[go: up one dir, main page]

IT1399351B1 - Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi - Google Patents

Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi

Info

Publication number
IT1399351B1
IT1399351B1 ITMI2009A001065A ITMI20091065A IT1399351B1 IT 1399351 B1 IT1399351 B1 IT 1399351B1 IT MI2009A001065 A ITMI2009A001065 A IT MI2009A001065A IT MI20091065 A ITMI20091065 A IT MI20091065A IT 1399351 B1 IT1399351 B1 IT 1399351B1
Authority
IT
Italy
Prior art keywords
conjugates
glycosaminoglican
gag
synthesis
procedure
Prior art date
Application number
ITMI2009A001065A
Other languages
English (en)
Inventor
Este Matteo D
Davide Renier
Gianfranco Pasut
Antonio Rosato
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2009A001065A priority Critical patent/IT1399351B1/it
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Priority to US13/378,660 priority patent/US9034624B2/en
Priority to BR112012000551A priority patent/BR112012000551A2/pt
Priority to HK13104285.1A priority patent/HK1176954B/xx
Priority to EP10725052.4A priority patent/EP2443156B1/en
Priority to MX2011013683A priority patent/MX2011013683A/es
Priority to PCT/EP2010/003634 priority patent/WO2010145821A1/en
Priority to CA2765739A priority patent/CA2765739C/en
Priority to CN201080026531.8A priority patent/CN102803297B/zh
Priority to SM20170012T priority patent/SMT201700012T1/it
Priority to RU2011151396/15A priority patent/RU2530649C2/ru
Priority to ES10725052.4T priority patent/ES2600358T3/es
Publication of ITMI20091065A1 publication Critical patent/ITMI20091065A1/it
Application granted granted Critical
Publication of IT1399351B1 publication Critical patent/IT1399351B1/it
Priority to SM201700012T priority patent/SMT201700012B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ITMI2009A001065A 2009-06-16 2009-06-16 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi IT1399351B1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITMI2009A001065A IT1399351B1 (it) 2009-06-16 2009-06-16 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
CN201080026531.8A CN102803297B (zh) 2009-06-16 2010-06-04 糖胺聚糖类(gag)与生物活性分子的缀合物的合成方法、聚合缀合物及其相关用途
HK13104285.1A HK1176954B (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (gag) with biologically active molecules, polymeric conjugates and relative uses thereof
EP10725052.4A EP2443156B1 (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (gag) with biologically active molecules, polymeric conjugates and relative uses thereof
MX2011013683A MX2011013683A (es) 2009-06-16 2010-06-04 Procecedimiento para la sintesis de conjugados de glicosaminoglicanos con moleculas biologicamente activas, conjugados polimericos y sus usos relativos.
PCT/EP2010/003634 WO2010145821A1 (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (gag) with biologically active molecules, polymeric conjugates and relative uses thereof
US13/378,660 US9034624B2 (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (GAG) with biologically active molecules, polymeric conjugates and relative uses thereof
BR112012000551A BR112012000551A2 (pt) 2009-06-16 2010-06-04 processo para a síntese de conjugados de glicosaminoglicanos (gags) com moléculas biologicamente ativas, conjugados poliméricos e usos relativos dos mesmos.
SM20170012T SMT201700012T1 (it) 2009-06-16 2010-06-04 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
RU2011151396/15A RU2530649C2 (ru) 2009-06-16 2010-06-04 Способ синтеза конъюгатов гликозаминогликанов (gag) с биологически активными молекулами, полимерные конъюгаты и их соответствующие применения
ES10725052.4T ES2600358T3 (es) 2009-06-16 2010-06-04 Procedimiento para la síntesis de conjugados de glicosaminoglicanos (GAG) con moléculas biológicamente activas, conjugados poliméricos y sus usos relativos
CA2765739A CA2765739C (en) 2009-06-16 2010-06-04 Process for the synthesis of conjugates of glycosaminoglycanes (gag) with biologically active molecules, polymeric conjugates and relative uses thereof
SM201700012T SMT201700012B (it) 2009-06-16 2017-01-12 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A001065A IT1399351B1 (it) 2009-06-16 2009-06-16 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi

Publications (2)

Publication Number Publication Date
ITMI20091065A1 ITMI20091065A1 (it) 2010-12-17
IT1399351B1 true IT1399351B1 (it) 2013-04-16

Family

ID=41571532

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A001065A IT1399351B1 (it) 2009-06-16 2009-06-16 Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi

Country Status (11)

Country Link
US (1) US9034624B2 (it)
EP (1) EP2443156B1 (it)
CN (1) CN102803297B (it)
BR (1) BR112012000551A2 (it)
CA (1) CA2765739C (it)
ES (1) ES2600358T3 (it)
IT (1) IT1399351B1 (it)
MX (1) MX2011013683A (it)
RU (1) RU2530649C2 (it)
SM (2) SMT201700012T1 (it)
WO (1) WO2010145821A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2656350T3 (es) 2008-03-28 2018-02-26 The Regents Of The University Of California Conjugados polipéptido-polímero y procedimientos de uso de los mismos
EP2682409B1 (en) * 2011-03-03 2017-07-05 Chugai Seiyaku Kabushiki Kaisha Derivative of hyaluronic acid modified with amino-carboxylic acid
ITMI20121597A1 (it) * 2012-09-25 2014-03-26 Beta Pharma S A Coniugato tra frammento di parete cellulare batterica ed un veicolo mucopolisaccaridico e suoi usi in ambito medico
CN104357433A (zh) * 2014-11-03 2015-02-18 山东大学 一种6-o-季铵化壳聚糖-超氧化物歧化酶修饰物及其制备
CN104910294B (zh) * 2015-06-05 2017-08-29 西北农林科技大学 一种高分子量去乙酰化透明质酸的制备方法及其应用
ES2925248T3 (es) 2015-12-09 2022-10-14 Univ California Métodos para tratar una enfermedad o un trastorno oculares
CN106421925B (zh) * 2016-09-08 2019-01-29 中国医学科学院生物医学工程研究所 基于糖胺聚糖仿生细胞外基质水凝胶作为胰岛培养支架的制备方法
JP7216006B2 (ja) 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
EP3661919A4 (en) * 2017-08-02 2021-03-31 Northwestern University SUBSTITUTED FUSION PYRIMIDINE COMPOUNDS AND THEIR USES
WO2020064844A1 (en) * 2018-09-26 2020-04-02 Ascendis Pharma A/S Treatment of infections
IL282609B2 (en) 2018-10-26 2025-05-01 St Oncologico Veneto Iov Irccs Hyaluronic acid as a natural adjuvant for protein and peptide-based vaccines
US11732060B2 (en) 2019-01-30 2023-08-22 Bausch & Lomb Incorporated Crosslinked polymeric network and use thereof
EP3962961A1 (en) 2019-04-29 2022-03-09 Bausch & Lomb Incorporated Glycophospholipid polymeric network and use thereof
AU2021325696A1 (en) * 2020-08-14 2023-02-16 Idris Oncology B.V. A process for applying a coating comprising hyaluronic acid onto the surface of a medical sampling device, and the medical sampling device for capture of circulating tumor cells provided with the coating
EP4198060A4 (en) * 2020-08-14 2024-09-04 The University of Tokyo Polysaccharide derivative, polysaccharide derivative-drug conjugate, and method for producing same
CN113402633B (zh) * 2021-07-22 2022-04-05 山东大学 一种透明质酸-超氧化物歧化酶结合物及其在皮肤护理产品中的应用
CN114805631A (zh) * 2022-03-01 2022-07-29 吉林省奇健生物技术有限公司 高活性透明质酸-多肽缀合物及其制备方法和应用
CN116239707B (zh) * 2023-05-08 2023-07-14 山东大学 一种胰岛素修饰的肝素衍生物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE57931B1 (en) 1983-10-11 1993-05-19 Fidia Spa Hyaluronic acid fractions having pharmaceutical activity,methods for preparation thereof,and pharmaceutical compositions containing the same
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
IT1317359B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
US7034127B2 (en) 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
AU2006248166B2 (en) * 2005-05-20 2012-11-01 Agency For Science, Technology And Research Aldehyde conjugated flavonoid preparations
RU2343932C1 (ru) * 2007-03-28 2009-01-20 Институт нефтехимии и катализа РАН Способ получения обладающих пониженной растворимостью в воде пленочных материалов на основе модифицированных аминосалициловыми кислотами карбоксилсодержащих полисахаридов
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative

Also Published As

Publication number Publication date
RU2011151396A (ru) 2013-07-27
SMT201700012B (it) 2017-03-08
CN102803297A (zh) 2012-11-28
CN102803297B (zh) 2014-12-10
CA2765739C (en) 2017-05-09
US20120114602A1 (en) 2012-05-10
ITMI20091065A1 (it) 2010-12-17
WO2010145821A1 (en) 2010-12-23
EP2443156B1 (en) 2016-09-28
CA2765739A1 (en) 2010-12-23
HK1176954A1 (en) 2013-08-09
ES2600358T3 (es) 2017-02-08
US9034624B2 (en) 2015-05-19
MX2011013683A (es) 2012-01-20
RU2530649C2 (ru) 2014-10-10
SMT201700012T1 (it) 2017-03-08
EP2443156A1 (en) 2012-04-25
BR112012000551A2 (pt) 2016-11-16

Similar Documents

Publication Publication Date Title
SMT201700012B (it) Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
DK2479174T3 (da) 6-aminoquinazolin- eller 3-cyanquinolinderivater, fremstillingsfremgangsmåder og farmaceutiske anvendelser deraf
BRPI1012861A2 (pt) catalisador, e, uso do catalisador
BRPI0821590A2 (pt) Eletrodo médico, conjunto de eletrodos e disposição de conjuntos de eletrodos
BRPI0812134A2 (pt) Anatagonistas de cxcr4 de peptídio cíclico
BR112012004335A2 (pt) composto, composição farmacêutica, e, uso do composto.
BRPI0818373A2 (pt) compostos de pelicetal, síntese e aplicações
BRPI0908885A2 (pt) sistemas de varredura
EP2425634A4 (en) HEADSET SYSTEM
BRPI0818453A2 (pt) sistema de cirurgia não-invasiva de base fotônica
BRPI1014876A2 (pt) "diamidas de azetidinila como inibidores de monoacilglicerol lipase."
BRPI0819301A2 (pt) Gerador de pontos, e , microscópio de varredura de multipontos
EP2144483A4 (en) DECAY-REDUCING FIXATION STRUCTURE
BR112012012934A2 (pt) ''formulações de espuma isentas de emulsificante, estabilizadas com polímero''
EP2146771A4 (en) INTRAKAVITARY RADIATION SYSTEM
DK3115370T3 (da) Biologisk aktive peptider
BRPI0817065A2 (pt) Produção de óxido de etileno usando concentração fixa de moderador.
BRPI1012156A2 (pt) instrumento endoscópico.
EP2331277A4 (en) BARBELL STRUCTURE OF HIGH STRENGTH AND LIGHT WEIGHT
BR112012008053A2 (pt) fermentação purificação de heparosano k5.
BRPI1006058A2 (pt) "fermentação de carboidrato"
EP2137404A4 (en) WAVE POWER PLANT
BR112012001346A2 (pt) catálise de formulações de resina de epóxido com catalisadores dificilmente solúveis
FR2937857B1 (fr) Membrane chirurgicale antiadherence
BRPI0911578A2 (pt) ensaio de acetaminofeno.