 1991-04-24 DE DE69112895A patent/DE69112895D1/de not_active Expired - Lifetime
- 1991-04-24 ZA ZA913085A patent/ZA913085B/xx unknown
- 1991-04-24 LU LU90009C patent/LU90009I2/fr unknown
- 1991-04-24 ES ES91303679T patent/ES2078440T3/es not_active Expired - Lifetime
- 1991-04-24 NZ NZ237932A patent/NZ237932A/en unknown
1992
- 1992-09-25 RU SU925052762A patent/RU2043992C1/ru active
1993
- 1993-06-08 LV LVP-93-517A patent/LV10262B/xx unknown
1994
- 1994-02-02 BG BG098434A patent/BG61710B2/bg unknown
1995
- 1995-02-08 IL IL11257595A patent/IL112575A0/xx unknown
- 1995-06-22 HU HU95P/P00335P patent/HU211575A9/hu unknown
- 1995-10-25 GR GR950402982T patent/GR3017877T3/el unknown
1996
- 1996-05-16 HK HK87596A patent/HK87596A/en not_active IP Right Cessation
1997
- 1997-03-21 NL NL970015C patent/NL970015I2/nl unknown
- 1997-05-12 NO NO1997005C patent/NO1997005I1/no unknown
2001
- 2001-10-18 GE GEAP20016159A patent/GEP20032965B/en unknown
- 2001-12-21 LU LU90869C patent/LU90869I2/fr unknown
- 2001-12-28 NO NO2001028C patent/NO2001028I1/no unknown
- 2001-12-28 NL NL300078C patent/NL300078I1/nl unknown

Also Published As

Publication number	Publication date
NO178766B (no)	1996-02-19
LU90869I2 (fr)	2002-02-21
CY1900A (en)	1991-04-24
CZ279937B6 (cs)	1995-09-13
ATE127804T1 (de)	1995-09-15
LV10262A (lv)	1994-10-20
DK0454436T3 (da)	1995-11-13
HUT60503A (en)	1992-09-28
HK87596A (en)	1996-05-24
KR910018387A (ko)	1991-11-30
CS9101168A2 (en)	1991-12-17
IE911348A1 (en)	1991-11-06
AU643267B2 (en)	1993-11-11
JP2527860B2 (ja)	1996-08-28
HU211575A9 (en)	1995-12-28
AU7518691A (en)	1991-11-07
EP0454436B1 (en)	1995-09-13
IL97912A (en)	1995-10-31
CA2041113C (en)	1998-07-14
NO1997005I1 (no)	1997-05-12
NO911624D0 (no)	1991-04-24
EP0454436A1 (en)	1991-10-30
LV10262B (en)	1995-04-20
NL300078I1 (nl)	2002-03-01
NL970015I2 (nl)	1997-09-01
YU73991A (sh)	1994-01-20
KR100195566B1 (ko)	1999-06-15
ZA913085B (en)	1992-12-30
NO178766C (no)	1996-05-29
PT97446A (pt)	1992-01-31
ES2078440T3 (es)	1995-12-16
FI911986A0 (fi)	1991-04-24
NL970015I1 (nl)	1997-06-02
RU2043992C1 (ru)	1995-09-20
MX25502A (es)	1993-10-01
HU212416B (en)	1996-06-28
CN1028429C (zh)	1995-05-17
IL97912A0 (en)	1992-06-21
DE69112895T4 (de)	2009-11-12
NZ237932A (en)	1993-08-26
FI101379B (fi)	1998-06-15
IE68401B1 (en)	1996-06-12
GB9009229D0 (en)	1990-06-20
LU90009I2 (fr)	1997-01-31
SI9110739A (en)	1997-10-31
JPH0789965A (ja)	1995-04-04
GEP20032965B (en)	2003-05-12
HU911372D0 (en)	1991-10-28
DE19675046I2 (de)	2001-05-23
FI101379B1 (fi)	1998-06-15
GR3017877T3 (en)	1996-01-31
PT97446B (pt)	1997-07-31
SK279196B6 (sk)	1998-07-08
CN1056693A (zh)	1991-12-04
DE69112895D1 (de)	1995-10-19
MX173791B (es)	1994-03-25
IL112575A0 (en)	1995-05-26
BG61710B2 (bg)	1998-03-31
YU48049B (sh)	1996-10-18
CA2041113A1 (en)	1991-10-26
DE69112895T2 (de)	1996-03-07
FI911986L (fi)	1991-10-26
NO2001028I1 (no)	2002-01-28

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