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EE200200161A - Asendatud püridiinid ja püridasiinid, nende kasutamine angiogeneesi pärssimiseks ning neid sisaldavfarmatseutiline kompositsioon - Google Patents

Asendatud püridiinid ja püridasiinid, nende kasutamine angiogeneesi pärssimiseks ning neid sisaldavfarmatseutiline kompositsioon

Info

Publication number
EE200200161A
EE200200161A EEP200200161A EEP200200161A EE200200161A EE 200200161 A EE200200161 A EE 200200161A EE P200200161 A EEP200200161 A EE P200200161A EE P200200161 A EEP200200161 A EE P200200161A EE 200200161 A EE200200161 A EE 200200161A
Authority
EE
Estonia
Prior art keywords
pyridazines
pharmaceutical composition
composition containing
inhibiting angiogenesis
substituted pyridines
Prior art date
Application number
EEP200200161A
Other languages
English (en)
Inventor
P. Dumas Jacques
J. Boyer Stephen
A. Dixon Julie
Kite Joe Teddy
C. E. Kluender Harold
Lee Wendy
Nagarathnam Dhanapalan
N. Sibley Robert
Su Ning
Original Assignee
Bayer Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corporation filed Critical Bayer Corporation
Publication of EE200200161A publication Critical patent/EE200200161A/et
Publication of EE05258B1 publication Critical patent/EE05258B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
EEP200200161A 1999-09-28 2000-09-26 Asendatud pridiinid ja pridasiinid, nende kasutamine angiogeneesi p„rssimiseks ning neid sisaldav farmatseutiline kompositsioon EE05258B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28
PCT/US2000/026500 WO2001023375A2 (en) 1999-09-28 2000-09-26 Substituted pyridines and pyridazines with angiogenesis inhibiting activity

Publications (2)

Publication Number Publication Date
EE200200161A true EE200200161A (et) 2003-08-15
EE05258B1 EE05258B1 (et) 2010-02-15

Family

ID=23612752

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200161A EE05258B1 (et) 1999-09-28 2000-09-26 Asendatud pridiinid ja pridasiinid, nende kasutamine angiogeneesi p„rssimiseks ning neid sisaldav farmatseutiline kompositsioon

Country Status (35)

Country Link
EP (1) EP1228063B1 (et)
JP (1) JP4919567B2 (et)
KR (3) KR100895572B1 (et)
CN (3) CN100374435C (et)
AR (3) AR025752A1 (et)
AT (1) ATE422494T1 (et)
AU (1) AU782820B2 (et)
BG (1) BG65860B1 (et)
BR (1) BRPI0014382B8 (et)
CA (1) CA2385817C (et)
CO (1) CO5200835A1 (et)
CZ (1) CZ304767B6 (et)
DE (1) DE60041548D1 (et)
DO (1) DOP2000000070A (et)
EE (1) EE05258B1 (et)
ES (1) ES2320525T3 (et)
GT (1) GT200000158A (et)
HR (1) HRP20020308A2 (et)
HU (1) HU230223B1 (et)
IL (3) IL148880A0 (et)
MA (1) MA25563A1 (et)
MX (1) MXPA02003156A (et)
MY (3) MY135058A (et)
NO (1) NO20021520L (et)
NZ (1) NZ518589A (et)
PA (1) PA8503201A1 (et)
PE (1) PE20010607A1 (et)
PL (1) PL205957B1 (et)
RS (1) RS50369B (et)
RU (1) RU2260008C2 (et)
SK (1) SK287417B6 (et)
TW (1) TW593315B (et)
UA (1) UA75053C2 (et)
WO (1) WO2001023375A2 (et)
ZA (1) ZA200202760B (et)

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WO2007136103A1 (ja) 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. 甲状腺癌に対する抗腫瘍剤
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EP2119707B1 (en) 2007-01-29 2015-01-14 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
ES2564797T3 (es) 2009-08-19 2016-03-29 Eisai R&D Management Co., Ltd. Composición farmacéutica con contenido en un derivado de quinolina
RU2560683C2 (ru) 2010-06-25 2015-08-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое средство, задействующее соединения с ингибирующим эффектом к киназам в комбинации
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ES2705950T3 (es) 2011-06-03 2019-03-27 Eisai R&D Man Co Ltd Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
WO2014098176A1 (ja) 2012-12-21 2014-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体のアモルファス及びその製造方法
RU2658601C2 (ru) 2013-05-14 2018-06-21 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
CN103396361B (zh) * 2013-07-24 2016-05-04 中国人民解放军第二军医大学 3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
RS65049B1 (sr) 2015-02-25 2024-02-29 Eisai R&D Man Co Ltd Metoda za suzbijanje gorčine derivata kinolina
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Also Published As

Publication number Publication date
SK5912002A3 (en) 2003-01-09
HRP20020308B1 (et) 2013-01-31
EE05258B1 (et) 2010-02-15
MY135058A (en) 2008-01-31
MY143580A (en) 2011-05-31
AU1569601A (en) 2001-04-30
KR100895571B1 (ko) 2009-04-29
MA25563A1 (fr) 2002-10-01
PL205957B1 (pl) 2010-06-30
JP2003526632A (ja) 2003-09-09
TW593315B (en) 2004-06-21
EP1228063B1 (en) 2009-02-11
KR100895572B1 (ko) 2009-04-29
BR0014382B1 (pt) 2014-04-01
CZ304767B6 (cs) 2014-10-08
BR0014382A (pt) 2003-06-24
IL193368A0 (en) 2009-02-11
RU2260008C2 (ru) 2005-09-10
MXPA02003156A (es) 2002-09-30
DOP2000000070A (es) 2002-02-28
HUP0202704A3 (en) 2003-12-29
AR082232A2 (es) 2012-11-21
RS50369B (sr) 2009-11-10
CN1769283A (zh) 2006-05-10
CA2385817A1 (en) 2001-04-05
IL193367A (en) 2011-03-31
PL366342A1 (en) 2005-01-24
KR20080086547A (ko) 2008-09-25
WO2001023375A3 (en) 2002-05-02
KR20080091505A (ko) 2008-10-13
CN1769282A (zh) 2006-05-10
EP1228063A2 (en) 2002-08-07
AU782820B2 (en) 2005-09-01
MY143377A (en) 2011-05-13
ATE422494T1 (de) 2009-02-15
KR100890473B1 (ko) 2009-03-26
PE20010607A1 (es) 2001-07-12
HRP20020308A2 (en) 2004-06-30
KR20020038775A (ko) 2002-05-23
DE60041548D1 (de) 2009-03-26
PA8503201A1 (es) 2002-08-26
HK1091818A1 (zh) 2007-01-26
ZA200202760B (en) 2003-10-29
ES2320525T3 (es) 2009-05-25
YU22902A (sh) 2004-12-31
IL193367A0 (en) 2009-02-11
JP4919567B2 (ja) 2012-04-18
NZ518589A (en) 2005-03-24
AR082231A2 (es) 2012-11-21
WO2001023375A2 (en) 2001-04-05
BG106637A (bg) 2003-02-28
NO20021520L (no) 2002-05-23
HU230223B1 (en) 2015-10-28
HUP0202704A2 (hu) 2002-12-28
CA2385817C (en) 2010-05-04
BRPI0014382B8 (pt) 2021-05-25
UA75053C2 (en) 2006-03-15
CN100422173C (zh) 2008-10-01
IL148880A0 (en) 2002-09-12
GT200000158A (es) 2002-03-16
IL193368A (en) 2011-05-31
CN1420879A (zh) 2003-05-28
BG65860B1 (bg) 2010-03-31
NO20021520D0 (no) 2002-03-26
AR025752A1 (es) 2002-12-11
CN100422172C (zh) 2008-10-01
HK1091819A1 (zh) 2007-01-26
CN100374435C (zh) 2008-03-12
SK287417B6 (sk) 2010-09-07
CZ20021444A3 (cs) 2002-08-14
CO5200835A1 (es) 2002-09-27

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Effective date: 20101231

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Effective date: 20170926