MX2019005029A - Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk). - Google Patents
Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk).Info
- Publication number
- MX2019005029A MX2019005029A MX2019005029A MX2019005029A MX2019005029A MX 2019005029 A MX2019005029 A MX 2019005029A MX 2019005029 A MX2019005029 A MX 2019005029A MX 2019005029 A MX2019005029 A MX 2019005029A MX 2019005029 A MX2019005029 A MX 2019005029A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- methods
- cell therapy
- compositions
- therapy
- Prior art date
Links
- 238000002659 cell therapy Methods 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 abstract 2
- 239000002955 immunomodulating agent Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002688 persistence Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Oncology (AREA)
Abstract
En la presente se proporcionan métodos, composiciones y usos que involucran inmunoterapias, tales como la terapia celular adoptiva, por ejemplo, terapia con células T, e inhibidores de una cinasa de la familia TEK, tal como BTK o ITK. Los métodos, composiciones y usos proporcionados incluyen aquellos para terapias de combinación que involucran la administración o el uso de uno o más inhibidores junto con otro agente, tal como un agente inmunoterapéutico dirigido a las células T, tal como un anticuerpo terapéutico, por ejemplo, un anticuerpo multiespecífico (por ejemplo, de activación de células T), y/o células T modificadas genéticamente, tales como las células T que expresan un receptor de antígeno quimérico (CAR). También se proporcionan métodos de fabricación de células T modificadas, composiciones, métodos de administración a sujetos, ácidos nucleicos, artículos de fabricación y kits para uso en los métodos. En algunos aspectos, las características de los métodos y las células proporcionan un aumento o mejora de la actividad, la eficacia, la persistencia, la expansión y/o la proliferación de células T para la terapia celular adoptiva o células T endógenas reclutadas por agentes inmunoterapéuticos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417312P | 2016-11-03 | 2016-11-03 | |
| US201662429735P | 2016-12-03 | 2016-12-03 | |
| US201762574706P | 2017-10-19 | 2017-10-19 | |
| PCT/US2017/060060 WO2018085731A2 (en) | 2016-11-03 | 2017-11-03 | Combination therapy of a t cell therapy and a btk inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019005029A true MX2019005029A (es) | 2019-10-24 |
Family
ID=60515805
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019005029A MX2019005029A (es) | 2016-11-03 | 2017-11-03 | Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk). |
| MX2023004707A MX2023004707A (es) | 2016-11-03 | 2019-04-29 | Combinacion de celulas t y un inhibidor de tirosina cinasa de bruton (btk) y su uso en terapia. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023004707A MX2023004707A (es) | 2016-11-03 | 2019-04-29 | Combinacion de celulas t y un inhibidor de tirosina cinasa de bruton (btk) y su uso en terapia. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20190298772A1 (es) |
| EP (1) | EP3534938A2 (es) |
| JP (2) | JP2019532997A (es) |
| CN (1) | CN110139669A (es) |
| AU (1) | AU2017355544A1 (es) |
| CA (1) | CA3042049A1 (es) |
| MA (1) | MA46783A (es) |
| MX (2) | MX2019005029A (es) |
| WO (1) | WO2018085731A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019006288A (es) | 2016-12-03 | 2020-10-01 | Juno Therapeutics Inc | Metodos y composiciones para el uso de celulas t terapeuticas en combinacion con inhibidores de quinasa. |
| KR20240139092A (ko) * | 2017-05-01 | 2024-09-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 세포 요법 및 면역조절 화합물의 조합 |
| WO2018223101A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| WO2019089982A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | Ｂ細胞成熟抗原（ｂｃｍａ）に特異的なキメラ抗原受容体 |
| JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| BR112021008930A2 (pt) | 2018-11-08 | 2021-11-03 | Juno Therapeutics Inc | Métodos e combinações para o tratamento e modulação de célula t |
| CN113164408B (zh) * | 2018-12-07 | 2025-07-22 | 克莱格医学有限公司 | 肿瘤联合免疫治疗 |
| KR102820082B1 (ko) * | 2019-07-26 | 2025-06-13 | 주식회사유한양행 | 항-her2/항-4-1bb 이중 특이 항체 및 이의 용도 |
| CN115087868A (zh) | 2019-11-05 | 2022-09-20 | 朱诺治疗学股份有限公司 | 确定治疗性t细胞组合物的属性的方法 |
| AU2021237717A1 (en) * | 2020-03-20 | 2022-10-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T-cells and T-cell receptors from tumor by single-cell analysis for immunotherapy |
| US20230178239A1 (en) | 2020-05-13 | 2023-06-08 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| WO2023278424A1 (en) * | 2021-06-28 | 2023-01-05 | The Regents Of The University Of California | Methods for treating and ameliorating t cell related diseases |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2025137059A1 (en) * | 2023-12-18 | 2025-06-26 | Corvus Pharmaceuticals, Inc. | Use of itk inhibitors and car t-cell therapy |
| WO2026020055A2 (en) | 2024-07-18 | 2026-01-22 | Juno Therapeutics, Inc. | Methods for assessing exosomes in a cell composition and related uses |
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-
2017
- 2017-11-03 MX MX2019005029A patent/MX2019005029A/es unknown
- 2017-11-03 CN CN201780082035.6A patent/CN110139669A/zh active Pending
- 2017-11-03 US US16/346,528 patent/US20190298772A1/en not_active Abandoned
- 2017-11-03 CA CA3042049A patent/CA3042049A1/en active Pending
- 2017-11-03 EP EP17807967.9A patent/EP3534938A2/en not_active Withdrawn
- 2017-11-03 JP JP2019523665A patent/JP2019532997A/ja not_active Withdrawn
- 2017-11-03 WO PCT/US2017/060060 patent/WO2018085731A2/en not_active Ceased
- 2017-11-03 MA MA046783A patent/MA46783A/fr unknown
- 2017-11-03 AU AU2017355544A patent/AU2017355544A1/en not_active Abandoned
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2019
- 2019-04-29 MX MX2023004707A patent/MX2023004707A/es unknown
-
2023
- 2023-06-23 JP JP2023103197A patent/JP2023120386A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3534938A2 (en) | 2019-09-11 |
| MX2023004707A (es) | 2023-05-09 |
| WO2018085731A3 (en) | 2018-07-12 |
| AU2017355544A1 (en) | 2019-05-16 |
| US20190298772A1 (en) | 2019-10-03 |
| MA46783A (fr) | 2019-09-11 |
| JP2023120386A (ja) | 2023-08-29 |
| CA3042049A1 (en) | 2018-05-11 |
| CN110139669A (zh) | 2019-08-16 |
| JP2019532997A (ja) | 2019-11-14 |
| WO2018085731A2 (en) | 2018-05-11 |
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