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DK2024368T3 - 6,7,8,9-tetrahydro-5H-pyrimido[4,5-D]azepin-4-yl]-aminderivater som modulatorer af TRPV1 til behandling af smerte - Google Patents

6,7,8,9-tetrahydro-5H-pyrimido[4,5-D]azepin-4-yl]-aminderivater som modulatorer af TRPV1 til behandling af smerte

Info

Publication number
DK2024368T3
DK2024368T3 DK07753768.6T DK07753768T DK2024368T3 DK 2024368 T3 DK2024368 T3 DK 2024368T3 DK 07753768 T DK07753768 T DK 07753768T DK 2024368 T3 DK2024368 T3 DK 2024368T3
Authority
DK
Denmark
Prior art keywords
trpv1
azepin
pyrimido
tetrahydro
modulators
Prior art date
Application number
DK07753768.6T
Other languages
English (en)
Inventor
Brett D Allison
Bryan James Branstetter
James Guy Breitenbucher
Michael D Hack
Natalie A Hawryluk
Alec D Lebsack
Kelly J Mcclure
Jeffrey E Merit
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK2024368T3 publication Critical patent/DK2024368T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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DK07753768.6T 2006-03-21 2007-03-21 6,7,8,9-tetrahydro-5H-pyrimido[4,5-D]azepin-4-yl]-aminderivater som modulatorer af TRPV1 til behandling af smerte DK2024368T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78541506P 2006-03-21 2006-03-21
PCT/US2007/007166 WO2007109355A2 (en) 2006-03-21 2007-03-21 6,7,8, 9 -tetrahydro- 5h- pyrimido [4, 5-d] azepin-4-yl] -amine derivatives as modulators of trpvl for the treatment of pain

Publications (1)

Publication Number Publication Date
DK2024368T3 true DK2024368T3 (da) 2014-05-19

Family

ID=38353855

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07753768.6T DK2024368T3 (da) 2006-03-21 2007-03-21 6,7,8,9-tetrahydro-5H-pyrimido[4,5-D]azepin-4-yl]-aminderivater som modulatorer af TRPV1 til behandling af smerte

Country Status (30)

Country Link
US (3) US8673895B2 (da)
EP (1) EP2024368B1 (da)
JP (1) JP5232768B2 (da)
KR (1) KR101461376B1 (da)
CN (1) CN101448835B (da)
AR (1) AR059985A1 (da)
AU (1) AU2007227203B2 (da)
BR (1) BRPI0709034B1 (da)
CA (1) CA2646977C (da)
CR (1) CR10387A (da)
DK (1) DK2024368T3 (da)
EA (1) EA017069B1 (da)
EC (1) ECSP088807A (da)
ES (1) ES2474152T3 (da)
HR (1) HRP20140664T1 (da)
MX (1) MX2008012163A (da)
NI (1) NI200800253A (da)
NO (1) NO341676B1 (da)
NZ (1) NZ571343A (da)
PE (1) PE20080145A1 (da)
PL (1) PL2024368T3 (da)
PT (1) PT2024368E (da)
RS (1) RS53436B (da)
SG (1) SG177176A1 (da)
SI (1) SI2024368T1 (da)
TW (1) TWI440639B (da)
UA (1) UA92636C2 (da)
UY (1) UY30229A1 (da)
WO (1) WO2007109355A2 (da)
ZA (1) ZA200808975B (da)

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