EE200000435A - Asendatud oksoasaheterotsüklilised ühendid faktori Xa inhibiitoritena, neid sisaldav farmatseutiline kompositsioon ning meetod faktori Xa toime pärssimiseks - Google Patents
Asendatud oksoasaheterotsüklilised ühendid faktori Xa inhibiitoritena, neid sisaldav farmatseutiline kompositsioon ning meetod faktori Xa toime pärssimiseksInfo
- Publication number
- EE200000435A EE200000435A EEP200000435A EEP200000435A EE200000435A EE 200000435 A EE200000435 A EE 200000435A EE P200000435 A EEP200000435 A EE P200000435A EE P200000435 A EEP200000435 A EE P200000435A EE 200000435 A EE200000435 A EE 200000435A
- Authority
- EE
- Estonia
- Prior art keywords
- factor
- oxoaza
- inhibitors
- substituted
- activity
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7270798P | 1998-01-27 | 1998-01-27 | |
| PCT/US1999/001682 WO1999037304A1 (fr) | 1998-01-27 | 1999-01-27 | COMPOSES OXOAZAHETEROCYCLYLE SUBSTITUES INHIBITEURS DU FACTEUR Xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200000435A true EE200000435A (et) | 2002-02-15 |
Family
ID=22109280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000435A EE200000435A (et) | 1998-01-27 | 1999-01-27 | Asendatud oksoasaheterotsüklilised ühendid faktori Xa inhibiitoritena, neid sisaldav farmatseutiline kompositsioon ning meetod faktori Xa toime pärssimiseks |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7612075B2 (fr) |
| EP (1) | EP1051176B1 (fr) |
| JP (1) | JP4676613B2 (fr) |
| KR (1) | KR20010034442A (fr) |
| CN (1) | CN1291892A (fr) |
| AP (1) | AP2000001889A0 (fr) |
| AT (1) | ATE346050T1 (fr) |
| AU (1) | AU745425B2 (fr) |
| BG (1) | BG104633A (fr) |
| BR (1) | BR9907300A (fr) |
| CA (1) | CA2319198C (fr) |
| DE (1) | DE69934093T2 (fr) |
| EA (1) | EA200000768A1 (fr) |
| EE (1) | EE200000435A (fr) |
| HU (1) | HUP0101810A3 (fr) |
| IL (2) | IL137517A0 (fr) |
| IS (1) | IS5574A (fr) |
| NO (1) | NO20003808L (fr) |
| PL (1) | PL342243A1 (fr) |
| SK (1) | SK11082000A3 (fr) |
| TR (1) | TR200002182T2 (fr) |
| UA (1) | UA59433C2 (fr) |
| WO (1) | WO1999037304A1 (fr) |
| YU (1) | YU47600A (fr) |
| ZA (1) | ZA99607B (fr) |
Families Citing this family (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID23991A (id) * | 1997-09-30 | 2000-06-14 | Daiichi Seiyaku Co | Turunan-turunan sulfonil |
| US6403595B1 (en) * | 1998-02-05 | 2002-06-11 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, processes for producing the same and utilization thereof |
| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| AU5196399A (en) * | 1998-08-11 | 2000-03-06 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| JP2003529531A (ja) * | 1998-11-25 | 2003-10-07 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換オキソアザへテロシクリルＸａ因子阻害剤 |
| WO2000038683A1 (fr) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | INHIBITEURS DU FACTEUR Xa OU DE LA THROMBINE |
| WO2000078747A1 (fr) | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Derives acylhydrazine, procede d'elaboration et utilisation |
| PL354998A1 (en) * | 1999-07-28 | 2004-03-22 | Aventis Pharmaceuticals Products Inc. | Substituted oxoazaheterocyclyl compounds |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| JP2001294572A (ja) * | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| DE10012732A1 (de) | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| AR030357A1 (es) | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | Derivados 4 -, 5 -, 6 - y 7-indol |
| WO2002026734A1 (fr) * | 2000-09-29 | 2002-04-04 | Cor Therapeutics, Inc. | Amides piperazine-2-un comme inhibiteurs du facteur xa |
| CA2428123A1 (fr) | 2000-11-08 | 2002-05-16 | Shuji Kitamura | Derives de carbamate, ainsi que procede de production et utilisation de ceux-ci |
| DE10105989A1 (de) | 2001-02-09 | 2002-08-14 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
| ES2322158T3 (es) | 2001-04-18 | 2009-06-17 | Euro-Celtique S.A. | Derivados 1-(4-piperidinil)-1,3-dihidro-2h-indol-2-ona y compuestos afines como analogos de la nociceptina y ligandos del orl-1 para el tratamiento del dolor. |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| GB0114005D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| RU2004100839A (ru) | 2001-07-02 | 2005-06-20 | Астразенека Аб (Se) | Производные пиперидина полезные в качестве модуляторов активности рецепторов хемокинов |
| DE10134482A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| DE10137163A1 (de) | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| CA2458009C (fr) | 2001-08-24 | 2011-08-16 | Yale University | Composes de piperazinone utilises comme agents antitumoraux et anticancereux et procedes de traitement |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| DE10155727A1 (de) * | 2001-11-13 | 2003-05-28 | Morphochem Ag | Serin Protease Inhibitoren |
| SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| EP1314733A1 (fr) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides comme inhibiteurs du facteur Xa |
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| WO2003066595A2 (fr) | 2002-02-01 | 2003-08-14 | Euro-Celtique S.A. | Agents therapeutiques utiles pour le traitement de la douleur |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| WO2003066589A1 (fr) * | 2002-02-08 | 2003-08-14 | Glaxo Group Limited | Derives piperidylcarboxamide, et leur utilisation dans le traitement des maladies dont la mediation est assuree par les tachykinines |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| CA2484261A1 (fr) | 2002-04-16 | 2003-10-23 | Teijin Limited | Derives de piperidine possedant un antagonisme de ccr3 |
| CN100360521C (zh) | 2002-04-25 | 2008-01-09 | 帝人株式会社 | 具有ccr3拮抗作用的4,4-二取代的哌啶衍生物 |
| KR20030084444A (ko) * | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| US6864261B2 (en) | 2002-05-02 | 2005-03-08 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
| US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| ATE423111T1 (de) | 2003-07-03 | 2009-03-15 | Euro Celtique Sa | 2-pyridin alkyne derivaten und ihre verwendung für die schmerzbehandlung |
| CA2533509C (fr) | 2003-07-24 | 2011-02-22 | Euro-Celtique S.A. | Composes de piperidine et compositions pharmaceutiques les contenant |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| EP1687294B1 (fr) | 2003-11-17 | 2014-05-21 | Boehringer Ingelheim International GmbH | Indoles substitués par une pipéridine ou hétérodérivés des mêmes et leur utilisation comme modulateurs du récepteur des chemokines (ccr-3) |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| EP1722792A1 (fr) * | 2004-03-03 | 2006-11-22 | Boehringer Ingelheim International GmbH | Antagonistes de cgrp selectionnes, procedes de fabrication et utilisation en tant que medicament |
| US7269708B2 (en) * | 2004-04-20 | 2007-09-11 | Rambus Inc. | Memory controller for non-homogenous memory system |
| GB0414093D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| EP1784402B1 (fr) * | 2004-09-03 | 2011-08-03 | Yuhan Corporation | Derives pyrrolo[3,2-c]pyridine et procedes de preparation de ces derniers |
| GB0420831D0 (en) | 2004-09-17 | 2004-10-20 | Glaxo Group Ltd | Novel compounds |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| MX2007005205A (es) | 2004-10-29 | 2007-05-11 | Kalypsys Inc | Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma. |
| EP1685841A1 (fr) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention et traitement de troubles thromboemboliques |
| US7919495B2 (en) | 2005-02-17 | 2011-04-05 | Astellas Pharma, Inc. | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound |
| US7918848B2 (en) | 2005-03-25 | 2011-04-05 | Maquet Cardiovascular, Llc | Tissue welding and cutting apparatus and method |
| US8197472B2 (en) | 2005-03-25 | 2012-06-12 | Maquet Cardiovascular, Llc | Tissue welding and cutting apparatus and method |
| WO2006117314A2 (fr) | 2005-04-30 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Nouveaux indoles substitues par piperidines |
| US20060281768A1 (en) * | 2005-06-10 | 2006-12-14 | Gaul Michael D | Thienopyrimidine and thienopyridine kinase modulators |
| JP2009501793A (ja) | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規ピペリジン誘導体 |
| US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
| WO2007029629A1 (fr) | 2005-09-06 | 2007-03-15 | Shionogi & Co., Ltd. | Dérivé d’acide indolécarboxylate ayant une activité à effet antagoniste du récepteur pgd2 |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| BRPI0616574A2 (pt) | 2005-09-27 | 2009-11-24 | Shionogi & Co | derivado de sulfonamida tendo atividade antagonìstica de receptor de pgd2 |
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-
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- 1999-01-27 AU AU26533/99A patent/AU745425B2/en not_active Ceased
- 1999-01-27 UA UA2000085034A patent/UA59433C2/uk unknown
- 1999-01-27 PL PL99342243A patent/PL342243A1/xx not_active Application Discontinuation
- 1999-01-27 JP JP2000528286A patent/JP4676613B2/ja not_active Expired - Fee Related
- 1999-01-27 KR KR1020007008221A patent/KR20010034442A/ko not_active Withdrawn
- 1999-01-27 YU YU47600A patent/YU47600A/sh unknown
- 1999-01-27 SK SK1108-2000A patent/SK11082000A3/sk unknown
- 1999-01-27 ZA ZA9900607A patent/ZA99607B/xx unknown
- 1999-01-27 DE DE69934093T patent/DE69934093T2/de not_active Expired - Lifetime
- 1999-01-27 EP EP99906684A patent/EP1051176B1/fr not_active Expired - Lifetime
- 1999-01-27 AT AT99906684T patent/ATE346050T1/de not_active IP Right Cessation
- 1999-01-27 CN CN99803501A patent/CN1291892A/zh active Pending
- 1999-01-27 AP APAP/P/2000/001889A patent/AP2000001889A0/en unknown
- 1999-01-27 CA CA2319198A patent/CA2319198C/fr not_active Expired - Fee Related
- 1999-01-27 BR BR9907300-5A patent/BR9907300A/pt not_active IP Right Cessation
- 1999-01-27 WO PCT/US1999/001682 patent/WO1999037304A1/fr not_active Ceased
- 1999-01-27 EE EEP200000435A patent/EE200000435A/xx unknown
- 1999-01-27 TR TR2000/02182T patent/TR200002182T2/xx unknown
- 1999-01-27 EA EA200000768A patent/EA200000768A1/ru unknown
- 1999-01-27 IL IL13751799A patent/IL137517A0/xx active IP Right Grant
- 1999-01-27 HU HU0101810A patent/HUP0101810A3/hu unknown
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- 2000-07-25 NO NO20003808A patent/NO20003808L/no not_active Application Discontinuation
- 2000-07-25 IS IS5574A patent/IS5574A/is unknown
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- 2000-07-25 IL IL137517A patent/IL137517A/en not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| JP4676613B2 (ja) | 2011-04-27 |
| EA200000768A1 (ru) | 2001-06-25 |
| CA2319198A1 (fr) | 1999-07-29 |
| DE69934093T2 (de) | 2007-06-21 |
| CN1291892A (zh) | 2001-04-18 |
| KR20010034442A (ko) | 2001-04-25 |
| WO1999037304A1 (fr) | 1999-07-29 |
| AP2000001889A0 (en) | 2000-09-30 |
| IL137517A (en) | 2006-12-10 |
| BR9907300A (pt) | 2000-10-24 |
| NO20003808L (no) | 2000-09-26 |
| AU2653399A (en) | 1999-08-09 |
| NO20003808D0 (no) | 2000-07-25 |
| ATE346050T1 (de) | 2006-12-15 |
| US20040102450A1 (en) | 2004-05-27 |
| AU745425B2 (en) | 2002-03-21 |
| TR200002182T2 (tr) | 2000-12-21 |
| CA2319198C (fr) | 2011-02-22 |
| US7612075B2 (en) | 2009-11-03 |
| BG104633A (bg) | 2001-03-30 |
| SK11082000A3 (sk) | 2001-01-18 |
| EP1051176A1 (fr) | 2000-11-15 |
| HUP0101810A3 (en) | 2002-05-28 |
| IS5574A (is) | 2000-07-25 |
| HUP0101810A2 (hu) | 2002-04-29 |
| JP2002501024A (ja) | 2002-01-15 |
| ZA99607B (en) | 1999-07-27 |
| EP1051176A4 (fr) | 2002-06-12 |
| YU47600A (sh) | 2002-09-19 |
| UA59433C2 (uk) | 2003-09-15 |
| IL137517A0 (en) | 2001-07-24 |
| PL342243A1 (en) | 2001-06-04 |
| DE69934093D1 (de) | 2007-01-04 |
| EP1051176B1 (fr) | 2006-11-22 |
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