DK1095064T3 - Amider af hyaluronsyre og derivater deraf og fremgangsmåde til fremstilling deraf - Google Patents

Amider af hyaluronsyre og derivater deraf og fremgangsmåde til fremstilling deraf

Info

Publication number: DK1095064T3
Authority: DK; Denmark
Prior art keywords: group; hyaluronic acid; arylaliphatic; cycloaliphatic; aliphatic
Prior art date: 1998-07-06

Application number

DK99929619T

Other languages

Danish (da)

English (en)

Inventor

Davide Bellini

Alessandra Topai

Original Assignee

Fidia Farmaceutici

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-07-06

Publication date

2005-10-03

1999-07-06 Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici

2005-10-03 Application granted granted Critical

2005-10-03 Publication of DK1095064T3 publication Critical patent/DK1095064T3/da

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 5
229920002674 hyaluronan Polymers 0.000 title abstract 4
229960003160 hyaluronic acid Drugs 0.000 title abstract 4
150000001408 amides Chemical class 0.000 title abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 5
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
125000003368 amide group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000003252 repetitive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/043—Mixtures of macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Materials Engineering (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Ophthalmology & Optometry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
External Artificial Organs (AREA)

DK99929619T 1998-07-06 1999-07-06 Amider af hyaluronsyre og derivater deraf og fremgangsmåde til fremstilling deraf DK1095064T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT98PD000169A ITPD980169A1 (it)	1998-07-06	1998-07-06	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
EP99929619A EP1095064B1 (en)	1998-07-06	1999-07-06	Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
PCT/IB1999/001254 WO2000001733A1 (en)	1998-07-06	1999-07-06	Amides of hyaluronic acid and the derivatives thereof and a process for their preparation

Publications (1)

Publication Number	Publication Date
DK1095064T3 true DK1095064T3 (da)	2005-10-03

Family

ID=11392271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99929619T DK1095064T3 (da)	1998-07-06	1999-07-06	Amider af hyaluronsyre og derivater deraf og fremgangsmåde til fremstilling deraf

Country Status (14)

Country	Link
US (2)	US7884087B1 (ja)
EP (2)	EP1589036A1 (ja)
JP (3)	JP2002519481A (ja)
AT (1)	ATE297413T1 (ja)
AU (1)	AU761986B2 (ja)
CA (1)	CA2339066C (ja)
DE (1)	DE69925733T2 (ja)
DK (1)	DK1095064T3 (ja)
ES (1)	ES2244198T3 (ja)
IL (2)	IL140604A0 (ja)
IT (1)	ITPD980169A1 (ja)
PT (1)	PT1095064E (ja)
SI (1)	SI1095064T1 (ja)
WO (1)	WO2000001733A1 (ja)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITPD980169A1 (it)	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
AU7399201A (en) *	2000-05-03	2001-11-12	Fidia Advanced Biopolymers Srl	Biomaterials comprised of preadipocyte cells for soft tissue repair
IT1317359B1 (it) *	2000-08-31	2003-06-16	Fidia Advanced Biopolymers Srl	Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
KR100375299B1 (ko) *	2000-10-10	2003-03-10	주식회사 엘지생명과학	히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
US7060297B2 (en)	2000-11-06	2006-06-13	Alcon, Inc.	Carrageenan viscoelastics for ocular surgery
SV2003000753A (es)	2000-12-05	2003-06-16	Brigham & Womens Hospital	Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
ITPD20010032A1 (it)	2001-02-09	2002-08-09	Fidia Advanced Biopolymers Srl	Innesti ingegnerizzati per la riparazione di difetti osteocondrali
ITTS20010013A1 (it) *	2001-06-04	2002-12-04	Ct Ricerche Poly Tec H A R L S	Nuovi derivati di ialuronano.
US7923431B2 (en)	2001-12-21	2011-04-12	Ferrosan Medical Devices A/S	Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
JP2003190259A (ja) *	2001-12-28	2003-07-08	Hisako Ogawara	人工臓器用チャンバー
ITPD20020003A1 (it) *	2002-01-11	2003-07-11	Fidia Advanced Biopolymers Srl	Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
ITPD20020064A1 (it)	2002-03-12	2003-09-12	Fidia Advanced Biopolymers Srl	Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US20040234575A1 (en) *	2002-05-09	2004-11-25	Roland Horres	Medical products comprising a haemocompatible coating, production and use thereof
ITMI20021666A1 (it) *	2002-07-26	2004-01-26	Jasper Ltd Liability Co	Derivati dell'acido ialuronico
ITPD20020271A1 (it) *	2002-10-18	2004-04-19	Fidia Farmaceutici	Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
KR20120008081A (ko) *	2002-10-25	2012-01-25	레반스 테라퓨틱스, 아이엔씨.	조직 특성을 개선하기 위한 아연 수준의 조절
JP2006509502A (ja)	2002-12-11	2006-03-23	フェローサンアクティーゼルスカブ	スワブとしてのゼラチンベースの材料
WO2004060404A1 (ja) *	2002-12-27	2004-07-22	Chugai Seiyaku Kabushiki Kaisha	薬物担体
US8138265B2 (en)	2003-01-10	2012-03-20	The Cleveland Clinic Foundation	Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en)	2003-01-10	2012-03-20	The Cleveland Clinic Foundation	Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en)	2004-01-08	2008-12-16	The Cleveland Clinic Foundation	Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en)	2003-01-10	2006-01-03	The Cleveland Clinic Foundation	Hydroxyphenyl cross-linked macromolecular network and applications thereof
CA2520865A1 (en)	2003-03-31	2004-10-21	The Brigham And Women's Hospital, Inc.	Zwitterionic immunomodulators for the treatment of asthma and allergy
WO2005023906A1 (ja) *	2003-09-08	2005-03-17	Chugai Seiyaku Kabushiki Kaisha	ヒアルロン酸修飾物、及びそれを用いた薬物担体
WO2005054302A1 (ja) *	2003-12-05	2005-06-16	Chugai Seiyaku Kabushiki Kaisha	薬物担体及びその製造方法
KR101142583B1 (ko) *	2004-01-07	2012-05-11	세이가가쿠 고교 가부시키가이샤	히알루론산 유도체 및 그것을 포함하는 약제
RU2377022C9 (ru)	2004-01-30	2010-08-10	Ферросан А/С	Гемостатические спреи и композиции
ITPD20040053A1 (it) *	2004-02-27	2004-05-27	Fidia Advanced Biopolymers Srl	Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
CN102382308B (zh) *	2004-07-09	2014-04-16	克利夫兰临床基金会	羟基苯交联大分子网络及其应用
ITMI20041373A1 (it)	2004-07-09	2004-10-09	Lima Lto S P A	N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
AU2005262070B2 (en)	2004-07-09	2011-01-27	Ferrosan Medical Devices A/S	Haemostatic composition comprising hyaluronic acid
US8143391B2 (en)	2004-09-07	2012-03-27	Chugai Seiyaku Kabushiki Kaisha	Process for producing water-soluble hyaluronic acid modification
ITPD20050056A1 (it)	2005-03-02	2006-09-03	Fidia Farmaceutici	Derivati ammidici del'acido ialuronico in osteoartrosi
JP4902134B2 (ja) *	2005-04-25	2012-03-21	帝人株式会社	癒着防止材
ITPD20050206A1 (it)	2005-07-07	2007-01-08	Fidia Advanced Biopolymers Srl	Biomateriali in forma di fibra da impiegarsi come dispositivi medici nel trattamento delle ferite e loro processi di produzione
WO2007008142A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
ITPD20050242A1 (it)	2005-08-03	2007-02-04	Fidia Farmaceutici	Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
CN103120702B (zh) *	2005-10-12	2014-11-05	生化学工业株式会社	包含疏水基团结合型糖胺聚糖在制备预防或治疗角膜上皮层病症的药物中的用途
AU2012201314B2 (en) *	2005-10-12	2014-04-10	Seikagaku Corporation	Agent for applying to mucosa and method for production thereof
US8206726B2 (en)	2006-02-06	2012-06-26	The Brigham And Women's Hospital, Inc.	Zwitterionic polysaccharides for promotion of immune system maturation and health
KR101460815B1 (ko) *	2006-12-06	2014-11-12	세이가가쿠 고교 가부시키가이샤	관절염 질환 치료의 지속성 효과를 갖는 제약 제제
AU2014200868B2 (en) *	2006-12-06	2016-01-07	Seikagaku Corporation	Pharmaceutical agent having long-lasting effect of treating arthritic disorders
EP2106263B1 (en)	2007-01-04	2016-12-21	Hepacore Ltd.	Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
CN101020725B (zh) *	2007-03-23	2010-09-15	天津大学	一类双亲性壳聚糖长链烷基季铵盐及其制备方法
ITMI20071267A1 (it)	2007-06-22	2008-12-23	Fidia Farmaceutici	Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it)	2007-09-05	2009-03-06	Fidia Farmaceutici	Formulazioni topiche antivirali in forma di gel bioadesivo
WO2009062132A2 (en)	2007-11-09	2009-05-14	California Institute Of Technology	Immunomodulating compounds and related compositions and methods
CA2703109C (en)	2007-11-16	2017-07-18	Vicept Therapeutics, Inc.	Compositions and methods for treating purpura
US8394782B2 (en)	2007-11-30	2013-03-12	Allergan, Inc.	Polysaccharide gel formulation having increased longevity
ITMI20072416A1 (it) *	2007-12-21	2009-06-22	Sigea Srl	Derivati polisaccaridici dell'acido lipoico, loro preparazione ed uso come dermocosmetici e presidi medicali
EP2249891B1 (en)	2008-02-13	2016-05-25	The Cleveland Clinic Foundation	Molecular enhancement of extracellular matrix and methods of use
CN102014973A (zh)	2008-02-29	2011-04-13	弗罗桑医疗设备公司	用于促进止血和/或伤口愈合的装置
US8410180B2 (en)	2008-04-30	2013-04-02	The Cleveland Clinic Foundation	Methods to treat urinary incontinence
US8450475B2 (en)	2008-08-04	2013-05-28	Allergan, Inc.	Hyaluronic acid-based gels including lidocaine
AU2009288118B2 (en)	2008-09-02	2014-12-11	Allergan, Inc.	Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
AU2009299453B2 (en)	2008-10-02	2014-10-02	L.R.R.& D. Ltd.	Interface layer wound dressing
JP2010163485A (ja) *	2009-01-13	2010-07-29	Teijin Ltd	カルボキシ多糖類の溶液
AU2010237752A1 (en) *	2009-04-17	2011-11-03	Teijin Limited	Polysaccharide derivative and hydrogel thereof
IT1399351B1 (it)	2009-06-16	2013-04-16	Fidia Farmaceutici	Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1394570B1 (it)	2009-07-02	2012-07-05	Fidia Farmaceutici	Materiale biologico adatto per la terapia dell osteoartrosi del danno dei legamenti e per il trattamento delle patologie delle articolazioni.
IT1395392B1 (it) *	2009-08-27	2012-09-14	Fidia Farmaceutici	Geli viscoelastici come nuovi filler
US20110172180A1 (en)	2010-01-13	2011-07-14	Allergan Industrie. Sas	Heat stable hyaluronic acid compositions for dermatological use
FR2957254B1 (fr)	2010-03-12	2016-10-14	Allergan Ind Sas	Compositions fluides pour ameliorer les etats de la peau
CA2794254C (en)	2010-03-22	2018-09-04	Allergan, Inc.	Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
EP2555753B1 (en)	2010-04-07	2018-08-01	California Institute of Technology	Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
US20110287048A1 (en)	2010-05-20	2011-11-24	Round June L	Antigen Specific Tregs and related compositions, methods and systems
WO2012008722A2 (ko) *	2010-07-12	2012-01-19	신풍제약 주식회사	조직 증강용 충전 조성물
US9005605B2 (en)	2010-08-19	2015-04-14	Allergan, Inc.	Compositions and soft tissue replacement methods
US8883139B2 (en)	2010-08-19	2014-11-11	Allergan Inc.	Compositions and soft tissue replacement methods
US8889123B2 (en)	2010-08-19	2014-11-18	Allergan, Inc.	Compositions and soft tissue replacement methods
CZ305040B6 (cs)	2010-09-14	2015-04-08	Contipro Biotech S.R.O.	Způsob přípravy vysoce substituovaných amidů kyseliny hyaluronové
CN101972489A (zh) *	2010-09-30	2011-02-16	吴奕光	一种新型创面自修复生物材料及其制备方法和用途
ES2385239B1 (es)	2010-09-30	2013-06-19	Proteos Biotech S.L.U.	Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
WO2012118189A1 (ja)	2011-03-03	2012-09-07	中外製薬株式会社	アミノ－カルボン酸により修飾されたヒアルロン酸誘導体
WO2012140650A2 (en)	2011-04-12	2012-10-18	Hepacore Ltd.	Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
KR102312056B1 (ko)	2011-06-03	2021-10-12	알러간 인더스트리 에스에이에스	항산화제를 포함하는 피부 충전제 조성물
US20130096081A1 (en)	2011-06-03	2013-04-18	Allergan, Inc.	Dermal filler compositions
US9408797B2 (en)	2011-06-03	2016-08-09	Allergan, Inc.	Dermal filler compositions for fine line treatment
US9393263B2 (en)	2011-06-03	2016-07-19	Allergan, Inc.	Dermal filler compositions including antioxidants
WO2012170504A2 (en) *	2011-06-06	2012-12-13	The Cleveland Clinic Foundation	Treatment of extracellular matrix to reduce inflammation
WO2013009945A1 (en)	2011-07-12	2013-01-17	The Brigham And Women's Hospital, Inc.	Lipid-containing psa compositions, methods of isolation and methods of use thereof
US9662422B2 (en)	2011-09-06	2017-05-30	Allergan, Inc.	Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en)	2011-09-06	2013-09-19	Allergan, Inc.	Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
JP6241624B2 (ja)	2012-03-06	2017-12-06	フェロサンメディカルデバイシーズエイ／エス	止血ペーストを収容する加圧容器
WO2013146381A1 (ja) *	2012-03-27	2013-10-03	テルモ株式会社	薬剤コート層およびこれを有する医療機器
WO2013146380A1 (ja) *	2012-03-27	2013-10-03	テルモ株式会社	コーティング組成物および医療機器
WO2013146376A1 (ja) *	2012-03-27	2013-10-03	テルモ株式会社	コーティング組成物および医療機器
ITPD20120098A1 (it) *	2012-03-30	2013-10-01	Fidia Farmaceutici	"nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
ITPD20120173A1 (it)	2012-05-31	2013-12-01	Fidia Farmaceutici	"nuovo sistema di rilascio di proteine idrofobiche"
JP6394916B2 (ja)	2012-06-12	2018-09-26	フェロサンメディカルデバイシーズエイ／エス	乾燥止血組成物
CA2884142C (en)	2012-09-05	2020-11-10	Chugai Seiyaku Kabushiki Kaisha	Hyaluronic acid derivative having amino acid and steryl group introduced thereinto
CN103720712A (zh) *	2012-10-10	2014-04-16	上海工程技术大学	一种制备季铵化壳聚糖纳米碘消毒剂的方法
CZ2012841A3 (cs) *	2012-11-27	2014-02-19	Contipro Biotech S.R.O.	Vlákna založená na hydrofobizovaném hyaluronanu, způsob jejich přípravy a použití, textilie na jejich bázi a použití
JP6363119B2 (ja)	2013-03-14	2018-07-25	アナコティリミテッド	ヒアルロン酸誘導体
ITPD20130110A1 (it)	2013-04-24	2014-10-25	Fidia Farmaceutici	Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc
EP2994161B1 (en)	2013-05-10	2020-10-28	California Institute of Technology	Probiotic prevention and treatment of colon cancer
US9724078B2 (en)	2013-06-21	2017-08-08	Ferrosan Medical Devices A/S	Vacuum expanded dry composition and syringe for retaining same
EP4137139A1 (en)	2013-07-10	2023-02-22	Matrix Biology Institute	Compositions of hyaluronan with high elasticity and uses thereof
US9572832B2 (en) *	2013-08-29	2017-02-21	Holy Stone Healthcare Co., Ltd.	Compound of glycosaminoglycan and its fabrication method as well as application
WO2015044455A1 (en)	2013-09-30	2015-04-02	Galderma S.A.	Single-step functionalization and cross-linking of hyaluronic acid
WO2015048988A1 (en)	2013-10-02	2015-04-09	Ao Technology Ag	Thermosensitive hyaluronic acid conjugates and methods for the preparation thereof
CN105828844B (zh)	2013-12-11	2019-09-27	弗罗桑医疗设备公司	包含挤出增强剂的干组合物
CA3187647A1 (en)	2014-06-15	2015-12-23	Yeda Research And Development Co. Ltd.	Surface treatment by water-soluble polymers and lipids/liposomes
CZ2014451A3 (cs) *	2014-06-30	2016-01-13	Contipro Pharma A.S.	Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
ES2761558T3 (es)	2014-09-30	2020-05-20	Allergan Ind Sas	Composiciones de hidrogel estables que incluyen aditivos
US11046818B2 (en)	2014-10-13	2021-06-29	Ferrosan Medical Devices A/S	Dry composition for use in haemostasis and wound healing
CN107206165B (zh)	2014-12-24	2020-10-23	弗罗桑医疗设备公司	用于保持并混合第一和第二物质的注射器
BR112017017346B1 (pt)	2015-02-13	2021-09-08	Allergan Industrie, Sas	Composição estéril, implantável de modo subdérmico ou supraperiosteal na área de queixo, linha da mandíbula ou nariz, usos de uma quantidade eficaz de ácido hialurônico (ha) reticulado com bdde e kit
US20180086852A1 (en) *	2015-03-31	2018-03-29	Kewpie Corporation	Hyaluronic Acid Derivative and Manufacturing Method Therefor and Cosmetics, Food Composition, and Pharmaceutical Composition Containing Hyaluronic Acid Derivative
US11331335B2 (en)	2015-06-10	2022-05-17	California Institute Of Technology	Sepsis treatment and related compositions methods and systems
AU2016290433B2 (en)	2015-07-03	2018-05-24	Ferrosan Medical Devices A/S	Syringe for mixing two components and for retaining a vacuum in a storage condition
CN113637040A (zh)	2015-08-19	2021-11-12	哈佛学院院长及董事	脂化psa组合物和方法
PL3352766T3 (pl)	2015-09-24	2021-08-02	Matrix Biology Institute	Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia
EP3252082A1 (en) *	2016-05-31	2017-12-06	Galderma S.A.	Method for deacetylation of biopolymers
US11254792B2 (en)	2015-12-29	2022-02-22	Galderma Holding SA	Method for deacetylation of biopolymers
CA3021764C (en)	2016-04-27	2021-01-19	Anika Therapeutics, Inc.	Compositions for use in treating tendon degeneration via intra-osteotendinous injection
PT3623390T (pt)	2016-05-31	2023-10-27	Galderma Sa	Reticulador de hidrato de carbono
WO2018014012A1 (en)	2016-07-15	2018-01-18	President And Fellows Of Harvard College	Glycolipid compositions and methods of use
WO2018024902A1 (en) *	2016-08-04	2018-02-08	Biokawthar Technologies	Uses of hydrophobically-modified hyaluronic acid through amide and/or hydrazide linkages in cosmetics and/or dermatology
CZ2016826A3 (cs)	2016-12-22	2018-07-04	Contipro A.S.	Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
JP7216006B2 (ja)	2017-03-22	2023-01-31	ジェネンテック，インコーポレイテッド	ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
IT201700122135A1 (it) *	2017-10-26	2019-04-26	Jointherapeutics S R L	Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
WO2020144372A1 (en)	2019-01-10	2020-07-16	The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin	Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
US11413023B2 (en)	2018-01-10	2022-08-16	The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin	System and methods for sealing a channel in tissue
IT201800001890A1 (it) *	2018-01-25	2019-07-25	Fidia Farm Spa	Composizioni farmaceutiche per il trattamento del dolore postoperatorio
IT201900006250A1 (it)	2019-04-23	2020-10-23	Fidia Farm Spa	Medicazione per il trattamento della cute lesa
EP3790600B1 (en)	2018-05-09	2023-12-27	Ferrosan Medical Devices A/S	Method for preparing a haemostatic composition
KR102240726B1 (ko) *	2019-01-31	2021-04-16	주식회사 에스엔비아	방사성 동위원소가 표지된 광가교성 하이드로젤 및 그 제조 방법
WO2020181356A1 (en) *	2019-03-08	2020-09-17	Queen's University At Kingston	Hyaluronic acid derivatives for wound healing
CN109762078B (zh) *	2019-04-09	2019-07-23	中国科学院烟台海岸带研究所	一种羟丙基三甲基氯化铵壳聚糖-羧基多糖复合盐及制备方法和应用
IT201900006038A1 (it)	2019-04-18	2020-10-18	Fidia Farm Spa	Composizioni farmaceutiche comprendenti statine e derivati dell’acido ialuronico
KR20220005465A (ko) *	2019-04-19	2022-01-13	조인테라퓨틱스 에스알엘	작용화된 히알루론산의 가교결합 중합체 및 염증 상태의 치료에서의 이의 용도
EP3969057B1 (en)	2019-05-17	2025-12-17	The Governing Council of the University of Toronto	Sustained release local anesthetic hydrogel composition
WO2020240034A1 (en)	2019-05-31	2020-12-03	University College Dublin	Hyaluronic acid-based hybrid hydrogel
IT201900009933A1 (it)	2019-06-24	2020-12-24	Fidia Farm Spa	Composizioni farmaceutiche comprendenti derivati ammidici dell'acido ialuronico per uso nel trattamento di traumi ossei, in particolare in pazienti con problemi di osteopenia o osteoporosi
US20230133656A1 (en)	2019-07-03	2023-05-04	Molly Sandra Shoichet	Hydrogel compositions and uses thereof
CN110760014A (zh) *	2019-11-19	2020-02-07	恩施徕福硒业有限公司	一种从茯苓中提取硒多糖的提取装置及工艺
EP4069753A1 (en)	2019-12-02	2022-10-12	Galderma Holding SA	High molecular weight esthetic compositions
IT202000005692A1 (it)	2020-03-17	2021-09-17	Fidia Farm Spa	Bio-inchiostro per stampa 3D, relativo coniugato e processo di preparazione di un intermedio costituito da un linker fotoreattivo
IT202100032111A1 (it)	2021-12-22	2023-06-22	Fidia Farm Spa	Nuovi sostituti biocompatibili dell’umor vitreo
IT202300023433A1 (it)	2023-11-07	2025-05-07	Univ Degli Studi Di Catania	Derivati di acido ialuronico fotogeneratori di ossido nitrico

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55161801A (en) *	1979-06-06	1980-12-16	Seikagaku Kogyo Co Ltd	Fluorescence-labeled acid mucopolysaccharide and preparation thereof
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
US4937270A (en) *	1987-09-18	1990-06-26	Genzyme Corporation	Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) *	1987-09-18	2001-01-16	Genzyme Corporation	Water insoluble derivatives of polyanionic polysaccharides
IT1217458B (it)	1988-05-02	1990-03-22	Crinos Ind Farmacoriologica S	Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
US5510418A (en)	1988-11-21	1996-04-23	Collagen Corporation	Glycosaminoglycan-synthetic polymer conjugates
JPH0755961B2 (ja) *	1989-04-18	1995-06-14	工業技術院長	新規なヒアルロン酸誘導体及びその製造方法
EP0416250A3 (en)	1989-08-01	1991-08-28	The Research Foundation Of State University Of New York	N-acylurea and o-acylisourea derivatives of hyaluronic acid
CA2070672C (en)	1990-10-18	2002-10-08	Kazuo Akima	Compound of medicinal ingredient and hyaluronic acid and process for producing the same
US5733891A (en) *	1990-10-18	1998-03-31	Shiseido Co., Ltd.	Compound for medicinal ingredient and hyaluronic acid and process for producing the same
JP2855307B2 (ja) *	1992-02-05	1999-02-10	生化学工業株式会社	光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
US5612360A (en)	1992-06-03	1997-03-18	Eli Lilly And Company	Angiotensin II antagonists
IT1260154B (it) *	1992-07-03	1996-03-28	Lanfranco Callegaro	Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
IT1263316B (it) *	1993-02-12	1996-08-05	Fidia Advanced Biopolymers Srl	Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
IT1268955B1 (it) *	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Esteri attivi di polisaccaridi carbossilici
CA2162957C (en)	1994-11-17	2011-08-02	Michinori Waki	Cinnamic acid derivative
IT1281876B1 (it) *	1995-05-10	1998-03-03	Fidia Advanced Biopolymers Srl	Acido ialuronico e suoi derivati esterei per la preparazione di matrici per il rilascio controllato di farmaci.
JP4018181B2 (ja)	1995-11-07	2007-12-05	生化学工業株式会社	グリコサミノグリカン誘導体およびその製造法
JP3047801B2 (ja)	1995-12-20	2000-06-05	株式会社日立製作所	プラズマ処理方法及び装置
JP3925955B2 (ja) *	1996-04-26	2007-06-06	株式会社クラレ	癒着防止材
JP3955652B2 (ja)	1996-10-15	2007-08-08	株式会社ネーテック	合成アミノ糖類誘導体及びその製造方法
JPH10298164A (ja) *	1997-02-27	1998-11-10	Tanabe Seiyaku Co Ltd	イソキノリノン誘導体、その製法及びその合成中間体
DE69809892T2 (de) *	1997-04-04	2003-08-28	Fidia Advanced Biopolymers S.R.L., Brindisi	N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
DE69814800T2 (de)	1997-04-18	2003-12-18	Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo	Epoxysuccinamid-derivate oder ihre salze
GB9710990D0 (en) *	1997-05-28	1997-07-23	Danisco	Modification process
ITPD980169A1 (it)	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1303735B1 (it)	1998-11-11	2001-02-23	Falorni Italia Farmaceutici S	Acidi ialuronici reticolati e loro usi medici.
KR100375299B1 (ko)	2000-10-10	2003-03-10	주식회사 엘지생명과학	히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
KR20040009891A (ko)	2002-07-26	2004-01-31	주식회사 엘지생명과학	히알루론산의 유도체 겔 및 그 제조방법

1998
- 1998-07-06 IT IT98PD000169A patent/ITPD980169A1/it unknown
1999
- 1999-07-06 AT AT99929619T patent/ATE297413T1/de active
- 1999-07-06 EP EP05011126A patent/EP1589036A1/en not_active Withdrawn
- 1999-07-06 AU AU46397/99A patent/AU761986B2/en not_active Expired
- 1999-07-06 US US10/220,853 patent/US7884087B1/en not_active Expired - Fee Related
- 1999-07-06 ES ES99929619T patent/ES2244198T3/es not_active Expired - Lifetime
- 1999-07-06 PT PT99929619T patent/PT1095064E/pt unknown
- 1999-07-06 CA CA2339066A patent/CA2339066C/en not_active Expired - Lifetime
- 1999-07-06 WO PCT/IB1999/001254 patent/WO2000001733A1/en not_active Ceased
- 1999-07-06 DK DK99929619T patent/DK1095064T3/da active
- 1999-07-06 JP JP2000558133A patent/JP2002519481A/ja active Pending
- 1999-07-06 SI SI9930816T patent/SI1095064T1/sl unknown
- 1999-07-06 IL IL14060499A patent/IL140604A0/xx unknown
- 1999-07-06 EP EP99929619A patent/EP1095064B1/en not_active Expired - Lifetime
- 1999-07-06 DE DE69925733T patent/DE69925733T2/de not_active Expired - Lifetime
2000
- 2000-12-28 IL IL140604A patent/IL140604A/en not_active IP Right Cessation
2006
- 2006-09-20 JP JP2006254511A patent/JP4791921B2/ja not_active Expired - Lifetime
2009
- 2009-11-20 US US12/623,253 patent/US8575129B2/en not_active Expired - Fee Related
2011
- 2011-04-07 JP JP2011085601A patent/JP2011174079A/ja not_active Withdrawn

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Publication number	Publication date
EP1095064B1 (en)	2005-06-08
JP4791921B2 (ja)	2011-10-12
ATE297413T1 (de)	2005-06-15
ITPD980169A1 (it)	2000-01-06
CA2339066C (en)	2012-04-03
US7884087B1 (en)	2011-02-08
JP2011174079A (ja)	2011-09-08
AU4639799A (en)	2000-01-24
SI1095064T1 (sl)	2005-12-31
DE69925733T2 (de)	2006-03-16
PT1095064E (pt)	2005-10-31
ES2244198T3 (es)	2005-12-01
IL140604A0 (en)	2002-02-10
US20100158796A1 (en)	2010-06-24
JP2007031721A (ja)	2007-02-08
WO2000001733A1 (en)	2000-01-13
JP2002519481A (ja)	2002-07-02
EP1589036A1 (en)	2005-10-26
IL140604A (en)	2010-06-16
DE69925733D1 (de)	2005-07-14
AU761986B2 (en)	2003-06-12
EP1095064A1 (en)	2001-05-02
CA2339066A1 (en)	2000-01-13
US8575129B2 (en)	2013-11-05

Publication	Publication Date	Title
DK1095064T3 (da)	2005-10-03	Amider af hyaluronsyre og derivater deraf og fremgangsmåde til fremstilling deraf
DK0731085T3 (da)	2000-04-17	Stilbenderivater og farmaceutiske sammensætinger indeholdende disse
FI950309A0 (fi)	1995-01-24	Proliiniamidijohdannaisia
AU8772691A (en)	1992-05-14	New compounds
WO2000046198A8 (en)	2001-04-19	Anti-inflammatory indole derivatives
ATE221064T1 (de)	2002-08-15	Cyclische amidderivate als neurokinin a antagonisten
EA200100983A1 (ru)	2002-10-31	Производные 13-метилэритромицина
HUT64842A (en)	1994-03-28	Method for producing pharmaceutical preparatives containing 2-[n-(2-amino-ethyl)-amino]-acetic acid derivatives
MX9705559A (es)	1998-05-31	Derivados de acido neuraminico, su preparacion y su uso en medicina.
EA200200108A1 (ru)	2002-06-27	Производные стрептограминов, способ их получения и композиции на их основе
NO924076L (no)	1992-12-21	Antihypertensive midler
MXPA01011955A (es)	2003-09-04	Aminoacidos policiclicos, fusionados, como agentes farmaceuticos.
DK1205476T3 (da)	2003-08-11	Fremgangsmåde til syntese af N-(mercaptoacyl)-aminosyrederivater ud fra alfa-substituerede acrylsyrer
ES525684A0 (es)	1985-07-01	Procedimiento para preparar derivados de prolina
ES2067635T3 (es)	1995-04-01	Derivados heterociclicos de beta-aminoacidos acilaminodiolicos.
PT643061E (pt)	2002-07-31	Novos antibioticos de cefalosporina e processos para a sua preparacao
ATE248802T1 (de)	2003-09-15	Neues amin-derivat, verfahren zur herstellung und dessen verwendung als anti-arrhythmisches mittel
DK0985665T3 (da)	2003-03-17	Fremgangsmåde til fremstilling af 3-amino-2-oxo-pyrrolidiner, mellemprodukter og anvendelse af disse
HU9700914D0 (en)	1997-07-28	Sulfur-containing heterocyclic bradiquinine-antagonists, process for producing and applicing them
ES2186127T3 (es)	2003-05-01	Sintesis de derivados de nucleosidos aciclicos.
IT1276710B1 (it)	1997-11-03	Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
ATE253048T1 (de)	2003-11-15	Verfahren zur herstellung von piperidincarbonsäureamiden
ATE421951T1 (de)	2009-02-15	Gabusectin-derivate, verfahren zur deren herstellung und deren verwendung
DK293889D0 (da)	1989-06-14	2-amino-7-hydroxytetralinethere
TW349099B (en)	1999-01-01	Apovincamine derivatives and the pharmaceutical composition thereof