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ECSP19015794A - Formas cristalinas de un inhibidor de tirosina quinasa de bruton - Google Patents

Formas cristalinas de un inhibidor de tirosina quinasa de bruton

Info

Publication number
ECSP19015794A
ECSP19015794A ECSENADI201915794A ECDI201915794A ECSP19015794A EC SP19015794 A ECSP19015794 A EC SP19015794A EC SENADI201915794 A ECSENADI201915794 A EC SENADI201915794A EC DI201915794 A ECDI201915794 A EC DI201915794A EC SP19015794 A ECSP19015794 A EC SP19015794A
Authority
EC
Ecuador
Prior art keywords
tyrosine kinase
crystalline forms
inhibitor
kinase inhibitor
conditions
Prior art date
Application number
ECSENADI201915794A
Other languages
English (en)
Inventor
David Wirth
Norbert Purro
Erick Goldman
Mark Smyth
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP19015794(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of ECSP19015794A publication Critical patent/ECSP19015794A/es

Links

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

Se describe aquí al inhibidor de tirosina quinasa (Btk) de Bruton 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo[3,4-d] pirimidin-1-il)piperidin-1-il)prop-2-en-1-ona, incluyendo las formas cristalinas, solvatos y sus sales aceptables en el campo farmacéutico. Se describe también composiciones farmacéuticas que incluyen al inhibidor Btk, así como métodos para usar a dicho inhibidor solo o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, incluyendo linfoma, así como enfermedades o condiciones inflamatorias.
ECSENADI201915794A 2012-06-04 2019-03-06 Formas cristalinas de un inhibidor de tirosina quinasa de bruton ECSP19015794A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261655381P 2012-06-04 2012-06-04

Publications (1)

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ECSP19015794A true ECSP19015794A (es) 2019-03-29

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ID=49712527

Family Applications (2)

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ECIEPI201433163A ECSP14033163A (es) 2012-06-04 2014-12-24 Formas cristalinas de un inhibidor de tirosina quinasa de bruton
ECSENADI201915794A ECSP19015794A (es) 2012-06-04 2019-03-06 Formas cristalinas de un inhibidor de tirosina quinasa de bruton

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US (26) US9296753B2 (es)
EP (1) EP2854859A4 (es)
JP (10) JP6236071B2 (es)
KR (8) KR20210033067A (es)
CN (2) CN110354132A (es)
AR (2) AR092844A1 (es)
AU (7) AU2013271918C1 (es)
BR (1) BR112014030424A8 (es)
CA (4) CA2991994C (es)
CL (3) CL2014003306A1 (es)
CO (1) CO7240408A2 (es)
CR (1) CR20140558A (es)
DO (3) DOP2014000274A (es)
EA (1) EA201492082A1 (es)
EC (2) ECSP14033163A (es)
GT (1) GT201400281A (es)
HK (1) HK1208803A1 (es)
IL (4) IL315394A (es)
JO (2) JO3754B1 (es)
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MY (2) MY187999A (es)
NZ (4) NZ737725A (es)
PE (3) PE20190390A1 (es)
PH (3) PH12021552282A1 (es)
SG (2) SG11201408067YA (es)
TN (1) TN2014000492A1 (es)
TW (3) TWI653041B (es)
UA (2) UA126959C2 (es)
UY (2) UY34848A (es)
WO (1) WO2013184572A1 (es)
ZA (4) ZA202105174B (es)

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EA018573B1 (ru) 2006-09-22 2013-09-30 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
JP5369183B2 (ja) 2008-07-16 2013-12-18 ファーマサイクリックス，インク． 固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
US20120087915A1 (en) 2010-06-03 2012-04-12 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)
SG10201600077RA (en) 2011-01-11 2016-02-26 Glaxosmithkline Llc Combination
CA2841080A1 (en) 2011-07-13 2013-01-17 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
PT3409278T (pt) 2011-07-21 2020-12-18 Sumitomo Dainippon Pharma Oncology Inc Inibidores de proteína cinase heterocíclicos
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US20170334921A1 (en) 2017-11-23
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US20150158871A1 (en) 2015-06-11
BR112014030424A8 (pt) 2017-07-11
AU2013271918A1 (en) 2015-01-22
EP2854859A4 (en) 2016-01-13
CO7240408A2 (es) 2015-04-17
US9725455B1 (en) 2017-08-08
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US10294232B2 (en) 2019-05-21
US20180362535A1 (en) 2018-12-20
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AR118108A2 (es) 2021-09-15
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US20140336203A1 (en) 2014-11-13
US20180179215A1 (en) 2018-06-28
AU2018211216B2 (en) 2020-06-25
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US10961251B1 (en) 2021-03-30
US20180319805A1 (en) 2018-11-08
CL2014003306A1 (es) 2015-04-17
CA3015208A1 (en) 2013-12-12
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US20170305919A1 (en) 2017-10-26
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US20210032258A1 (en) 2021-02-04
US20180362536A1 (en) 2018-12-20
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PE20150174A1 (es) 2015-02-12
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US20210070759A1 (en) 2021-03-11
CL2017003496A1 (es) 2018-06-22
UY39740A (es) 2022-06-30
US10125140B1 (en) 2018-11-13
DOP2014000274A (es) 2015-03-31
CA2875986A1 (en) 2013-12-12
US20220112196A1 (en) 2022-04-14
KR20210033067A (ko) 2021-03-25
US20180362534A1 (en) 2018-12-20
GT201400281A (es) 2019-08-12
IL315394A (en) 2024-11-01
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TW201402122A (zh) 2014-01-16
US20180155352A1 (en) 2018-06-07
PE20190390A1 (es) 2019-03-13
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CA3218491A1 (en) 2013-12-12
US9713617B2 (en) 2017-07-25
US20190248799A1 (en) 2019-08-15
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