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DE60018792D1 - Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen - Google Patents

Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen

Info

Publication number
DE60018792D1
DE60018792D1 DE60018792T DE60018792T DE60018792D1 DE 60018792 D1 DE60018792 D1 DE 60018792D1 DE 60018792 T DE60018792 T DE 60018792T DE 60018792 T DE60018792 T DE 60018792T DE 60018792 D1 DE60018792 D1 DE 60018792D1
Authority
DE
Germany
Prior art keywords
alkylsulfonylpyrazole
imflammatory
heterocyclo
derivatives
analgetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60018792T
Other languages
English (en)
Other versions
DE60018792T2 (de
Inventor
Hengmiao Cheng
Jin Li
Kristin M Lundy
Martha Lou Minich
Subas Man Sakya
Chikara Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of DE60018792D1 publication Critical patent/DE60018792D1/de
Application granted granted Critical
Publication of DE60018792T2 publication Critical patent/DE60018792T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
DE60018792T 1999-12-03 2000-11-24 Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen Expired - Fee Related DE60018792T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16870199P 1999-12-03 1999-12-03
US168701P 1999-12-03
PCT/IB2000/001748 WO2001040216A1 (en) 1999-12-03 2000-11-24 Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

Publications (2)

Publication Number Publication Date
DE60018792D1 true DE60018792D1 (de) 2005-04-21
DE60018792T2 DE60018792T2 (de) 2006-01-26

Family

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DE60018792T Expired - Fee Related DE60018792T2 (de) 1999-12-03 2000-11-24 Heterocyclo-alkylsulfonylpyrazolderivate zur verwendung als anti-imflammatorische oder analgetische verbindungen

Country Status (34)

Country Link
US (2) US6531492B1 (de)
EP (1) EP1233959B1 (de)
JP (1) JP2003517475A (de)
KR (1) KR20020058074A (de)
CN (1) CN1423646A (de)
AP (1) AP2002002532A0 (de)
AR (1) AR026711A1 (de)
AT (1) ATE291019T1 (de)
AU (1) AU783359B2 (de)
BG (1) BG106694A (de)
BR (1) BR0016031A (de)
CA (1) CA2392931A1 (de)
CO (1) CO5261496A1 (de)
DE (1) DE60018792T2 (de)
DZ (1) DZ3246A1 (de)
EA (1) EA200200520A1 (de)
ES (1) ES2238324T3 (de)
GT (1) GT200000204A (de)
HK (1) HK1052701A1 (de)
HU (1) HUP0300157A3 (de)
IL (1) IL149581A0 (de)
IS (1) IS6376A (de)
MA (1) MA26848A1 (de)
MX (1) MXPA02005539A (de)
NO (1) NO20022624L (de)
OA (1) OA12100A (de)
PA (1) PA8508201A1 (de)
PE (1) PE20010962A1 (de)
PL (1) PL356669A1 (de)
SK (1) SK7412002A3 (de)
TN (1) TNSN00235A1 (de)
WO (1) WO2001040216A1 (de)
YU (1) YU35102A (de)
ZA (1) ZA200204285B (de)

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US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US20040248945A1 (en) * 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
AP2002002532A0 (en) * 1999-12-03 2002-06-30 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole derivatives as ant-inflammatory/analgesic agents.
ATE298749T1 (de) * 2001-07-05 2005-07-15 Pfizer Prod Inc Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel
DE10135027A1 (de) * 2001-07-18 2003-02-06 Solvay Pharm Gmbh Verwendung Trifluoracetylalkyl-substituierter Phenyl-, Phenol- und Benzoylderivate in der Behandlung und/oder Prophylaxe von Obestias und deren Begleit- und/oder Folgeerkrankungen
EP1419770A4 (de) * 2001-08-24 2005-08-03 Shionogi & Co Mittel zur beschleunigung der expression von apo ai
GT200200183A (es) 2001-09-28 2003-05-23 Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
YU67702A (sh) * 2001-09-28 2004-12-31 Pfizer Products Inc. Postupak za dobijanje alkansulfonil piridina
DK1441714T3 (da) * 2001-10-25 2008-03-31 Novartis Ag Kombinationer omfattende en selektiv cyclooxygenase-2-inhibitor
WO2003037351A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors
WO2003037330A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors
WO2003037335A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. 5-heteroatom-substituted pyrazoles
JP2005515171A (ja) 2001-11-02 2005-05-26 ファイザー・プロダクツ・インク ５−ヘテロ原子含有ピラゾールの効率的な合成法
WO2003037352A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders
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IS6376A (is) 2002-05-10
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KR20020058074A (ko) 2002-07-12
JP2003517475A (ja) 2003-05-27
AU783359B2 (en) 2005-10-20
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ATE291019T1 (de) 2005-04-15
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