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EA201000866A1 - Производные амидов 6,7-дигидро-5н-имидазо[1,2-а]имидазол-3-карбоновой кислоты - Google Patents

Производные амидов 6,7-дигидро-5н-имидазо[1,2-а]имидазол-3-карбоновой кислоты

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Publication number
EA201000866A1
EA201000866A1 EA201000866A EA201000866A EA201000866A1 EA 201000866 A1 EA201000866 A1 EA 201000866A1 EA 201000866 A EA201000866 A EA 201000866A EA 201000866 A EA201000866 A EA 201000866A EA 201000866 A1 EA201000866 A1 EA 201000866A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazo
dihydro
derivatives
imidazol
amides
Prior art date
Application number
EA201000866A
Other languages
English (en)
Other versions
EA017688B1 (ru
Inventor
Рене М. Лемьё
Антонио Хосе Дель Мораль Барбоса
Йёрг Мартин Бентцин
Стивен Ричард Брюнетте
Чжидон Чэнь
Дерек Коган
Донхон А. Гао
Александер Хайм-Ритер
Джошуа Кортни Хоран
Дженнифер А. Ковальски
Майкл Дейвид Лолор
Вэйминь Лю
Брайан МакКиббен
Крейг Эндрью Миллер
Нил Мосс
Матт Аарон Чантц
Чжаомин Сюйн
Сюй Ю
Ян Ю
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201000866A1 publication Critical patent/EA201000866A1/ru
Publication of EA017688B1 publication Critical patent/EA017688B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке описаны производные амида 6,7-дигидро-5Н-имидазо[1,2-а]имидазол-3-карбоновой кислоты, оказывающие значительное ингибирующее воздействие на взаимодействие CAMs с лейкоинтегринами и поэтому применимые для лечения воспалительного заболевания.
EA201000866A 2007-11-29 2008-11-20 ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5Н-ИМИДАЗО[1,2-a]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ EA017688B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99096007P 2007-11-29 2007-11-29
US4795708P 2008-04-25 2008-04-25
PCT/US2008/084149 WO2009070485A1 (en) 2007-11-29 2008-11-20 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES

Publications (2)

Publication Number Publication Date
EA201000866A1 true EA201000866A1 (ru) 2010-12-30
EA017688B1 EA017688B1 (ru) 2013-02-28

Family

ID=40193954

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000866A EA017688B1 (ru) 2007-11-29 2008-11-20 ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5Н-ИМИДАЗО[1,2-a]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ

Country Status (31)

Country Link
US (1) US8552205B2 (ru)
EP (1) EP2225238B1 (ru)
JP (1) JP5485164B2 (ru)
KR (1) KR20100101095A (ru)
CN (1) CN101889011B (ru)
AR (1) AR069513A1 (ru)
AU (1) AU2008329909B2 (ru)
BR (1) BRPI0819831A2 (ru)
CA (1) CA2705583A1 (ru)
CL (1) CL2008003576A1 (ru)
CO (1) CO6210701A2 (ru)
CY (1) CY1115857T1 (ru)
DK (1) DK2225238T3 (ru)
EA (1) EA017688B1 (ru)
EC (1) ECSP10010196A (ru)
ES (1) ES2525237T3 (ru)
HR (1) HRP20141171T1 (ru)
IL (1) IL205189A (ru)
MA (1) MA31905B1 (ru)
MX (1) MX2010004995A (ru)
MY (1) MY151004A (ru)
NZ (1) NZ585640A (ru)
PE (1) PE20091427A1 (ru)
PL (1) PL2225238T3 (ru)
PT (1) PT2225238E (ru)
RS (1) RS53602B1 (ru)
SI (1) SI2225238T1 (ru)
TN (1) TN2010000240A1 (ru)
TW (2) TWI475990B (ru)
UY (1) UY31493A1 (ru)
WO (1) WO2009070485A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141330A1 (en) * 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
PL2445909T3 (pl) * 2009-06-02 2014-04-30 Boehringer Ingelheim Int Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego
DK2491028T3 (da) 2009-10-21 2014-01-13 Boehringer Ingelheim Int Indazol og pyrazolopyridine forbindelser som CCR1 receptor antagonister
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
DK2703392T3 (en) 2011-04-27 2017-09-25 Shionogi & Co AROMATIC HETEROCYCLIC DERIVATIVE IN THE FORM OF A 5-JOINT RING WITH NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY
KR20140051998A (ko) 2011-08-03 2014-05-02 교와 핫꼬 기린 가부시키가이샤 디벤조옥세핀 유도체
US9475814B2 (en) 2011-10-03 2016-10-25 Euroscreen S.A. Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
US9809524B1 (en) 2014-10-14 2017-11-07 Syngenta Participations Process for the preparation of 1-(3,5-dichloro-4-fluoro-phenyl)-2,2,2-trifluoro-ethanone
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CN106631827B (zh) * 2016-12-30 2018-10-23 上海毕得医药科技有限公司 一种(1-环丙基-1-甲基)乙基胺及其盐酸盐的合成方法
CN109369432B (zh) * 2018-11-02 2021-06-25 永农生物科学有限公司 (s)-4-氯-2-氨基丁酸酯的制备方法
EP4285723A3 (en) 2019-12-20 2024-03-27 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof
CN111848521A (zh) * 2020-08-26 2020-10-30 韶远科技（上海)有限公司 一种2-取代-4-烷氧基咪唑化合物的制备方法
WO2024013736A1 (en) * 2022-07-12 2024-01-18 Adama Makhteshim Ltd. Process for preparing substituted benzamides
WO2025021943A1 (en) 2023-07-26 2025-01-30 Neuralis Quinazolinone, benzoxazinone and benzoxazepinone derivatives as protein kinase inhibitors

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2015493A1 (ru) 1968-08-12 1970-04-30 Sumitomo Chemical Co
DK123717B (da) 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS5136332B1 (ru) 1970-12-09 1976-10-07
DE3382406D1 (de) 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
JPS63270665A (ja) 1987-04-30 1988-11-08 Wakamoto Pharmaceut Co Ltd イミダゾ−ル誘導体
JPS63270667A (ja) 1987-04-30 1988-11-08 Wakamoto Pharmaceut Co Ltd １−ベンジルイミダゾ−ル誘導体
IE940525L (en) 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
US5306822A (en) 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
US5208250A (en) 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
US4977270A (en) 1988-12-01 1990-12-11 Ici Americas Inc. Substituted 2,4-dioxodiazolidines and -thiadiazolidines and their use as herbicides
US4911748A (en) 1988-12-22 1990-03-27 Ici Americas Inc. Herbicidal 5-substituted-3-phenyl-imidazolidine-2,4-diones
JPH04273877A (ja) 1991-02-28 1992-09-30 Sumitomo Pharmaceut Co Ltd 新規なイミダゾール誘導体
EP0545478A1 (en) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
JPH05188631A (ja) 1992-01-10 1993-07-30 Mita Ind Co Ltd 電子写真感光体
TW521073B (en) 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
US20040006011A1 (en) 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
NZ335000A (en) 1996-10-28 2000-12-22 Univ Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
TR199902124T2 (xx) 1997-03-03 2000-06-21 Boehringer Ingelheim Pharmaceuticals, Inc. �ltihapl� hastal�klar�n tedavisinde yararl� k���k molek�ller.
US6355664B1 (en) 1997-03-03 2002-03-12 Boehringer Ingelheim Pharmaceuticals, Inc. Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease
EP1007033B1 (en) 1997-08-28 2008-04-23 Novartis AG Lymphocyte function antigen-1 antagonists
EP1063982B1 (en) 1998-03-27 2007-02-14 Genentech, Inc. Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
WO2001007052A1 (en) 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
US6350763B1 (en) 1999-07-21 2002-02-26 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammation disease
WO2001007044A1 (en) 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
EP1399155B1 (en) 1999-07-21 2008-05-28 Boehringer Ingelheim Pharmaceuticals Inc. Small molecules useful in the treatment of inflammatory disease
US6492408B1 (en) 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
CN1185232C (zh) 1999-10-20 2005-01-19 田边制药株式会社 αLβ2介导细胞粘连抑制剂
US20030008848A1 (en) 2000-12-19 2003-01-09 Fleck Roman Wolfgang Small molecules useful in the treatment of inflammatory disease
BR0206698A (pt) * 2001-01-26 2004-04-20 Bristol Myers Squibb Co Derivados de imidazolila como inibidores de fator de liberação de corticotropina.
US20030232817A1 (en) 2002-05-29 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful for the treatment of inflammatory disease
US6852748B1 (en) 2002-10-30 2005-02-08 Boehringer Ingelheim Pharmaceuticals, Inc. Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
US6844360B2 (en) 2002-10-30 2005-01-18 Boehringer Ingelheim Pharmaceuticals, Inc. Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide
CN101027304A (zh) 2004-07-27 2007-08-29 贝林格尔·英格海姆国际有限公司 6,7－二氢－5h－咪唑并[1,2－a]咪唑－3－磺酰胺的合成
EP1869012A1 (en) 2005-04-05 2007-12-26 Boehringer Ingelheim International Gmbh Substituted benzylimidazoles useful for the treatment of inflammatory diseases
EP1868603A1 (en) 2005-04-06 2007-12-26 Boehringer Ingelheim Pharma GmbH & Co. KG DERIVATIVES OF Ý6,7-DIHYDRO-5HIMIDAZO Ýl,2-ALPHA¨IMIDAZOLE-3-SULFONYL¨-AZETEDINE-CARBOXYLIC ACIDS, ESTERS AND AMIDES AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS
AU2006285401A1 (en) 2005-05-19 2007-03-08 Boehringer Ingelheim International, Gmbh Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid
TW200831488A (en) 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
KR101178319B1 (ko) 2007-11-29 2012-09-07 액테리온 파마슈티칼 리미티드 포스폰산 유도체 및 ｐ2ｙ12 수용체 길항물질로서 이들의 용도
AR069740A1 (es) 2007-11-29 2010-02-17 Metabasis Therapeutics Inc Compuestos nucleosidos antivirales
JP2009149609A (ja) 2007-11-29 2009-07-09 Sumitomo Chemical Co Ltd アミド化合物及びその用途
EP2080758A3 (de) 2007-11-29 2009-08-26 Bayer CropScience AG Halogen substituierte delta-1-Pyrroline
PL2445909T3 (pl) 2009-06-02 2014-04-30 Boehringer Ingelheim Int Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego
WO2010141330A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES

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MA31905B1 (fr) 2010-12-01
CL2008003576A1 (es) 2010-02-12
MX2010004995A (es) 2010-05-20
SI2225238T1 (sl) 2014-12-31
BRPI0819831A2 (pt) 2019-09-24
CY1115857T1 (el) 2017-01-25
ES2525237T3 (es) 2014-12-19
RS53602B1 (sr) 2015-02-27
JP2011505359A (ja) 2011-02-24
CN101889011B (zh) 2014-05-28
AU2008329909B2 (en) 2013-10-03
US20110224188A1 (en) 2011-09-15
WO2009070485A1 (en) 2009-06-04
PL2225238T3 (pl) 2015-03-31
KR20100101095A (ko) 2010-09-16
WO2009070485A8 (en) 2014-08-14
MY151004A (en) 2014-03-31
AU2008329909A1 (en) 2009-06-04
TWI475990B (zh) 2015-03-11
DK2225238T3 (en) 2014-11-24
HRP20141171T1 (hr) 2015-01-30
UY31493A1 (es) 2009-07-17
IL205189A (en) 2014-09-30
EP2225238A1 (en) 2010-09-08
TW200922562A (en) 2009-06-01
EA017688B1 (ru) 2013-02-28
AU2008329909A8 (en) 2010-06-03
JP5485164B2 (ja) 2014-05-07
PT2225238E (pt) 2014-12-18
TN2010000240A1 (en) 2011-11-11
EP2225238B1 (en) 2014-09-03
AR069513A1 (es) 2010-01-27
TWI475991B (zh) 2015-03-11
CA2705583A1 (en) 2009-06-04
PE20091427A1 (es) 2009-10-19
NZ585640A (en) 2011-03-31
ECSP10010196A (es) 2010-07-30
HK1145683A1 (en) 2011-04-29
IL205189A0 (en) 2010-12-30
TW201417810A (zh) 2014-05-16
CN101889011A (zh) 2010-11-17
CO6210701A2 (es) 2010-10-20
US8552205B2 (en) 2013-10-08

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