[go: up one dir, main page]

MX2010004995A - Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico. - Google Patents

Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico.

Info

Publication number
MX2010004995A
MX2010004995A MX2010004995A MX2010004995A MX2010004995A MX 2010004995 A MX2010004995 A MX 2010004995A MX 2010004995 A MX2010004995 A MX 2010004995A MX 2010004995 A MX2010004995 A MX 2010004995A MX 2010004995 A MX2010004995 A MX 2010004995A
Authority
MX
Mexico
Prior art keywords
imidazo
dihydro
imidazole
derivatives
carboxylic acid
Prior art date
Application number
MX2010004995A
Other languages
English (en)
Inventor
Zhidong Chen
Weimin Liu
Derek Cogan
Craig Andrew Miller
Jennifer A Kowalski
Rene M Lemieux
Antonio Jose Del Moral Barbosa
Joerg Martin Bentzien
Steven Richard Brunette
Donghong A Gao
Alexander Heim-Riether
Joshua Courtney Horan
Michael David Lawlor
Bryan Mckibben
Neil Moss
Matt Aaron Tschantz
Zhaoming Xiong
Hui Yu
Yang Yu
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2010004995A publication Critical patent/MX2010004995A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de amida del ácido 6,7-dihidro-5H-imidazo [1,2-a] imidazol-3-carboxílico exhiben buen efecto inhibidor tras la interacción entre CAM y Leucointegrinas y, por consiguiente, son útiles en el tratamiento de enfermedades inflamatorias.
MX2010004995A 2007-11-29 2008-11-20 Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico. MX2010004995A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99096007P 2007-11-29 2007-11-29
US4795708P 2008-04-25 2008-04-25
PCT/US2008/084149 WO2009070485A1 (en) 2007-11-29 2008-11-20 DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES

Publications (1)

Publication Number Publication Date
MX2010004995A true MX2010004995A (es) 2010-05-20

Family

ID=40193954

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004995A MX2010004995A (es) 2007-11-29 2008-11-20 Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico.

Country Status (31)

Country Link
US (1) US8552205B2 (es)
EP (1) EP2225238B1 (es)
JP (1) JP5485164B2 (es)
KR (1) KR20100101095A (es)
CN (1) CN101889011B (es)
AR (1) AR069513A1 (es)
AU (1) AU2008329909B2 (es)
BR (1) BRPI0819831A2 (es)
CA (1) CA2705583A1 (es)
CL (1) CL2008003576A1 (es)
CO (1) CO6210701A2 (es)
CY (1) CY1115857T1 (es)
DK (1) DK2225238T3 (es)
EA (1) EA017688B1 (es)
EC (1) ECSP10010196A (es)
ES (1) ES2525237T3 (es)
HR (1) HRP20141171T1 (es)
IL (1) IL205189A (es)
MA (1) MA31905B1 (es)
MX (1) MX2010004995A (es)
MY (1) MY151004A (es)
NZ (1) NZ585640A (es)
PE (1) PE20091427A1 (es)
PL (1) PL2225238T3 (es)
PT (1) PT2225238E (es)
RS (1) RS53602B1 (es)
SI (1) SI2225238T1 (es)
TN (1) TN2010000240A1 (es)
TW (2) TWI475991B (es)
UY (1) UY31493A1 (es)
WO (1) WO2009070485A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120024699A (ko) * 2009-06-02 2012-03-14 베링거 인겔하임 인터내셔날 게엠베하 ６，７－디하이드로－５Ｈ-이미다조［１，２－ａ］이미다졸－３－카복실산 아미드의 유도체
US8481750B2 (en) 2009-06-02 2013-07-09 Boehringer Ingelheim International Gmbh Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides
SI2491028T1 (sl) 2009-10-21 2014-03-31 Boehringer Ingelheim International Gmbh Indazolne in pirazolopiridinske spojine kot antagonisti receptorja CCR1
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
SG194621A1 (en) 2011-04-27 2013-12-30 Shionogi & Co 5-membered ring aromatic heterocyclic derivative having npy y5 receptor antagonistic activity
EP2740730B1 (en) 2011-08-03 2016-11-16 Kyowa Hakko Kirin Co., Ltd. Dibenzooxepin derivative
WO2013050424A1 (en) 2011-10-03 2013-04-11 Euroscreen S.A. NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
CN117550960A (zh) 2014-10-14 2024-02-13 先正达参股股份有限公司 用于制备1-(3,5-二氯-4-氟-苯基)-2,2,2-三氟-乙酮的方法
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
CN106631827B (zh) * 2016-12-30 2018-10-23 上海毕得医药科技有限公司 一种(1-环丙基-1-甲基)乙基胺及其盐酸盐的合成方法
CN109369432B (zh) * 2018-11-02 2021-06-25 永农生物科学有限公司 (s)-4-氯-2-氨基丁酸酯的制备方法
EP4285723A3 (en) 2019-12-20 2024-03-27 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof
CN111848521A (zh) * 2020-08-26 2020-10-30 韶远科技（上海)有限公司 一种2-取代-4-烷氧基咪唑化合物的制备方法
CN119698408A (zh) * 2022-07-12 2025-03-25 安道麦马克西姆有限公司 制备取代的苯甲酰胺的方法
WO2025021943A1 (en) 2023-07-26 2025-01-30 Neuralis Quinazolinone, benzoxazinone and benzoxazepinone derivatives as protein kinase inhibitors

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2015493A1 (es) 1968-08-12 1970-04-30 Sumitomo Chemical Co
DK123717B (da) 1968-11-25 1972-07-24 Sumitomo Chemical Co 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning.
JPS5136332B1 (es) 1970-12-09 1976-10-07
DE3382406D1 (de) 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
JPS63270665A (ja) 1987-04-30 1988-11-08 Wakamoto Pharmaceut Co Ltd イミダゾ−ル誘導体
JPS63270667A (ja) 1987-04-30 1988-11-08 Wakamoto Pharmaceut Co Ltd １−ベンジルイミダゾ−ル誘導体
US5208250A (en) 1988-05-25 1993-05-04 Warner-Lambert Company Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
US5306822A (en) 1988-05-25 1994-04-26 Warner-Lambert Company Arylmethylenyl derivatives of oxazolidinone
IE940525L (en) 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
US4977270A (en) 1988-12-01 1990-12-11 Ici Americas Inc. Substituted 2,4-dioxodiazolidines and -thiadiazolidines and their use as herbicides
US4911748A (en) 1988-12-22 1990-03-27 Ici Americas Inc. Herbicidal 5-substituted-3-phenyl-imidazolidine-2,4-diones
JPH04273877A (ja) 1991-02-28 1992-09-30 Sumitomo Pharmaceut Co Ltd 新規なイミダゾール誘導体
CA2083891A1 (en) 1991-12-03 1993-06-04 Angus Murray Macleod Heterocyclic compounds, compositions containing them and their use in therapy
JPH05188631A (ja) 1992-01-10 1993-07-30 Mita Ind Co Ltd 電子写真感光体
TW521073B (en) 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
US20040006011A1 (en) 1996-07-12 2004-01-08 Gour Barbara J. Peptidomimetic modulators of cell adhesion
NZ507848A (en) 1996-10-28 2005-01-28 Univ Washington Method of increasing the mutation rate of a virus in a non-human by administering an RNA nucleoside analogue to a virally infected cell
US6355664B1 (en) 1997-03-03 2002-03-12 Boehringer Ingelheim Pharmaceuticals, Inc. Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease
SK117499A3 (en) 1997-03-03 2000-05-16 Boehringer Ingelheim Pharma Small molecules useful in the treatment of inflammatory and immune cell-mediated diseases, small molecules and pharmaceutical composition with their content
DE69839399T2 (de) 1997-08-28 2009-05-20 Novartis Ag Lymphozyten funktion antigen-1 antagonisten
WO1999049856A2 (en) 1998-03-27 1999-10-07 Genentech, Inc. Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
WO2001007044A1 (en) 1999-07-21 2001-02-01 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
US6365615B1 (en) 1999-07-21 2002-04-02 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
US6492408B1 (en) * 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
ATE396722T1 (de) 1999-07-21 2008-06-15 Boehringer Ingelheim Pharma Kleine moleküle zur behandlung von endzündlichen erkrankungen
US6350763B1 (en) 1999-07-21 2002-02-26 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammation disease
CA2388639C (en) 1999-10-20 2007-07-17 Tanabe Seiyaku Co., Ltd. Inhibitors of .alpha.l.beta.2 mediated cell adhesion
WO2002050080A1 (en) 2000-12-19 2002-06-27 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
RU2003126188A (ru) * 2001-01-26 2005-03-27 Бристол-Маерс Сквибб Компани (Us) Имидазолильные производные как ингибиторы кортикотропин-рилизинг фактора
US20030232817A1 (en) 2002-05-29 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful for the treatment of inflammatory disease
US6844360B2 (en) 2002-10-30 2005-01-18 Boehringer Ingelheim Pharmaceuticals, Inc. Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide
US6852748B1 (en) 2002-10-30 2005-02-08 Boehringer Ingelheim Pharmaceuticals, Inc. Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
KR20070047798A (ko) 2004-07-27 2007-05-07 베링거 인겔하임 인터내셔날 게엠베하 6,7-디하이드로-5Ｈ-이미다조[1,2-ａ]이미다졸-3-설폰산아미드의 합성
US7572921B2 (en) 2005-04-05 2009-08-11 Boehringer Ingelheim International Gmbh Substituted benzylimidazoles useful for the treatment of inflammatory diseases
EP1868603A1 (en) 2005-04-06 2007-12-26 Boehringer Ingelheim Pharma GmbH & Co. KG DERIVATIVES OF Ý6,7-DIHYDRO-5HIMIDAZO Ýl,2-ALPHA¨IMIDAZOLE-3-SULFONYL¨-AZETEDINE-CARBOXYLIC ACIDS, ESTERS AND AMIDES AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS
BRPI0610354A2 (pt) * 2005-05-19 2010-06-15 Boehringer Ingelheim Internac derivados de ácido 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-slfÈnico, bem como composição farmacêutica e uso dos mesmos
TW200831488A (en) 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
CL2008003511A1 (es) 2007-11-29 2010-02-19 Metabasis Therapeutics Inc Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c.
JP2009149609A (ja) 2007-11-29 2009-07-09 Sumitomo Chemical Co Ltd アミド化合物及びその用途
US8518912B2 (en) 2007-11-29 2013-08-27 Actelion Pharmaceuticals Ltd. Phosphonic acid derivates and their use as P2Y12 receptor antagonists
EP2080758A3 (de) 2007-11-29 2009-08-26 Bayer CropScience AG Halogen substituierte delta-1-Pyrroline
KR20120024699A (ko) 2009-06-02 2012-03-14 베링거 인겔하임 인터내셔날 게엠베하 ６，７－디하이드로－５Ｈ-이미다조［１，２－ａ］이미다졸－３－카복실산 아미드의 유도체
US8481750B2 (en) 2009-06-02 2013-07-09 Boehringer Ingelheim International Gmbh Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides

Also Published As

Publication number Publication date
US8552205B2 (en) 2013-10-08
PL2225238T3 (pl) 2015-03-31
JP2011505359A (ja) 2011-02-24
UY31493A1 (es) 2009-07-17
ECSP10010196A (es) 2010-07-30
EP2225238A1 (en) 2010-09-08
EA201000866A1 (ru) 2010-12-30
CA2705583A1 (en) 2009-06-04
US20110224188A1 (en) 2011-09-15
TWI475990B (zh) 2015-03-11
EP2225238B1 (en) 2014-09-03
TW201417810A (zh) 2014-05-16
JP5485164B2 (ja) 2014-05-07
RS53602B1 (sr) 2015-02-27
DK2225238T3 (en) 2014-11-24
CO6210701A2 (es) 2010-10-20
SI2225238T1 (sl) 2014-12-31
CN101889011A (zh) 2010-11-17
WO2009070485A1 (en) 2009-06-04
TW200922562A (en) 2009-06-01
IL205189A0 (en) 2010-12-30
MY151004A (en) 2014-03-31
BRPI0819831A2 (pt) 2019-09-24
MA31905B1 (fr) 2010-12-01
CN101889011B (zh) 2014-05-28
AU2008329909A8 (en) 2010-06-03
AR069513A1 (es) 2010-01-27
AU2008329909A1 (en) 2009-06-04
ES2525237T3 (es) 2014-12-19
EA017688B1 (ru) 2013-02-28
PT2225238E (pt) 2014-12-18
TN2010000240A1 (en) 2011-11-11
CL2008003576A1 (es) 2010-02-12
IL205189A (en) 2014-09-30
NZ585640A (en) 2011-03-31
CY1115857T1 (el) 2017-01-25
HRP20141171T1 (hr) 2015-01-30
TWI475991B (zh) 2015-03-11
PE20091427A1 (es) 2009-10-19
AU2008329909B2 (en) 2013-10-03
KR20100101095A (ko) 2010-09-16
WO2009070485A8 (en) 2014-08-14
HK1145683A1 (en) 2011-04-29

Similar Documents

Publication Publication Date Title
MX2010004995A (es) Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico.
CY2024025I2 (el) ΥΠΟΚΑΤΕΣΤΗΜΕΝΑ ΠΑΡΑΓΩΓΑ 1,2,3,4- ΤΕΤΡΑΫΔΡΟΚΥΚΛΟΠΕΝΤΑ[b]ΙΝΔΟΛ-3-ΥΛ-ΟΞΙΚΟΥ ΟΞΕΟΣ ΧΡΗΣΙΜΑ ΣΤΗΝ ΑΓΩΓΗ ΑΥΤΟΑΝΟΣΩΝ ΚΑΙ ΦΛΕΓΜΟΝΩΔΩΝ ΔΙΑΤΑΡΑΧΩΝ
IL195906A (en) History of α - Aminoamide is useful in the treatment of conscious irregularities
IL185546A0 (en) N - (n - sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain
ZA200805163B (en) Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer
IL185484A0 (en) Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
GEP20135780B (en) Novel pyrazolo [3,4-d] pyrimidine derivatives as anti-cancer agents
MX2009002995A (es) Derivados de pirazolo-[1,5-a]-pirimidina y su uso terapeutico.
EP1954132A4 (en) AMID DERIVATIVES AS ION CHANNEL AND PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF
WO2009158371A8 (en) Inhibitors of akt activity
ZA201000581B (en) 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide and 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazepine-7-carboxamide derivatives,preparation and therapeutic use thereof
MY136822A (en) Derivatives of [6, 7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of cams and leukointegrins
MX2011012717A (es) Derivados de amidas del acido 6,7-dihidro-5h-imidazo[1,2-a]imidazo l-3-carboxilico.
TW200722426A (en) Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonic acid
EP1863757A4 (en) AMIDE DERIVATIVES AS IONIC CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
MY146444A (en) Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases
TW200738723A (en) 1-(1-(2-Ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)piperidine-4-carboxylic acid and salts thereof
UA94054C2 (en) Nitrocatechol derivatives as comt inhibitors
IL185205A0 (en) Amide derivatives as ion-channel ligands and pharmaceutical composition and methods of using the same
UA100871C2 (ru) ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5H-ИМИДАЗО[1,2-б]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ
IL187419A0 (en) Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
ZA200706197B (en) Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP1712553A3 (en) Derivates of [6, 7-dihydro - 5H - imidazo[1,2- alpha]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of CAMS and leukointegrins
IL208308A0 (en) 1,3 imidazolidine derivatives and their use in the production of carbapenem
HK1111892A (en) Use of pyrazolyl-pyrimidine derivatives in the treatment of pain

Legal Events

Date Code Title Description
FG Grant or registration