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AR118108A2 - Formas cristalinas de un inhibidor de tirosina quinasa de bruton - Google Patents

Formas cristalinas de un inhibidor de tirosina quinasa de bruton

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Publication number
AR118108A2
AR118108A2 ARP200100425A ARP200100425A AR118108A2 AR 118108 A2 AR118108 A2 AR 118108A2 AR P200100425 A ARP200100425 A AR P200100425A AR P200100425 A ARP200100425 A AR P200100425A AR 118108 A2 AR118108 A2 AR 118108A2
Authority
AR
Argentina
Prior art keywords
minus
plus
weight
pharmaceutical preparation
diluent
Prior art date
Application number
ARP200100425A
Other languages
English (en)
Inventor
David D Wirth
Erick Goldman
Mark Smyth
Norbert Purro
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR118108(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of AR118108A2 publication Critical patent/AR118108A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se describe aquí al inhibidor de tirosina quinasa (Btk) de Bruton 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo[3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1-ona, incluyendo las formas cristalinas, solvatos y sus sales aceptables en el campo farmacéutico. Se describe también composiciones farmacéuticas que incluyen al inhibidor Btk, así como métodos para usar a dicho inhibidor solo o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, incluyendo linfoma, así como enfermedades o condiciones inflamatorias. Reivindicación 1: Una preparación farmacéutica para administración oral caracterizada porque comprende: (a) más o menos 40 a más o menos 200 mgs de 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo[3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1-ona; (b) más o menos 40% en peso a más o menos 50% en peso de un diluyente; (c) más o menos 3% en peso a más o menos 10% en peso de un agente desintegrador; (d) más o menos 2% en peso a más o menos 7% en peso de un agente de actividad superficial; y (e) más o menos 0,2% en peso a más o menos 1,0% en peso de un lubricante. Reivindicación 2: La preparación farmacéutica, de acuerdo con la reivindicación 1, caracterizada porque el diluyente está seleccionado a partir del grupo que consiste de lactosa, sucrosa, dextrosa, dextratos, maltodextrin, manitol, xilitol, sorbitol, ciclodextrinas, fosfato de calcio, sulfato de calcio, almidones, almidones modificados, celulosa microcristalina, microcelulosa, etc. Reivindicación 3: La preparación farmacéutica, de acuerdo con la reivindicación 2, caracterizada porque el diluyente es una celulosa microcristalina. Reivindicación 11: La preparación farmacéutica, de acuerdo con cualesquiera reivindicaciones 1 - 10, caracterizada porque la forma de dosificación es una cápsula de gelatina dura.
ARP200100425A 2012-06-04 2020-02-14 Formas cristalinas de un inhibidor de tirosina quinasa de bruton AR118108A2 (es)

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AR118108A2 true AR118108A2 (es) 2021-09-15

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ARP200100425A AR118108A2 (es) 2012-06-04 2020-02-14 Formas cristalinas de un inhibidor de tirosina quinasa de bruton

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EP (1) EP2854859A4 (es)
JP (10) JP6236071B2 (es)
KR (8) KR20230170108A (es)
CN (2) CN110354132A (es)
AR (2) AR092844A1 (es)
AU (7) AU2013271918C1 (es)
BR (1) BR112014030424A8 (es)
CA (4) CA2991994C (es)
CL (3) CL2014003306A1 (es)
CO (1) CO7240408A2 (es)
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DO (3) DOP2014000274A (es)
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EC (2) ECSP14033163A (es)
GT (1) GT201400281A (es)
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TW (3) TWI662964B (es)
UA (2) UA114421C2 (es)
UY (2) UY39740A (es)
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Families Citing this family (128)

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IL235894B (en) 2020-03-31
AU2016250445A1 (en) 2016-11-17
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