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AR069740A1 - Compuestos nucleosidos antivirales - Google Patents

Compuestos nucleosidos antivirales

Info

Publication number
AR069740A1
AR069740A1 ARP080105126A ARP080105126A AR069740A1 AR 069740 A1 AR069740 A1 AR 069740A1 AR P080105126 A ARP080105126 A AR P080105126A AR P080105126 A ARP080105126 A AR P080105126A AR 069740 A1 AR069740 A1 AR 069740A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
pyridinyl
heteroaryl
cycloalkyl
Prior art date
Application number
ARP080105126A
Other languages
English (en)
Inventor
David Bernard Smith
Brett C Bookser
Scott J Hecker
Zhili Sun
K Raja Reddy
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40679083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069740(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of AR069740A1 publication Critical patent/AR069740A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Son inhibidores de la polimerasa NS5b del virus de la hepatitis C. También se describen composiciones y métodos para el tratamiento de una infeccion por VHC y que inhiben la replicacion de VHC3. Reivindicacion 1: Un compuesto con la formula general (1) o (2) en el que y es fenilo o piridinilo, estando dicho fenilo o piridinilo opcionalmente sustituido con uno a tres sustituyentes seleccionado de entre el grupo que consiste en halogeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, o ciano; B es (B-1), (B-2) o (B-3); R1 y R2 se seleccionan independientemente a partir de H y/o COR4; Y es O o NH; R3 es alquilo C1-6 o COR4 y, R4 es alquilo C1-6, alcoxi C1-3 alquilo -C1-6, cicloalquilo C3-6, cicloalquil C3-6 alquilo -C1-3, alcoxi C1-6 o heteroarilo en la que el heteroarilo es un anillo de cinco miembros que contiene uno o dos heteroátomos seleccionados de nitrogeno, oxígeno o azufre o piridina o un anillo de seis miembros con uno o dos átomos de nitrogeno; o, una sal farmacéuticamente aceptable de los mismos.
ARP080105126A 2007-11-29 2008-11-26 Compuestos nucleosidos antivirales AR069740A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99116307P 2007-11-29 2007-11-29
US8454408P 2008-07-29 2008-07-29

Publications (1)

Publication Number Publication Date
AR069740A1 true AR069740A1 (es) 2010-02-17

Family

ID=40679083

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105126A AR069740A1 (es) 2007-11-29 2008-11-26 Compuestos nucleosidos antivirales

Country Status (20)

Country Link
US (2) US8063025B2 (es)
EP (1) EP2227481A4 (es)
JP (1) JP2011505351A (es)
KR (1) KR20100103793A (es)
CN (1) CN102164939A (es)
AR (1) AR069740A1 (es)
AU (1) AU2008331158A1 (es)
BR (1) BRPI0819797A2 (es)
CA (1) CA2706432A1 (es)
CL (1) CL2008003511A1 (es)
CO (1) CO6382185A2 (es)
CR (1) CR11453A (es)
EC (1) ECSP10010210A (es)
IL (1) IL205625A0 (es)
MA (1) MA31864B1 (es)
MX (1) MX2010005885A (es)
RU (1) RU2010126050A (es)
TW (1) TW200936146A (es)
WO (1) WO2009069095A2 (es)
ZA (1) ZA201003438B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY151004A (en) 2007-11-29 2014-03-31 Boehringer Ingelheim Int Derivatives of 6,7-dihydro-5h-imidazo[1,2-?]imidazole-3-carboxylic acid amides
WO2011092158A1 (en) 2010-01-28 2011-08-04 F. Hoffmann-La Roche Ag 4 ' - azido - nucleosides as anti - hcv compunds
CA2812962C (en) 2010-09-22 2020-03-31 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
EP2776438A4 (en) * 2011-11-10 2015-04-29 Inhibitex Inc SUBSTITUTED PURIN NUCLEOSIDES, PHOSPHORAMIDATE AND PHOSPHORDIAMIDATE DERIVATIVES FOR THE TREATMENT OF VIRUS INFECTIONS
US9676809B2 (en) 2013-11-22 2017-06-13 Ligand Pharmaceuticals Incorporated Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections
CN103848877B (zh) * 2013-12-16 2016-08-24 安徽贝克联合制药有限公司 核苷环磷酸酯化合物及其制备方法和其应用
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN108137639B (zh) 2015-08-05 2021-10-08 麦德龙国际生物科技有限责任公司 烟酰胺单核苷酸衍生物及其用途
WO2018129039A1 (en) 2017-01-04 2018-07-12 President And Fellows Of Harvard College Modulating nudix homology domain (nhd) with nicotinamide mononucleotide analogs and derivatives of same
CN108727450B (zh) * 2017-04-18 2024-02-20 浙江柏拉阿图医药科技有限公司 肝递送抗丙肝前体药物核苷环磷酸酯化合物及应用
CN109956986B (zh) * 2017-12-22 2021-04-27 浙江柏拉阿图医药科技有限公司 肝递送吉西他滨前体药物核苷环磷酸酯化合物及应用
CN109956985A (zh) * 2017-12-22 2019-07-02 浙江柏拉阿图医药科技有限公司 肝递送阿糖胞苷前体药物核苷环磷酸酯化合物及应用
CN109956975B (zh) * 2017-12-22 2020-11-06 浙江柏拉阿图医药科技有限公司 肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
CN111434671B (zh) * 2019-01-11 2023-07-11 凯思凯迪（上海）医药科技有限公司 肝脏特异性ampk激动剂及其制法和应用
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
CN118598916A (zh) 2020-02-18 2024-09-06 吉利德科学公司 抗病毒化合物
CN117120444A (zh) 2021-04-16 2023-11-24 吉利德科学公司 使用酰胺制备卡巴核苷的方法
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ， インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045016A2 (en) * 1998-03-06 1999-09-10 Metabasis Therapeutics, Inc. Novel prodrugs for phosphorus-containing compounds
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
JP4689274B2 (ja) * 2002-10-31 2011-05-25 リガンド・ファーマシューティカルズ・インコーポレイテッド 新規なシタラビン・モノホスフェートプロドラッグ
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US20050075309A1 (en) * 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
EP1781101A2 (en) 2004-07-29 2007-05-09 Metabasis Therapeutics, Inc. Novel nucleoside derivatives
EP1928475B1 (en) * 2005-08-15 2018-05-23 Riboscience LLC Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides
JP4954573B2 (ja) * 2006-02-28 2012-06-20 オリンパス株式会社 内視鏡システム

Also Published As

Publication number Publication date
IL205625A0 (en) 2010-11-30
US20090209481A1 (en) 2009-08-20
ZA201003438B (en) 2011-04-28
US20120039845A1 (en) 2012-02-16
WO2009069095A3 (en) 2009-12-23
US8063025B2 (en) 2011-11-22
EP2227481A4 (en) 2011-03-09
MA31864B1 (fr) 2010-11-01
CO6382185A2 (es) 2012-02-15
WO2009069095A2 (en) 2009-06-04
MX2010005885A (es) 2010-11-24
CN102164939A (zh) 2011-08-24
CA2706432A1 (en) 2009-06-04
KR20100103793A (ko) 2010-09-28
CL2008003511A1 (es) 2010-02-19
CR11453A (es) 2010-10-27
BRPI0819797A2 (pt) 2019-09-24
JP2011505351A (ja) 2011-02-24
RU2010126050A (ru) 2012-01-10
TW200936146A (en) 2009-09-01
EP2227481A2 (en) 2010-09-15
ECSP10010210A (es) 2010-08-31
AU2008331158A1 (en) 2009-06-04

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Legal Events

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