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IT1268955B1 - Esteri attivi di polisaccaridi carbossilici - Google Patents

Esteri attivi di polisaccaridi carbossilici

Info

Publication number
IT1268955B1
IT1268955B1 IT1994PD000043A ITPD940043A IT1268955B1 IT 1268955 B1 IT1268955 B1 IT 1268955B1 IT 1994PD000043 A IT1994PD000043 A IT 1994PD000043A IT PD940043 A ITPD940043 A IT PD940043A IT 1268955 B1 IT1268955 B1 IT 1268955B1
Authority
IT
Italy
Prior art keywords
polysaccharides
active esters
carboxy
pct
modified
Prior art date
Application number
IT1994PD000043A
Other languages
English (en)
Inventor
Zefferino Righetto
Davide Bellini
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of ITPD940043A0 publication Critical patent/ITPD940043A0/it
Priority to IT1994PD000043A priority Critical patent/IT1268955B1/it
Priority to DK95913099T priority patent/DK0749446T3/da
Priority to PT95913099T priority patent/PT749446E/pt
Priority to ES95913099T priority patent/ES2141925T3/es
Priority to AT95913099T priority patent/ATE186916T1/de
Priority to PCT/EP1995/000932 priority patent/WO1995024429A1/en
Priority to DE69513507T priority patent/DE69513507T2/de
Priority to US08/702,673 priority patent/US5856299A/en
Priority to EP95913099A priority patent/EP0749446B1/en
Priority to CA002184899A priority patent/CA2184899C/en
Publication of ITPD940043A1 publication Critical patent/ITPD940043A1/it
Application granted granted Critical
Publication of IT1268955B1 publication Critical patent/IT1268955B1/it
Priority to GR20000400284T priority patent/GR3032589T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
IT1994PD000043A 1994-03-11 1994-03-11 Esteri attivi di polisaccaridi carbossilici IT1268955B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT1994PD000043A IT1268955B1 (it) 1994-03-11 1994-03-11 Esteri attivi di polisaccaridi carbossilici
DE69513507T DE69513507T2 (de) 1994-03-11 1995-03-13 Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide
PT95913099T PT749446E (pt) 1994-03-11 1995-03-13 Esteres altamente reactivos de carboxi-polissacaridos e novos carboxi-polissacaridos derivados desses compostos
ES95913099T ES2141925T3 (es) 1994-03-11 1995-03-13 Esteres altamente reactivos de carboxi polisacaridos y nuevos carboxi polisacaridos derivados de los mismos.
AT95913099T ATE186916T1 (de) 1994-03-11 1995-03-13 Hochreactive estern von karboxylgruppen enthaltenden polysachariden und die daraus hergestellte carboxypolysaccharide
PCT/EP1995/000932 WO1995024429A1 (en) 1994-03-11 1995-03-13 Highly reactive esters of carboxy polysaccharides and novel carboxy polysaccharides derived therefrom
DK95913099T DK0749446T3 (da) 1994-03-11 1995-03-13 Stærkt reaktive estere af carboxypolysaccharider og hidtil ukendte carboxypolysaccharider afledt deraf
US08/702,673 US5856299A (en) 1994-03-11 1995-03-13 Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom
EP95913099A EP0749446B1 (en) 1994-03-11 1995-03-13 Highly reactive esters of carboxy polysaccharides and novel carboxy polysaccharides derived therefrom
CA002184899A CA2184899C (en) 1994-03-11 1995-03-13 Highly reactive esters of carboxy polysaccharides and novel carboxy polysaccharides derived therefrom
GR20000400284T GR3032589T3 (en) 1994-03-11 2000-02-04 Highly reactive esters of carboxy polysaccharides and novel carboxy polysaccharides derived therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1994PD000043A IT1268955B1 (it) 1994-03-11 1994-03-11 Esteri attivi di polisaccaridi carbossilici

Publications (3)

Publication Number Publication Date
ITPD940043A0 ITPD940043A0 (it) 1994-03-11
ITPD940043A1 ITPD940043A1 (it) 1995-09-11
IT1268955B1 true IT1268955B1 (it) 1997-03-18

Family

ID=11390595

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1994PD000043A IT1268955B1 (it) 1994-03-11 1994-03-11 Esteri attivi di polisaccaridi carbossilici

Country Status (11)

Country Link
US (1) US5856299A (it)
EP (1) EP0749446B1 (it)
AT (1) ATE186916T1 (it)
CA (1) CA2184899C (it)
DE (1) DE69513507T2 (it)
DK (1) DK0749446T3 (it)
ES (1) ES2141925T3 (it)
GR (1) GR3032589T3 (it)
IT (1) IT1268955B1 (it)
PT (1) PT749446E (it)
WO (1) WO1995024429A1 (it)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
IT1287698B1 (it) * 1996-08-29 1998-08-18 Fidia Advanced Biopolymers Srl Fili da sutura essenzialmente costituiti da derivati esterei dello acido ialuronico
US6632802B2 (en) * 1996-08-29 2003-10-14 Fidia Advanced Biopolymers S.R.L. Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
EP1806367A3 (en) * 1996-09-19 2007-11-28 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates
AU733716B2 (en) * 1996-09-19 2001-05-24 Regents Of The University Of Michigan, The Polymers containing polysaccharides such as alginates or modified alginates
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
IT1301994B1 (it) * 1998-08-05 2000-07-20 Jasper Ltd Liability Co Derivati dell'acido ialuronico.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6398911B1 (en) 2000-01-21 2002-06-04 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing polysiloxane moieties
US6596126B1 (en) * 1999-01-25 2003-07-22 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing aliphatic hydrocarbon moieties
US6896769B2 (en) 1999-01-25 2005-05-24 Kimberly-Clark Worldwide, Inc. Modified condensation polymers containing azetidinium groups in conjunction with amphiphilic hydrocarbon moieties
US6517678B1 (en) 2000-01-20 2003-02-11 Kimberly-Clark Worldwide, Inc. Modified polysaccharides containing amphiphillic hydrocarbon moieties
US6465602B2 (en) 2000-01-20 2002-10-15 Kimberly-Clark Worldwide, Inc. Modified condensation polymers having azetidinium groups and containing polysiloxane moieties
IT1317091B1 (it) * 2000-02-08 2003-05-26 S F I R Societa Fondaria Ind R Gel di acido ialuronico cross-linked con l-amminoacidi ol-amminoesteri bifunzionali.
US20030049253A1 (en) * 2001-08-08 2003-03-13 Li Frank Q. Polymeric conjugates for delivery of MHC-recognized epitopes via peptide vaccines
AU2003294318A1 (en) * 2002-11-15 2004-06-15 Arizona Board Of Regents Arizona State University Therapeutic bioconjugates
EP1595892A4 (en) 2003-02-21 2007-06-20 Terumo Corp NETWORKABLE POLYSACCHARIDE DERIVATIVE, PRODUCTION PROCESS THEREFOR, COMPOSIBLE POLYSACCHARID DERIVATIVE COMPOSITION, AND MATERIAL FOR MEDICAL TREATMENT
US20050095219A1 (en) * 2003-10-29 2005-05-05 Shu-Ping Yang Compositions for promoting vaginal cell proliferation and maturation
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
ITPD20050056A1 (it) 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
EP2106263B1 (en) 2007-01-04 2016-12-21 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
WO2009133763A1 (ja) * 2008-05-01 2009-11-05 テルモ株式会社 視認性医療用処置材
ITMI20080981A1 (it) * 2008-05-27 2009-11-28 Fidia Advanced Biopolymers Srl Processo per la preparazione di microsfere di polimeri semi-sintetici
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
JP5604072B2 (ja) * 2009-09-28 2014-10-08 テルモ株式会社 活性エステル化多糖およびその製造方法
FR2966248B1 (fr) 2010-10-18 2020-05-01 Centre National De La Recherche Scientifique (Cnrs) Procede de fonctionnalisation de surfaces pour la detection d'analytes
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
FR3066386B1 (fr) * 2017-05-18 2020-08-28 Bioxis Pharmaceuticals Procede de preparation d'un gel aqueux d'acide hyaluronique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2881161A (en) * 1955-03-25 1959-04-07 Henkel & Cie Gmbh Amides of alginic acid
DD121785A1 (it) * 1975-08-06 1976-08-20
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
IT1203814B (it) * 1986-06-30 1989-02-23 Fidia Farmaceutici Esteri dell'acido alginico
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5332809A (en) * 1991-02-11 1994-07-26 Fidia S.P.A. Partial esters of gellan

Also Published As

Publication number Publication date
WO1995024429A1 (en) 1995-09-14
DE69513507T2 (de) 2000-07-06
CA2184899A1 (en) 1995-08-14
ES2141925T3 (es) 2000-04-01
CA2184899C (en) 2006-05-30
EP0749446A1 (en) 1996-12-27
DK0749446T3 (da) 2000-05-08
PT749446E (pt) 2000-05-31
US5856299A (en) 1999-01-05
DE69513507D1 (de) 1999-12-30
GR3032589T3 (en) 2000-05-31
ITPD940043A1 (it) 1995-09-11
ATE186916T1 (de) 1999-12-15
EP0749446B1 (en) 1999-11-24
ITPD940043A0 (it) 1994-03-11

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990210