EE04617B1 - 2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena - Google Patents

2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena

Info

Publication number: EE04617B1
Authority: EE; Estonia
Prior art keywords: diarylpyrazolo; cox; inhibitors; preparation; pyridazine derivatives
Prior art date: 1997-09-05

Application number

EEP200000113A

Other languages

English (en)

Inventor

John Beswick Paul

Baxter Campbell Ian

Mathews Neil

Naylor Alan

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-05

Filing date

1998-09-03

Publication date

2006-04-17

1997-09-05 Priority claimed from GBGB9718792.6A external-priority patent/GB9718792D0/en

1997-12-23 Priority claimed from GBGB9727116.7A external-priority patent/GB9727116D0/en

1998-09-03 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2000-12-15 Publication of EE200000113A publication Critical patent/EE200000113A/et

2006-04-17 Publication of EE04617B1 publication Critical patent/EE04617B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Communicable Diseases (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)

EEP200000113A 1997-09-05 1998-09-03 2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena EE04617B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9718792.6A GB9718792D0 (en)	1997-09-05	1997-09-05	Chemical compounds
GBGB9727116.7A GB9727116D0 (en)	1997-12-23	1997-12-23	Chemical compounds
PCT/EP1998/005558 WO1999012930A1 (en)	1997-09-05	1998-09-03	2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their prepa ration and their use as cyclooxygenase 2 (cox-2) inhibitors

Publications (2)

Publication Number	Publication Date
EE200000113A EE200000113A (et)	2000-12-15
EE04617B1 true EE04617B1 (et)	2006-04-17

Family

ID=26312181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000113A EE04617B1 (et)	1997-09-05	1998-09-03	2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena

Country Status (28)

Country	Link
US (4)	US6451794B1 (et)
EP (3)	EP1510519B1 (et)
KR (1)	KR100382619B1 (et)
CN (1)	CN1155600C (et)
AP (1)	AP1354A (et)
AT (3)	ATE317845T1 (et)
AU (1)	AU744997B2 (et)
BG (1)	BG64420B1 (et)
BR (1)	BR9812046A (et)
CA (1)	CA2303152A1 (et)
DE (3)	DE69827419T2 (et)
DK (1)	DK1032575T3 (et)
EA (1)	EA002775B1 (et)
EE (1)	EE04617B1 (et)
ES (3)	ES2231757T3 (et)
HR (1)	HRP20000122B1 (et)
HU (1)	HUP0003644A3 (et)
IL (1)	IL134688A (et)
IS (1)	IS5389A (et)
NO (1)	NO315559B1 (et)
NZ (1)	NZ502985A (et)
PL (1)	PL194557B1 (et)
PT (1)	PT1032575E (et)
SK (1)	SK283922B6 (et)
TR (1)	TR200000595T2 (et)
TW (1)	TW570922B (et)
WO (1)	WO1999012930A1 (et)
YU (1)	YU11900A (et)

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CZ302448B6 (cs)	2000-07-20	2011-05-25	Lauras As	Farmaceutický prostredek
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GB0025449D0 (en) *	2000-10-17	2000-11-29	Glaxo Group Ltd	Chemical compounds
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ES2262893T3 (es)	2001-10-05	2006-12-01	Smithkline Beecham Corporation	Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes.
GB0124934D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124941D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124938D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124932D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124933D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124939D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124931D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
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AU2002357164A1 (en)	2001-12-17	2003-06-30	Smithkline Beecham Corporation	Pyrazolopyridazine derivatives
KR100686537B1 (ko)	2001-12-28	2007-02-27	씨제이 주식회사	사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
KR100840907B1 (ko) *	2001-12-28	2008-06-24	씨제이제일제당 (주)	사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난바이피리디닐 유도체
KR101058292B1 (ko) *	2002-02-12	2011-08-22	글락소스미스클라인 엘엘씨	Ｐ38 억제제로 유용한 니코틴아미드 유도체
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EP1539679A4 (en)	2002-06-28	2007-07-04	Nitromed Inc	OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS
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GB0221443D0 (en)	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
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US20040220155A1 (en) *	2003-03-28	2004-11-04	Pharmacia Corporation	Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
GB0308201D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308186D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308185D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
DE602004002832T2 (de)	2003-05-07	2007-06-06	Osteologix A/S	Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
US20050014729A1 (en) *	2003-07-16	2005-01-20	Pharmacia Corporation	Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
GB0318814D0 (en) *	2003-08-11	2003-09-10	Smithkline Beecham Corp	Novel compounds
GB0319037D0 (en) *	2003-08-13	2003-09-17	Glaxo Group Ltd	7-Azaindole Derivatives
US20050119262A1 (en) *	2003-08-21	2005-06-02	Pharmacia Corporation	Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
WO2005023189A2 (en) *	2003-09-03	2005-03-17	Pharmacia Corporation	Method of cox-2 selective inhibitor and nitric oxide-donating agent
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Publication number	Publication date
US20030040517A1 (en)	2003-02-27
CA2303152A1 (en)	1999-03-18
JP2001515901A (ja)	2001-09-25
SK2942000A3 (en)	2001-03-12
EP1032575A1 (en)	2000-09-06
KR20010023669A (ko)	2001-03-26
DK1032575T3 (da)	2003-10-20
HRP20000122B1 (en)	2003-06-30
BR9812046A (pt)	2000-09-26
WO1999012930A1 (en)	1999-03-18
BG104279A (en)	2000-12-29
EE200000113A (et)	2000-12-15
TR200000595T2 (tr)	2000-12-21
AU9439598A (en)	1999-03-29
ES2256817T3 (es)	2006-07-16
HUP0003644A2 (hu)	2001-09-28
EP1510519A1 (en)	2005-03-02
US20030008872A1 (en)	2003-01-09
EP1369421A1 (en)	2003-12-10
YU11900A (sh)	2002-11-15
AU744997B2 (en)	2002-03-07
NZ502985A (en)	2002-04-26
DE69833464T2 (de)	2006-08-24
EP1032575B1 (en)	2003-07-23
ATE317845T1 (de)	2006-03-15
US6451794B1 (en)	2002-09-17
PL339059A1 (en)	2000-12-04
US6861429B2 (en)	2005-03-01
HUP0003644A3 (en)	2002-11-28
HRP20000122A2 (en)	2001-02-28
DE69816651D1 (de)	2003-08-28
EA002775B1 (ru)	2002-08-29
JP3167700B2 (et)	2001-05-21
PL194557B1 (pl)	2007-06-29
EA200000188A1 (ru)	2000-10-30
DE69827419D1 (de)	2004-12-09
DE69816651T2 (de)	2004-04-01
DE69827419T2 (de)	2005-10-27
ES2203985T3 (es)	2004-04-16
ATE281458T1 (de)	2004-11-15
NO20001102L (no)	2000-05-03
US6831097B2 (en)	2004-12-14
EP1510519B1 (en)	2006-02-15
AP2000001753A0 (en)	2000-03-31
ATE245649T1 (de)	2003-08-15
IL134688A (en)	2005-05-17
AP1354A (en)	2004-12-29
CN1155600C (zh)	2004-06-30
NO20001102D0 (no)	2000-03-03
CN1278263A (zh)	2000-12-27
NO315559B1 (no)	2003-09-22
ES2231757T3 (es)	2005-05-16
PT1032575E (pt)	2003-11-28
IS5389A (is)	2000-02-25
SK283922B6 (sk)	2004-05-04
EP1369421B1 (en)	2004-11-03
BG64420B1 (bg)	2005-01-31
TW570922B (en)	2004-01-11
DE69833464D1 (de)	2006-04-20
IL134688A0 (en)	2001-04-30
US20050113377A1 (en)	2005-05-26
KR100382619B1 (ko)	2003-05-09

Publication	Publication Date	Title
EE04617B1 (et)	2006-04-17	2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena
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EE200200080A (et)	2003-06-16	Imidaso[1,2a]püridiini ja pürasolo[2,3a]püridiiniderivaadid
FI961457L (fi)	1997-09-30	Uusi kompleksiyhdiste, sen valmistus ja käyttö
FI951468A7 (fi)	1995-10-01	Lipopeptidijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö
EE200000037A (et)	2000-10-16	Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
EE200200160A (et)	2003-04-15	2'-asendatud 1,1'-bifenüül-2-karboksamiidid, nende kasutamine ja farmatseutilised preparaadid
EE200000621A (et)	2002-06-17	Pikornaviirusevastased ühendid, nende valmistamine ja kasutamine
FI990134A0 (fi)	1999-01-25	Pyridatsino-(4,5-beta)-kinoliini-5-oksidijohdannaisia, niiden valmistus ja niiden käyttö glysiiniantagonisteina
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EE200000056A (et)	2000-10-16	4-okso-3,5-dihüdro-4H-püridasino[4.5-b]indool-1-etaanamiidi derivaadid, nende valmistamine ja kasutamine raviks
EE9800333A (et)	1999-04-15	Uued furaandiarüülmetülideeni derivaadid, nende valmistamise meetod ja kasutamine teraapias
EE200000207A (et)	2001-04-16	8-asabitsüklo[3.2.1]oktaan-3-metaanamiini derivaadid, nende valmistamine ja terapeutiline kasutamine
FI970750L (fi)	1997-03-13	Indoli-2,3-dioni-3-oksimijohdannaisia, niiden valmistus ja käyttö
AU6120298A (en)	1998-09-22	2-peperazinone-1-acetic acid derivatives and their use
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HK1028770A (en)	2001-03-02	2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) inhibitors
SI1032575T1 (en)	2003-12-31	2,3-diaryl-pyrazolo(1,5-b)pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) inhibitors
AU5522499A (en)	2000-04-03	2-aminoethyl-quinoline derivatives, preparation and therapeutic use
AU1476900A (en)	2000-06-05	1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors
FI950021A7 (fi)	1995-12-30	Tienopyrimidiinijohdannaiset, niiden valmistus ja käyttö
SI0977741T1 (en)	2003-12-31	Substituted phenyl derivatives, their preparation and use
FI945314L (fi)	1996-05-12	Tetrasolijohdannaiset, niiden valmistus ja käyttö

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